Effects of Supplemental Vitamin D3, Omega-3 Fatty Acids on Physical Performance Measures in VITamin D and OmegA-3 TriaL
CONCLUSIONS: Neither supplemental vitamin D3 nor marine omega-3 fatty acids for 2 years improved physical performance in this generally healthy adult population.PMID:38488491 | DOI:10.1210/clinem/dgae150 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 15, 2024 Category: Endocrinology Authors: Sharon H Chou Nancy R Cook Gregory Kotler Eunjung Kim Trisha Copeland I-Min Lee Peggy M Cawthon Julie E Buring JoAnn E Manson Meryl S LeBoff Source Type: research
Comprehensive analysis of vitamin D3 impurities in oily drug products using supercritical fluid chromatography –mass spectrometry
This study presents the development of a method for detecting and quantifying seven impurities of vitamin D3 in oily drug products using supercritical fluid chromatography –mass spectrometry (SFC-MS). Targeted impurities include two esters of vitamin D3 and five non-esters including four that are isobaric to vitamin D3. Firstly, a screening study highlighted the Torus 1-AA column and acetonitrile modifier as adequate for the separation, followed by optimization of the SFC conditions. Secondly, make-up solvent composition and MS settings were optimized to reach high sensitivity. For both the separation and MS response, th...
Source: Drug Testing and Analysis - March 14, 2024 Category: Drugs & Pharmacology Authors: Hugues Jambo,
Amandine Dispas,
Leticia P érez‐Mayán,
Isaac Rodríguez,
Éric Ziemons,
Philippe Hubert Tags: SPECIAL ISSUE ‐ RESEARCH ARTICLE Source Type: research
The Association between the Expression of MicroRNA-4270 and MicroRNA-4441 with some Metabolic Factors in Iranian Rheumatoid Arthritis Patients
Iran J Allergy Asthma Immunol. 2023 Dec 28;22(6):536-550. doi: 10.18502/ijaai.v22i6.14643.ABSTRACTMicroRNAs (miRs) play a role in several diseases, such as rheumatoid arthritis (RA). The purpose of this study was to discover new microRNAs and investigate their involvement in RA, examining their connections with inflammation and metabolic markers. New microRNAs related to RA were predicted using Mirbase and TargetScan databases based on RA target genes. The relationships between miRNAs and targets were visualized with Cytoscape software. Real-time polymerase chain reaction confirmed detectable miRNAs and metabolic factors w...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Sepideh Ghodoosifar Gholamreza Dehghan Reza Safaralizadeh Behzad Baradaran Mehrzad Hajialiloo Source Type: research
The Association between the Expression of MicroRNA-4270 and MicroRNA-4441 with some Metabolic Factors in Iranian Rheumatoid Arthritis Patients
Iran J Allergy Asthma Immunol. 2023 Dec 28;22(6):536-550. doi: 10.18502/ijaai.v22i6.14643.ABSTRACTMicroRNAs (miRs) play a role in several diseases, such as rheumatoid arthritis (RA). The purpose of this study was to discover new microRNAs and investigate their involvement in RA, examining their connections with inflammation and metabolic markers. New microRNAs related to RA were predicted using Mirbase and TargetScan databases based on RA target genes. The relationships between miRNAs and targets were visualized with Cytoscape software. Real-time polymerase chain reaction confirmed detectable miRNAs and metabolic factors w...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Sepideh Ghodoosifar Gholamreza Dehghan Reza Safaralizadeh Behzad Baradaran Mehrzad Hajialiloo Source Type: research
GSE260981 Transcriptome of vitamin D3 bolus supplementation in a cohort of 25 individuals
In this study, we analyse the in-vivo modulation of the transcriptome of human PBMCs by a bolus of vitamin D3 (80,000 IU) after 24 hours. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 11, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Smooth muscle cell-specific MMP-3 deletion reduces osteogenic transformation and medial artery calcification
CONCLUSION: These findings suggest that MMP-3 expression in vascular SMCs is an important regulator of medial calcification and that targeting MMP-3 could provide a therapeutic strategy to reduce it and address its consequences in patients with PAD.PMID:38454645 | DOI:10.1093/cvr/cvae035 (Source: Cell Research)
Source: Cell Research - March 8, 2024 Category: Cytology Authors: Yangzhouyun Xie Tonghui Lin Ying Jin Alexa G Berezowitz Xue-Lin Wang Jinny Lu Yujun Cai Raul J Guzman Source Type: research
Smooth muscle cell-specific MMP-3 deletion reduces osteogenic transformation and medial artery calcification
CONCLUSION: These findings suggest that MMP-3 expression in vascular SMCs is an important regulator of medial calcification and that targeting MMP-3 could provide a therapeutic strategy to reduce it and address its consequences in patients with PAD.PMID:38454645 | DOI:10.1093/cvr/cvae035 (Source: Atherosclerosis)
Source: Atherosclerosis - March 8, 2024 Category: Cardiology Authors: Yangzhouyun Xie Tonghui Lin Ying Jin Alexa G Berezowitz Xue-Lin Wang Jinny Lu Yujun Cai Raul J Guzman Source Type: research
Chitin nanocrystals/alginate complex for tuning stability, rheology and bioavailability of cholecalciferol in Pickering emulsions
Int J Biol Macromol. 2024 Mar 6:130671. doi: 10.1016/j.ijbiomac.2024.130671. Online ahead of print.ABSTRACTIn this paper we investigate polyelectrolyte complexes of sodium alginate (Alg) and chitin nanocrystals (ChNC). Formation, stability and transport properties of O/W sunflower oil emulsions stabilized by ChNC-Alg complex were studied using dynamic light scattering (DLS), laser Doppler electrophoresis, optical microscopy, potentiometric titration, rheology and simulated digestion. It has been established that during emulsions formation, the ChNC-Alg complex is rearranged at the interface and the formation of a two-layer...
Source: International Journal of Biological Macromolecules - March 8, 2024 Category: Biochemistry Authors: Mikhail A Torlopov Irina N Vaseneva Vasily I Mikhaylov Ilia S Martakov Philipp V Legki Petr A Sitnikov Source Type: research
Smooth muscle cell-specific MMP-3 deletion reduces osteogenic transformation and medial artery calcification
CONCLUSION: These findings suggest that MMP-3 expression in vascular SMCs is an important regulator of medial calcification and that targeting MMP-3 could provide a therapeutic strategy to reduce it and address its consequences in patients with PAD.PMID:38454645 | DOI:10.1093/cvr/cvae035 (Source: Atherosclerosis)
Source: Atherosclerosis - March 8, 2024 Category: Cardiology Authors: Yangzhouyun Xie Tonghui Lin Ying Jin Alexa G Berezowitz Xue-Lin Wang Jinny Lu Yujun Cai Raul J Guzman Source Type: research
Molecules, Vol. 29, Pages 1153: Vitamin D3 Bioaccessibility from Supplements and Foods & mdash;Gastric pH Effect Using a Static In Vitro Gastrointestinal Model
Molecules, Vol. 29, Pages 1153: Vitamin D3 Bioaccessibility from Supplements and Foods—Gastric pH Effect Using a Static In Vitro Gastrointestinal Model
Molecules doi: 10.3390/molecules29051153
Authors:
Evangelia Pasidi
Patroklos Vareltzis
Vitamin D3 deficiency is a global phenomenon, which can be managed with supplementation and food fortification. However, vitamin D3 bioaccessibility may depend on factors such as matrix composition and interactions throughout the gastrointestinal (GI) tract. This research focused on the effect of different matrices on vitamin D3 content during digestion, as well as the...
Source: Molecules - March 5, 2024 Category: Chemistry Authors: Evangelia Pasidi Patroklos Vareltzis Tags: Article Source Type: research
A study to assess the relationship between vitamin D3 levels and the risk of acute exacerbation in patients with chronic obstructive pulmonary disease
Monaldi Arch Chest Dis. 2024 Mar 1. doi: 10.4081/monaldi.2024.2885. Online ahead of print.ABSTRACTChronic obstructive pulmonary disease (COPD) is one of the top three causes of mortality worldwide. Vitamin D deficiency in COPD has been associated with poor lung function and decreased muscle power, which further increases the risk of exacerbations. The role of vitamin D in preventing acute exacerbations of COPD has conflicting results in the literature. Hence, we planned this study to assess the relationship between vitamin D3 levels and the risk of acute exacerbations among COPD patients in a tertiary care center in north ...
Source: Monaldi Archives for Chest Disease - March 4, 2024 Category: Respiratory Medicine Authors: Ankit Lakra Balbir Singh Ashok Kumar Janmeja Vanita Sharma Arjun Kumar Source Type: research
Network pharmacology analysis and clinical efficacy of the traditional Chinese medicine Bu-Shen-Jian-Pi. Part 3: Alleviation of hypoxia, muscle-wasting, and modulation of redox functions in amyotrophic lateral sclerosis
CONCLUSION: BSJP treatment reduced the rate of progression of amyotrophic lateral sclerosis according to the ALS-SSITS and ALSFRS scores and significantly reduced the rate of deterioration in muscle function in the limbs of amyotrophic lateral sclerosis patients. The modes of action of BSJP in treating amyotrophic lateral sclerosis are probably diverse and multi targeted, some of which may involve regulation of serum vitamin D3 and alleviation of the impairments in liver and kidney function.PMID:38431830 | DOI:10.5414/CP204520 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - March 3, 2024 Category: Drugs & Pharmacology Authors: Rui Li Xiaojing Han Qiudong Wang Chenghui Wang Wei Jing Haihan Zhang Jun Wang Weidong Pan Source Type: research
Network pharmacology analysis and clinical efficacy of the traditional Chinese medicine Bu-Shen-Jian-Pi. Part 3: Alleviation of hypoxia, muscle-wasting, and modulation of redox functions in amyotrophic lateral sclerosis
CONCLUSION: BSJP treatment reduced the rate of progression of amyotrophic lateral sclerosis according to the ALS-SSITS and ALSFRS scores and significantly reduced the rate of deterioration in muscle function in the limbs of amyotrophic lateral sclerosis patients. The modes of action of BSJP in treating amyotrophic lateral sclerosis are probably diverse and multi targeted, some of which may involve regulation of serum vitamin D3 and alleviation of the impairments in liver and kidney function.PMID:38431830 | DOI:10.5414/CP204520 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - March 3, 2024 Category: Drugs & Pharmacology Authors: Rui Li Xiaojing Han Qiudong Wang Chenghui Wang Wei Jing Haihan Zhang Jun Wang Weidong Pan Source Type: research
