Telmisartan Ameliorates Nephropathy and Restores the Hippo Pathway in Rats with Metabolic Syndrome
Eur J Pharmacol. 2024 Apr 21:176605. doi: 10.1016/j.ejphar.2024.176605. Online ahead of print.ABSTRACTThe main objective of this study was to determine if the telmisartan-ameliorative effects of metabolic syndrome (MetS)-evoked nephropathy are attributed to the Hippo pathway. A secondary objective was to investigate the potential of vitamin D3 to enhance telmisartan-favourable effects. A diet composed of 24% fat and 3% salt, along with drinking water containing 10% fructose, was administered for 12 weeks to induce MetS. MetS-rats were given telmisartan (5 mg/kg/day), vitamin D3 (10 μg/kg/day) or both by gavage, starting i...
Source: European Journal of Pharmacology - April 23, 2024 Category: Drugs & Pharmacology Authors: Badria Mohamed Salah A Ghareib Amira Ebrahim Alsemeh Shaimaa S El-Sayed Source Type: research
Telmisartan ameliorates nephropathy and restores the hippo pathway in rats with metabolic syndrome
Eur J Pharmacol. 2024 Apr 21;973:176605. doi: 10.1016/j.ejphar.2024.176605. Online ahead of print.ABSTRACTThe main objective of this study was to determine if the telmisartan-ameliorative effects of metabolic syndrome (MetS)-evoked nephropathy are attributed to the Hippo pathway. A secondary objective was to investigate the potential of vitamin D3 to enhance telmisartan-favourable effects. A diet composed of 24% fat and 3% salt, along with drinking water containing 10% fructose, was administered for 12 weeks to induce MetS. MetS-rats were given telmisartan (5 mg/kg/day), vitamin D3 (10 μg/kg/day) or both by gavage, starti...
Source: European Journal of Pharmacology - April 23, 2024 Category: Drugs & Pharmacology Authors: Badria Mohamed Salah A Ghareib Amira Ebrahim Alsemeh Shaimaa S El-Sayed Source Type: research
Correlation between maternal and umbilical cord 25-hydroxy-vitamin D levels over a range of values. A prospective observational study from the United Arab Emirates
by Magnus Jutell, Shakura Bhat, Maria Lindstrom Bagge, Per-Erik Isberg, Nana Wiberg
Worldwide vitamin D insufficiency is remarkably prevalent in both children and adults, including pregnant women. The total amount of the vitamin is best measured by 25-hydroxy-vitamin D (25(OH)D), which is a measurement of total serum cholecalciferol 25(OH)D3 and ergocalciferol 25(OH)D2. There is a known correlation between maternal and umbilical cord blood (UCB) 25(OH)D; however, whether specific maternal demographics or comorbidities influence the correlation remains uncertain. This prospective observational study was designed to study i...
Source: PLoS One - April 23, 2024 Category: Biomedical Science Authors: Magnus Jutell Source Type: research
Vitamin D3 among neonates born after in vitro fertilization compared with neonates from the general population
ConclusionsIn this study, children born after in vitro fertilization have a higher vitamin D3 than a random sample of neonates in Denmark. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - April 19, 2024 Category: OBGYN Authors: Karen Christina Walker,
Sofie Gry Pristed,
Fanney Thorsteinsdottir,
Ina Olmer Specht,
Arieh Cohen,
Berit Lilienthal Heitmann,
Ulrik Schi øler Kesmodel Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
The effects of cholecalciferol and afamelanotide on vitamin D levels in erythropoietic protoporphyria; a multicentre cohort study
CONCLUSION: Cholecalciferol remains essential for treatment of vitamin D deficiency in EPP, irrespective of new treatment options like afamelanotide. Afamelanotide treatment did not affect vitamin D levels. We suggest that future guidelines include continuous monitoring of vitamin D and prescription of cholecalciferol in all patients with EPP, including those treated with afamelanotide.PMID:38634774 | DOI:10.1093/bjd/ljae148 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 18, 2024 Category: Dermatology Authors: Louisa G Kluijver Mitra Nekouei Shahraki Margreet A E M Wagenmakers Bettina E Hanssen Viola Kuerten Kathrin Schelonke Bernhard Homey Janneke G Langendonk Source Type: research
Vitamin D3 and zinc supplements augment the antimanic efficacy of lithium and olanzapine treatments in an animal model of mania
. (Source: Nutritional Neuroscience)
Source: Nutritional Neuroscience - April 18, 2024 Category: Nutrition Authors: Aya A. S. HuzayyinMichael K. IbrahimNahed M. A. HassaneinHelmy M. S. Ahmeda Central Administration of Drug Control, Egyptian Drug Authority (EDA), Giza, Egyptb Central Administration of Biological and Innovative Products and Clinical Studies, Egyptian Dru Source Type: research
Differential effects of cholecalciferol and calcitriol on muscle proteolysis and oxidative stress in angiotensin II ‐induced C2C12 myotube atrophy
Cholecalciferol exhibited beneficial roles, whereas calcitriol possessed the negative impact on skeletal muscle proteostasis in angiotensin II-induced muscle atrophy. AbstractRenin –angiotensin system activation contributes to skeletal muscle atrophy in aging individuals with chronic diseases. We aimed to explore the effects of cholecalciferol (VD3) and calcitriol (1,25VD3) on signaling of muscle proteolysis and oxidative stress in myotubes challenged with angiotensin II (AII). The mouse C2C12 myotubes were assigned to vehicle, AII, AII + VD3, AII + 1,25VD3, and AII + losartan groups. The expression levels...
Source: Physiological Reports - April 17, 2024 Category: Physiology Authors: Muthita Hirunsai,
Ratchakrit Srikuea Tags: ORIGINAL ARTICLE Source Type: research
Recent Advances in the Nutrition and Metabolism of Dogs and Cats
Adv Exp Med Biol. 2024;1446:1-14. doi: 10.1007/978-3-031-54192-6_1.ABSTRACTDomestic dogs (facultative carnivores) and cats (obligate carnivores) have been human companions for at least 12,000 and 9000 years, respectively. These animal species have a relatively short digestive tract but a large stomach volume and share many common features of physiological processes, intestinal microbes, and nutrient metabolism. The taste buds of the canine and feline tongues can distinguish sour, umami, bitter, and salty substances. Dogs, but not cats, possess sweet receptors. α-Amylase activity is either absent or very low in canine and ...
Source: Advances in Experimental Medicine and Biology - April 16, 2024 Category: Research Authors: Guoyao Wu Source Type: research
Characteristics of Nutrition and Metabolism in Dogs and Cats
Adv Exp Med Biol. 2024;1446:55-98. doi: 10.1007/978-3-031-54192-6_4.ABSTRACTDomestic dogs and cats have evolved differentially in some aspects of nutrition, metabolism, chemical sensing, and feeding behavior. The dogs have adapted to omnivorous diets containing taurine-abundant meat and starch-rich plant ingredients. By contrast, domestic cats must consume animal-sourced foods for survival, growth, and development. Both dogs and cats synthesize vitamin C and many amino acids (AAs, such as alanine, asparagine, aspartate, glutamate, glutamine, glycine, proline, and serine), but have a limited ability to form de novo arginine...
Source: Advances in Experimental Medicine and Biology - April 16, 2024 Category: Research Authors: Peng Li Guoyao Wu Source Type: research
Recent Advances in the Nutrition and Metabolism of Dogs and Cats
Adv Exp Med Biol. 2024;1446:1-14. doi: 10.1007/978-3-031-54192-6_1.ABSTRACTDomestic dogs (facultative carnivores) and cats (obligate carnivores) have been human companions for at least 12,000 and 9000 years, respectively. These animal species have a relatively short digestive tract but a large stomach volume and share many common features of physiological processes, intestinal microbes, and nutrient metabolism. The taste buds of the canine and feline tongues can distinguish sour, umami, bitter, and salty substances. Dogs, but not cats, possess sweet receptors. α-Amylase activity is either absent or very low in canine and ...
Source: Advances in Experimental Medicine and Biology - April 16, 2024 Category: Research Authors: Guoyao Wu Source Type: research
Characteristics of Nutrition and Metabolism in Dogs and Cats
Adv Exp Med Biol. 2024;1446:55-98. doi: 10.1007/978-3-031-54192-6_4.ABSTRACTDomestic dogs and cats have evolved differentially in some aspects of nutrition, metabolism, chemical sensing, and feeding behavior. The dogs have adapted to omnivorous diets containing taurine-abundant meat and starch-rich plant ingredients. By contrast, domestic cats must consume animal-sourced foods for survival, growth, and development. Both dogs and cats synthesize vitamin C and many amino acids (AAs, such as alanine, asparagine, aspartate, glutamate, glutamine, glycine, proline, and serine), but have a limited ability to form de novo arginine...
Source: Advances in Experimental Medicine and Biology - April 16, 2024 Category: Research Authors: Peng Li Guoyao Wu Source Type: research
Recent Advances in the Nutrition and Metabolism of Dogs and Cats
Adv Exp Med Biol. 2024;1446:1-14. doi: 10.1007/978-3-031-54192-6_1.ABSTRACTDomestic dogs (facultative carnivores) and cats (obligate carnivores) have been human companions for at least 12,000 and 9000 years, respectively. These animal species have a relatively short digestive tract but a large stomach volume and share many common features of physiological processes, intestinal microbes, and nutrient metabolism. The taste buds of the canine and feline tongues can distinguish sour, umami, bitter, and salty substances. Dogs, but not cats, possess sweet receptors. α-Amylase activity is either absent or very low in canine and ...
Source: Advances in Experimental Medicine and Biology - April 16, 2024 Category: Research Authors: Guoyao Wu Source Type: research
Characteristics of Nutrition and Metabolism in Dogs and Cats
Adv Exp Med Biol. 2024;1446:55-98. doi: 10.1007/978-3-031-54192-6_4.ABSTRACTDomestic dogs and cats have evolved differentially in some aspects of nutrition, metabolism, chemical sensing, and feeding behavior. The dogs have adapted to omnivorous diets containing taurine-abundant meat and starch-rich plant ingredients. By contrast, domestic cats must consume animal-sourced foods for survival, growth, and development. Both dogs and cats synthesize vitamin C and many amino acids (AAs, such as alanine, asparagine, aspartate, glutamate, glutamine, glycine, proline, and serine), but have a limited ability to form de novo arginine...
Source: Advances in Experimental Medicine and Biology - April 16, 2024 Category: Research Authors: Peng Li Guoyao Wu Source Type: research
