Vitamin D metabolism is altered during aging alone or combined with obesity in male mice
We report for the first time the effect of aging process alone or in combination with obesity on vitamin D metabolism as a whole and leading to modulation of 25(OH)D plasma levels. Our data strongly suggest that the enzymes involved in vitamin D metabolism, notably in liver, kidneys, and adipose tissue, are transcriptionally modified under aging or combined effect of aging and obesity, contributing to the reduction of the plasma 25(OH)D. AbstractAging and obesity are associated with a decrease in plasma 25-hydroxyvitamin D (25(OH)D) levels. In the context of a growing aging population and the rising incidence of obesity, w...
Source: BioFactors - February 25, 2024 Category: Biochemistry Authors: Lorrine Bournot,
Thomas Payet,
Julie Marcotorchino,
Manar Awada,
Tha ïs Rouquet,
Thomas Breniere,
Charlène Couturier,
Julien Astier,
Charlotte Halimi,
Emmanuelle Reboul,
Flavie Sicard,
Lourdes Mounien,
Julien Roux,
Bruno Bariohay,
Jean Fra Tags: RESEARCH ARTICLE Source Type: research
An 8-week vitamin D3-fortified fruit drink supplementation increases serum ferritin concentration: a randomized controlled trial in Malaysian women with low iron stores.
Limited randomized controlled trial (RCT) evidence supports the association between vitamin D deficiency and anemia risk, highlighting the necessity for further investigations into the role of vitamin D in influencing iron status (Source: Journal of the American Dietetic Association)
Source: Journal of the American Dietetic Association - February 24, 2024 Category: Nutrition Authors: Nursyafiqah Aqilah Suhaimi, Loh Su Peng, Norhafizah Ab. Manan, Nurzalinda Zalbahar, Muhammad Najib Mohamad Alwi, Salma Faeza Ahmad Fuzi Tags: Research Paper Source Type: research
VD/VDR-mediated ATG16L1 activation reduces Alzheimer ’s disease-like pathology and cognitive decline
ConclusionCCE exhibits potential in safeguarding hippocampal neurons against AD-induced harm, stimulating autophagy, and suppressing inflammation. These effects may be regulated by VD/VDR/ATG16L1 signaling. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - February 24, 2024 Category: Cytology Source Type: research
An 8-Week Vitamin D3 –Fortified Fruit Drink Supplementation Increases Serum Ferritin Concentration: A Randomized Controlled Trial in Malaysian Women With Low Iron Stores
There is limited randomized controlled trial evidence to support the association between vitamin D deficiency and anemia risk, highlighting the necessity for further investigations into the role of vitamin D in influencing iron status. (Source: Journal of the American Dietetic Association)
Source: Journal of the American Dietetic Association - February 24, 2024 Category: Nutrition Authors: Nursyafiqah Aqilah Suhaimi, Su Peng Loh, Norhafizah Ab. Manan, Nurzalinda Zalbahar, Muhammad Najib Mohamad Alwi, Salma Faeza Ahmad Fuzi Tags: Research Source Type: research
Vitamin D3 improves iminodipropionitrile-induced tic-like behavior in rats through regulation of GDNF/c-Ret signaling activity
AbstractChildren with chronic tic disorders (CTD), including Tourette syndrome (TS), have significantly reduced serum 25-hydroxyvitamin D [25(OH)D]. While vitamin D3 supplementation (VDS) may reduce tic symptoms in these children, its mechanism is unclear. The study aim was to investigate the effects and mechanisms of vitamin D deficiency (VDD) and VDS on TS model behavior. Forty 5-week-old male Sprague –Dawley rats were randomly divided into (n = 10 each): control, TS model, TS model with VDD (TS + VDD), or TS model with VDS (TS + VDS; two intramuscular injections of 20,000 IU/200 g) groups. The VDD model ...
Source: European Child and Adolescent Psychiatry - February 23, 2024 Category: Psychiatry Source Type: research
Identification of trans-genus biomarkers for early diagnosis of intestinal schistosomiasis and progression of gut pathology in a mouse model using metabolomics
by Peerut Chienwichai, Phornpimon Tipthara, Joel Tarning, Yanin Limpanont, Phiraphol Chusongsang, Yupa Chusongsang, Nuttapohn Kiangkoo, Poom Adisakwattana, Onrapak Reamtong
Schistosomiasis is one of the most devastating human diseases worldwide. The disease is caused by six species ofSchistosoma blood fluke; five of which cause intestinal granulomatous inflammation and bleeding. The current diagnostic method is inaccurate and delayed, hence, biomarker identification using metabolomics has been applied. However, previous studies only investigated infection caused by oneSchistosoma spp., leaving a gap in the use of biomarke...
Source: PLoS Neglected Tropical Diseases - February 21, 2024 Category: Tropical Medicine Authors: Peerut Chienwichai Source Type: research
Two Sesterterpene Synthases from Lentzea atacamensis Demonstrate the Role of Conformational Variability in Terpene Biosynthesis
Angew Chem Int Ed Engl. 2024 Feb 19:e202401539. doi: 10.1002/anie.202401539. Online ahead of print.ABSTRACTMining of two multiproduct sesterterpene synthases from Lentzea atacamensis resulted in the identification of the synthases for lentzeadiene (LaLDS) and atacamatriene (LaATS). The main product of LaLDS (lentzeadiene) is a new compound, while one of the side products (lentzeatetraene) is the enantiomer of brassitetraene B and the other side product (sestermobaraene F) is known from a surprisingly distantly related sesterterpene synthase. LaATS produces six new compounds, one of which is the enantiomer of the known sest...
Source: Angewandte Chemie - February 19, 2024 Category: Chemistry Authors: Binbin Gu Bernd Goldfuss Jeroen S Dickschat Source Type: research
Two Sesterterpene Synthases from Lentzea atacamensis Demonstrate the Role of Conformational Variability in Terpene Biosynthesis
Angew Chem Int Ed Engl. 2024 Feb 19:e202401539. doi: 10.1002/anie.202401539. Online ahead of print.ABSTRACTMining of two multiproduct sesterterpene synthases from Lentzea atacamensis resulted in the identification of the synthases for lentzeadiene (LaLDS) and atacamatriene (LaATS). The main product of LaLDS (lentzeadiene) is a new compound, while one of the side products (lentzeatetraene) is the enantiomer of brassitetraene B and the other side product (sestermobaraene F) is known from a surprisingly distantly related sesterterpene synthase. LaATS produces six new compounds, one of which is the enantiomer of the known sest...
Source: Angewandte Chemie - February 19, 2024 Category: Chemistry Authors: Binbin Gu Bernd Goldfuss Jeroen S Dickschat Source Type: research
Tremendous Fidelity of Vitamin D3 in Age-related Neurological Disorders
AbstractVitamin D3 (VD) is a secosteroid hormone and shows a pleiotropic effect in brain-related disorders where it regulates redox imbalance, inflammation, apoptosis, energy production, and growth factor synthesis. Vitamin D3 ’s active metabolic form, 1,25-dihydroxy Vitamin D3 (1,25(OH)2D3 or calcitriol), is a known regulator of several genes involved in neuroplasticity, neuroprotection, neurotropism, and neuroinflammation. Multiple studies suggest that VD deficiency can be proposed as a risk factor for the development of several age-related neurological disorders. The evidence for low serum levels of 25-hydroxy Vitamin...
Source: Molecular Neurobiology - February 19, 2024 Category: Neurology Source Type: research
Hypercalcaemia: intensive care or general ward
Aktuelle Urol. 2024 Feb;55(1):54-59. doi: 10.1055/a-2201-6428. Epub 2024 Feb 8.ABSTRACTHypercalcaemia is a life-threatening electrolyte imbalance, which not only occurs in the context of an endocrinological disease but is also frequently associated with a tumour. Its severity is determined by the level of deviation from normal, acuity of occurrence, and severity of the symptoms. These are unspecific, can affect any organ system and ultimately result in a life-threatening hypercalcaemic crisis characterised by cardiac arrhythmia, metabolic acidosis, exsiccosis, fever, psychotic states and, ultimately, coma. Endocrinological...
Source: Aktuelle Urologie - February 8, 2024 Category: Urology & Nephrology Authors: Jenny Mauch Katerina Cascetta Source Type: research
Hypercalcaemia: intensive care or general ward
Aktuelle Urol. 2024 Feb;55(1):54-59. doi: 10.1055/a-2201-6428. Epub 2024 Feb 8.ABSTRACTHypercalcaemia is a life-threatening electrolyte imbalance, which not only occurs in the context of an endocrinological disease but is also frequently associated with a tumour. Its severity is determined by the level of deviation from normal, acuity of occurrence, and severity of the symptoms. These are unspecific, can affect any organ system and ultimately result in a life-threatening hypercalcaemic crisis characterised by cardiac arrhythmia, metabolic acidosis, exsiccosis, fever, psychotic states and, ultimately, coma. Endocrinological...
Source: Aktuelle Urologie - February 8, 2024 Category: Urology & Nephrology Authors: Jenny Mauch Katerina Cascetta Source Type: research
Hypercalcaemia: intensive care or general ward
Aktuelle Urol. 2024 Feb;55(1):54-59. doi: 10.1055/a-2201-6428. Epub 2024 Feb 8.ABSTRACTHypercalcaemia is a life-threatening electrolyte imbalance, which not only occurs in the context of an endocrinological disease but is also frequently associated with a tumour. Its severity is determined by the level of deviation from normal, acuity of occurrence, and severity of the symptoms. These are unspecific, can affect any organ system and ultimately result in a life-threatening hypercalcaemic crisis characterised by cardiac arrhythmia, metabolic acidosis, exsiccosis, fever, psychotic states and, ultimately, coma. Endocrinological...
Source: Aktuelle Urologie - February 8, 2024 Category: Urology & Nephrology Authors: Jenny Mauch Katerina Cascetta Source Type: research
Hypercalcaemia: intensive care or general ward
Aktuelle Urol. 2024 Feb;55(1):54-59. doi: 10.1055/a-2201-6428. Epub 2024 Feb 8.ABSTRACTHypercalcaemia is a life-threatening electrolyte imbalance, which not only occurs in the context of an endocrinological disease but is also frequently associated with a tumour. Its severity is determined by the level of deviation from normal, acuity of occurrence, and severity of the symptoms. These are unspecific, can affect any organ system and ultimately result in a life-threatening hypercalcaemic crisis characterised by cardiac arrhythmia, metabolic acidosis, exsiccosis, fever, psychotic states and, ultimately, coma. Endocrinological...
Source: Aktuelle Urologie - February 8, 2024 Category: Urology & Nephrology Authors: Jenny Mauch Katerina Cascetta Source Type: research
