C. elegans ACAT regulates lipolysis and its related lifespan in fasting through modulation of the genes in lipolysis and insulin/IGF ‐1 signaling
AbstractOverly active acyl ‐coenzyme A: cholesterol acyltransferases (ACATs) are known to contribute to the development of atherosclerosis, cancer cell proliferation and de novo lipogenesis. However, the role of ACAT in systemic lipid metabolism and its consequence of aging is unknown. Using avasimibe, a clinically proven A CAT inhibitor, andmboa ‐1 mutant strain, a homologous to mammalianACAT, herein, we found that Ava treatment andmboa ‐1 mutant exhibited a decreased fat accumulation during feeding and increased lipolysis with extended lifespan ofC. elegans during fasting. Our study highlights the essential role of...
Source: BioFactors - July 8, 2020 Category: Biochemistry Authors: Juan Bai, Renalison Farias ‐Pereira, Yuan Zhang, Miran Jang, Yeonhwa Park, Kee‐Hong Kim Tags: Research Communication Source Type: research

Cyanidin ‐3‐O‐glucoside attenuates endothelial cell dysfunction by modulating miR‐204‐5p/SIRT1‐mediated inflammation and apoptosis
AbstractEndothelial cell (EC) dysfunction is a major symptom associated with the initiation of atherosclerosis (AS). Cyanidin ‐3‐O‐glucoside (C3G) has the potentials to attenuate AS symptoms. In the current study, the mechanism driving the effects of C3G on AS rabbits and injured ECs were explored by focusing on the changes in miR‐204‐5p/SIRT1 axis. AS symptoms were induced in rabbits using high‐fatty diet (HFD) plus b alloon catheter injured method and handled with C3G of two doses. Then the changes in artery wall structure, hemodynamics parameters, blood lipid level, systemic inflammation, and miR‐204‐5p/...
Source: BioFactors - June 27, 2020 Category: Biochemistry Authors: Zhihong Wang, Min Zhang, Zhong Wang, Zongjun Guo, Zongqiu Wang, Qun Chen Tags: Research Communication Source Type: research

POTEE stimulates the proliferation of pancreatic cancer by activating the PI3K/Akt/GSK ‐3β/β‐catenin signaling
AbstractTo explore the role of POTEE in the malignant development of pancreatic cancer and the possible mechanism. POTEE levels in pancreatic cancer samples were detected. The relationship between POTEE level and clinical data of pancreatic cancer patients was analyzed. After knockdown of POTEE or treatment of the GSK ‐3β inhibitor, proliferative change in pancreatic cancer cells was assessed. Protein levels of vital genes in the PI3K/Akt/GSK‐3β/β‐catenin signaling influenced by POTEE were examined. POTEE was upregulated in pancreatic cancer samples. High level of POTEE indicated advanced tumor staging...
Source: BioFactors - June 26, 2020 Category: Biochemistry Authors: Qingya Hao, Lihua Gao, Wenyang Niu, Liang Chen, Peng Zhang, Zhong Chen Tags: Research Communication Source Type: research

Circular RNA DOCK1 downregulates microRNA ‐124 to induce the growth of human thyroid cancer cell lines
ConclusioncircDOCK1 contributed to thyroid carcinogenesis through inhibition of miR ‐124 in thyroid cancer cells with dampening signaling transduction of JAK/STAT/AMPK in virtue of miR‐124 downregulation. (Source: BioFactors)
Source: BioFactors - June 25, 2020 Category: Biochemistry Authors: Wei Cui, Jun Xue Tags: RESEARCH COMMUNICATION Source Type: research

Issue highlights
BioFactors, Volume 46, Issue 3, May/June 2020. (Source: BioFactors)
Source: BioFactors - June 12, 2020 Category: Biochemistry Tags: ISSUE HIGHLIGHTS Source Type: research

Issue Information
BioFactors, Volume 46, Issue 3, Page 301-304, May/June 2020. (Source: BioFactors)
Source: BioFactors - June 12, 2020 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research

Issue Information ‐ Cover
BioFactors, Volume 46, Issue 3, May/June 2020. (Source: BioFactors)
Source: BioFactors - June 12, 2020 Category: Biochemistry Tags: ISSUE INFORMATION ‐ COVER Source Type: research

Issue highlights
BioFactors, Volume 46, Issue 3, May/June 2020. (Source: BioFactors)
Source: BioFactors - June 12, 2020 Category: Biochemistry Tags: ISSUE HIGHLIGHTS Source Type: research

Issue Information
BioFactors, Volume 46, Issue 3, Page 301-304, May/June 2020. (Source: BioFactors)
Source: BioFactors - June 12, 2020 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research

Issue Information ‐ Cover
BioFactors, Volume 46, Issue 3, May/June 2020. (Source: BioFactors)
Source: BioFactors - June 12, 2020 Category: Biochemistry Tags: ISSUE INFORMATION ‐ COVER Source Type: research

LncRNA H19 aggravates TNF ‐α‐induced inflammatory injury via TAK1 pathway in MH7A cells
AbstractRheumatoid arthritis (RA) is a common chronic autoimmune disease in women. This research aims to disclose the probable function of lncRNA H19 in MH7A cells.The influences of tumor necrosis factor ‐α (TNF‐α) on cell viability, apoptosis, and inflammatory factor expression were, respectively, detected through cell counting kit‐8 (CCK‐8), flow cytometry, quantitative reverse transcription polymerase chain reaction (qRT‐PCR), enzyme‐linked immunosorbent assay (ELISA) assay and West ern Blot. The levels of H19 and TAK1 were, respectively, tested through qRT‐PCR and Western blot. The expression ...
Source: BioFactors - June 11, 2020 Category: Biochemistry Authors: Jialiang Yang, Yixuan Li, Lili Wang, Zhenchun Zhang, Zunzhong Li, Qian Jia Tags: Research Communication Source Type: research

Reduction of senescence ‐associated beta‐galactosidase activity by vitamin E in human fibroblasts depends on subjects’ age and cell passage number
AbstractCell senescence is due to the permanent cell cycle arrest that occurs as a result of the inherent limited replicative capacity toward the Hayflick limit (replicative senescence), or in response to various stressors (stress ‐induced premature senescence, SIPS). With the acquisition of the senescence‐associated secretory phenotype (SASP), cells release several molecules (cytokines, proteases, lipids), and express the senescence‐associated beta‐galactosidase (SA‐β‐Gal). Here we tested whether vitamin E affec ts SA‐β‐Gal in an in vitro model of cell ageing. Skin fibroblasts from human subjects...
Source: BioFactors - June 1, 2020 Category: Biochemistry Authors: Roberta Ricciarelli, Angelo Azzi, Jean ‐Marc Zingg Tags: RESEARCH COMMUNICATION Source Type: research

The roles of melatonin on kidney injury in obese and diabetic conditions
AbstractObesity is a common and complex health problem worldwide and can induce the development of Type 2 diabetes. Chronic kidney disease (CKD) is a complication occurring as a result of obesity and diabetic conditions that lead to an increased mortality rate. There are several mechanisms and pathways contributing to kidney injury in obese and diabetic conditions. The expansion of adipocytes triggers proinflammatory cytokines release into blood circulation and bind with the receptors at the cell membranes of renal tissues leading to kidney injury. Obesity ‐mediated inflammation, oxidative stress, apoptosis, and mitochon...
Source: BioFactors - May 24, 2020 Category: Biochemistry Authors: Sasivimon Promsan, Anusorn Lungkaphin Tags: Review Article Source Type: research

Anticancer targets and mechanisms of calycosin to treat nasopharyngeal carcinoma
AbstractCalycosin is a naturally occurring phytoestrogen, and it has the anti ‐nasopharyngeal carcinoma (NPC) action played by calycosin. However, the elaborate mechanisms of calycosin treating NPC remain to be unrevealed. In current report, a promising tool of network pharmacology method was used to uncover the anti‐NPC targets and therapeutic mechanisms played by calyco sin. Furthermore, were conducted to validate the bioinformatic findings in human and preclinical studies. As results, the bioinformatic findings showed the core anti‐NPC targets played by calycosin included tumor protein p53 (TP53), mitogen‐activa...
Source: BioFactors - May 24, 2020 Category: Biochemistry Authors: Fangxian Liu, Qijin Pan, Liangliang Wang, Shijiang Yi, Peng Liu, Wenjun Huang Tags: Research Communication Source Type: research

The roles of melatonin on kidney injury in obese and diabetic conditions
AbstractObesity is a common and complex health problem worldwide and can induce the development of Type 2 diabetes. Chronic kidney disease (CKD) is a complication occurring as a result of obesity and diabetic conditions that lead to an increased mortality rate. There are several mechanisms and pathways contributing to kidney injury in obese and diabetic conditions. The expansion of adipocytes triggers proinflammatory cytokines release into blood circulation and bind with the receptors at the cell membranes of renal tissues leading to kidney injury. Obesity ‐mediated inflammation, oxidative stress, apoptosis, and mitochon...
Source: BioFactors - May 24, 2020 Category: Biochemistry Authors: Sasivimon Promsan, Anusorn Lungkaphin Tags: Review Article Source Type: research

Anticancer targets and mechanisms of calycosin to treat nasopharyngeal carcinoma
AbstractCalycosin is a naturally occurring phytoestrogen, and it has the anti ‐nasopharyngeal carcinoma (NPC) action played by calycosin. However, the elaborate mechanisms of calycosin treating NPC remain to be unrevealed. In current report, a promising tool of network pharmacology method was used to uncover the anti‐NPC targets and therapeutic mechanisms played by calyco sin. Furthermore, were conducted to validate the bioinformatic findings in human and preclinical studies. As results, the bioinformatic findings showed the core anti‐NPC targets played by calycosin included tumor protein p53 (TP53), mitogen‐activa...
Source: BioFactors - May 24, 2020 Category: Biochemistry Authors: Fangxian Liu, Qijin Pan, Liangliang Wang, Shijiang Yi, Peng Liu, Wenjun Huang Tags: Research Communication Source Type: research

New insights into the core Hippo signaling and biological macromolecules interactions in the biology of solid tumors
AbstractAs an evolutionarily conserved pathway, Hippo signaling pathway impacts different pathology and physiology processes such as wound healing, tissue repair/size and regeneration. When some components of Hippo signaling dysregulated, it affects cancer cells proliferation. Moreover, the relation Hippo pathway with other signaling including Wnt, TGF β, Notch, and EGFR signaling leaves effect on the proliferation of cancer cells. Utilizing a number of therapeutic approaches, such as siRNAs and long noncoding RNA (lncRNA) to prevent cancer cells through the targeting of Hippo pathways, can provide new insights into c...
Source: BioFactors - May 22, 2020 Category: Biochemistry Authors: Solmaz Mohammadi, Reza Arefnezhad, Shahla Danaii, Mehdi Yousefi Tags: Review Article Source Type: research

Dicer and Drosha expression in patients with nephrotic syndrome
In conclusion, dysregulation in expression level of Dicer and Drosha and consequently, alteration in miRNA levels are involved in the pathophysiology of NS. (Source: BioFactors)
Source: BioFactors - May 15, 2020 Category: Biochemistry Authors: Seyyedeh Mina Hejazian, Yalda Rahbar Saadat, Zahra Bahmanpour, Seyed Mahdi Hosseiniyan Khatibi, Mohammadreza Ardalan, Sepideh Zununi Vahed Tags: Research Communication Source Type: research

High ‐throughput profiling reveals perturbation of endoplasmic reticulum stress‐related genes in atherosclerosis induced by high‐cholesterol diet and the protective role of vitamin E
AbstractFormation of atherosclerotic plaques, called atherogenesis, is a complex process affected by genetic and environmental factors. It was proposed that endoplasmic reticulum (ER) stress is an important factor in the pathogenesis of atherosclerosis and that vitamin E affects atherosclerotic plaque formation via its antioxidant properties. Here, we investigated ER stress ‐related molecular mechanisms in high‐cholesterol diet (HCD, 2%)‐induced atherosclerosis model and the role of vitamin E supplementation in it, beyond its antioxidant properties. The consequences of HCD and vitamin E supplementation were examined ...
Source: BioFactors - May 8, 2020 Category: Biochemistry Authors: Perinur Bozaykut, Ruchan Ekren, Osman Ugur Sezerman, Vadim N. Gladyshev, Nesrin Kartal Ozer Tags: Research Communication Source Type: research

A systematic review and meta ‐analysis of the effect of Vitamin D‐fortified food on glycemic indices
AbstractSome reports indicated that Vitamin D may improve glycaemia indices in diabetic patients. The aim of this systematic and meta ‐analysis was to evaluate effects of Vitamin D fortification on indices of glycemic control. Six databases (PubMed/Medline, ISI Web of Knowledge, Cochrane Library, Science Direct, Scopus, and Google Scholar) were searched, for randomized controlled trials that were published up to September 2018 a nd that compared the effect of Vitamin D‐fortified food versus regular diet in relation to glycemic control. Of the 4,379 studies originally found, 11 articles remained to be assessed for meta...
Source: BioFactors - April 29, 2020 Category: Biochemistry Authors: Maryam Emadzadeh, Reza Sahebi, Hamed Khedmatgozar, Ramin Sadeghi, Mahsa Farjami, Payam Sharifan, Yalda Ravanshad, Gordon A. Ferns, Majid Ghayour ‐Mobarhan Tags: Review Article Source Type: research

COVID ‐19, pulmonary mast cells, cytokine storms, and beneficial actions of luteolin
BioFactors, EarlyView. (Source: BioFactors)
Source: BioFactors - April 27, 2020 Category: Biochemistry Authors: Theoharis C. Theoharides Tags: HYPOTHESIS Source Type: research

Issue Information
BioFactors, Volume 46, Issue 2, Page 187-190, March/April 2020. (Source: BioFactors)
Source: BioFactors - April 10, 2020 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research

Issue Information ‐ Cover
BioFactors, Volume 46, Issue 2, March/April 2020. (Source: BioFactors)
Source: BioFactors - April 10, 2020 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research

Issue Information
BioFactors, Volume 46, Issue 2, Page 187-190, March/April 2020. (Source: BioFactors)
Source: BioFactors - April 10, 2020 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research

Protective effect of rutin against bleomycin induced lung fibrosis: Involvement of TGF ‐β1/α‐SMA/Col I and III pathway
In conclusion, rutin can be proposed to be a potential therapeutic agent for the managem ent of lung fibrosis. (Source: BioFactors)
Source: BioFactors - March 31, 2020 Category: Biochemistry Authors: Linlin Bai, Aimin Li, Cuike Gong, Xuecong Ning, Zhihua Wang Tags: Research Communication Source Type: research

Challenges in redox biology
BioFactors, EarlyView. (Source: BioFactors)
Source: BioFactors - March 31, 2020 Category: Biochemistry Authors: Bato Korac, Francesco Galli Tags: Editorial Source Type: research

Protective effect of rutin against bleomycin induced lung fibrosis: Involvement of TGF ‐β1/α‐SMA/Col I and III pathway
In conclusion, rutin can be proposed to be a potential therapeutic agent for the managem ent of lung fibrosis. (Source: BioFactors)
Source: BioFactors - March 31, 2020 Category: Biochemistry Authors: Linlin Bai, Aimin Li, Cuike Gong, Xuecong Ning, Zhihua Wang Tags: Research Communication Source Type: research

Challenges in redox biology
BioFactors, EarlyView. (Source: BioFactors)
Source: BioFactors - March 31, 2020 Category: Biochemistry Authors: Bato Korac, Francesco Galli Tags: Editorial Source Type: research

Plasmatic lipocalin ‐2 levels in chronic low‐grade inflammation syndromes: Comparison between metabolic syndrome, total and partial adult growth hormone deficiency
AbstractLipocalin ‐2 (LCN2) is a secreted glycoprotein involved in several chronic inflammatory processes. Metabolic syndrome (MetS) and adult growth hormone deficiency (GHD) are known as chronic inflammatory conditions. The primary objective of this observational cross‐sectional study was to compare LCN2 plasmat ic levels in these clinical settings, whereas the secondary objective was to investigate any possible correlation between LCN2 and BMI and/or indexes of insulin sensitivity/resistance. Seventy‐four patients were divided as follows: Group A, MetS (18 patients, 13 females and 5 males, mean ±&thin...
Source: BioFactors - March 30, 2020 Category: Biochemistry Authors: Diego Curr ò, Edoardo Vergani, Carmine Bruno, Simone Comi, Claudia D'Abate, Antonio Mancini Tags: Research Communication Source Type: research

Skullcapflavone I has a potent anti ‐pancreatic cancer activity by targeting miR‐23a
AbstractBaicalein has been widely studied and showed a potent activity against pancreatic cancer in both in vivo and in vitro studies. Little is known regarding the effects of Skullcapflavone I (SFI), despite they have similar structures. So, this study was to explore the function of SFI on human pancreatic cancer. Panc ‐1 cells were transfected with miR‐23a precursor, miR‐23a inhibitor or the negative controls, and subsequently treated by SFI. Cell viability, Bromodeoxyuridine (BrdU)‐positive cell rate, apoptosis, migration, invasion, and related protein expression were assessed by utilizing Cell Counting Kit‐8 ...
Source: BioFactors - March 10, 2020 Category: Biochemistry Authors: Jing Cui, Hao Li, Ying Wang, Tian Tian, Chao Liu, Yanan Wang, Shukai Sun, Baisui Feng Tags: Research Communication Source Type: research

Quercetin alleviates hyperthyroidism ‐induced liver damage via Nrf2 Signaling pathway
In this study, we evaluated the therapeutic effect of quercetin on thyroid dysfunction in L ‐thyroxin (LT4)‐induced hyperthyroidism rats. LT4 was used to prepare the experimental hyperthyroidism model via the intraperitoneal injection. Quercetin was injected at a series doses (5, 50, and 100 mg/kg) to LT4‐induced hypothyroidism rats once a day for 14 days. The body weight and foo d intake were measured once a week. The levels of thyroid hormones, liver function, oxidative stress markers, and antioxidant markers were measured using commercial enzyme‐linked immunosorbent assay kits. Hematoxylin–eo...
Source: BioFactors - March 4, 2020 Category: Biochemistry Authors: Pengxin Zhao, Zhigang Hu, Weiyuan Ma, Leilei Zang, Zhisheng Tian, Qian Hou Tags: Research Communication Source Type: research

Anti ‐invasive effect and pharmacological mechanism of genistein against colorectal cancer
AbstractColorectal cancer (CRC) refers to a deadly carcinoma following potent invasiveness and metastasis in advanced stage. Unfortunately, existing anti ‐CRC medicine is insufficient for chemotherapy in addition to adverse effects. Consequently, the candidate natural ingredient for treating CRC needs to be further developed. Our previous experiments report that genistein exerts beneficial effects to inhibit CRC cells via an antiproliferative mecha nism. Based on the metastatic characteristics of staging CRC, anti‐invasive and antimetastatic pharmacological activities using genistein remain uninvestigated. The scientif...
Source: BioFactors - March 4, 2020 Category: Biochemistry Authors: Xiaoyu Chen, Youjun Wu, Junzhao Gu, Ping Liang, Meizhen Shen, Jiaxi Xi, Jian Qin Tags: Research Communication Source Type: research

CircPRKCI relieves lipopolysaccharide ‐induced HK2 cell injury by upregulating the expression of miR‐545 target gene ZEB2
AbstractThe aim of this study was to investigate the possible influences of circPRKCI abnormal expression on lipopolysaccharide (LPS) ‐induced HK2 cell injury and its mechanism. The circPRKCI level was identified in serum samples from patients with urosepsis and healthy subjects, as well as LPS‐treated HK2 cells by qRT‐PCR. Cell viability, apoptosis, expression of proteins associated with apoptosis, and expression of pro‐i nflammatory cytokines in LPS‐treated HK2 cells were measured. Effects of circPRKCI abnormal expression on LPS‐induced HK2 cell injury were then evaluated. Afterward, the binding miRNA of circ...
Source: BioFactors - March 4, 2020 Category: Biochemistry Authors: Xiaofeng Shi, Wei Ma, Yongqi Li, Han Wang, Shuang Pan, Yongquan Pan, Caiming Xu, Lei Li Tags: Research Communication Source Type: research

Quercetin alleviates hyperthyroidism ‐induced liver damage via Nrf2 Signaling pathway
In this study, we evaluated the therapeutic effect of quercetin on thyroid dysfunction in L ‐thyroxin (LT4)‐induced hyperthyroidism rats. LT4 was used to prepare the experimental hyperthyroidism model via the intraperitoneal injection. Quercetin was injected at a series doses (5, 50, and 100 mg/kg) to LT4‐induced hypothyroidism rats once a day for 14 days. The body weight and foo d intake were measured once a week. The levels of thyroid hormones, liver function, oxidative stress markers, and antioxidant markers were measured using commercial enzyme‐linked immunosorbent assay kits. Hematoxylin–eo...
Source: BioFactors - February 20, 2020 Category: Biochemistry Authors: Pengxin Zhao, Zhigang Hu, Weiyuan Ma, Leilei Zang, Zhisheng Tian, Qian Hou Tags: Research Communication Source Type: research

Anti ‐invasive effect and pharmacological mechanism of genistein against colorectal cancer
AbstractColorectal cancer (CRC) refers to a deadly carcinoma following potent invasiveness and metastasis in advanced stage. Unfortunately, existing anti ‐CRC medicine is insufficient for chemotherapy in addition to adverse effects. Consequently, the candidate natural ingredient for treating CRC needs to be further developed. Our previous experiments report that genistein exerts beneficial effects to inhibit CRC cells via an antiproliferative mecha nism. Based on the metastatic characteristics of staging CRC, anti‐invasive and antimetastatic pharmacological activities using genistein remain uninvestigated. The scientif...
Source: BioFactors - February 20, 2020 Category: Biochemistry Authors: Xiaoyu Chen, Youjun Wu, Junzhao Gu, Ping Liang, Meizhen Shen, Jiaxi Xi, Jian Qin Tags: Research Communication Source Type: research

Circular RNA ‐0072309 has antitumor influences in Hep3B cell line by targeting microRNA‐665
AbstractLiver cancer is a malignant tumor that occurs in the liver and has a high mortality rate. We strived to detect the role and mechanism of circRNA ‐0072309 in liver cancer. Hep3B cell line was transfected with pc‐circ and si‐circ for viability, colony formation, apoptosis, migration, and invasion tests, which were individually performed by CCK‐8, colony formation detection, flow cytometry assay, migration and invasion assays. What is m ore, the luciferase reporter assay was conducted to determine the target relationship between the circRNA‐0072309 and microRNA (miR)‐665. The expression of circRNA‐007230...
Source: BioFactors - February 15, 2020 Category: Biochemistry Authors: Qiuyun Yu, Jinhua Dai, Ming Shu Tags: Research Communication Source Type: research