Issue Highlights
(Source: BioFactors)
Source: BioFactors - October 21, 2021 Category: Biochemistry Tags: ISSUE HIGHLIGHTS Source Type: research

Issue Information
(Source: BioFactors)
Source: BioFactors - October 21, 2021 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research

Issue Information ‐ Cover
(Source: BioFactors)
Source: BioFactors - October 21, 2021 Category: Biochemistry Tags: ISSUE INFORMATION ‐ COVER Source Type: research

FERM domain ‐containing protein 6 exerts a tumor‐inhibiting role in thyroid cancer by antagonizing oncogenic YAP1
AbstractThe emerging role of FERM domain-containing protein 6 (FRMD6) in cancer progression has been revealed in several malignancies. However, its relevance on thyroid cancer is not well understood. This work evaluated the possible role and mechanism of FRMD6 in thyroid cancer. We demonstrated that FRMD6 expression was downregulated in thyroid cancer by analyzing the Cancer Genome Atlas data. Remarkable reductions in FRMD6 expression were also confirmed in the clinical specimens and cell lines of thyroid cancer. The upregulation of FRMD6 restrained the proliferation, epithelial –mesenchymal transition, and invasion ...
Source: BioFactors - October 20, 2021 Category: Biochemistry Authors: Wei Wang, Chang'an Zhao, Fang Quan, Pengfei Zhang, Yuan Shao, Lifeng Liu Tags: Research Communication Source Type: research

Transplantation of high fat fed mouse microbiota into zebrafish larvae identifies MyD88 ‐dependent acceleration of hyperlipidaemia by Gram‐positive cell wall components
AbstractGut dysbiosis is an important modifier of pathologies including cardiovascular disease but our understanding of the role of individual microbes is limited. Here, we have used transplantation of mouse microbiota into microbiota-deficient zebrafish larvae to study the interaction between members of a mammalian high fat diet-associated gut microbiota with a lipid rich diet challenge in a tractable model species. We find zebrafish larvae are more susceptible to hyperlipidaemia when exposed to the mouse high fat-diet-associated microbiota and that this effect can be driven by two individual bacterial species fractionate...
Source: BioFactors - October 20, 2021 Category: Biochemistry Authors: Pradeep Manuneedhi Cholan, Simone Morris, Kaiming Luo, Jinbiao Chen, Jade A. Boland, Geoff W. McCaughan, Warwick J. Britton, Stefan H. Oehlers Tags: Research Communication Source Type: research

Ammonia induces autophagy via circ ‐IFNLR1/miR‐2188‐5p/RNF182 axis in tracheas of chickens
AbstractAmmonia (NH3), an air pollutant in the living environment, has many toxic effects on various tissues and organs. However, the underlying mechanisms of NH3-induced tracheal cell autophagy remains poorly understood. In present study, chickens and LMH cells were used as NH3 exposure models to investigate toxic effects. The change of tracheal tissues ultrastructure showed that NH3 exposure induced autolysosomes. The differential expression of 12 circularRNAs (circRNAs) was induced by NH3 exposure using circRNAs transcriptome analysis in broiler tracheas. We further found that circ-IFNLR1 was down-regulated, and miR-218...
Source: BioFactors - October 19, 2021 Category: Biochemistry Authors: Tian ‐yi Zhang, Ting Chen, Wan‐ying Hu, Ji‐chang Li, Meng‐yao Guo Tags: Research Communication Source Type: research

(Source: BioFactors)
Source: BioFactors - October 12, 2021 Category: Biochemistry Tags: Erratum Source Type: research

A pilot study of the effects of crocin on high ‐density lipoprotein cholesterol uptake capacity in patients with metabolic syndrome: A randomized clinical trial
AbstractA randomized clinical trial high-density lipoprotein (HDL) cholesterol uptake capacity (CUC) is reduced in patients with metabolic syndrome (MetS). We have assessed the effect of crocin supplementation on HDL CUC in patients with MetS. Forty-four subjects with MetS were randomly allocated to one of two groups: one group received placebo and the other group received crocin at a dose of 30  mg (two tablets of 15 mg per day) for 8 weeks. Serum biochemical parameters were measured using an AutoAnalyzer BT3000 (BioTechnica). The modified CUC method is a cell free, simple, and high-throughput assay t...
Source: BioFactors - October 7, 2021 Category: Biochemistry Authors: Maryam Saberi ‐Karimian, Hamideh Safarian‐Bana, Elham Mohammadzadeh, Tooba Kazemi, Amin Mansoori, Hamideh Ghazizadeh, Sara Samadi, Irandokht Nikbakht‐Jam, Mina Nosrati, Gordon A. Ferns, Habibollah Esmaily, Malihe Aghasizadeh, Majid Ghayo Tags: Research Communication Source Type: research

Reactive oxygen species as a double ‐edged sword: The role of oxidative enzymes in antitumor therapy
AbstractA number of approaches have been developed over the years to manage cancer, such as chemotherapy using low-molecular-mass molecules and radiotherapy. Here, enzymes can also find useful applications. Among them, oxidases have attracted attention because of their ability to produce reactive oxygen species (ROS, especially hydrogen peroxide) in tumors and potentially modulate the production of this cytotoxic compound when enzymes active on substrates present in low amounts are used, such as thed-amino acid oxidase andd-amino acid couple system. These treatments have been also developed for additional cancer treatment ...
Source: BioFactors - October 5, 2021 Category: Biochemistry Authors: Elena Rosini, Loredano Pollegioni Tags: Review Article Source Type: research

Redox ‐sensitive signaling pathways in renal cell carcinoma
AbstractRenal cell carcinoma (RCC) is one of the most lethal urological cancers, highly resistant to chemo and radiotherapy. Obesity and smoking are the best-known risk factors of RCC, both related to oxidative stress presence, suggesting a significant role in RCC development and maintenance. Surgical resection is the treatment of choice for localized RCC; however, this neoplasia is hardly diagnosable at its initial stages, occurring commonly in late phases and even when metastasis is already present. Systemic therapies are the option against RCC in these more advanced stages, such as cytokine therapy or a combination of t...
Source: BioFactors - September 30, 2021 Category: Biochemistry Authors: Alfredo Cruz ‐Gregorio, Ana Karina Aranda‐Rivera, José Pedraza‐Chaverri, José D. Solano, María Elena Ibarra‐Rubio Tags: Review Article Source Type: research

Melatonin ameliorates trimethyltin chloride ‐induced cardiotoxicity: The role of nuclear xenobiotic metabolism and Keap1‐Nrf2/ARE axis‐mediated pyroptosis
AbstractTrimethyltin chloride (TMT) is a stabilizer for polyvinyl chloride plastics that causes serious health hazards in nontarget organisms. Melatonin (MT) exhibits powerful protective effects in cardiac diseases. As a new environmental pollutant, TMT-induced cardiotoxicity and the protective effects of MT remain unclear. To explore this, the mice were treated with TMT (2.8  mg/kg) and/or MT (10 mg/kg) for 7 days. Firstly, the histopathological and ultrastructural evaluation showed that TMT induced cardiac damage, tumescent rupture and nuclear pyknosis. Moreover, TMT elevated the expressions of pyroptosi...
Source: BioFactors - September 28, 2021 Category: Biochemistry Authors: Jingzeng Cai, Jie Yang, Xiaoming Chen, Haoran Zhang, Yue Zhu, Qi Liu, Ziwei Zhang Tags: Research Communication Source Type: research

Tangeretin promotes lifespan associated with insulin/insulin ‐like growth factor‐1 signaling pathway and heat resistance in Caenorhabditis elegans
In this study, we used the model organismC. elegans to conduct a lifespan test, observed the aging-related functional changes of nematodes, the fluorescence changes of stress-related proteins (DAF-16 and HSP-16.2) and its response to stress assay, and monitored the effect of tangeretin on the mRNA expression levels. The results showed that tangeretin supplementation (30 and 100  μM) extended the mean lifespan, slowed aging-related functional declines, and increased the resistance against heat-shock stress. Furthermore, tangeretin upregulated the mRNA expression ofdaf-16,hsp-16.2, andhsp-16.49, promoted the nuclea...
Source: BioFactors - September 27, 2021 Category: Biochemistry Authors: Yalei Liu, Zhenyu Zhou, Liufang Yin, Mengnan Zhu, Fei Wang, Lijun Zhang, Hongqing Wang, Zhiqin Zhou, Huanhu Zhu, Cheng Huang, Shengjie Fan Tags: Research Communication Source Type: research

Vitamin D and colorectal cancer: Chemopreventive perspectives through the gut microbiota and the immune system
AbstractVitamin D and its receptor are involved in health and diseases through multiple mechanisms including the immune system and gut microbiota modulations. Gut microbiota variations have huge implications in intestinal and extra-intestinal disorders such as colorectal cancer (CRC). This review highlights the preventive role of vitamin D in colorectal tumorigenesis through the effects on the immune system and gut microbiota modulation. The different associations between vitamin D, gut microbial homeostasis, immune system, and CRC, are dissected. Vitamin D is supposed to exert several chemopreventive effects on CRC includ...
Source: BioFactors - September 24, 2021 Category: Biochemistry Authors: Emanuele Rinninella, Maria Cristina Mele, Pauline Raoul, Marco Cintoni, Antonio Gasbarrini Tags: Review Article Source Type: research

Interactions between dietary polyphenols and aging gut microbiota: A review
AbstractAging induces significant shifts in the composition of gut microbiota associated with decreased microbial diversity. Age-related changes in gut microbiota include a loss of commensals and an increase in disease-associated pathobionts. These alterations are accelerated by lifestyle factors, such as poor nutritional habits, physical inactivity, and medications. Given that diet is one of the main drivers shaping the gut microbiota, nutritional interventions for restoring gut homeostasis are of great importance to the overall health of older adults. Polyphenols, ubiquitously present in fruits and vegetables, have emerg...
Source: BioFactors - September 24, 2021 Category: Biochemistry Authors: Sergio Davinelli, Giovanni Scapagnini Tags: Review Article Source Type: research

Biological and pharmacological activities of noscapine: Focusing on its receptors and mechanisms
AbstractNoscapine has been mentioned as one of the effective drugs with potential therapeutic applications. With few side effects and amazing capabilities, noscapine can be considered different from other opioids-like structure compounds. Since 1930, extensive studies have been conducted in the field of pharmacological treatments from against malaria to control cough and cancer treatment. Furthermore, recent studies have shown that noscapine and some analogues, like 9-bromonoscapine, amino noscapine, and 9-nitronoscapine, can be used to treat polycystic ovaries syndrome, stroke, and other diseases. Given the numerous resul...
Source: BioFactors - September 21, 2021 Category: Biochemistry Authors: Fahimeh Nourbakhsh, Vahid Reza Askari Tags: Review Article Source Type: research

Golgi stress response: A regulatory mechanism of Golgi function
AbstractThe organelle of eukaryotes is a finely regulated system. Once disturbed, it activates the specific autoregulatory systems, namely, organelle autoregulation. Among which, the Golgi stress response accounts for one. When the abundance and capacity of the Golgi apparatus are insufficient compared with cellular demand, the Golgi stress response is activated to enhance the function of the Golgi apparatus. Although the molecular mechanism of the Golgi stress response has not been well characterized yet, it seems to be an important part of the mammalian stress response. In this review, we discuss the current status of re...
Source: BioFactors - September 11, 2021 Category: Biochemistry Authors: Jiayin Gao, Anbo Gao, Wei Liu, Linxi Chen Tags: Review Article Source Type: research

Protein networks linking Warburg and reverse Warburg effects to cancer cell metabolism
AbstractIt was 80  years after the Otto Warburg discovery of aerobic glycolysis, a major hallmark in the understanding of cancer. The Warburg effect is the preference of cancer cell for glycolysis that produces lactate even when sufficient oxygen is provided. “reverse Warburg effect” refers to the interstitial tissue communications with adjacent epithelium, that in the process of carcinogenesis, is needed to be explored. Among these cell–cell communications, the contact between epithelial cells; between epithelial cells and matrix; and between fibroblasts and inflammatory cells in the underlying ma...
Source: BioFactors - August 29, 2021 Category: Biochemistry Authors: Dina Johar, Ahmed O. Elmehrath, Rania M. Khalil, Mostafa H. Elberry, Samy Zaky, Samy A. Shalabi, Larry H. Bernstein Tags: Review Article Source Type: research

O ‐GlcNAcylation drives calcium signaling toward osteoblast differentiation: A bioinformatics‐oriented study
This study aimed to reveal the possible mechanisms by whichO-linked-N-acetylglucosaminylation (O-GlcNAcylation) regulates osteoblast differentiation using a series of bioinformatics-oriented experiments. To examine the influence of O-GlcNAcylation levels on osteoblast differentiation, osteoblastic MC3T3-E1 cells were treated with O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) inhibitors. Correlations between the levels of O-GlcNAcylation and the expression of osteogenic markers as well as OGT were evaluated by qPCR and western blotting. The O-GlcNAcylated proteins assumed to correlate with Runx2 expression were retrieved...
Source: BioFactors - August 23, 2021 Category: Biochemistry Authors: Yao Weng, Ziyi Wang, Yoko Fukuhara, Airi Tanai, Mika Ikegame, Daisuke Yamada, Takeshi Takarada, Takashi Izawa, Satoru Hayano, Kaya Yoshida, Hiroshi Kamioka, Hirohiko Okamura Tags: Research Communication Source Type: research

Promising effects of gingerol against toxins: A review article
AbstractGinger is a medicinal and valuable culinary plant. Gingerols, as an active constituent in the fresh ginger rhizomes ofZingiber officinale, exhibit several promising pharmacological properties. This comprehensive literature review was performed to assess gingerol's protective and therapeutic efficacy against the various chemical, natural, and radiational stimuli. Another objective of this study was to investigate the mechanism of anti-inflammatory, antioxidant, and antiapoptotic properties of gingerol. It should be noted that the data were gathered from in vivo and in vitro experimental studies. Gingerols can exert ...
Source: BioFactors - August 21, 2021 Category: Biochemistry Authors: Roghayeh Yahyazadeh, Vafa Baradaran Rahimi, Ahmad Yahyazadeh, Seyed Ahmad Mohajeri, Vahid Reza Askari Tags: Review Article Source Type: research

Clinical significance of novel identified high ‐frequency tumor‐specific peptides associated signature in predicting disease status of gastric cancer patients
AbstractThe effectively early detection and determination of disease progression of gastric cancer (GC) are still required. An emerging demand for identifying the novel targets adherent to cancer cells has been still challenged since those valuable profilings not only could act as for early gastric tumor discovery but also being potential therapeutic views. We have retrospectively analyzed GC biopsies to identify those specific target peptides in association with disease progression. We have detected the polypeptide by liquid mass technology initiated BIO-HIGH innovational assay technology for tumor-specific target peptide...
Source: BioFactors - August 21, 2021 Category: Biochemistry Authors: Bin Li, Huizhen Geng, Zibo Li, Bing Peng, Jinfeng Wang, Xiaolei Yin, Ning Li, Jianfei Shi, Man Zhao, Cuizhen Li, Fei Yin Tags: Research Communication Source Type: research

Polyphenols as modulators of pre ‐established gut microbiota dysbiosis: State‐of‐the‐art
AbstractThe human intestine contains an intricate ecological community of bacteria, referred as the gut microbiota, which plays a pivotal role in the host homeostasis. Multiple factors could interfere with this delicate balance, thus causing a disruption of the microbiota equilibrium, the so called dysbiosis. Gut microbiota dysbiosis is involved in gastrointestinal and extra-intestinal metabolic diseases, as obesity and diabetes. Polyphenols, present in a broad range of plant foods, are known to have numerous health benefits; however, their beneficial effect on pre-existing dysbiosis is less clear. Indeed, in most of the c...
Source: BioFactors - August 17, 2021 Category: Biochemistry Authors: Romina Molinari, Nicol ò Merendino, Lara Costantini Tags: Review Article Source Type: research

Ginger: A complementary approach for management of cardiovascular diseases
In this report, we summarize the biochemical pathologies underpinning a variety of CVDs and the effects of ginger a nd its bioactive components, including 6-shogaol, 6-gingerol, and 10-dehydrogingerdione. The properties of ginger and its phenolic components, mechanism of action, biological functions, side effects, and methods for enhanced cell delivery are also discussed. Together with preclinical and clinical st udies, the positive biological effects of ginger and its bioactive components in CVD support the undertaking of further in vivo and especially clinical studies. (Source: BioFactors)
Source: BioFactors - August 14, 2021 Category: Biochemistry Authors: Nazanin Momeni Roudsari, Naser ‐Aldin Lashgari, Saeideh Momtaz, Basil Roufogalis, Amir Hossein Abdolghaffari, Amirhossein Sahebkar Tags: Review Article Source Type: research

New biomarkers and therapeutic targets of human liver cancer: Transcriptomic findings
ABSTRACTHepatocellular carcinoma (HCC) is one of the most common causes of cancer-related deaths worldwide, causing 782,000 deaths in 2018. Poor prognosis and lack of treatment are the reasons for the high mortality rate of HCC. In the current study, we conducted a comparative transcriptomic analysis, followed by a series of bioinformatics analyses, including Gene Ontology (GO) enrichment analysis and Ingenuity Pathway Analysis (IPA), aiming to unfold the detailed molecular mechanisms underlying the development of HCC. In the comparative transcriptomic analysis of 10 pairs of HCC tumoral tissues and adjunct nontumoral tiss...
Source: BioFactors - August 12, 2021 Category: Biochemistry Authors: Li Qin, Dongning Huang, Jian Huang, Haixin Huang Tags: Research Communication Source Type: research

Targeting of the tumor microenvironment by curcumin
AbstractThe tumor microenvironment (TME) is made up of several cells and molecules that affect the survival of cancer cells. Indeed, certain (immunosuppressive) cells which promote tumors can promote the growth of tumors by stimulating the proliferation of cancer cells and promoting angiogenesis. During tumor growth, antitumoral immunity includes natural killer cells and CD8+ T cells cannot overcome immunosuppressive responses and cancer cell proliferation. In order to achieve the appropriate therapeutic response, we must kill cancer cells and suppress the release of immunosuppressive molecules. The balance between anti-tu...
Source: BioFactors - August 11, 2021 Category: Biochemistry Authors: Xiao Fu, Yingni He, Mu Li, Zezhi Huang, Masoud Najafi Tags: Review Article Source Type: research

Issue Highlights
(Source: BioFactors)
Source: BioFactors - August 10, 2021 Category: Biochemistry Tags: ISSUE HIGHLIGHTS Source Type: research

Issue Information
(Source: BioFactors)
Source: BioFactors - August 10, 2021 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research

Issue Information ‐ Cover
(Source: BioFactors)
Source: BioFactors - August 10, 2021 Category: Biochemistry Tags: ISSUE INFORMATION ‐ COVER Source Type: research

Issue Highlights
(Source: BioFactors)
Source: BioFactors - August 10, 2021 Category: Biochemistry Tags: ISSUE HIGHLIGHTS Source Type: research

Issue Information
(Source: BioFactors)
Source: BioFactors - August 10, 2021 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research

Issue Information ‐ Cover
(Source: BioFactors)
Source: BioFactors - August 10, 2021 Category: Biochemistry Tags: ISSUE INFORMATION ‐ COVER Source Type: research

CDCA7 ‐regulated inflammatory mechanism through TLR4/NF‐κB signaling pathway in stomach adenocarcinoma
ABSTRACTTo investigate the role of cell division cycle associated 7 (CDCA7) in stomach carcinoma, detect whether CDCA7 knockdown could regulate the development of stomach carcinoma, and further observe the relationship between CDCA7 and inflammation through TLR4/NF- κB signaling pathway in stomach adenocarcinoma (STAD) in vitro and in vivo. TIMER2.0, Kaplan–Meier plotter, Target Gene, and GEPIA systems were used to predict the potential function of CDCA7. Western blot and immunohistochemistry was used to analyze the expression of CDCA7 at different tissue or cell lines. The proliferation, development, inflammat...
Source: BioFactors - August 4, 2021 Category: Biochemistry Authors: Yu Guo, Kaimei Zhou, Xiang Zhuang, Junjie Li, Xianglin Shen Tags: Research Communication Source Type: research

Notch1 signaling enhances collagen expression and fibrosis in mouse uterus
In this study, we further detected expressions of all 44 collagen genes in these Notch1 gain-of-function transgenic mice and found that 18 collagens have been largely affected. In another aspect, using an intrauterine adhesion model (IUA), we mimicked fibrosis in the mouse uterine. The results suggested that Notch receptors were upregulated only 3  days after induction, and most of the fibril-forming collagen began to upregulate 6 days after the surgery. Furthermore, when induced IUA in the N1ICD-OEx mice, the expression of collagens and fibrosis levels were significantly enhanced. At last, as a Notch signali...
Source: BioFactors - July 29, 2021 Category: Biochemistry Authors: Qi ‐Xin Xu, Wang‐Qing Zhang, Xiao‐Zheng Liu, Wan‐Kun Yan, Lei Lu, Shan‐Shan Song, Shu‐Wen Wei, Ying‐Nan Liu, Jin‐Wen Kang, Ren‐Wei Su Tags: Research Communication Source Type: research

Factors determining the serum 25 ‐hydroxyvitamin D response to vitamin D supplementation: Data mining approach
We examined the relationship between 76 potential influencing factors on vitamin D response using RF. We found several features that were highly correlated to the serum vitamin D response to supplementation by RF including anthropometric factors (body mass index [BMI], free fat mass [FFM], fat percentage, waist-to-hip ratio [WHR]), liver function tests (serum gamma-glutamyl transferase [GGT], total bilirubin, total protein), hematological parameters (mean corpuscular volume [MCV], mean corpuscular hemoglobin concentration [MCHC], hematocrit), and measurement of insulin sensitivity (homeostatic model assessment of insulin r...
Source: BioFactors - July 18, 2021 Category: Biochemistry Authors: Zahra Amiri, Mina Nosrati, Payam Sharifan, Sara Saffar Soflaei, Susan Darroudi, Hamideh Ghazizadeh, Maryam Mohammadi Bajgiran, Fahimeh Moafian, Maryam Tayefi, Elahe Hasanzade, Mahdi Rafiee, Gordon A. Ferns, Habibollah Esmaily, Mahnaz Amini, Tags: Research Communication Source Type: research

Temporal correlation of morphological and biochemical changes with the recruitment of different mechanisms of reactive oxygen species formation during human SW872 cell adipogenic differentiation
In conclusion, the morphological and biochemical changes of differentiating SW872 cells are accompanied by the discontinuous formation of ROS derived from NOX-2, increasingly implicated in adipogenesis and adipose tissue dysfunction. In addition, mROS formation was significant only in the late phase of differentiation and was associated with mitochondrial dysfunction. (Source: BioFactors)
Source: BioFactors - July 15, 2021 Category: Biochemistry Authors: Mara Fiorani, Rita De Matteis, Barbara Canonico, Giulia Blandino, Alessandro Mazzoli, Mariele Montanari, Andrea Guidarelli, Orazio Cantoni Tags: Research Communication Source Type: research

Rapid and simultaneous determination of histidine metabolism intermediates in human and mouse microbiota and biomatrices
AbstractHistidine metabolism is a key pathway physiologically involved in satiety, recognition memory, skin, and neural protection and allergic diseases. Microbiologically-produced imidazole propionate induces type II diabetes and interferes with glucose lowering drugs. Despite their determinant health implications, no single method simultaneously assesses histidine metabolites in urine, feces, and microbiota. The aim of this study was to develop a simple, rapid, and sensitive method for the determination of histidine and its major bioactive metabolites histamine, N-acetylhistamine, imidazole-4-acetate,cis-urocanate,trans-...
Source: BioFactors - July 11, 2021 Category: Biochemistry Authors: Inmaculada Acu ña, Alicia Ruiz, Tomás Cerdó, Samuel Cantarero, Ana López‐Moreno, Margarita Aguilera, Cristina Campoy, Antonio Suárez Tags: Research Communication Source Type: research