Fisetin, a phytopolyphenol, targets apoptotic and necroptotic cell death in HepG2 cells
AbstractFisetin (3,7,3 ′,4′‐tetrahydroxyflavone), a bioactive dietary flavonoid, intrigued scientists for its anticancer potential against various cancer types. We investigated the fisetin‐induced inhibition of growth and survival of human hepatocellular carcinoma. Fisetin decreased cell viability and proliferatio n of HepG2 cells as revealed from MTT and clonogenicity assays. Cell cycle arrest in the G2/M phase was observed. Annexin V/propidium iodide (PI) staining followed by flow cytometry revealed that fisetin induced both apoptosis and necroptosis in HepG2 cells. Apoptotic cells were significantly incr...
Source: BioFactors - October 21, 2019 Category: Biochemistry Authors: Kiruthika Sundarraj, Azhwar Raghunath, Lakshmikanthan Panneerselvam, Ekambaram Perumal Tags: RESEARCH COMMUNICATION Source Type: research

Comparison of the therapeutic effect of amniotic fluid stem cells and their exosomes on monoiodoacetate ‐induced animal model of osteoarthritis
In conclusion, this study demonstrates for the first time the efficacy of human AFSC exosomes in counteract cartilage damage, showing a positive correlation with their TGFβ content. (Source: BioFactors)
Source: BioFactors - October 18, 2019 Category: Biochemistry Authors: Manuela Zavatti, Francesca Beretti, Francesca Casciaro, Emma Bertucci, Tullia Maraldi Tags: RESEARCH COMMUNICATION Source Type: research

microRNA ‐29b inhibits cell growth and promotes sensitivity to oxaliplatin in colon cancer by targeting FOLR1
AbstractThe present study was aimed to explore the functional role of microRNA (miR) ‐29b in colon cancer, as well as underlying mechanisms. Expressions of miR‐29b and folate receptor 1 (FOLR1) were measured in both human colon tumor samples and cell lines. Colon cancer cell lines SW480 and SW620 were transfected with miR‐29b mimic, antisense oligonucleotides (ASO)‐miR‐29b , small interfering (siRNA) against FOLR1 (si‐FOLR1), or corresponding negative controls (NCs), and then were incubated with or without oxaliplatin (L‐OHP). Thereafter, cell viability, cytotoxicity, cell apoptosis, and expression of FOLR1, ...
Source: BioFactors - October 17, 2019 Category: Biochemistry Authors: Qiang Fu, Jindai Zhang, Gaofeng Huang, Yonglei Zhang, Minghai Zhao, Yongchao Zhang, Jianguo Xie Tags: RESEARCH COMMUNICATION Source Type: research

MiR ‐183‐5p protects rat hearts against myocardial ischemia/reperfusion injury through targeting VDAC1
In conclusion, miR‐183‐5p can efficiently attenuate I/ R injury and miR‐183‐5p may exert its effect through repressing VDAC1 expression. (Source: BioFactors)
Source: BioFactors - October 16, 2019 Category: Biochemistry Authors: Duomao Lin, Boqun Cui, Jun Ma, Jiayue Ren Tags: RESEARCH COMMUNICATION Source Type: research

Nrf2 ‐modulation by seleno‐hormetic agents and its potential for radiation protection
AbstractThe trace element selenium (Se) is an essential component of selenoproteins and plays a critical role in redox signaling via regulating the activity of selenoenzymes such as thioredoxin reductase ‐1 and glutathione peroxidases. Se compounds and its metabolites possess a wide range of biological functions including anticancer and cytoprotection effects, modulation of hormetic genes and antioxidant enzyme activities. Radiation‐induced injury of normal tissues is a significant side effect f or cancer patients who receive radiotherapy in the clinic and the development of new and effective radioprotectors is an impo...
Source: BioFactors - October 16, 2019 Category: Biochemistry Authors: Desir ée Bartolini, Kenneth D. Tew, Rita Marinelli, Francesco Galli, Gavin Y. Wang Tags: REVIEW ARTICLE Source Type: research

MiR ‐183‐5p protects rat hearts against myocardial ischemia/reperfusion injury through targeting VDAC1
In conclusion, miR‐183‐5p can efficiently attenuate I/ R injury and miR‐183‐5p may exert its effect through repressing VDAC1 expression. (Source: BioFactors)
Source: BioFactors - October 16, 2019 Category: Biochemistry Authors: Duomao Lin, Boqun Cui, Jun Ma, Jiayue Ren Tags: RESEARCH COMMUNICATION Source Type: research

Nrf2 ‐modulation by seleno‐hormetic agents and its potential for radiation protection
AbstractThe trace element selenium (Se) is an essential component of selenoproteins and plays a critical role in redox signaling via regulating the activity of selenoenzymes such as thioredoxin reductase ‐1 and glutathione peroxidases. Se compounds and its metabolites possess a wide range of biological functions including anticancer and cytoprotection effects, modulation of hormetic genes and antioxidant enzyme activities. Radiation‐induced injury of normal tissues is a significant side effect f or cancer patients who receive radiotherapy in the clinic and the development of new and effective radioprotectors is an impo...
Source: BioFactors - October 16, 2019 Category: Biochemistry Authors: Desir ée Bartolini, Kenneth D. Tew, Rita Marinelli, Francesco Galli, Gavin Y. Wang Tags: REVIEW ARTICLE Source Type: research

Issue Information
BioFactors, Volume 45, Issue 5, Page 627-630, September/October 2019. (Source: BioFactors)
Source: BioFactors - October 13, 2019 Category: Biochemistry Tags: Issue Information Source Type: research

Issue Information ‐ Cover
BioFactors, Volume 45, Issue 5, Page spcone-spcone, September/October 2019. (Source: BioFactors)
Source: BioFactors - October 13, 2019 Category: Biochemistry Tags: Issue Information Source Type: research

Issue Information
BioFactors, Volume 45, Issue 5, Page 627-630, September/October 2019. (Source: BioFactors)
Source: BioFactors - October 13, 2019 Category: Biochemistry Tags: Issue Information Source Type: research

Issue Information ‐ Cover
BioFactors, Volume 45, Issue 5, Page spcone-spcone, September/October 2019. (Source: BioFactors)
Source: BioFactors - October 13, 2019 Category: Biochemistry Tags: Issue Information Source Type: research

A novel variant in LPL gene is associated with familial combined hyperlipidemia
In this study, we characterized a large pedigree from MASHAD study in northeast Iran with coinheritance of FCHL and early‐onset cor onary heart disease. In this family, we used whole‐exome sequencing and Sanger sequencing to determine the disease‐associated gene. We identified a novel variant in theLPL gene, leading to a substitution of an asparagine for aspartic acid at position 151. The D151N substitution cosegregated with these characters in all affected family members in the pedigree but it was absent in all unaffected members in this family. We speculated that the mutation D151N inLPL gene might be associated wi...
Source: BioFactors - October 10, 2019 Category: Biochemistry Authors: Eskandar Taghizadeh, Majid Ghayour ‐Mobarhan, Gordon A. Ferns, Alireza Pasdar Tags: RESEARCH COMMUNICATION Source Type: research

Sitagliptin protects liver against aflatoxin B1 ‐induced hepatotoxicity through upregulating Nrf2/ARE/HO‐1 pathway
ABSTRACTDipeptidyl peptidase ‐4 inhibitor (DPP‐4 inhibitor) such as sitagliptin has been presented as antidiabetic drugs and has numerous restorative advantages over different diseases; however, its defensive role against aflatoxin b1 (AFB1) liver toxicity has not been previously examined. Wistar rats (65 weeks, male) wer e utilized in the investigation. Animals were divided into five different groups (n = 10): control; AFB1; AFB1  + Sita (50); AFB1 + Sita (100); and Sita (100). Sitagliptin significantly (*p ≤ .05, **p ≤ .01, and ***p ≤&thin...
Source: BioFactors - October 10, 2019 Category: Biochemistry Authors: Yujiang Ji, Sanatkumar B. Nyamagoud, Nagaraja SreeHarsha, Anurag Mishra, Shiva K. Gubbiyappa, Yogendra Singh Tags: RESEARCH COMMUNICATION Source Type: research

A novel variant in LPL gene is associated with familial combined hyperlipidemia
In this study, we characterized a large pedigree from MASHAD study in northeast Iran with coinheritance of FCHL and early‐onset cor onary heart disease. In this family, we used whole‐exome sequencing and Sanger sequencing to determine the disease‐associated gene. We identified a novel variant in theLPL gene, leading to a substitution of an asparagine for aspartic acid at position 151. The D151N substitution cosegregated with these characters in all affected family members in the pedigree but it was absent in all unaffected members in this family. We speculated that the mutation D151N inLPL gene might be associated wi...
Source: BioFactors - October 10, 2019 Category: Biochemistry Authors: Eskandar Taghizadeh, Majid Ghayour ‐Mobarhan, Gordon A. Ferns, Alireza Pasdar Tags: RESEARCH COMMUNICATION Source Type: research

Sitagliptin protects liver against aflatoxin B1 ‐induced hepatotoxicity through upregulating Nrf2/ARE/HO‐1 pathway
ABSTRACTDipeptidyl peptidase ‐4 inhibitor (DPP‐4 inhibitor) such as sitagliptin has been presented as antidiabetic drugs and has numerous restorative advantages over different diseases; however, its defensive role against aflatoxin b1 (AFB1) liver toxicity has not been previously examined. Wistar rats (65 weeks, male) wer e utilized in the investigation. Animals were divided into five different groups (n = 10): control; AFB1; AFB1  + Sita (50); AFB1 + Sita (100); and Sita (100). Sitagliptin significantly (*p ≤ .05, **p ≤ .01, and ***p ≤&thin...
Source: BioFactors - October 10, 2019 Category: Biochemistry Authors: Yujiang Ji, Sanatkumar B. Nyamagoud, Nagaraja SreeHarsha, Anurag Mishra, Shiva K. Gubbiyappa, Yogendra Singh Tags: RESEARCH COMMUNICATION Source Type: research

Glucorticoid ‐induced obesity individuals have distinct signatures of the gut microbiome
AbstractThe human intestine and its resident microbiota are known to play an essential role in the pathogenesis of primary obesity. However, a little is known of the gut microbiota profiles in individuals with obesity induced by glucocorticoid (GC) therapy. Here, we recruited 28 people with GC ‐induced obesity and 27 age‐ and gender‐matched healthy controls, whose feces have been collected separately, to delineate the gut microbial characteristics in GC‐induced obesity individuals. High‐throughput Illumina sequencing targeting the V4 region of the 16S rRNA gene has been applied to analyze the structure of the int...
Source: BioFactors - October 6, 2019 Category: Biochemistry Authors: Dongxu Qiu, Zhiwei Xia, Jun Deng, Xiao Jiao, Lanzhi Liu, Jing Li Tags: RESEARCH COMMUNICATION Source Type: research

Discovery of a role of the novel hepatokine, hepassocin, in obesity
AbstractObesity is a public health problem that has raised concerns worldwide and is often associated with hepatic steatosis. Hepassocin is a novel hepatokine that causes hepatic steatosis and induces insulin resistance (IR). However, the role of hepassocin in obesity remains obscure. Thus, the aim of this study was to investigate the relationship between hepassocin levels and obesity. In total, 371 subjects who had a normal weight (NW), were overweight, or were obese were enrolled. We found that hepassocin levels in subjects who were overweight (6,705  ± 1,707 pg/ml) or obese (7,335 &plu...
Source: BioFactors - October 6, 2019 Category: Biochemistry Authors: Ru ‐Lai Huang, Chung‐Hao Li, Ye‐Fong Du, Kai‐Pi Cheng, Ching‐Han Lin, Che‐Yuan Hu, Jin Shang Wu, Chih‐Jen Chang, Hung‐Tsung Wu, Horng‐Yih Ou Tags: RESEARCH COMMUNICATION Source Type: research

Variation in energy metabolism arising from the effect of the tumor microenvironment on cell biological behaviors of bladder cancer cells and endothelial cells
AbstractTumor energy metabolism and angiogenesis play significant roles in tumor genesis and development, while the effect of the tumor microenvironment (TME), which tumors rely on, is always ignored. In this research, we cocultured bladder cancer (BC) T24 cells with tumor ‐associated human umbilical vein endothelial cells (HUVECs) under normoxic and hypoxic conditions and detected proliferation, migration, oxidative phosphorylation (OXPHOS) and glycolysis to reveal the energy metabolism characteristics and their effect on cell biological behaviors (CBBs) in the TME . Compared with single‐cultured cells, both coculture...
Source: BioFactors - October 3, 2019 Category: Biochemistry Authors: Dan Li, Wei Jiao, Zhijuan Liang, Liping Wang, Yuanbin Chen, Yonghua Wang, Ye Liang, Haitao Niu Tags: RESEARCH COMMUNICATION Source Type: research

Effects of curcumin on mitochondria in neurodegenerative diseases
AbstractNeurodegenerative diseases (NDs) result from progressive deterioration of selectively susceptible neuron populations in different central nervous system (CNS) regions. NDs are classified in accordance with the primary clinical manifestations (e.g., parkinsonism, dementia, or motor neuron disease), the anatomic basis of neurodegeneration (e.g., frontotemporal degenerations, extrapyramidal disorders, or spinocerebellar degenerations), and fundamental molecular abnormalities (e.g., mutations, mitochondrial dysfunction, and its related molecular alterations). NDs include the Alzheimer disease and Parkinson disease, amo...
Source: BioFactors - October 3, 2019 Category: Biochemistry Authors: Hossein Bagheri, Faezeh Ghasemi, George E. Barreto, Rouhullah Rafiee, Thozhukat Sathyapalan, Amirhossein Sahebkar Tags: REVIEW ARTICLE Source Type: research

Variation in energy metabolism arising from the effect of the tumor microenvironment on cell biological behaviors of bladder cancer cells and endothelial cells
AbstractTumor energy metabolism and angiogenesis play significant roles in tumor genesis and development, while the effect of the tumor microenvironment (TME), which tumors rely on, is always ignored. In this research, we cocultured bladder cancer (BC) T24 cells with tumor ‐associated human umbilical vein endothelial cells (HUVECs) under normoxic and hypoxic conditions and detected proliferation, migration, oxidative phosphorylation (OXPHOS) and glycolysis to reveal the energy metabolism characteristics and their effect on cell biological behaviors (CBBs) in the TME . Compared with single‐cultured cells, both coculture...
Source: BioFactors - October 3, 2019 Category: Biochemistry Authors: Dan Li, Wei Jiao, Zhijuan Liang, Liping Wang, Yuanbin Chen, Yonghua Wang, Ye Liang, Haitao Niu Tags: RESEARCH COMMUNICATION Source Type: research

Effects of curcumin on mitochondria in neurodegenerative diseases
AbstractNeurodegenerative diseases (NDs) result from progressive deterioration of selectively susceptible neuron populations in different central nervous system (CNS) regions. NDs are classified in accordance with the primary clinical manifestations (e.g., parkinsonism, dementia, or motor neuron disease), the anatomic basis of neurodegeneration (e.g., frontotemporal degenerations, extrapyramidal disorders, or spinocerebellar degenerations), and fundamental molecular abnormalities (e.g., mutations, mitochondrial dysfunction, and its related molecular alterations). NDs include the Alzheimer disease and Parkinson disease, amo...
Source: BioFactors - October 3, 2019 Category: Biochemistry Authors: Hossein Bagheri, Faezeh Ghasemi, George E. Barreto, Rouhullah Rafiee, Thozhukat Sathyapalan, Amirhossein Sahebkar Tags: REVIEW ARTICLE Source Type: research

A systematic review on the mechanisms of vitamin K effects on the complications of diabetes and pre ‐diabetes
In conclusion, clinical trials and animal studies confirm that vitamin K supplementation may improve both clinical features and complications of diabetes and pre‐diabetes. However, quantification of clinical effic acy in the pre‐diabetic population and among individuals with comorbidities requires further investigation. (Source: BioFactors)
Source: BioFactors - October 1, 2019 Category: Biochemistry Authors: Nahid Karamzad, Vahid Maleki, Kristin Carson ‐Chahhoud, Samaneh Azizi, Amirhossein Sahebkar, Bahram Pourghassem Gargari Tags: REVIEW ARTICLE Source Type: research

Ginkgolide B and bilobalide promote the growth and increase β‐catenin expression in hair follicle dermal papilla cells of American minks
In conclusion, although the two components influenced the β‐catenin signaling activity in distinct mechanisms, they both increased the viability of DP cells and promoted the cycle of hair follicles . (Source: BioFactors)
Source: BioFactors - September 14, 2019 Category: Biochemistry Authors: Haihua Zhang, Qiumei Shi, Weixiao Nan, Yaqi Wang, Shiyong Wang, Fuhe Yang, Guangyu Li Tags: RESEARCH COMMUNICATION Source Type: research

Transplantation of fecal microbiota from patients with alcoholism induces anxiety/depression behaviors and decreases brain mGluR1/PKC ε levels in mouse
AbstractRecent studies have revealed that the gut microbiota participates in the psychiatric behavior changes in disorders associated with alcohol. But it still remains unknown whether alcoholism is involved in changes in gut microbiota and its underlying mechanism is also not clear. Here, we tested the gut microbiota of patients with alcoholism and conducted fecal microbiota transplantation (FMT) from patients with alcoholism to C57BL/6J mice whose gut microbiota had been sharply suppressed with antibiotics (ABX). Then we evaluated their alcohol preference degree, anxiety, and depression ‐like behaviors and social inter...
Source: BioFactors - September 13, 2019 Category: Biochemistry Authors: Wenbo Zhao, Ying Hu, Chuangang Li, Ning Li, Shaowei Zhu, Xu Tan, Meng Li, Yue Zhang, Zheng Xu, Zhaoxi Ding, Lingming Hu, Zengxun Liu, Jinhao Sun Tags: RESEARCH COMMUNICATION Source Type: research

Serum vitamin D concentrations are inversely related to prevalence of metabolic syndrome in Qatari women
AbstractHypovitaminosis D has reached epidemic proportions in Qatar. Vitamin D is linked to several cardiometabolic diseases such as metabolic syndrome (MetSyn), diabetes, and atherosclerosis. It is not known if vitamin D status is linked to cardiometabolic risk factors in Qatari women. Therefore, a relationship between serum 25 ‐hydroxyvitmain D [25(OH)D] concentrations and MetSyn was investigated in Qatari women using the Qatar Biobank database. Study sample consisted of 700 women, aged 20–80 years old. A multivariate‐adjusted logistic regression was used to determine relation between serum 25(OH)D and M...
Source: BioFactors - September 12, 2019 Category: Biochemistry Authors: Vijay Ganji, Ayah Sukik, Haya Alaayesh, Hodais Rasoulinejad, Mujahed Shraim Tags: RESEARCH COMMUNICATION Source Type: research

Modulation of cardiac optogenetics by vitamin A
In this study, we explored whether exogenous vitamin A can be a limiting factor in the light responsiveness of cardiomyocytes‐expressing ChR2. We showed that in cardiomyocytes virally transduced with ChR2 (H134R)‐enhanced yellow fluorescent protein, vitamin A supplements lower than 10 μM significantly increased ChR2 expression. Adding 1 μM vitamin A changed light‐induced transmembrane potential difference significantly, whereas 5 μM dramatically induced membrane depolarization and triggered intracellular calcium elevation. We concluded that vitamin A supp lementation can modulate the eff...
Source: BioFactors - September 11, 2019 Category: Biochemistry Authors: Hoda Keshmiri Neghab, Bahram Goliaei, Ali A. Saboury, Gholamreza Esmaeeli Djavid, Majid Pornour, Jun Hong, Michael Grusch Tags: RESEARCH COMMUNICATION Source Type: research

Mesenchymal stromal cell secretome as a therapeutic strategy for traumatic brain injury
AbstractTraumatic brain injury (TBI) is a global health problem that is a common cause of disability and mortality. Despite the availability of many treatment options, none is capable of restoring functional and structural recovery of the damaged brain. Both the results of preclinical and clinical studies suggest the use of mesenchymal stromal cells (MSCs) as a therapeutic strategy for structural and functional recovery in TBI. However, recent evidence shows that the neuroprotective potential of MSCs is due to multiple secretions of bioactive molecules that modulate tissue microenvironment for tissue repair and regeneratio...
Source: BioFactors - September 9, 2019 Category: Biochemistry Authors: Suleiman A. Muhammad Tags: REVIEW ARTICLE Source Type: research

Bioinformatic analysis of the prognostic value and potential regulatory network of FOXF1 in papillary thyroid cancer
In this study, we aimed to explore the expression profile ofFOXF1 in papillary thyroid cancer (PTC) and corresponding adjacent normal tissues, by using data from The Cancer Genome Atlas ‐Thyroid Cancer (TCGA‐THCA) and The Genotype‐Tissue Expression (GTEx) project. Also, we studied its prognostic significance in PTC and its potential regulatory network. Results showed thatFOXF1 expression was significantly lower in PTC tissues compared with adjacent normal tissues. Subgroup analysis only confirmed the downregulation in classical histological variant, but not in tall ‐cell and follicular variants.FOXF1 downregulation...
Source: BioFactors - September 9, 2019 Category: Biochemistry Authors: Yi Gu, Chunmei Hu Tags: RESEARCH COMMUNICATION Source Type: research

Mesenchymal stromal cell secretome as a therapeutic strategy for traumatic brain injury
AbstractTraumatic brain injury (TBI) is a global health problem that is a common cause of disability and mortality. Despite the availability of many treatment options, none is capable of restoring functional and structural recovery of the damaged brain. Both the results of preclinical and clinical studies suggest the use of mesenchymal stromal cells (MSCs) as a therapeutic strategy for structural and functional recovery in TBI. However, recent evidence shows that the neuroprotective potential of MSCs is due to multiple secretions of bioactive molecules that modulate tissue microenvironment for tissue repair and regeneratio...
Source: BioFactors - September 9, 2019 Category: Biochemistry Authors: Suleiman A. Muhammad Tags: REVIEW ARTICLE Source Type: research

Bioinformatic analysis of the prognostic value and potential regulatory network of FOXF1 in papillary thyroid cancer
In this study, we aimed to explore the expression profile ofFOXF1 in papillary thyroid cancer (PTC) and corresponding adjacent normal tissues, by using data from The Cancer Genome Atlas ‐Thyroid Cancer (TCGA‐THCA) and The Genotype‐Tissue Expression (GTEx) project. Also, we studied its prognostic significance in PTC and its potential regulatory network. Results showed thatFOXF1 expression was significantly lower in PTC tissues compared with adjacent normal tissues. Subgroup analysis only confirmed the downregulation in classical histological variant, but not in tall ‐cell and follicular variants.FOXF1 downregulation...
Source: BioFactors - September 9, 2019 Category: Biochemistry Authors: Yi Gu, Chunmei Hu Tags: RESEARCH COMMUNICATION Source Type: research

Redox control of vascular biology
AbstractRedox control is lost when the antioxidant defense system cannot remove abnormally high concentrations of signaling molecules, such as reactive oxygen species (ROS). Chronically elevated levels of ROS cause oxidative stress that may eventually lead to cancer and cardiovascular and neurodegenerative diseases. In this review, we focus on redox effects in the vascular system. We pay close attention to the subcompartments of the vascular system (endothelium, smooth muscle cell layer) and give an overview of how redox changes influence those different compartments. We also review the core aspects of redox biology, cardi...
Source: BioFactors - September 4, 2019 Category: Biochemistry Authors: Milan Obradovic, Magbubah Essack, Sonja Zafirovic, Emina Sudar ‐Milovanovic, Vladan P. Bajic, Christophe Van Neste, Andreja Trpkovic, Julijana Stanimirovic, Vladimir B. Bajic, Esma R. Isenovic Tags: REVIEW ARTICLE Source Type: research

Glutathione transferase genotypes may serve as determinants of risk and prognosis in renal cell carcinoma
AbstractRenal cell carcinoma (RCC) represents a group of histologically similar neoplasms with significant intratumor and intertumor genetic heterogeneity. Recognized risk factors for RCC development include smoking, hypertension, obesity, as well as von Hippel –Lindau (VHL) disease. Inactivation of VHL, deregulated nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2) pathway, and altered redox homeostasis, together with changes in glutathione transferase (GST) profile, are considered as important contributing factors in RCC development and progression . Although the available results of both gene–gene and ge...
Source: BioFactors - September 4, 2019 Category: Biochemistry Authors: Marija Pljesa ‐Ercegovac, Ana Savic‐Radojevic, Vesna Coric, Tanja Radic, Tatjana Simic Tags: REVIEW ARTICLE Source Type: research

Redox control of vascular biology
AbstractRedox control is lost when the antioxidant defense system cannot remove abnormally high concentrations of signaling molecules, such as reactive oxygen species (ROS). Chronically elevated levels of ROS cause oxidative stress that may eventually lead to cancer and cardiovascular and neurodegenerative diseases. In this review, we focus on redox effects in the vascular system. We pay close attention to the subcompartments of the vascular system (endothelium, smooth muscle cell layer) and give an overview of how redox changes influence those different compartments. We also review the core aspects of redox biology, cardi...
Source: BioFactors - September 4, 2019 Category: Biochemistry Authors: Milan Obradovic, Magbubah Essack, Sonja Zafirovic, Emina Sudar ‐Milovanovic, Vladan P. Bajic, Christophe Van Neste, Andreja Trpkovic, Julijana Stanimirovic, Vladimir B. Bajic, Esma R. Isenovic Tags: REVIEW ARTICLE Source Type: research

Glutathione transferase genotypes may serve as determinants of risk and prognosis in renal cell carcinoma
AbstractRenal cell carcinoma (RCC) represents a group of histologically similar neoplasms with significant intratumor and intertumor genetic heterogeneity. Recognized risk factors for RCC development include smoking, hypertension, obesity, as well as von Hippel –Lindau (VHL) disease. Inactivation of VHL, deregulated nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2) pathway, and altered redox homeostasis, together with changes in glutathione transferase (GST) profile, are considered as important contributing factors in RCC development and progression . Although the available results of both gene–gene and ge...
Source: BioFactors - September 4, 2019 Category: Biochemistry Authors: Marija Pljesa ‐Ercegovac, Ana Savic‐Radojevic, Vesna Coric, Tanja Radic, Tatjana Simic Tags: REVIEW ARTICLE Source Type: research

Network analysis, and human and animal studies disclose the anticystitis glandularis effects of vitamin C
ConclusionCollectively, these bioinformatic findings and experimentative data uncover the therapeutic targets and biological mechanisms of VC for treating CG, in which the key biomarkers of TNF ‐α, IL6, and c‐Jun may be the potential molecules for treating CG in clinical application. (Source: BioFactors)
Source: BioFactors - August 30, 2019 Category: Biochemistry Authors: Bo Ge, Chao Guo, Yujia Liang, Meizhen Liu, Ka Wu Tags: RESEARCH COMMUNICATION Source Type: research

Docosahexaenoic acid and hydroxytyrosol co ‐administration fully prevents liver steatosis and related parameters in mice subjected to high‐fat diet: A molecular approach
AbstractAttenuation of high ‐fat diet (HFD)‐induced liver steatosis is accomplished by different nutritional interventions. Considering that the n‐3 PUFA docosahexaenoic acid (DHA) modulates lipid metabolism and the antioxidant hydroxytyrosol (HT) diminishes oxidative stress underlying fatty liver, it is hypothesized tha t HFD‐induced steatosis is suppressed by DHA and HT co‐administration. Male C57BL/6J mice were fed a control diet (CD; 10% fat, 20% protein, 70% carbohydrates) or a HFD (60% fat, 20% protein, 20% carbohydrates) for 12 weeks, without and with supplementation of DHA (50 mg/kg/day), HT...
Source: BioFactors - August 27, 2019 Category: Biochemistry Authors: Sandra A. Soto ‐Alarcón, Macarena Ortiz, Paula Orellana, Francisca Echeverría, Andrés Bustamante, Alejandra Espinosa, Paola Illesca, Daniel Gonzalez‐Mañán, Rodrigo Valenzuela, Luis A. Videla Tags: RESEARCH COMMUNICATION Source Type: research

Proline ‐containing peptides—New insight and implications: A Review
AbstractThe family of regulatory proline ‐containing peptides (PCPs), also known as glyprolines, exhibit significant biological activity. The group of glyprolines includes Gly‐Pro (GP), Pro‐Gly‐Pro (PGP), cyclic Gly‐Pro (cGP), as well as PGP derivatives, for example, N‐acetylated PGP (N‐a‐PGP) and N‐methylated PGP (N‐m‐ PGP). PCPs are engaged in various biological processes including the proinflammatory neutrophil chemoattraction in lung diseases, inflammatory bowel diseases or ischemic stroke. Glyprolines have been also postulated to play an important role as atheroprotective and anticoagulant agents...
Source: BioFactors - August 20, 2019 Category: Biochemistry Authors: Magdalena Misiura, Wojciech Miltyk Tags: REVIEW ARTICLE Source Type: research

Therapeutic effects of Crocin in autoimmune diseases: A review
AbstractThe immune system when acts against selfmolecules results in an imbalance in immunologic tolerance leading to the development of several autoimmune diseases (ADs) such as rheumatoid arthritis, asthma, ulcerative colitis, type 1 diabetes, and multiple sclerosis. Improved recognition of the mechanisms of ADs has led to the advancement of the management of these diseases. The principal mediators of ADs are inflammatory molecules. The herbal medicines due to their antioxidant and antiinflammatory properties have an important role in the management of ADs. Crocin is the principal chemical component extracted from saffro...
Source: BioFactors - August 20, 2019 Category: Biochemistry Authors: Shahla Korani, Mitra Korani, Thozhukat Sathyapalan, Amirhossein Sahebkar Tags: REVIEW ARTICLE Source Type: research

Proline ‐containing peptides—New insight and implications: A Review
AbstractThe family of regulatory proline ‐containing peptides (PCPs), also known as glyprolines, exhibit significant biological activity. The group of glyprolines includes Gly‐Pro (GP), Pro‐Gly‐Pro (PGP), cyclic Gly‐Pro (cGP), as well as PGP derivatives, for example, N‐acetylated PGP (N‐a‐PGP) and N‐methylated PGP (N‐m‐ PGP). PCPs are engaged in various biological processes including the proinflammatory neutrophil chemoattraction in lung diseases, inflammatory bowel diseases or ischemic stroke. Glyprolines have been also postulated to play an important role as atheroprotective and anticoagulant agents...
Source: BioFactors - August 20, 2019 Category: Biochemistry Authors: Magdalena Misiura, Wojciech Miltyk Tags: REVIEW ARTICLE Source Type: research

Therapeutic effects of Crocin in autoimmune diseases: A review
AbstractThe immune system when acts against selfmolecules results in an imbalance in immunologic tolerance leading to the development of several autoimmune diseases (ADs) such as rheumatoid arthritis, asthma, ulcerative colitis, type 1 diabetes, and multiple sclerosis. Improved recognition of the mechanisms of ADs has led to the advancement of the management of these diseases. The principal mediators of ADs are inflammatory molecules. The herbal medicines due to their antioxidant and antiinflammatory properties have an important role in the management of ADs. Crocin is the principal chemical component extracted from saffro...
Source: BioFactors - August 20, 2019 Category: Biochemistry Authors: Shahla Korani, Mitra Korani, Thozhukat Sathyapalan, Amirhossein Sahebkar Tags: REVIEW ARTICLE Source Type: research