PAF ‐induced inflammatory and immuno‐allergic ophthalmic diseases and their mitigation with PAF receptor antagonists: Cell and nuclear effects
AbstractOcular allergies are becoming more prevalent as more airborne pollutants, irritants and microbes pervade our environment. Inflammatory and allergic mediators released by dendritic and mast cells within the conjunctiva cause allergic conjunctivitis (AC), a prevalent ocular surface disorder that affects>40% of the world's human population on a seasonal or perennial basis. Even though histamine is a major culprit, platelet-activating factor (PAF) also contributes to AC, acting either directly or synergistically with histamine and other mediators. PAF receptor-meditated inflammatory reactions, via cell-membrane-boun...
Source: BioFactors - May 21, 2022 Category: Biochemistry Authors: Najam A. Sharif Tags: Review Article Source Type: research
Carboxylative efficacy of trans and cis MK7 and comparison with other vitamin K isomers
AbstractCarboxylative enzymes are involved in many pathways and their regulation plays a crucial role in many of these pathways. In particular, γ-glutamylcarboxylase (GGCX) converts glutamate residues (Glu) into γ-carboxyglutamate (Gla) of the vitamin K-dependent proteins (VKDPs) activating them. VKDPs include at least 17 proteins involved in processes such as blood coagulation, blood vessels calcification, and bone mineralization. VKDPs are activated by the reduced form of vitamin K, naturally occurring as vitamin K1 (phylloquinone) and K2 (menaquinones, MKs). Among these, MK7 is the most efficient in terms of bioavaila...
Source: BioFactors - May 19, 2022 Category: Biochemistry Authors: Ilenia Cirilli, Patrick Orlando, Sonia Silvestri, Fabio Marcheggiani, Phiwayinkosi V. Dludla, Nadine Kaesler, Luca Tiano Tags: Research Communication Source Type: research
HDL ‐mediated reduction of cholesterol content inhibits the proliferation of prostate cancer cells induced by LDL: Role of ABCA1 and proteasome inhibition
In conclusion, the antiproliferative activity of HDL on AR-positive and AR-null PCa cells also rely on cholesterol removal, a process in which the ABCA1 transporter plays a key role. (Source: BioFactors)
Source: BioFactors - May 18, 2022 Category: Biochemistry Authors: Alice Ossoli, Eleonora Giorgio, Federica Cetti, Massimiliano Ruscica, Claudio Rabacchi, Patrizia Tarugi, Paolo Parini, Matteo Pedrelli, Monica Gomaraschi Tags: Research Communication Source Type: research
Selective inhibition of phosphodiesterase 4D increases tau phosphorylation at Ser214 residue
AbstractTau is a protein that normally participates in the assembly and stability of microtubules. However, it can form intraneuronal hyperphosphorylated aggregates that are hallmarks of Alzheimer's disease and other neurodegenerative disorders known as tauopathies. Tau can be phosphorylated by multiple kinases at several sites. Among such kinases, the cAMP-dependent protein kinase A (PKA) phosphorylates tau at Ser214 (pTAU-S214), an event that was shown to reduce the pathological assembly of the protein. Given that the neuronal cAMP/PKA-activated cascade is involved in synaptic plasticity and memory, and that cAMP-enhanci...
Source: BioFactors - May 15, 2022 Category: Biochemistry Authors: Viviana Villa, Giulia Montalto, Francesca Caudano, Ernesto Fedele, Roberta Ricciarelli Tags: Research Communication Source Type: research
Experimental and clinical evidence on the effect of carvacrol on respiratory, allergic, and immunologic disorders: A comprehensive review
AbstractCarvacrol (CAR) showed various pharmacological and therapeutic effects in different disorders. In the current article, the experimental and clinical effects of CAR on respiratory, allergic, and immunologic disorders are described. Various databases, including PubMed, Science Direct, and Scopus, were searched regarding the effects of CAR on respiratory and allergic disorders until the end of October 2021. CAR showed the relaxant effect, with various possible mechanisms suggesting the bronchodilatory effect in obstructive pulmonary diseases. The preventive effects of CAR on experimental animal models of respiratory d...
Source: BioFactors - May 13, 2022 Category: Biochemistry Authors: Mahammad R. Khazdair, Vahideh Ghorani, Mohammad H. Boskabady Tags: Review Article Source Type: research
Docosahexaenoic acid may promote immune evasion of colorectal cancer cells through targeting immune checkpoint and immunomodulator genes and their controlling microRNAs
This study showed that DHA has anti-proliferative and anti-metastatic properties by downregulation of proteins involved in the growth and invasion of colorectal tumors. DHA could be used as a potential immune checkpoint inhibitor for the treatment of colorectal cancers. (Source: BioFactors)
Source: BioFactors - May 11, 2022 Category: Biochemistry Authors: Manouchehr Fadaee, Hajar Abbasi, Sepideh Maralbashi, Behzad Baradaran, Dariush Shanehbandi, Masood Faghih Dinevari, Tohid Kazemi Tags: Research Communication Source Type: research
Lipid bilayer composition as a determinant of cancer cell sensitivity to tumoricidal protein ‐lipid complexes
This study examined membrane lipid composition as a determinant of tumor cell reactivity. Bladder cancer tissue showed a higher abundance of unsaturated lipids enriched in phosphatidylcholine, PC (36:4) and PC (38:4), and sphingomyelin, SM (36:1) than healthy bladder tissue, where saturated lipids predominated and the lipid extracts from bladder cancer tissue inhibited the tumoricidal effect of the complex more effectively than healthy tissue extracts. Furthermore, unsaturated PC in solution inhibited tumor cell death, and the complex interacted with giant unilamellar vesicles formed by PC, confirming the affinity of alpha...
Source: BioFactors - April 7, 2022 Category: Biochemistry Authors: James C. S. Ho, Sartaj Ahmad Mir, Michele Cavalera, Parisa Esmaeili, Tuan Hiep Tran, Zandra Chew Yann, Thi Hien Tran, Arunima Chaudhuri, Anne K. Bendt, Markus R. Wenk, Catharina Svanborg Tags: Research Communication Source Type: research