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Guggulsterone Selectively Modulates STAT-3, mTOR, and PPAR-Gamma Signaling in a Methylmercury-Exposed Experimental Neurotoxicity: Evidence from CSF, Blood Plasma, and Brain Samples
AbstractAmyotrophic lateral sclerosis (ALS) is a paralytic disease that damages the brain and spinal cord motor neurons. Several clinical and preclinical studies have found that methylmercury (MeHg+) causes ALS. In ALS, MeHg+-induced neurotoxicity manifests as oligodendrocyte destruction; myelin basic protein (MBP) deficiency leads to axonal death. ALS development has been connected to an increase in signal transducer and activator of transcription-3 (STAT-3), a mammalian target of rapamycin (mTOR), and a decrease in peroxisome proliferator-activated receptor (PPAR)-gamma. Guggulsterone (GST), a plant-derived chemical prod...
Source: Molecular Neurobiology - January 3, 2024 Category: Neurology Source Type: research

Multiple brown tumors: a bone complication due to long-term untreated pseudohypoparathyroidism
We describe the case of a 33-year-old woman, referred for the diagnostic evaluation of lytic bone lesions of the lower limbs, in the context of asymptomatic pseudohypoparathyroidism. She had been treated with alfacalcidol and calcium during her childhood. Treatment was discontinued at the age of 18 years old because of the lack of symptoms. A femur biopsy revealed a lesion rich in giant cells, without malignancy, consistent with a brown tumor. Laboratory tests showed a parathyroid level at 1387 pg/ml (14 –50). Whole-body Fluorocholine PET/CT revealed hypermetabolism of bone lesions. The final diagnosis was brown tumors r...
Source: Osteoporosis International - January 1, 2024 Category: Orthopaedics Source Type: research

Cardioprotective effect of vitamin D3 on cisplatin-induced cardiotoxicity in male mice: role of oxidative stress
Naunyn Schmiedebergs Arch Pharmacol. 2023 Dec 27. doi: 10.1007/s00210-023-02848-0. Online ahead of print.ABSTRACTCisplatin (CP) is a chemotherapy drug used in a broad spectrum of cancer. The current study investigated the protective effect of vitamin D3 (vit-D3) on CP-induced cardiotoxicity. Forty-two male Balb-c mice (20-25 g) were divided into seven groups (GP), 6 per/group were included: GP1 was considered the control group, GP2 received a single dose of I.V. injection of cisplatin (10 mg/kg). Seven days before cisplatin injection on GP3 and GP4 as pre-treatment, vit-D3 was injected I.P. with the doses of 500 IU/kg and ...
Source: Cancer Control - December 27, 2023 Category: Cancer & Oncology Authors: Iman Samavati Akram Ranjbar Rasool Haddadi Source Type: research

1,25(OH) < sub > 2 < /sub > D < sub > 3 < /sub > alleviates oxidative stress and inflammation through up-regulating HMGCS2 in DSS-induced colitis
CONCLUSION: 1,25(OH)2D3 supplementation up-regulates HMGCS2, which is responsible for 1,25(OH)2D3-mediated protection against oxidative stress and inflammation in DSS-induced colitis. These findings provide a potential therapeutic strategy for alleviating colitis-associated oxidative stress and inflammation.PMID:38149572 | DOI:10.1016/j.intimp.2023.111131 (Source: International Immunopharmacology)
Source: International Immunopharmacology - December 27, 2023 Category: Allergy & Immunology Authors: Hong-Qian Wang Meng-Xue Zhao Shao-Cheng Hong Xue He Li Tao Cheng-Cheng Tong None Jing Guan De-Xiang Xu Xi Chen Source Type: research

Vitamin D3 promotes fish oocyte development by directly regulating gonadal steroid hormone synthesis
In conclusion, this study shows that an appropriate concentration of VD3 can promote zebrafish ovarian development and affect VTG synthesis through the vdr/cyp19a1a/er/vtg gene axis.PMID:38145497 | DOI:10.1093/biolre/ioad176 (Source: Biology of Reproduction)
Source: Biology of Reproduction - December 25, 2023 Category: Reproduction Medicine Authors: Gang Yang Ke Cheng Yanqing Huang Chunfang Wang Source Type: research

Vitamin D3 promotes fish oocyte development by directly regulating gonadal steroid hormone synthesis
In conclusion, this study shows that an appropriate concentration of VD3 can promote zebrafish ovarian development and affect VTG synthesis through the vdr/cyp19a1a/er/vtg gene axis.PMID:38145497 | DOI:10.1093/biolre/ioad176 (Source: Reproductive Biology)
Source: Reproductive Biology - December 25, 2023 Category: Reproduction Medicine Authors: Gang Yang Ke Cheng Yanqing Huang Chunfang Wang Source Type: research