1,25(OH) < sub > 2 < /sub > D < sub > 3 < /sub > alleviates oxidative stress and inflammation through up-regulating HMGCS2 in DSS-induced colitis

CONCLUSION: 1,25(OH)2D3 supplementation up-regulates HMGCS2, which is responsible for 1,25(OH)2D3-mediated protection against oxidative stress and inflammation in DSS-induced colitis. These findings provide a potential therapeutic strategy for alleviating colitis-associated oxidative stress and inflammation.PMID:38149572 | DOI:10.1016/j.intimp.2023.111131

Source: International Immunopharmacology - December 27, 2023 Category: Allergy & Immunology Authors: Hong-Qian Wang Meng-Xue Zhao Shao-Cheng Hong Xue He Li Tao Cheng-Cheng Tong None Jing Guan De-Xiang Xu Xi Chen Source Type: research