Vitamin D3 Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Resveratrol modulates the Nrf2/NF- κB pathway and inhibits TSLP-mediated atopic march
CONCLUSION: Resveratrol attenuates TSLP-reduced atopic march through ameliorating inflammation and cell infiltration in pulmonary and ear skin tissues by inhibiting the abnormal activation of NF-κB signaling pathway.PMID:38186188 | DOI:10.15586/aei.v52i1.963 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - January 8, 2024 Category: Allergy & Immunology Authors: Quan He Weihua Liu Zi Chen Guangfei Wei Jingxian Jiang Liuchao Zhang Linfu Zhou Source Type: research

The Effect of Vitamin D3 on Neutrophil Extracellular Trap Formation in High-Glucose Conditions
NETosis,i.e., the formation of neutrophil extracellular traps (NET), and neutrophil autophagy are important elements in the pathogenesis and the development of complications of type 2 diabetes mellitus (T2DM). Therefore, the search of drugs that can regulate the level of NETosis and autophagy in T2DM is relevant. Here we studied anex vivo NET formation and neutrophil death in whole blood from healthy subjects upon the addition of glucose up to a high concentration of 15 mM or/and the phorbol ester PMA (phorbol-12-myristate-13-acetate). Their individual and combined action caused neutrophil death and an increase in NET cont...
Source: Bulletin of Experimental Biology and Medicine - January 8, 2024 Category: Biology Source Type: research

GSE222269 Antifibrogenic activities of CYP11A1-derived vitamin D3-hydroxyderivatives are modified by ROR γ expression [II]
Contributors : Andrzej T Slominski ; Zorica JanjetovicSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe aim of this study was to test the role of ROR γ in the action of the above analogs using murine fibroblasts isolated from the skin of wild type (RORg+/+) and knock out (RORg-/-) mice. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - January 7, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Vitamin D Levels as a Potential Modifier of Eosinophilic Esophagitis Severity in Adults
ConclusionsAfter adjusting for age, sex, and race, 25(OH)D3 levels were lower in EoE cases than controls, but deficiency was not common. 25(OH)D3 levels were generally similar across most EoE disease features. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - January 6, 2024 Category: Gastroenterology Source Type: research

High-dose vitamin D < sub > 3 < /sub > supplementation shows no beneficial effects on white blood cell counts, acute phase reactants, or frequency of respiratory infections
CONCLUSIONS: High-dose vitamin D3 supplementation did not alter WBCs or APRs, but a higher prevalence of respiratory infections was observed in the vitamin D3 group. Serum 25(OH)D3 was negatively correlated with most WBCs, indicating that vitamin D status may be linked with inflammation and WBC turnover, but not an important determinant of developing RTIs.TRIAL REGISTRATION: NCT01304927 (ClinicalTrials.gov). Registered February 20, 2011.PMID:38178229 | DOI:10.1186/s12931-023-02642-9 (Source: Cell Research)
Source: Cell Research - January 4, 2024 Category: Cytology Authors: Gustav Wall-Gremstrup Rune Holt Sam Kafai Yahyavi Mads Joon Jorsal Anders Juul Niels J ørgensen Martin Blomberg Jensen Source Type: research

Vitamin D ameliorates age-induced nonalcoholic fatty liver disease by increasing the mitochondrial contact site and cristae organizing system (MICOS) 60 level
Experimental & Molecular Medicine, Published online: 04 January 2024; doi:10.1038/s12276-023-01125-7Nonalcoholic fatty liver disease (a condition in which fat builds up in the liver) (NAFLD) is increasingly affecting health, especially among the older population. The causes behind this disease are still unclear, but a fresh study by Lim and colleagues adds to our knowledge. They discovered that a reduction in a protein named Mic60 in the liver mitochondria of old mice leads to fat buildup, a major sign of NAFLD. However, when the mice consumed a diet enriched with vitamin D3, the Mic60 protein levels returned to normal...
Source: Experimental and Molecular Medicine - January 4, 2024 Category: Molecular Biology Authors: Gyu Hee Kim Hyeon-Ju Jeong Yoo Jeong Lee Hyeon Young Park Soo Kyung Koo Joo Hyun Lim Source Type: research

Aortic calcification accelerates cardiac dysfunction via inducing apoptosis of cardiomyocytes
Int J Med Sci. 2024 Jan 1;21(2):306-318. doi: 10.7150/ijms.90324. eCollection 2024.ABSTRACTVascular calcification (VC) is a known predictor of cardiovascular events in patients with atherosclerosis and chronic renal disease. However, the exact relationship between VC and cardiovascular mortality remains unclear. Herein, we investigated the underlying mechanisms between VC progression, arterial stiffness, and cardiac dysfunction. C57BL/6 mice were administered intraperitoneally vitamin D3 (VD3) at a dosage of 35×104 IU/day for 14 days. At day 42, VC extent, artery elasticity, carotid artery blood flow, aorta pulse propagat...
Source: International Journal of Medical Sciences - January 3, 2024 Category: Biomedical Science Authors: Nannan Hao Hui Yong Feifei Zhang Chang Liu Yulu Qiu Yumeng Shi Chunjian Li Fang Wang Source Type: research

Empagliflozin ameliorates vascular calcification in diabetic mice through inhibiting Bhlhe40-dependent NLRP3 inflammasome activation
Acta Pharmacol Sin. 2024 Jan 3. doi: 10.1038/s41401-023-01217-0. Online ahead of print.ABSTRACTType 2 diabetes mellitus (T2DM) patients exhibit greater susceptibility to vascular calcification (VC), which has a higher risk of death and disability. However, there is no specific drug for VC therapy. NLRP3 inflammasome activation as a hallmark event of medial calcification leads to arterial stiffness, causing vasoconstrictive dysfunction in T2DM. Empagliflozin (EMPA), a sodium-glucose co-transporter 2 inhibitor (SGLT2i), restrains hyperglycemia with definite cardiovascular benefits. Given the anti-inflammatory activity of EMP...
Source: Acta Pharmacologica Sinica - January 3, 2024 Category: Drugs & Pharmacology Authors: Xiao-Xue Li Zheng-Dong Chen Xue-Jiao Sun Yi-Qing Yang Hong Jin Nai-Feng Liu Source Type: research