Smooth muscle cell-specific MMP-3 deletion reduces osteogenic transformation and medial artery calcification

CONCLUSION: These findings suggest that MMP-3 expression in vascular SMCs is an important regulator of medial calcification and that targeting MMP-3 could provide a therapeutic strategy to reduce it and address its consequences in patients with PAD.PMID:38454645 | DOI:10.1093/cvr/cvae035

Source: Atherosclerosis - March 8, 2024 Category: Cardiology Authors: Yangzhouyun Xie Tonghui Lin Ying Jin Alexa G Berezowitz Xue-Lin Wang Jinny Lu Yujun Cai Raul J Guzman Source Type: research