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Inappropriate laboratory test utilization in outpatient tertiary care: Implications for value-based healthcare
CONCLUSION: The study identified significantly high rates of inadequate repetitions of frequently requested laboratory tests. Urgent action is therefore crucial to overcoming such an issue.PMID:38657991 | DOI:10.15537/smj.2024.45.4.20230512 (Source: Saudi Medical Journal)
Source: Saudi Medical Journal - April 24, 2024 Category: Middle East Health Authors: Nouf F Almasoud Mohammed A Aldosari Ahmed S Mahmoud Yaser A Alendijani Abdullah H Alkhenizan Source Type: research

The role of vitamin D in outcomes of critical care in COVID-19 patients: Evidence from an umbrella meta-analysis of interventional and observational studies
CONCLUSION: Overall, vitamin D status is a critical factor influencing the mortality rate, disease severity, admission to ICU and being detached from mechanical ventilation. It is vital to monitor the vitamin D status in all patients with critical conditions including COVID patients.PMID:38654693 | DOI:10.1017/S1368980024000934 (Source: Public Health Nutrition)
Source: Public Health Nutrition - April 24, 2024 Category: International Medicine & Public Health Authors: Abdolreza Jamilian Faezeh Ghalichi Fatemeh Hamedi Kalajahi Nima Radkhah Neda Jourabchi Vali Musazadeh Ehsan Amini-Salehi Meysam Zarezadeh Alireza Ostadrahimi Source Type: research

Chronic Pancreatitis-Associated Metabolic Bone Diseases: Epidemiology, Mechanisms, and Clinical Advances
Am J Physiol Endocrinol Metab. 2024 Apr 24. doi: 10.1152/ajpendo.00113.2024. Online ahead of print.ABSTRACTChronic pancreatitis (CP) is a progressive inflammatory disease with an increasing global prevalence. In recent years, a strong association between CP and metabolic bone diseases (MBDs), especially osteoporosis, has been identified, attracting significant attentions in the research field. Epidemiological data suggest a rising trend in the incidence of MBDs among CP patients. Notably, recent studies have highlighted a profound interplay between CP and altered nutritional and immune profiles, offering insights into its ...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 24, 2024 Category: Physiology Authors: Tianlin Wang Ke Xiong Yanli He Binbin Feng Linbin Guo Jingliang Gu Hong Wang Xiaohao Wu Source Type: research

Chronic Pancreatitis-Associated Metabolic Bone Diseases: Epidemiology, Mechanisms, and Clinical Advances
Am J Physiol Endocrinol Metab. 2024 Apr 24. doi: 10.1152/ajpendo.00113.2024. Online ahead of print.ABSTRACTChronic pancreatitis (CP) is a progressive inflammatory disease with an increasing global prevalence. In recent years, a strong association between CP and metabolic bone diseases (MBDs), especially osteoporosis, has been identified, attracting significant attentions in the research field. Epidemiological data suggest a rising trend in the incidence of MBDs among CP patients. Notably, recent studies have highlighted a profound interplay between CP and altered nutritional and immune profiles, offering insights into its ...
Source: Am J Physiol Endocri... - April 24, 2024 Category: Endocrinology Authors: Tianlin Wang Ke Xiong Yanli He Binbin Feng Linbin Guo Jingliang Gu Hong Wang Xiaohao Wu Source Type: research

Clinical Pathologic Conference Case #6: Oral and Cutaneous Findings in a 14-year-old Female
A 14-year-old female with a history of Kawasaki disease was referred to a university oral medicine clinic by her orthodontist due to swollen, hemorrhagic gingiva and tooth mobility. Scurvy was suspected by the patient's nurse practitioner and confirmed by a measure of ascorbic acid in plasma of less than 5 μmol per liter (0.1 mg per deciliter; reference range, 23 to 114 μmol per liter [0.4 to 2.0 mg per deciliter]). Laboratory testing also revealed vitamin D deficiency with a measured 25-hydroxyvitamin D level of less than 23.3 ng per milliliter (50 nmol per liter; reference range 32.0-100.0 ng per milliliter). (Source: ...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - April 24, 2024 Category: ENT & OMF Authors: Sarah Glass, Mark Mintline Source Type: research

1,25(OH)2D3 inhibits pancreatic stellate cells activation and promotes insulin secretion in T2DM
ConclusionOur findings identify that PSCs activation contributes to islet fibrosis and β-cell dysfunction. 1,25(OH)2D3 exerts beneficial effects on T2DM potentially by inhibiting PSCs activation and inflammatory response, highlighting promising control strategies of T2DM by vitamin D.Graphical AbstractFig. 7 Molecular mechanism of 1,25(OH)2D3 in β cell damage following PSCs activation in T2DM mice. (Source: Endocrine)
Source: Endocrine - April 24, 2024 Category: Endocrinology Source Type: research

Sunlight: Time for a Rethink?
UVR is a skin carcinogen, yet no studies link sun exposure to increased all-cause mortality. Epidemiological studies from the United Kingdom and Sweden link sun exposure with reduced all-cause, cardiovascular, and cancer mortality. Vitamin D synthesis is dependent on UVB exposure. Individuals with higher serum levels of vitamin D are healthier in many ways, yet multiple trials of oral vitamin D supplementation show little benefit. Growing evidence shows that sunlight has health benefits through vitamin D–independent pathways, such as photomobilization of nitric oxide from cutaneous stores with reduction in cardiovascu...
Source: Journal of Investigative Dermatology - April 24, 2024 Category: Dermatology Authors: Richard B. Weller Tags: Review Source Type: research

Association between serum 25 ‐hydroxyvitamin D level and inflammatory markers in hemodialysis‐treated patients
ConclusionCollectively, serum 25(OH)D level has a negative correlation with inflammatory markers. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - April 23, 2024 Category: Allergy & Immunology Authors: Chunlei Luo, Xueyan Bian, Lingling Bao, Qingqing Xu, Chunyang Ji Tags: ORIGINAL ARTICLE Source Type: research

Association of IL-1 β 542 T & gt;A gene polymorphism with Recurrent Aphthous Stomatitis in Erbil City population
Cell Mol Biol (Noisy-le-grand). 2024 Mar 31;70(3):7-12. doi: 10.14715/cmb/2024.70.3.2.ABSTRACTRecurrent Aphthous stomatitis (RAS) is common oral mucosal condition. The pathophysiology of RAS is affected by a variety of variables, including microbial, genetic, immunological and local and systemic diseases. Interleukin IL-1β, a cytokine that promotes inflammation, has been found in high concentrations in the circulation of RAS. The goal of current investigation was to determine whether RAS is connected with polymorphisms of the IL-1β 542 T>A gene. A total of 60 RAS patients and 30 controls were included in the study. Bi...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Asma Qasim Rahman Reiadh Kamal Al-Kamali Source Type: research

Magnesium and vitamin D in long COVID syndrome; do they help?
Magnes Res. 2024 Apr 23;0(0). doi: 10.1684/mrh.2024.0521. Online ahead of print.ABSTRACTSince the start of the COVID-19 pandemic, it has become increasingly clear that the disease can have relevant multisystemic and long-term effects, and several studies have attempted to identify key determinants of the disease course. Here we discuss recent evidence suggesting that, in long COVID patients, combined magnesium and vitamin D deficiencies associate with a higher number of clinical manifestations, as compared to patients with normal levels of both nutrients. We highlight the potential synergistic effects of these deficiencies...
Source: Magnesium Research - April 23, 2024 Category: Biochemistry Authors: Federica I Wolf Valentina Trapani Source Type: research