Why have SGLT2 Inhibitors Failed to Achieve the Desired Success in COVID-19?
This article aims to uncover the reasons for the confusion in the literature and to unravel why SGLT2i failed to succeed in COVID-19 based on some solid evidence as well as speculative and personal perspectives.PMID:38566383 | DOI:10.2174/0113816128300162240322075423 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 3, 2024 Category: Drugs & Pharmacology Authors: Medine Cumhur Cure Erkan Cure Source Type: research
Vitamin D loaded into lipid nanoparticles shows insulinotropic effect in INS-1E cells
Eur J Pharm Sci. 2024 Apr 1:106758. doi: 10.1016/j.ejps.2024.106758. Online ahead of print.ABSTRACTIncreasing evidence suggests a beneficial role of vitamin D (VitD) supplementation in addressing the widespread VitD deficiency, but currently used VitD3 formulations present low bioavailability and toxicity constrains. Hence, poly(L-lactide-co-glycolide) (PLGA) nanoparticles (NPs), solid-lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) were investigated to circumvent these issues. PLGA NPs prepared by emulsification or nanoprecipitation presented 74 or 200 nm, and association efficiency (AE) of 68 % and 17...
Source: European Journal of Pharmaceutical Sciences - April 3, 2024 Category: Drugs & Pharmacology Authors: Cec ília Cristelo Ana Filipa S á Marlene L úcio Bruno Sarmento Francisco Miguel Gama Source Type: research
Effects of VDR and CYP24A1 gene polymorphisms on the outcome of supraglottic larynx cancer
CONCLUSIONS: This study has demonstrated the possible effects of VDR rs731236 SNP on the locoregional recurrence and prognosis of supraglottic larynx cancer.PMID:38567579 | DOI:10.26355/eurrev_202403_35720 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - April 3, 2024 Category: Drugs & Pharmacology Authors: D T Edizer A Leblebici U Ergun F Yilmaz A Koc Y Basbinar E B Ellidokuz Source Type: research
Enhancement of innate immunity in gingival epithelial cells by vitamin D and HDAC inhibitors
CONCLUSIONS: Our results demonstrate that a combination of inactive vitamin D and sodium butyrate could be developed as a safe treatment for periodontal disease.PMID:38567313 | PMC:PMC10986367 | DOI:10.3389/froh.2024.1378566 (Source: Herpes)
Source: Herpes - April 3, 2024 Category: Infectious Diseases Authors: Erika L Figgins Payal Arora Denny Gao Emily Porcelli Rabab Ahmed Carlo Amorin Daep Garrett Keele Lisa K Ryan Gill Diamond Source Type: research
Effects of VDR and CYP24A1 gene polymorphisms on the outcome of supraglottic larynx cancer
CONCLUSIONS: This study has demonstrated the possible effects of VDR rs731236 SNP on the locoregional recurrence and prognosis of supraglottic larynx cancer.PMID:38567579 | DOI:10.26355/eurrev_202403_35720 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 3, 2024 Category: Drugs & Pharmacology Authors: D T Edizer A Leblebici U Ergun F Yilmaz A Koc Y Basbinar E B Ellidokuz Source Type: research
The Critical Role of Intracellular Bacterial Communities in Uncomplicated Recurrent Urinary Cystitis: A Comprehensive Review of Detection Methods and Diagnostic Potential
Int Neurourol J. 2024 Mar;28(1):4-10. doi: 10.5213/inj.2448066.033. Epub 2024 Mar 31.ABSTRACTUrinary tract infections (UTIs) are among the most common bacterial infections worldwide and are particularly prevalent in women. Recurrent UTIs significantly diminish quality of life due to their symptoms and frequent relapses. Patients often experience immediate relapse following slightly strenuous activities or intense psychological stress. In this review, we explore why infections persist despite the advent of various treatments and suggest strategies to manage recurrent cystitis by targeting the mechanisms of adhesion and infe...
Source: International Neurourology Journal - April 3, 2024 Category: Urology & Nephrology Authors: Yeonjoo Kwak Hyeong Gon Kim Jaekwon Seok Sehwan Kim Eun-Mee Kim Aram Kim Source Type: research
Why have SGLT2 Inhibitors Failed to Achieve the Desired Success in COVID-19?
This article aims to uncover the reasons for the confusion in the literature and to unravel why SGLT2i failed to succeed in COVID-19 based on some solid evidence as well as speculative and personal perspectives.PMID:38566383 | DOI:10.2174/0113816128300162240322075423 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 3, 2024 Category: Drugs & Pharmacology Authors: Medine Cumhur Cure Erkan Cure Source Type: research
Vitamin D loaded into lipid nanoparticles shows insulinotropic effect in INS-1E cells
Eur J Pharm Sci. 2024 Apr 1:106758. doi: 10.1016/j.ejps.2024.106758. Online ahead of print.ABSTRACTIncreasing evidence suggests a beneficial role of vitamin D (VitD) supplementation in addressing the widespread VitD deficiency, but currently used VitD3 formulations present low bioavailability and toxicity constrains. Hence, poly(L-lactide-co-glycolide) (PLGA) nanoparticles (NPs), solid-lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) were investigated to circumvent these issues. PLGA NPs prepared by emulsification or nanoprecipitation presented 74 or 200 nm, and association efficiency (AE) of 68 % and 17...
Source: European Journal of Pharmaceutical Sciences - April 3, 2024 Category: Drugs & Pharmacology Authors: Cec ília Cristelo Ana Filipa S á Marlene L úcio Bruno Sarmento Francisco Miguel Gama Source Type: research
Effects of VDR and CYP24A1 gene polymorphisms on the outcome of supraglottic larynx cancer
CONCLUSIONS: This study has demonstrated the possible effects of VDR rs731236 SNP on the locoregional recurrence and prognosis of supraglottic larynx cancer.PMID:38567579 | DOI:10.26355/eurrev_202403_35720 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - April 3, 2024 Category: Drugs & Pharmacology Authors: D T Edizer A Leblebici U Ergun F Yilmaz A Koc Y Basbinar E B Ellidokuz Source Type: research
Enhancement of innate immunity in gingival epithelial cells by vitamin D and HDAC inhibitors
CONCLUSIONS: Our results demonstrate that a combination of inactive vitamin D and sodium butyrate could be developed as a safe treatment for periodontal disease.PMID:38567313 | PMC:PMC10986367 | DOI:10.3389/froh.2024.1378566 (Source: Herpes)
Source: Herpes - April 3, 2024 Category: Infectious Diseases Authors: Erika L Figgins Payal Arora Denny Gao Emily Porcelli Rabab Ahmed Carlo Amorin Daep Garrett Keele Lisa K Ryan Gill Diamond Source Type: research
