Review of childhood genetic nephrolithiasis and nephrocalcinosis
Nephrolithiasis (NL) is a common condition worldwide. The incidence of NL and nephrocalcinosis (NC) has been increasing, along with their associated morbidity and economic burden. The etiology of NL and NC is multifactorial and includes both environmental components and genetic components, with multiple studies showing high heritability. Causative gene variants have been detected in up to 32% of children with NL and NC. Children with NL and NC are genotypically heterogenous, but often phenotypically relatively homogenous, and there are subsequently little data on the predictors of genetic childhood NL and NC. Most genetic ...
Source: Frontiers in Genetics - March 28, 2024 Category: Genetics & Stem Cells Source Type: research

An updated systematic review of neuroprotective agents in the treatment of spinal cord injury
We examined the effects of 15 substances/drugs: methylprednisolone, tirilazad mesylate, erythropoietin, nimodipine, naloxone, Sygen, Rho protein antagonist, granulocyte colony-stimulating factor, autologous macrophages, autologous bone marrow cells, vitamin D, progesterone, riluzole, minocycline, and blood alcohol concentration. Notable improvements in neurological outcomes were observed with progesterone plus vitamin D and granulocyte colony-stimulating factor. In contrast, results for methylprednisolone, erythropoietin, Sygen, Rho Protein, and Riluzole were inconclusive, primarily due to insufficient sample size or outda...
Source: Neurosurgical Review - March 28, 2024 Category: Neurosurgery Source Type: research

Denosumab as treatment of central giant cell granuloma of the jaws. a scoping review
This study aimed to perform a scoping review of CGCG treated with Denosumab. The research question was: What is Denosumab ’s effectiveness in treating CGCG of the jaws? Studies that used Denosumab as a treatment for CGCGs in the jaws were selected following PRISMA-ScR guidelines, using Pubmed/Medline, Scopus, and Springer Link databases, among others. Demographics, clinical information, dosing, efficacy, adverse drug reactions (ADRs), and imaging tests used to assess the evolution of the lesions were extracted. Twenty-one studies were selected. Sixty patients with a mean age of 23.2 years were treated with Denosumab, 42...
Source: Oral and Maxillofacial Surgery - March 28, 2024 Category: ENT & OMF Source Type: research

Surgical Considerations for Osteoporosis, Osteopenia, and Vitamin D Deficiency in Upper Extremity Surgery
Fragility fractures as a result of osteoporosis, osteopenia, or vitamin D deficiency are some of the most common injuries encountered in orthopedics and require careful consideration when determining the appropriate management and treatment options. A thorough perioperative evaluation can identify causes of low bone mineral density allowing for initiation of appropriate therapy. Surgical treatment of these fractures can be difficult, and techniques should be employed to ensure stable fixation. It is important to understand the potential pitfalls associated with treatment of fragility fractures to prevent avoidable complica...
Source: Orthopedic Clinics of North America - March 28, 2024 Category: Orthopaedics Authors: Paul T. Greenfield, Tori J. Coble, Jared A. Bell, James H. Calandruccio, William J. Weller Source Type: research

Hypocalcemia in combination with hyperphosphatemia impairs muscle cell differentiation in vitro
ConclusionsOur results showed that a condition of hypocalcemia with hyperphosphatemia induced an alteration of muscle cell differentiation in vitro. In particular, we observed the reduction of myogenic differentiation markers, IGF-1 signaling pathway, and ERK phosphorylation in differentiated skeletal myoblasts. These data suggest that this altered extracellular condition might contribute to the mechanisms causing persistence of symptoms in patients affected by hypoparathyroidism. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 27, 2024 Category: Endocrinology Source Type: research

Assessing the interaction effects of mitochondrial DNA polymorphisms and lifestyle on heel bone mineral density
CONCLUSIONS: Our study suggests the candidate interaction between mitochondria and lifestyles on heel BMD, providing novel clues for exploring the pathogenesis of osteoporosis.PMID:38536958 | DOI:10.1210/clinem/dgae195 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 27, 2024 Category: Endocrinology Authors: Dan He Huan Liu Yijing Zhao Wenming Wei Qingqing Cai Sirong Shi Xiaoge Chu Na Zhang Xiaoyue Qin Yumeng Jia Yan Wen Bolun Cheng Feng Zhang Source Type: research

Evaluation of vitamin D levels in children and adolescents after the first year of the COVID-19 pandemic: 1-year results of a secondary-level state hospital
CONCLUSIONS: Vitamin D deficiency remains a serious public health problem. Since the most important production source is exposure to the sun, it must be kept in mind that vitamin D should be supported during lockdown pandemic processes.PMID:38538466 | DOI:10.1016/j.arcped.2023.11.001 (Source: Archives de Pediatrie)
Source: Archives de Pediatrie - March 27, 2024 Category: Pediatrics Authors: Fatma Özgüç Çömlek Ali Toprak Ahmet Ziya Birbilen Semine Özdemir Dilek Fatma Co şkun Source Type: research

Effect of vitamin D3 supplementation on blood parameters and liver gene expression in female rats
CONCLUSIONS: Our results support the anti-inflammatory, anitioxidant and anticholesterologenic potential of vitamin D but suggest that high doses of vitamin D are needed to obtain significant results in this regard.PMID:38536498 | DOI:10.1007/s11033-024-09408-6 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 27, 2024 Category: Molecular Biology Authors: Maria Oczkowicz Beata Szymczyk Ma łgorzata Świątkiewicz Alicja Wierzbicka Anna Steg Tomasz Szmato ła Source Type: research

Pseudotumor cerebri with status epilepticus in a child: A rare presentation of vitamin D deficiency
Key Clinical MessagePseudotumor cerebri (PTC) encompasses a constellation of symptoms caused by elevated intracranial pressure of unclear etiology. Various associations have been described, rarely hypovitaminosis D. Vitamin D deficiency should be considered as a potential etiology of neurological manifestations like PTC and seizures in children. Early diagnosis and correction of vitamin D deficiency is key to preventing morbidity and achieving good outcomes. (Source: Clinical Case Reports)
Source: Clinical Case Reports - March 27, 2024 Category: General Medicine Authors: Soumya Pahari, Prakash Kunwar, Subi Acharya, Pallavi Rauniyar, C. K. Sagar  Bahadur Tags: CASE REPORT Source Type: research

The Alarming Rate of Malnutrition after Single Anastomosis Sleeve Ileal Bypass. A single Centre Experience
ConclusionDespite good short-term weight loss and improvement of obesity-associated complications, SASI is accompanied by high alarming malnutrition, even in short-term follow-up. Novel MBS should be judged for their long-term effects and compared to well-tested standard operations before they are used in routine clinical practice.Graphical Abstract (Source: Obesity Surgery)
Source: Obesity Surgery - March 27, 2024 Category: Surgery Source Type: research

The effects of popular diets on bone health in the past decade: a narrative review
Bone health encompasses not only bone mineral density but also bone architecture and mechanical properties that can impact bone strength. While specific dietary interventions have been proposed to treat various diseases such as obesity and diabetes, their effects on bone health remain unclear. The aim of this review is to examine literature published in the past decade, summarize the effects of currently popular diets on bone health, elucidate underlying mechanisms, and provide solutions to neutralize the side effects. The diets discussed in this review include a ketogenic diet (KD), a Mediterranean diet (MD), caloric rest...
Source: Frontiers in Endocrinology - March 26, 2024 Category: Endocrinology Source Type: research

Association of vitamin D with disease severity in infants with bronchiolitis
Conclusion:  Infants with Vitamin D insufficiency experienced more severe bronchiolitis with elevated BSS scores. It highlights the potential role of vitamin D deficiency in severe bronchiolitis.What is Known:• Vitamin D level is low in infants with bronchiolitis.What is New:• Infant with low vitamin D level experienced more severe bronchiolitis. (Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - March 26, 2024 Category: Pediatrics Source Type: research

Low vitamin D levels accelerates muscle mass loss in patients with chronic liver disease
This study aimed to clarify the relationship between vitamin D levels and muscle mass loss. A total of 166 patients with chronic liver disease were enrolled in this study. Skeletal muscle mass index (SMI) was me asured by bioelectrical impedance analysis at baseline and after 1 year. The rate of change in SMI from baseline after 1 year was calculated: ΔSMI (%) = [(1-year SMI − baseline SMI) / baseline SMI] × 100. Muscle mass loss was defined as ΔSMI ≤ −2%. The median 25-hydroxyvitamin D was 15.2 (1 1.2–19.3) ng/mL. The median SMI were 6.8 (5.9–7.8) kg/m2 at baseline and 6.7 (5.9 –7.6) kg/m2 after 1 year. The...
Source: PLoS One - March 26, 2024 Category: Biomedical Science Authors: Tomomi Okubo Source Type: research

Post-diagnosis serum 25-hydroxyvitamin D concentrations in women treated for breast cancer participating in a lifestyle trial in Italy
CONCLUSIONS: Hypovitaminosis D in women recently diagnosed with BC and participating in a lifestyle trial in Italy was widespread and highest with obesity, hypertriglyceridemia, and chemotherapy use. Considering that hypovitaminosis D is a risk factor for lower efficacy of bone density treatments and possibly BC mortality, our results suggest the need to promptly address and treat vitamin D deficiency.PMID:38523582 | DOI:10.4081/reumatismo.2024.1632 (Source: Reumatismo)
Source: Reumatismo - March 25, 2024 Category: Rheumatology Authors: A Fassio G Porciello G Carioli E Palumbo S Vitale A Luongo C Montagnese M Prete M Grimaldi R Pica E Rotondo L Falzone I Calabrese A Minopoli B Grilli M Cuomo P C Fiorillo C Evangelista E Cavalcanti M De Laurentiis D Cianniello C Pacilio M Pinto G Thomas M Source Type: research

Vitamin D Status in an Italian Pediatric Cohort: Is There a Role for Tobacco Smoking Exposure?
CONCLUSION: Our results further prove that hypovitaminosis D is common in the Italian children and documented that passive smoke exposure is a significant risk factor for hypovitaminosis D.PMID:38523346 | DOI:10.4274/jcrpe.galenos.2024.2023-11-16 (Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology)
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - March 25, 2024 Category: Endocrinology Authors: Maria Grazia Clemente Dario Argiolas Stefania Bassu Angela Bitti Cristian Locci Mauro Argiolas Lino Argiolas Laura Saderi Mariangela V Puci Giovanni Sotgiu Mary E Blue Roberto Antonucci Source Type: research