Correct estimates of hydrated ionic radius should be used when discussing the permeation of topically applied magnesium ions.
PMID: 31427274 [PubMed - as supplied by publisher] (Source: Magnesium Research)
Source: Magnesium Research - August 19, 2019 Category: Biochemistry Authors: Chandrasekaran NC, Barnard RT Tags: Magnes Res Source Type: research

The effects of magnesium supplementation on gene expression related to inflammatory markers, vascular endothelial growth factor, and pregnancy outcomes in patients with gestational diabetes.
Abstract Magnesium has been introduced as one of the micronutrients with several metabolic benefits, mainly anti-inflammatory properties. The aim of this study was to evaluate the effects of magnesium supplementation on gene expression of inflammatory markers, vascular endothelial growth factor (VEGF), and pregnancy outcomes in women diagnosed with gestational diabetes mellitus (GDM). This randomized, double-blinded, placebo-controlled trial was conducted among 36 women, aged 18-40 years old, diagnosed with GDM. Study participants were randomly allocated into two groups to receive either 250 mg/day magnesiu...
Source: Magnesium Research - May 17, 2019 Category: Biochemistry Authors: Ahmadi S, Naderifar M, Samimi M, Mirhosseini N, Amirani E, Aghadavod E, Asemi Z Tags: Magnes Res Source Type: research

Effect of magnesium gluconate administration on lipid metabolism, antioxidative status, and related gene expression in rats fed a high-fat diet.
Abstract To explore the effect of magnesium gluconate (MgG) on lipid metabolism and its regulation mechanism through animal experiments, and to provide basis for MgG dietary intervention in hyperlipidemia. The first four weeks was hyperlipidemia-inducing period through high-fat diet and the following eight weeks was the MgG supplementation. At the end of the experiment, blood and liver samples were collected for the measurements of lipid profile, antioxidative indexes, pathological examination, and cholesterol metabolism-related gene expression. Oral administration of MgG notably decreased the blood levels of TC, ...
Source: Magnesium Research - May 17, 2019 Category: Biochemistry Authors: Zhang Q, Zhou PH, Zhou XL, Zhang DL, Gu Q, Zhang SJ, Zhang J, Zhang JS, Qian ZY Tags: Magnes Res Source Type: research

Magnesium and thiazide diuretics.
r U PMID: 31088779 [PubMed - as supplied by publisher] (Source: Magnesium Research)
Source: Magnesium Research - May 14, 2019 Category: Biochemistry Authors: Kisters K, Gröber U Tags: Magnes Res Source Type: research

Correlations between feeding type and blood ionized magnesium levels in Japanese preterm infants.
We examined the influence of feeding type on serum Mg and whole blood ionized Mg (iMg) levels in preterm infants soon after birth. We included 115 preterm infants born between gestational weeks 32 and 35. Infants were separated into two groups: breast milk (BM) dominant group (n = 30) receiving ≥70% of Mg intake from BM and mixed-fed (MF) group (n = 85) receiving ≥30% of Mg intake from formula. Blood levels of Mg, iMg, Ca, and iCa at day 1 of age and at discharge from the hospital were compared between the groups. No differences in the Mg and iMg levels at day 1 of age were observed b...
Source: Magnesium Research - May 14, 2019 Category: Biochemistry Authors: Watanabe A, Shoji H, Awaji A, Ikeda N, Ohkawa N, Suganuma H, Kantake M, Shimizu T Tags: Magnes Res Source Type: research

Varying magnesium concentration elicits changes in inflammatory response in human umbilical vein endothelial cells (HUVECs).
Abstract The aims of this study were to determine whether low concentrations of magnesium in vitro exacerbated the human umbilical vein endothelial cell (HUVEC) response to inflammatory challenge, and whether expression of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) through the toll-like receptor 4 (TLR4) played a role in this process. HUVECs were incubated with different concentrations of Mg (low- 0.1mM, control- 1mM, high- 5mM) for 72 h before being stimulated with bacterial lipopolysaccharide (LPS) for 4 h. The response of cells to LPS was greater in cells cultured in low Mg...
Source: Magnesium Research - December 10, 2018 Category: Biochemistry Authors: Almousa LA, Salter AM, Langley-Evans SC Tags: Magnes Res Source Type: research

Down-regulation of magnesium transporting molecule, claudin-16, as a possible cause of hypermagnesiuria with the development of tubulo-interstitial nephropathy.
We examined the correlation between the development of TIN and the changes in the mRNA expression of renal magnesium-transporting molecules in rats with unilateral ureter obstruction (UUO). Ureter-ligated kidney was sampled at day-0 (control), day-1 (early phase) and day-7 (late phase). The development of TIN was assessed by immunohistochemistry and the real-time PCR of fibrosis-related genes (MCP-1: 105.1 ± 14.8% on day-0, 132.9 ± 25.7% on day-1, 302.7 ± 32.7% on day-7, TGF-β: 101.1 ± 7.6% on day-0, 93.6 ± 4.1% on day-1, 338.9 &...
Source: Magnesium Research - July 10, 2018 Category: Biochemistry Authors: Shimizu T, Takayanagi K, Iwashita T, Ikari A, Anzai N, Okazaki S, Hara H, Hatano M, Sano T, Ogawa T, Kanozawa K, Hasegawa H Tags: Magnes Res Source Type: research

A single dose of magnesium, as well as chronic administration, enhances long-term memory in novel object recognition test, in healthy and ACTH-treated rats.
ić V Abstract Although a magnesium-mediated attenuation of memory deficits was reported in animal models of ageing and traumatic brain injury, a possible memory enhancement in healthy subjects has not been investigated yet. We used novel object recognition test (NORT) to examine the effects of acute (30 mg/kg) and chronic (50 mg/kg, 28 days) Mg-sulfate treatment on the long-term memory (LTM) in healthy adult male rats, and to test the sustainability of magnesium effects in the models of acute and chronic (21 days) ACTH administration (10 μg/animal), mimicking the stress- and depression-like cond...
Source: Magnesium Research - July 10, 2018 Category: Biochemistry Authors: Đurić V, Batinić B, Petrović J, Stanić D, Bulat Z, Pešić V Tags: Magnes Res Source Type: research

Jean Durlach (1925-2017).
PMID: 29637895 [PubMed - in process] (Source: Magnesium Research)
Source: Magnesium Research - November 1, 2017 Category: Biochemistry Authors: Rayssiguier Y Tags: Magnes Res Source Type: research

Effect of urine pH and magnesium on calcium oxalate saturation.
uf NM Abstract Hypomagnesiuria is a common biochemical finding in patients with calcium oxalate (CaOx) nephrolithiasis. Clinical trials using Mg supplements as therapy against CaOx stones have shown mixed results. We tested the effect of Mg administration in healthy subjects under conditions of controlled urine pH (UpH) on urinary Ca excretion rate (UCaV) and CaOx saturation. This is a 4-phase, double blind, placebo-controlled, metabolic crossover study performed in healthy volunteers. Mg lactate (MgLact2) was used as Mg supplement. High UpH and low UpH were achieved by administration of potassium citrate (K3Citra...
Source: Magnesium Research - November 1, 2017 Category: Biochemistry Authors: Ferrè S, Grange JS, Adams-Huet Ms B, Moe OW, Maalouf NM Tags: Magnes Res Source Type: research

The effect of magnesium supplementation on muscle fitness: a meta-analysis and systematic review.
Abstract Increasing evidence supports a role of magnesium (Mg) in skeletal muscle function. However, no systematic review or meta-analysis has summarized data on Mg supplementation in relation to muscle fitness in humans. Thus, this study aimed to quantitatively assess the effect of Mg supplementation on muscle fitness. A meta-analysis and systematic review. Medline database and other sources were searched for randomized clinical trials through July 2017. Studies that reported results regarding at least one of the following outcomes: leg strength, knee extension strength, peak torque, muscle power, muscle work, ju...
Source: Magnesium Research - November 1, 2017 Category: Biochemistry Authors: Wang R, Chen C, Liu W, Zhou T, Xun P, He K, Chen P Tags: Magnes Res Source Type: research

A 6-month follow-up of disability, quality of life, and depressive and anxiety symptoms in pediatric migraine with magnesium prophylaxis.
Abstract Magnesium is frequently used for pediatric migraine prophylaxis. The aim of this study was to evaluate to which extent the disability levels, quality of life (QOL), and anxiety and depressive symptoms change after 6-month magnesium prophylaxis in pediatric migraine. This is a follow-up study of 34 children aged 7-17 years with migraine treated with oral magnesium. Disability due to migraine was assessed by the Pediatric Migraine Disability Assessment tool (PedMIDAS), QOL was assessed by the KIDSCREEN-27, and anxiety and depressive symptoms were assessed by the Revised Child Anxiety and Depression Scale (R...
Source: Magnesium Research - November 1, 2017 Category: Biochemistry Authors: Kovacevic G, Stevanovic D, Bogicevic D, Nikolic D, Ostojic S, Tadic BV, Nikolic B, Bosiocic I, Ivancevic N, Jovanovic K, Samardzic J, Jancic J Tags: Magnes Res Source Type: research

Effect of magnesium supplementation on muscular damage markers in basketball players during a full season.
In conclusion, these results suggest that the supplementation with Mg during the season of competition may prevent associated tissue damage. PMID: 28816171 [PubMed - as supplied by publisher] (Source: Magnesium Research)
Source: Magnesium Research - August 17, 2017 Category: Biochemistry Authors: Córdova Martínez A, Fernández-Lázaro D, Mielgo-Ayuso J, Seco Calvo J, Caballero García A Tags: Magnes Res Source Type: research

Magnesium in the gynecological practice: a literature review.
Abstract A growing amount of evidence suggests that magnesium deficiency may play an important role in several clinical conditions concerning women health such as premenstrual syndrome, dysmenorrhea, and postmenopausal symptoms. A number of studies highlighted a positive correlation between magnesium administration and relief or prevention of these symptoms, thus suggesting that magnesium supplementation may represent a viable treatment for these conditions. Despite this amount of evidence describing the efficacy of magnesium, few and un-systematize data are available about the pharmacological mechanism of this io...
Source: Magnesium Research - April 6, 2017 Category: Biochemistry Authors: Parazzini F, Di Martino M, Pellegrino P Tags: Magnes Res Source Type: research

Burning magnesium, a sparkle in acute inflammation: gleams from experimental models.
Abstract Magnesium contributes to the regulation of inflammatory responses. Here, we focus on the role of magnesium in acute inflammation. Although present knowledge is incomplete to delineate an accurate scenario and a schedule of the events occurring under magnesium deficiency, it emerges that low magnesium status favors the induction of acute inflammation by sensitizing sentinel cells to the noxious agent, and then by participating to the orchestration of the vascular and cellular events that characterize the process. PMID: 28392499 [PubMed - as supplied by publisher] (Source: Magnesium Research)
Source: Magnesium Research - April 6, 2017 Category: Biochemistry Authors: Castiglioni S, Cazzaniga A, Locatelli L, Maier JA Tags: Magnes Res Source Type: research

Coordination between antioxidant defences might be partially modulated by magnesium status.
Abstract The aim of this study was to compare the redox balance in competitive adult swimmers against recreational practitioners, controlling for Mg intake. Fifteen, competitive swimmers and 16 recreational practitioners, all male and aged 18-25years, were recruited into the study. Oxidative and muscle damage markers, and antioxidant enzymes and non-enzymatic antioxidants were evaluated by photometry (except for thiobarbituric reactive substances (TBARS), which was assessed by fluorimetry). Controlling for the level of exercise, inverse correlations were observed for uric acid and glutathione reductase (GR) or sus...
Source: Magnesium Research - January 6, 2017 Category: Biochemistry Authors: Monteiro CP, Matias CN, Bicho M, Santa-Clara H, Laires MJ Tags: Magnes Res Source Type: research

Magnesium-based interventions for normal kidney function and chronic kidney disease.
Abstract Magnesium (Mg) is one of the most important cations in the body, playing an essential role in biological systems as co-factor for more than 300 essential enzymatic reactions. In the general population, low levels of Mg are associated with a high risk of cardio-vascular disease (CVD). Despite the accumulating literature data, the effect of Mg administration on mortality in chronic kidney disease (CKD) patients has never been investigated as a primary end-point. We conducted a systematic search of studies assessing the benefits and harms of Mg in CKD (stages 1 to 5 and 5D), and considered all randomized con...
Source: Magnesium Research - December 22, 2016 Category: Biochemistry Authors: Massy ZA, Nistor I, Apetrii M, Brandenburg VM, Bover J, Evenepoel P, Goldsmith D, Mazzaferro S, Urena-Torres P, Vervloet MG, Cozzolino M, Covic A, Era-Edta OB Tags: Magnes Res Source Type: research

Impact of sevelamer hydrochloride on serum magnesium concentrations in hemodialysis patients.
Abstract Serum Mg levels are elevated in patients with renal insufficiency: harmful effects of hypomagnesemia have been reported in patients receiving hemodialysis (HD). In this cross-sectional study, which included 86 HD patients (male : female = 56:30, age 68 ± 12 years), we examined the clinical factors associated with serum Mg levels, with a focus on sevelamer, a phosphate binder widely used to control the hyperphosphatemia of HD patients. The mean serum Mg concentration among our patients was 2.48 ± 0.37 mg/dL (1.02 ± 0.15 mmol/L). Sevelam...
Source: Magnesium Research - December 12, 2016 Category: Biochemistry Authors: Ikee R, Toyoyama T, Endo T, Tsunoda M, Hashimoto N Tags: Magnes Res Source Type: research

Magnesium, C-reactive protein, and cortisol in drug-na ïve patients with short illness-duration, first episode major depressive disorder: possible immunomodulatory role for magnesium.
Magnesium, C-reactive protein, and cortisol in drug-naïve patients with short illness-duration, first episode major depressive disorder: possible immunomodulatory role for magnesium. Magnes Res. 2016 Dec 12; Authors: Cubała WJ, Landowski J, Dziadziuszko M, Chrzanowska A, Wielgomas B Abstract Plasma magnesium concentration alterations, hypercortisolaemia, and systemic inflammation are observed in major depressive disorder (MDD). This exploratory study examined whether, and to what extent, plasma magnesium is related to C-reactive protein (CRP) levels and cortisolaemia in MDD. The concentrations o...
Source: Magnesium Research - December 12, 2016 Category: Biochemistry Authors: Cubała WJ, Landowski J, Dziadziuszko M, Chrzanowska A, Wielgomas B Tags: Magnes Res Source Type: research

The effects of magnesium supplementation on subjective anxiety.
CONCLUSIONS: The efficacy of Mg in the treatment of anxiety in the mildly anxious and those reporting premenstrual syndrome-related anxiety is suggestive of a beneficial effect of Mg intake. Further randomised controlled trials are warranted to further establish the efficacy of Mg as a novel treatment for subjective anxiety. PMID: 27869100 [PubMed - as supplied by publisher] (Source: Magnesium Research)
Source: Magnesium Research - November 17, 2016 Category: Biochemistry Authors: Boyle NB, Lawton CL, Dye L Tags: Magnes Res Source Type: research

Magnesium in metabolic syndrome: a review based on randomized, double-blind clinical trials.
án M Abstract A growing body of evidence shows the effect of magnesium on serum glucose, HDL-cholesterol, and triglycerides levels, as well as on blood pressure, which strongly suggests that magnesium might play an important role in metabolic syndrome (MetS), a cluster of risk factors for cardiovascular disease and type 2 diabetes. We performed a systematic review of clinical evidence derived from randomized, double-blind, controlled clinical trials, regarding the efficacy of magnesium supplementation on the components of MetS. Using the electronic databases of Medline, Embase, and the Cochrane Controlled T...
Source: Magnesium Research - November 10, 2016 Category: Biochemistry Authors: Guerrero-Romero F, Jaquez-Chairez FO, Rodríguez-Morán M Tags: Magnes Res Source Type: research

A guided tour of presentations at the XIV International Magnesium Symposium.
PMID: 27829571 [PubMed - as supplied by publisher] (Source: Magnesium Research)
Source: Magnesium Research - November 9, 2016 Category: Biochemistry Authors: Rosanoff A, Wolf FI Tags: Magnes Res Source Type: research

Magnesium in the CNS: recent advances and developments.
Abstract A potential neuroprotective role for magnesium in neurological disease has been appreciated for almost three decades, yet translation to the clinical arena has proven elusive. Accumulating experimental evidence continues to suggest that magnesium plays a critical role in a number of neurological conditions including headache, stress, alcohol/drug intoxication, acute brain injury, seizures, Parkinson's disease and Alzheimer's disease. Simple administration of a magnesium salt in these conditions has not always been therapeutically successful, with a number of studies showing poor penetration of serum magne...
Source: Magnesium Research - November 9, 2016 Category: Biochemistry Authors: Vink R Tags: Magnes Res Source Type: research

Call for unpublished findings.
Authors: PMID: 27624530 [PubMed - in process] (Source: Magnesium Research)
Source: Magnesium Research - June 1, 2016 Category: Biochemistry Tags: Magnes Res Source Type: research

Permeation of topically applied Magnesium ions through human skin is facilitated by hair follicles.
Abstract Magnesium is an important micronutrient essential for various biological processes and its deficiency has been linked to several inflammatory disorders in humans. Topical magnesium delivery is one of the oldest forms of therapy for skin diseases, for example Dead Sea therapy and Epsom salt baths. Some anecdotal evidence and a few published reports have attributed amelioration of inflammatory skin conditions to the topical application of magnesium. On the other hand, transport of magnesium ions across the protective barrier of skin, the stratum corneum, is contentious. Our primary aim in this study was to ...
Source: Magnesium Research - June 1, 2016 Category: Biochemistry Authors: Chandrasekaran NC, Sanchez WY, Mohammed YH, Grice JE, Roberts MS, Barnard RT Tags: Magnes Res Source Type: research

Hypomagnesemia associated with hypocalcemia after total thyroidectomy: an observational study.
CONCLUSION: Hypomagnesemia is significantly associated with early hypocalcemia following thyroidectomy. PMID: 27624532 [PubMed - in process] (Source: Magnesium Research)
Source: Magnesium Research - June 1, 2016 Category: Biochemistry Authors: Mahmoud RR, Neto VJ, Alves W, Lin CS, Leite AK, Matos LL, Filho VJ, Cernea CR Tags: Magnes Res Source Type: research

Changes in circulating levels of fibroblast growth factor 23 induced by short-term dietary magnesium deficiency in rats.
Abstract Fibroblast growth factor 23 (FGF23) is a potent regulator of phosphorus (P) and vitamin D metabolism. Long-term dietary magnesium (Mg) deficiency increases circulating levels of FGF23, whereas the effects of short-term dietary Mg deficiency are unclear. Thus, the present study investigated whether short-term dietary Mg deficiency affects circulating levels of FGF23. We also assessed changes in renal mRNA expression of vitamin D metabolizing enzymes and type II sodium-phosphate (Na/Pi) cotransporters, since these are regulated by FGF23. Rats were fed a control diet (control group) or an Mg-deficient diet (...
Source: Magnesium Research - June 1, 2016 Category: Biochemistry Authors: Matsuzaki H, Katsumata S, Maeda Y, Kajita Y Tags: Magnes Res Source Type: research

Effect of proton pump inhibitors on magnesium balance: is there a link to cardiovascular risk?
Abstract Magnesium (Mg(2+)) is the second most copious element inside human cells and the fourth most abundant positively charged ion in the human body. It is of central importance for a broad variety of physiological processes, including intracellular signaling, neuronal excitability, muscle contraction, bone formation and enzyme activation. Its overall balance is tightly regulated by the concerted actions of the intestine, bones and kidneys. Disturbance of this balance can have serious consequences. Symptoms of hypomagnesaemia include tetany, seizures and cardiac arrhythmias, whereas hypermagnesaemia may cause c...
Source: Magnesium Research - April 14, 2016 Category: Biochemistry Authors: Pisani LF, Filippi E, Vavassori S, Munizio N, Vecchi M, Pastorelli L Tags: Magnes Res Source Type: research

Abdominal obesity and gestational diabetes: the interactive role of magnesium.
Abstract Magnesium is a cofactor for numerous metabolic enzymatic reactions. It is required for glucose utilization and insulin signaling. We compared plasma magnesium concentrations in pregnant women with and without abdominal obesity, and investigated the interactive roles of magnesium and obesity in the development of gestational diabetes mellitus (GDM). Pregnant women with and without abdominal obesity (n = 40 in each group) were followed during gestation. Oral glucose tolerance tests (OGTT) were performed at 24-28 weeks of pregnancy to diagnose GDM. Plasma glucose, insulin, triglycerides, high-sensi...
Source: Magnesium Research - December 1, 2015 Category: Biochemistry Authors: Mostafavi E, Nargesi AA, Asbagh FA, Ghazizadeh Z, Heidari B, Mirmiranpoor H, Esteghamati A, Vigneron C, Nakhjavani M Tags: Magnes Res Source Type: research

Hyperphosphatemia, hypocalcemia and increased serum potassium concentration as distinctive features of early hypomagnesemia in magnesium-deprived mice.
This study compares the effect of both short- and long-term Mg(2+) restriction on the electrolyte balance in mice. Mice were fed control or Mg(2+)-deficient diets for one to three days, one week, or three weeks. Prior to killing the mice, urine was collected over 24 h using metabolic cages. Within 24 h of Mg(2+) deprivation, hypomagnesemia, hypocalcemia and hyperphosphatemia developed, and after three days of Mg(2+) deprivation, serum potassium (K(+)) was increased. These changes were accompanied by a reduction in urinary volume, hyperphosphaturia, hypocalciuria and decreased Mg(2+), sodium (Na(+)) and K(+) excre...
Source: Magnesium Research - December 1, 2015 Category: Biochemistry Authors: Ortega B, MacWilliams JR, Dey JM, Courtright VB Tags: Magnes Res Source Type: research

An approach to the diagnosis and management of a case presenting with recurrent hypomagnesemia secondary to the chronic use of a proton pump inhibitor.
CONCLUSION: this report emphasizes that even if long-term PPI users appear largely asymptomatic, life-threatening arrhythmias can present very suddenly. Long-term PPI users should be monitored for otherwise unexplained hypomagnesemia, hypocalcemia, functional hypoparathyroidism and associated symptoms. PMID: 26878253 [PubMed - in process] (Source: Magnesium Research)
Source: Magnesium Research - December 1, 2015 Category: Biochemistry Authors: Dos Santos LM, Guerra RA, Lazaretti-Castro M, H Vieira JG, de Souza Portes E, Dias-da-Silva MR Tags: Magnes Res Source Type: research

Magnesium and healthy aging.
Abstract Magnesium (Mg) is relatively stable in the intracellular compartment, although decreases linearly with advancing age. This begs the question as to whether Mg could be used as biomarker of aging. A biomarker of aging is a biological parameter of an organism that, in the absence of disease, better predicts functional capability at a later age than the chronological age. Bone and muscle Mg content might be useful biomarkers, but the need for biopsies and the heterogeneous distribution of Mg in bones and muscles strongly limit the application of these methods in clinical practice. Similar considerations can b...
Source: Magnesium Research - October 7, 2015 Category: Biochemistry Authors: Veronese N, Zanforlini BM, Manzato E, Sergi G Tags: Magnes Res Source Type: research

The art of magnesium transport.
Abstract Patients with hypomagnesemia suffer from a wide range of symptoms including muscle cramps, cardiac arrhythmias and epilepsy. Disturbances in body Mg(2+) homeostasis can often be attributed to increased Mg(2+) excretion by the kidney. Within the kidney, the distal convoluted tubule (DCT) segment determines the final Mg(2+) excretion, since no reabsorption takes place beyond this segment of the nephron. On 21(st) of January 2015, Jeroen de Baaij defended his thesis "The Distal Convoluted Tubule: the Art of Magnesium Transport", in which he aimed to identify new g...
Source: Magnesium Research - October 7, 2015 Category: Biochemistry Authors: de Baaij JH Tags: Magnes Res Source Type: research

Dietary magnesium: The magic mineral that protects from colon cancer?
PMID: 26446806 [PubMed - as supplied by publisher] (Source: Magnesium Research)
Source: Magnesium Research - October 7, 2015 Category: Biochemistry Authors: Trapani V, Wolf FI, Scaldaferri F Tags: Magnes Res Source Type: research

Association between low serum magnesium concentration and hyperuricemia.
CONCLUSION: Serum Mg is inversely associated with HU. This association remains valid for the male subgroup, but not for the female subgroup. PMID: 26105980 [PubMed - as supplied by publisher] (Source: Magnesium Research)
Source: Magnesium Research - June 24, 2015 Category: Biochemistry Authors: Zeng C, Wang YL, Wei J, Yang T, Li H, Xie DX, Li YS, Lei GH Tags: Magnes Res Source Type: research

Magnesium intervention studies -methodological aspects.
PMID: 26106042 [PubMed - as supplied by publisher] (Source: Magnesium Research)
Source: Magnesium Research - June 24, 2015 Category: Biochemistry Authors: Rylander R, Vormann J Tags: Magnes Res Source Type: research

A study of water hardness and the prevalence of hypomagnesaemia and hypocalcaemia in healthy subjects of Surat district (Gujarat).
This study was performed to assess the concentrations of calcium and magnesium, and total hardness in filtered and non-filtered water and the relationship with serum magnesium and calcium levels in normal subjects consuming such water. Methodology: Three water samples were collected, at 15-day intervals, from 12 urban and rural areas of Surat; and also 10 different brands of bottled water. Samples were analyzed for total hardness and calcium by complexometric and EDTA methods respectively. Magnesium concentrations were obtained by subtraction of the calcium concentration from total hardness. Serum samples from healthy indi...
Source: Magnesium Research - February 6, 2015 Category: Biochemistry Authors: Kanadhia KC, Ramavataram DV, Nilakhe SP, Patel S Tags: Magnes Res Source Type: research

Variations in serum magnesium and hormonal levels during incremental exercise.
In this study, we examined the relationship between plasma magnesium levels and hormonal variations during an incremental exercise test until exhaustion in 27, well-trained, male endurance athletes. After a warm-up of 10 min at 2 W/kg, the test began at an initial workload of 2.5 W/kg and continued with increments of 0.5 W/kg every 10 min until exhaustion. Plasma magnesium, catecholamine, insulin, glucagon, parathyroid hormone (PTH), calcitonin, aldosterone and cortisol levels were determined at rest, at the end of each stage and three, five and seven minutes post-exercise. With the incremental exercise test...
Source: Magnesium Research - February 3, 2015 Category: Biochemistry Authors: Soria M, González-Haro C, Ansón MA, Iñigo C, Calvo ML, Escanero JF Tags: Magnes Res Source Type: research

Bioavailability of magnesium from inorganic and organic compounds is similar in rats fed a high phytic acid diet.
This study compared the relative ability of inorganic and organic Mg compounds to preserve the Mg status of rats when fed at amounts insufficient to retain optimal Mg status. Male Sprague-Dawley rats (n=12/diet group) were fed one of eight test diets supplemented with phytic acid (5 g/kg diet) and low levels of Mg (155 mg elemental Mg/kg diet) from Mg oxide, Mg sulphate, Mg chloride, Mg citrate, Mg gluconate, Mg orotate, Mg malate or ethylenediaminetetraacetic acid disodium Mg salt for five weeks. Rats were also fed three control diets that did not contain added phytic acid but were supplemented with 500 (NMgO, normal), 15...
Source: Magnesium Research - January 30, 2015 Category: Biochemistry Authors: Bertinato J, Plouffe LJ, Lavergne C, Ly C Tags: Magnes Res Source Type: research

Abstracts.
Authors: PMID: 25613491 [PubMed - as supplied by publisher] (Source: Magnesium Research)
Source: Magnesium Research - January 23, 2015 Category: Biochemistry Tags: Magnes Res Source Type: research

No effect of magnesium supplementation on metabolic control and insulin sensitivity in type 2 diabetic patients with normomagnesemia.
ra MD Abstract There are limited and conflicting data from clinical trials concerning the beneficial effects of magnesium supplementation on diabetic patients. We investigated the effects of magnesium supplementation on metabolic control and insulin sensitivity in type 2 diabetic patients with normomagnesemia. A total of 98 normomagnesemic subjects with type 2 diabetes were enrolled in a randomized, crossover, double-blind, placebo-controlled trial. Participants were randomly assigned to receive magnesium lactate (360 mg elemental magnesium) or placebo for three months, followed by a three-month washout period. Tr...
Source: Magnesium Research - September 9, 2014 Category: Biochemistry Authors: Navarrete-Cortes A, Ble-Castillo JL, Guerrero-Romero F, Cordova-Uscanga R, Juárez-Rojop IE, Aguilar-Mariscal H, Tovilla-Zarate CA, Lopez-Guevara MD Tags: Magnes Res Source Type: research

Anti-hyperalgesic effect of systemic magnesium sulfate in carrageenan-induced inflammatory pain in rats: influence of the nitric oxide pathway.
This study investigated whether systemic magnesium sulfate (an antagonist at the glutamate subtype of N-methyl-D-aspartate receptor) affects inflammatory pain, and whether the nitric oxide pathway is involved. Carrageenan (0.5%, 0.1 mL, intraplantar)-induced mechanical hyperalgesia was evaluated using the electronic von Frey test in male Wistar rats. Magnesium sulfate had no effect when injected locally into the inflamed rat paw. However, subcutaneous magnesium sulfate, at doses of 0.5, 5, 15 and 30 mg/kg, reduced the hyperalgesia by 44.4 ± 8.8, 68 ± 8.4, 24.6 ± ...
Source: Magnesium Research - September 9, 2014 Category: Biochemistry Authors: Srebro DP, Vučković S, Vujović KS, Prostran M Tags: Magnes Res Source Type: research

Protective effect of magnesium and metformin on endometrium and ovary in experimental diabetes mellitus.
Abstract We evaluated the effect of magnesium and metformin on streptozotocin (STZ)-induced diabetes mellitus (DM) in non-pregnant female rats. The study comprised four groups, each consisting of eight, non-pregnant, adult Wistar female rats with a weight range of 170-250 g, maintained under the usual laboratory conditions. One group of female rats was the control group that received no treatment. To induce DM, the other three groups of animals received streptozotocin (STZ), 60 mg/kg i.p. (in a single dose). The first STZ group received no additional treatment. The second group received MgCl2 1 mmol/kg/d...
Source: Magnesium Research - August 14, 2014 Category: Biochemistry Authors: Gales C, Zamfir C, Radulescu D, Stoica B, Nechifor M Tags: Magnes Res Source Type: research

Effects of supplementation with different Mg salts in cells: is there a clue?
Abstract The differing bioavailability of magnesium salts remains an open question, both at the cellular and systemic level. However, this issue is relevant for identifying the most effective magnesium supplement. We compared the effects of three widely used magnesium salts: MgSO4, MgCl2 and Mg pidolate, on the proliferation of four human cell types: promyelocytic leukaemia HL60, osteoblast-like Saos-2 and U-2 OS, and endothelial cells from the umbilical vein. The three magnesium salts had no effect on endothelial and leukemic cell growth, but magnesium pidolate impaired cell growth in osteoblast-like cells. In pa...
Source: Magnesium Research - April 28, 2014 Category: Biochemistry Authors: Farruggia G, Castiglioni S, Sargenti A, Marraccini C, Cazzaniga A, Merolle L, Iotti S, Cappadone C, Maier JA Tags: Magnes Res Source Type: research

The channel-kinase TRPM7, revealing the untold story of Mg(2+) in cellular signaling.
Abstract Ion homeostasis dysregulations have severe effects on human health, impairing the effectiveness and appropriateness of major cellular events, including immune responses. The adverse effects of Mg(2+) deficiency on cellular physiology are well known and documented, but mechanistic insights into Mg(2+) sensitive signal transduction are still lacking. TRPM7 and its sister channel TRPM6 stand out as the only known fusions of an ion pore with a Ser/Thr kinase domain. Both channels are permeable to divalent cations and are central regulators of Mg(2+) homeostasis. One crucial aspect of TRPM7 function we have ex...
Source: Magnesium Research - April 22, 2014 Category: Biochemistry Authors: Schmitz C, Brandao K, Perraud AL Tags: Magnes Res Source Type: research

Magnesium and embryonic development.
Abstract Important for energy metabolism, neurotransmission, bone stability, and other cellular functions, Mg(2+) has well-established and undisputedly critical roles in adult tissues. Its contributions to early embryonic development are less clearly understood. For decades it has been known that gestational Mg(2+) deficiency in rodents produces teratogenic effects. More recent studies have linked deficiency in this vital cation to birth defects in humans, including spina bifida, a neural fold closure defect in humans that occurs at an average rate of 1 per 1000 pregnancies. The first suggestion that Mg(2+) may be...
Source: Magnesium Research - April 11, 2014 Category: Biochemistry Authors: Komiya Y, Su LT, Chen HC, Habas R, Runnels LW Tags: Magnes Res Source Type: research

Magnesium attenuates carbon tetrachloride-induced hepatic injury in rats.
Abstract In the present study, we investigated the protective effects of magnesium sulfate (MgSO4) against carbon tetrachloride (CCl4)-induced liver damage in rats. MgSO4 (0.001, 0.01, 0.05 and 0.1 Mg(2+) g/kg b.wt.) was administered intragastrically for 28 consecutive days to male, CCl4-treated rats. The hepatoprotective activity was assessed using various biochemical parameters such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), γ-glutamyltransferase (GGT) and superoxide dismutase (SOD) activity. Histopathological changes in the liver, of different gro...
Source: Magnesium Research - February 8, 2014 Category: Biochemistry Authors: Eidi A, Mortazavi P, Moradi F, Rohani AH, Safi S Tags: Magnes Res Source Type: research

Magnesium in drug-naïve patients with a short-duration, first episode of major depressive disorder: impact on psychopathological features.
This study was designed to examine whether and to what extent plasma magnesium is related to the psychopathological features of depression including severity of symptoms and specific psychopathological aspects. Plasma magnesium levels were studied in this cross-sectional, case-control study and involved 20, non-late-life adults who were treatment-naïve, short- duration, first episode, MDD patients, and 20 age- and sex-matched, healthy controls. Psychometric evaluations were performed using the Hamilton Rating Scale for Depression (HAMD-17) and the Spielberger State-Trait Anxiety Inventory (STAI). A significantly highe...
Source: Magnesium Research - February 8, 2014 Category: Biochemistry Authors: Cubała WJ, Landowski J, Szyszko M, Czarnowski W Tags: Magnes Res Source Type: research

Systemic magnesium to improve quality of post-surgical recovery in outpatient segmental mastectomy: a randomized, double-blind, placebo-controlled trial.
Abstract Background: It remains to be determined if perioperative systemic magnesium can improve postoperative quality of recovery of patients undergoing ambulatory procedures. The main objective of the current investigation was to evaluate the effect of systemic magnesium on postoperative quality of recovery in patients undergoing outpatient segmental mastectomies. Methods: The study was a prospective randomized, double-blind, placebo-controlled, clinical trial. Female subjects were randomized to receive intravenous magnesium (MgSO4 50mg/kg in 100 mL of normal saline over 15 min before anesthesia induction, ...
Source: Magnesium Research - February 3, 2014 Category: Biochemistry Authors: De Oliveira GS, Bialek J, Fitzgerald P, Kim JY, McCarthy RJ Tags: Magnes Res Source Type: research

"Inside-in" or "inside-out"? The membrane topology of SLC41A1.
"Inside-in" or "inside-out"? The membrane topology of SLC41A1. Magnes Res. 2014 Feb 3; Authors: Sponder G, Rutschmann K, Kolisek M Abstract Membrane topology is an important parameter for understanding the function and regulation of any integral protein. This aspect of the NME SLC41A1 is currently under debate. The most probable model, which has been computer-predicted, exhibits ten TMh with both termini being oriented intracellularly. However, other freely accessible online prediction programs predict that SLC41A1 possesses eleven ("outside-in" configuration), nine ("out...
Source: Magnesium Research - February 3, 2014 Category: Biochemistry Authors: Sponder G, Rutschmann K, Kolisek M Tags: Magnes Res Source Type: research