Vitamin deficiencies in children: Lessons from clinical and neuroimaging findings
CONCLUSIONS: Acquired vitamin deficiencies may display reversible clinical symptoms mimicking inherited metabolic disorders. Some situations raise suspicion for diagnosis: concordant clinical presentation, suggestive neuroimaging findings, and/or biochemical evidence. Any acute neurological condition should be treated without waiting for definitive biochemical confirmation.PMID:38520815 | DOI:10.1016/j.ejpn.2024.02.013 (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - March 23, 2024 Category: Neurology Authors: Gabrielle Dupuy Charles-Joris Roux R émi Barrois Apolline Imbard Cl ément Pontoizeau Marie Th érèse Dangles M élodie Aubart Jean-Baptiste Arnoux Diane Margoses Ana ïs Brassier Clothilde Marbach Claire-Marine B érat Eug énie Sarda Cyril Gitiaux Pas Source Type: research
Global DNA Methylation and Cognitive Impairment: A Population-Based Study from Haryana, North India
This study was conducted among 614 individuals, aged 30 to 79 years from Palwal, Haryana. Cognitive impairment (CI) was assessed using Mini-Mental State Examination (MMSE). Folate, vitamin B12, and homocysteine levels were estimated using chemiluminescence technique. Estimation of global DNA methylation (5mC) levels was performed using the ELISA-based colo rimetric technique. Appropriate comparison tests (based on normality distribution) were applied to compare the levels of global DNA methylation in different study groups. Logistic regression models were run to examine association between global DNA methylation and CI...
Source: Indian Journal of Clinical Biochemistry - March 23, 2024 Category: Biochemistry Source Type: research
Potential Micronutrient Deficiencies in the First 1000 Days of Life: The Pediatrician on the Side of the Weakest
This study is to examine potential micronutrient deficiencies and any need for supplementation in children following specific diet plans in the first 1000 days of life.RECENT FINDINGS: Optimal nutrition in the first 1000 days of life has a lifelong positive impact on child development. Specific intrauterine and perinatal factors, pathological conditions, and dietary restrictions can represent potential risk factors for micronutrient deficiencies in the first 1000 days of life, which can have negative systemic consequences. Preterm and low-birth-weight infants are intrinsically at risk because of immature body systems. Chil...
Source: Epilepsy Curr - March 21, 2024 Category: Neurology Authors: Carol à Panzeri Luca Pecoraro Alice Dianin Andrea Sboarina Olivia C Arnone Giorgio Piacentini Angelo Pietrobelli Source Type: research
Potential Micronutrient Deficiencies in the First 1000 Days of Life: The Pediatrician on the Side of the Weakest
This study is to examine potential micronutrient deficiencies and any need for supplementation in children following specific diet plans in the first 1000 days of life.RECENT FINDINGS: Optimal nutrition in the first 1000 days of life has a lifelong positive impact on child development. Specific intrauterine and perinatal factors, pathological conditions, and dietary restrictions can represent potential risk factors for micronutrient deficiencies in the first 1000 days of life, which can have negative systemic consequences. Preterm and low-birth-weight infants are intrinsically at risk because of immature body systems. Chil...
Source: Epilepsy Curr - March 21, 2024 Category: Neurology Authors: Carol à Panzeri Luca Pecoraro Alice Dianin Andrea Sboarina Olivia C Arnone Giorgio Piacentini Angelo Pietrobelli Source Type: research
Potential Micronutrient Deficiencies in the First 1000 Days of Life: The Pediatrician on the Side of the Weakest
This study is to examine potential micronutrient deficiencies and any need for supplementation in children following specific diet plans in the first 1000 days of life.RECENT FINDINGS: Optimal nutrition in the first 1000 days of life has a lifelong positive impact on child development. Specific intrauterine and perinatal factors, pathological conditions, and dietary restrictions can represent potential risk factors for micronutrient deficiencies in the first 1000 days of life, which can have negative systemic consequences. Preterm and low-birth-weight infants are intrinsically at risk because of immature body systems. Chil...
Source: Epilepsy Curr - March 21, 2024 Category: Neurology Authors: Carol à Panzeri Luca Pecoraro Alice Dianin Andrea Sboarina Olivia C Arnone Giorgio Piacentini Angelo Pietrobelli Source Type: research
Potential Micronutrient Deficiencies in the First 1000 Days of Life: The Pediatrician on the Side of the Weakest
This study is to examine potential micronutrient deficiencies and any need for supplementation in children following specific diet plans in the first 1000 days of life.RECENT FINDINGS: Optimal nutrition in the first 1000 days of life has a lifelong positive impact on child development. Specific intrauterine and perinatal factors, pathological conditions, and dietary restrictions can represent potential risk factors for micronutrient deficiencies in the first 1000 days of life, which can have negative systemic consequences. Preterm and low-birth-weight infants are intrinsically at risk because of immature body systems. Chil...
Source: Epilepsy Curr - March 21, 2024 Category: Neurology Authors: Carol à Panzeri Luca Pecoraro Alice Dianin Andrea Sboarina Olivia C Arnone Giorgio Piacentini Angelo Pietrobelli Source Type: research
Potential Micronutrient Deficiencies in the First 1000 Days of Life: The Pediatrician on the Side of the Weakest
This study is to examine potential micronutrient deficiencies and any need for supplementation in children following specific diet plans in the first 1000 days of life.Recent FindingsOptimal nutrition in the first 1000 days of life has a lifelong positive impact on child development. Specific intrauterine and perinatal factors, pathological conditions, and dietary restrictions can represent potential risk factors for micronutrient deficiencies in the first 1000 days of life, which can have negative systemic con sequences. Preterm and low-birth-weight infants are intrinsically at risk because of immature body systems. ...
Source: Current Obesity Reports - March 21, 2024 Category: Eating Disorders & Weight Management Source Type: research
Intratracheal cobinamide (vitamin B12 analog) administration increases survivability in rabbits exposed to a lethal dose of inhaled hydrogen sulfide
Volume 62, Issue 2, February 2024, Page 94-100 . (Source: Clinical Toxicology)
Source: Clinical Toxicology - March 21, 2024 Category: Toxicology Authors: Seungyong ParkDavid MukaiJangweon LeeTanya BurneyGerry BossPhillipe HaouziJane Annabelle LeeMark Thomas KimAlexis Makenna FoxGeorge PhilipopoulosMatthew Brennera Beckman Laser Institute, University of CA, Irvine, CA, USAb Division of Pulmonary and Critica Source Type: research
Peeling back the many layers of competitive exclusion
This study indicates complex community interactions that modulate Salmonella metabolism and pathogenic behavior and reduce growth through antagonism may be key to exclusion. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - March 21, 2024 Category: Microbiology Source Type: research
Progressive multifocal leukoencephalopathy associated with systemic lupus erythematosus: longitudinal observation of lymphocytes, JC virus in cerebrospinal fluid, and brain magnetic resonance imaging
This report presents the case of a patient who developed PML due to SLE-associated multiple factors. A 60-year-old woman diagnosed with SLE undergoing multiple immunosuppressive therapies, including azathioprine, presented with cerebral cortical symptoms, lymphocytopenia, and vitamin B12 deficiency and was subsequently diagnosed with SLE-associated PML. We evaluated the cause and disease activity of PML, focusing on the longitudinal assessment of lymphocytopenia, JC virus (JCV) DNA copy number in the cerebrospinal fluid, and magnetic resonance imaging (MRI) findings. Discontinuing azathioprine and initiating alternative im...
Source: Journal of NeuroVirology - March 19, 2024 Category: Neurology Source Type: research
Iron deficiency in pernicious anemia: specific features of iron deficient patients and preliminary data on response to iron supplementation
While vitamin B12 (B12) deficiency is considered as the hallmark of pernicious anemia (PA), iron deficiency (ID) is also prevalent. Indeed, this auto immune gastritis is responsible for parietal cell atrophy and increase in gastric pH, leading to impaired iron absorption. We compared PA patients ’ features according to their iron status at PA diagnosis, and we assessed the iron status recovery after oral or intravenous iron supplementation. (Source: Clinical Nutrition)
Source: Clinical Nutrition - March 19, 2024 Category: Nutrition Authors: Juliette Rogez, Geoffrey Urbanski, Emeline Vinatier, Christian Lavigne, L éa Emmanuel, Iris Dupin, Camille Ravaiau, Valentin Lacombe Tags: Original article Source Type: research
Fatal coinfection of blastocystosis and intestinal trichomoniasis in a rhesus macaque (Macaca mulatta)
AbstractA 3-year-old male rhesus macaque was presented at Referral Veterinary Polyclinic-Teaching Veterinary Clinical Complex, with a chief complaint of chronic diarrhoea and swelling of dependent body parts. The patient's history indicates that the monkey had been experiencing diarrhoea for the past month, with 2 –3 episodes of vomiting in the last 2 days. Additionally, oedema has developed within the last 2 weeks. The clinical examination findings revealed dullness and depression, the mucus membrane appeared pale, with a temperature-102.1 °F, a respiration rate-28/min, and a heart rate-92/min. The cap illary refill...
Source: Journal of Parasitic Diseases - March 19, 2024 Category: Parasitology Source Type: research
Hematological parameters in patients with recurrent Aphthous Stomatitis: a systematic review and meta-analysis
CONCLUSION: The results of the meta-analysis indicated that the SMD of vitamin B12 serum and Hb levels in the case group was 52%. Our result have also showed that the odds ratio of vitamin B12, ferritin deficiencies, and decreased Hb level in case group was 2.93, 2.50, and 2.14 times more than healthy group.PMID:38493289 | DOI:10.1186/s12903-024-04072-5 (Source: Cancer Control)
Source: Cancer Control - March 17, 2024 Category: Cancer & Oncology Authors: Tahoora Mousavi Hossein Jalali Mahmood Moosazadeh Source Type: research
Identification of novel pathogenic variants of CUBN in patients with isolated proteinuria
ConclusionThese results demonstrate that aboveCUBN mutations may cause non-progressive and isolated proteinuria, expanding the variant spectrum ofCUBN and benefiting our understanding of proteinuria and renal function. (Source: Molecular Genetics & Genomic Medicine)
Source: Molecular Genetics & Genomic Medicine - March 15, 2024 Category: Genetics & Stem Cells Authors: Huihui Yang,
Lanfen He,
Hongjian Gong,
Chunhui Wan,
Juanjuan Ding,
Panli Liao,
Xiaowen Wang Tags: ORIGINAL ARTICLE Source Type: research
Identification of novel pathogenic variants of CUBN in patients with isolated proteinuria
CONCLUSION: These results demonstrate that above CUBN mutations may cause non-progressive and isolated proteinuria, expanding the variant spectrum of CUBN and benefiting our understanding of proteinuria and renal function.PMID:38488435 | DOI:10.1002/mgg3.2353 (Source: Molecular Medicine)
Source: Molecular Medicine - March 15, 2024 Category: Molecular Biology Authors: Huihui Yang Lanfen He Hongjian Gong Chunhui Wan Juanjuan Ding Panli Liao Xiaowen Wang Source Type: research
