The boon and bane of nitrous oxide
AbstractNitrous oxide (N2O) has been known since the end of the eighteenth century. Today, N2O plays a huge role as a greenhouse gas and an ozone-depleting stratospheric molecule. The main sources of anthropogenic N2O emissions are agriculture, fuel combustion, wastewater treatment, and various industrial processes. By contrast, the contribution of medical N2O to the greenhouse effect appears to be small. The recreational and medical uses of N2O gradually diverged over time. N2O has analgesic and anesthetic effects, making it widely used in modern dentistry and surgery. New research has also begun studying N2O ’s antidep...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 13, 2024 Category: Neuroscience Source Type: research

Validating nutrient selection for product-group-specific nutrient indices for use as functional units in life cycle assessment of foods
Br J Nutr. 2024 Apr 12:1-23. doi: 10.1017/S0007114524000709. Online ahead of print.ABSTRACTThe ability to provide adequate nutrition is considered a key factor in evaluating the sustainability of foods and diets. Nutrient indices are used as functional units (FUs) in life cycle assessment of foods to include nutritional performance in the environmental assessment of a product. Several general and food group-specific nutrient indices exist but many lack validation, particularly when used as FU. In addition, the nutrient selection strategies and reference units for nutrient intake can vary considerably among studies. To vali...
Source: The British Journal of Nutrition - April 12, 2024 Category: Nutrition Authors: Anna K årlund Venla Kytt ä Tiina Pellinen Hanna L Tuomisto Anne-Maria Pajari Marjukka Kolehmainen Merja Saarinen Source Type: research

Validating nutrient selection for product-group-specific nutrient indices for use as functional units in life cycle assessment of foods
Br J Nutr. 2024 Apr 12:1-23. doi: 10.1017/S0007114524000709. Online ahead of print.ABSTRACTThe ability to provide adequate nutrition is considered a key factor in evaluating the sustainability of foods and diets. Nutrient indices are used as functional units (FUs) in life cycle assessment of foods to include nutritional performance in the environmental assessment of a product. Several general and food group-specific nutrient indices exist but many lack validation, particularly when used as FU. In addition, the nutrient selection strategies and reference units for nutrient intake can vary considerably among studies. To vali...
Source: The British Journal of Nutrition - April 12, 2024 Category: Nutrition Authors: Anna K årlund Venla Kytt ä Tiina Pellinen Hanna L Tuomisto Anne-Maria Pajari Marjukka Kolehmainen Merja Saarinen Source Type: research

Role of one-carbon nutrient intake and diabetes during pregnancy in children ’s growth and neurodevelopment: a 2-year follow-up study of a prospective cohort
This study aimed to determine how maternal 1C nutrient intake was associated with DNA methylation and further, development of children, as well as whether maternal GDM status modified the association in a prospective cohort. (Source: Clinical Nutrition)
Source: Clinical Nutrition - April 12, 2024 Category: Nutrition Authors: Isma ’il Kadam, Mudar Dalloul, Jeanette Hausser, Doron Vaday, Ella Gilboa, Liang Wang, Joan Hittelman, Lori Hoepner, Lawrence Fordjour, Pavani Chitamanni, Anjana Saxena, Xinyin Jiang Source Type: research

Microalgae/cyanobacteria: the potential green future of vitamin B12 production
(Source: Critical Reviews in Food Science and Nutrition)
Source: Critical Reviews in Food Science and Nutrition - April 6, 2024 Category: Nutrition Authors: Durdakova, Michaela Kolackova, Martina Janova, Anna Krystofova, Olga Adam, Vojtech Huska, Dalibor Source Type: research

Clinico-Etiopathogenesis of Vitamin B12, Folic Acid and Iron Deficiency in Severe Acute Malnutrition Children: A Tertiary Care Hospital Experience from Central India
In this study, haematological indices are recommended for predicting severity of anemia, and hematopoietic changes are described, in order to improve anticipatory care and outcome in children with SAM.PMID:38577146 | PMC:PMC10987456 | DOI:10.1007/s12291-022-01100-5 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - April 5, 2024 Category: Biochemistry Authors: Priyanka Shukla Sanjay Kumar Pandey Jyoti Singh Naresh Bajaj Gaurav Tripathi Sudhakar Dwivedi Source Type: research

Clinico-Etiopathogenesis of Vitamin B12, Folic Acid and Iron Deficiency in Severe Acute Malnutrition Children: A Tertiary Care Hospital Experience from Central India
In this study, haematological indices are recommended for predicting severity of anemia, and hematopoietic changes are described, in order to improve anticipatory care and outcome in children with SAM.PMID:38577146 | PMC:PMC10987456 | DOI:10.1007/s12291-022-01100-5 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - April 5, 2024 Category: Biochemistry Authors: Priyanka Shukla Sanjay Kumar Pandey Jyoti Singh Naresh Bajaj Gaurav Tripathi Sudhakar Dwivedi Source Type: research

Cobalamins function as allosteric activators of an Angelman syndrome-associated UBE3A/E6AP variant
Chembiochem. 2024 Apr 4:e202400184. doi: 10.1002/cbic.202400184. Online ahead of print.ABSTRACTGenetic aberrations of the maternal UBE3A allele, which encodes the E3 ubiquitin ligase E6AP, are the cause of Angelman syndrome (AS), an imprinting disorder. In most cases, the maternal UBE3A allele is not expressed. Yet, approximately 10 percent of AS individuals harbor distinct point mutations in the maternal allele resulting in the expression of full-length E6AP variants that frequently display compromised ligase activity. In a high-throughput screen, we identified cyanocobalamin, a vitamin B12-derivative, and several alloxaz...
Source: Chembiochem - April 4, 2024 Category: Biochemistry Authors: Franziska M üller Jasmin Jansen Fabian Offensperger Daniela Eichbichler Florian Stengel Martin Scheffner Source Type: research

The Effects of an Eight-Week Swimming Program on Body Composition and Assessment of Dietary Intake in Post-COVID-19 Patients
J Nutr Metab. 2024 Mar 27;2024:3037784. doi: 10.1155/2024/3037784. eCollection 2024.ABSTRACTCOVID-19 infection and its consequences (long-term COVID-19 syndrome) have implications for weight loss, body composition, and diet quality. In the context of the "PostCovSwim" project, which is part of a broader international study, the impact of an eight-week swimming program on post-COVID-19 patients' nutritional status (i.e., body composition and dietary intake) was evaluated. Body composition and dietary intake were assessed by medically approved and calibrated bioelectrical impedance (Tanita 780 S MA) and food frequency questi...
Source: Journal of Nutrition and Metabolism - April 4, 2024 Category: Nutrition Authors: Bostjan Jak še Barbara Gili ć Marko Đurović Dorica Šajber Source Type: research

Diabetic Peripheral Neuropathy: Prevention and Treatment
Am Fam Physician. 2024 Mar;109(3):226-232.ABSTRACTDiabetic peripheral neuropathy occurs in up to 50% of patients with diabetes mellitus and increases the risk of diabetic foot ulcers and infections. Consistent screening and clear communication are essential to decrease disparities in assessment of neuropathic symptoms and diagnosis. Physicians should address underlying risk factors such as poor glycemic control, vitamin B12 deficiency, elevated blood pressure, and obesity to reduce the likelihood of developing neuropathy. First-line drug therapy for painful diabetic peripheral neuropathy includes duloxetine, gabapentin, am...
Source: American Family Physician - April 4, 2024 Category: Primary Care Authors: Scott Bragg Sarah Tucker Marrison Sean Haley Source Type: research

Diabetic Peripheral Neuropathy: Prevention and Treatment
Am Fam Physician. 2024 Mar;109(3):226-232.ABSTRACTDiabetic peripheral neuropathy occurs in up to 50% of patients with diabetes mellitus and increases the risk of diabetic foot ulcers and infections. Consistent screening and clear communication are essential to decrease disparities in assessment of neuropathic symptoms and diagnosis. Physicians should address underlying risk factors such as poor glycemic control, vitamin B12 deficiency, elevated blood pressure, and obesity to reduce the likelihood of developing neuropathy. First-line drug therapy for painful diabetic peripheral neuropathy includes duloxetine, gabapentin, am...
Source: Pain Physician - April 4, 2024 Category: Anesthesiology Authors: Scott Bragg Sarah Tucker Marrison Sean Haley Source Type: research

Cobalamins function as allosteric activators of an Angelman syndrome-associated UBE3A/E6AP variant
Chembiochem. 2024 Apr 4:e202400184. doi: 10.1002/cbic.202400184. Online ahead of print.ABSTRACTGenetic aberrations of the maternal UBE3A allele, which encodes the E3 ubiquitin ligase E6AP, are the cause of Angelman syndrome (AS), an imprinting disorder. In most cases, the maternal UBE3A allele is not expressed. Yet, approximately 10 percent of AS individuals harbor distinct point mutations in the maternal allele resulting in the expression of full-length E6AP variants that frequently display compromised ligase activity. In a high-throughput screen, we identified cyanocobalamin, a vitamin B12-derivative, and several alloxaz...
Source: Chembiochem - April 4, 2024 Category: Biochemistry Authors: Franziska M üller Jasmin Jansen Fabian Offensperger Daniela Eichbichler Florian Stengel Martin Scheffner Source Type: research

Diabetic Peripheral Neuropathy: Prevention and Treatment
Am Fam Physician. 2024 Mar;109(3):226-232.ABSTRACTDiabetic peripheral neuropathy occurs in up to 50% of patients with diabetes mellitus and increases the risk of diabetic foot ulcers and infections. Consistent screening and clear communication are essential to decrease disparities in assessment of neuropathic symptoms and diagnosis. Physicians should address underlying risk factors such as poor glycemic control, vitamin B12 deficiency, elevated blood pressure, and obesity to reduce the likelihood of developing neuropathy. First-line drug therapy for painful diabetic peripheral neuropathy includes duloxetine, gabapentin, am...
Source: American Family Physician - April 4, 2024 Category: Primary Care Authors: Scott Bragg Sarah Tucker Marrison Sean Haley Source Type: research

The Effects of an Eight-Week Swimming Program on Body Composition and Assessment of Dietary Intake in Post-COVID-19 Patients
J Nutr Metab. 2024 Mar 27;2024:3037784. doi: 10.1155/2024/3037784. eCollection 2024.ABSTRACTCOVID-19 infection and its consequences (long-term COVID-19 syndrome) have implications for weight loss, body composition, and diet quality. In the context of the "PostCovSwim" project, which is part of a broader international study, the impact of an eight-week swimming program on post-COVID-19 patients' nutritional status (i.e., body composition and dietary intake) was evaluated. Body composition and dietary intake were assessed by medically approved and calibrated bioelectrical impedance (Tanita 780 S MA) and food frequency questi...
Source: Journal of Nutrition and Metabolism - April 4, 2024 Category: Nutrition Authors: Bostjan Jak še Barbara Gili ć Marko Đurović Dorica Šajber Source Type: research

Cobalamins function as allosteric activators of an Angelman syndrome-associated UBE3A/E6AP variant
Chembiochem. 2024 Apr 4:e202400184. doi: 10.1002/cbic.202400184. Online ahead of print.ABSTRACTGenetic aberrations of the maternal UBE3A allele, which encodes the E3 ubiquitin ligase E6AP, are the cause of Angelman syndrome (AS), an imprinting disorder. In most cases, the maternal UBE3A allele is not expressed. Yet, approximately 10 percent of AS individuals harbor distinct point mutations in the maternal allele resulting in the expression of full-length E6AP variants that frequently display compromised ligase activity. In a high-throughput screen, we identified cyanocobalamin, a vitamin B12-derivative, and several alloxaz...
Source: Chembiochem - April 4, 2024 Category: Biochemistry Authors: Franziska M üller Jasmin Jansen Fabian Offensperger Daniela Eichbichler Florian Stengel Martin Scheffner Source Type: research