Dietary vitamin B12 deficiency impairs motor function and changes neuronal survival and choline metabolism after ischemic stroke in middle-aged male and female mice
. (Source: Nutritional Neuroscience)
Source: Nutritional Neuroscience - March 18, 2023 Category: Nutrition Authors: Gyllian B. Yahn MBS Brandi Wasek Teodoro Bottiglieri Olga Malysheva Marie A. Caudill Nafisa M. Jadavji Source Type: research
Reprocessing of side-streams towards obtaining valuable bacterial metabolites
Appl Microbiol Biotechnol. 2023 Mar 16. doi: 10.1007/s00253-023-12458-8. Online ahead of print.ABSTRACTEvery year, all over the world, the industry generates huge amounts of residues. Side-streams are most often used as feed, landfilled, incinerated, or discharged into sewage. These disposal methods are far from perfect. Taking into account the composition of the side-streams, it seems that they should be used as raw materials for further processing, in accordance with the zero-waste policy and sustainable development. The article describes the latest achievements in biotechnology in the context of bacterial reprocessing o...
Source: Applied Microbiology and Biotechnology - March 17, 2023 Category: Microbiology Authors: Kamil Piwowarek Edyta Lipi ńska Marek Kieliszek Source Type: research
Reprocessing of side-streams towards obtaining valuable bacterial metabolites
Appl Microbiol Biotechnol. 2023 Mar 16. doi: 10.1007/s00253-023-12458-8. Online ahead of print.ABSTRACTEvery year, all over the world, the industry generates huge amounts of residues. Side-streams are most often used as feed, landfilled, incinerated, or discharged into sewage. These disposal methods are far from perfect. Taking into account the composition of the side-streams, it seems that they should be used as raw materials for further processing, in accordance with the zero-waste policy and sustainable development. The article describes the latest achievements in biotechnology in the context of bacterial reprocessing o...
Source: Applied Microbiology and Biotechnology - March 17, 2023 Category: Microbiology Authors: Kamil Piwowarek Edyta Lipi ńska Marek Kieliszek Source Type: research
Idiopathic recurrent pyoderma gangrenosum with cobalamin deficiency in a 62-year-old male: a case report
CONCLUSION: PG is a rare form of neutrophilic dermatosis that can be difficult to diagnose and treat. PG has a mixed nutritional deficiency and a history of ulcers. It is crucial to have a high degree of suspicion when making a diagnosis, as well as to look for associated diseases and start treatment as soon as possible.PMID:36923778 | PMC:PMC10010805 | DOI:10.1097/MS9.0000000000000253 (Source: Hand Surgery)
Source: Hand Surgery - March 16, 2023 Category: Surgery Authors: Seema Sitaula Sanjeev Kharel Aakash Sherpali Vijay Shrees Atul Mainali Source Type: research
Idiopathic recurrent pyoderma gangrenosum with cobalamin deficiency in a 62-year-old male: a case report
CONCLUSION: PG is a rare form of neutrophilic dermatosis that can be difficult to diagnose and treat. PG has a mixed nutritional deficiency and a history of ulcers. It is crucial to have a high degree of suspicion when making a diagnosis, as well as to look for associated diseases and start treatment as soon as possible.PMID:36923778 | PMC:PMC10010805 | DOI:10.1097/MS9.0000000000000253 (Source: Annals of Medicine)
Source: Annals of Medicine - March 16, 2023 Category: Internal Medicine Authors: Seema Sitaula Sanjeev Kharel Aakash Sherpali Vijay Shrees Atul Mainali Source Type: research
Idiopathic recurrent pyoderma gangrenosum with cobalamin deficiency in a 62-year-old male: a case report
CONCLUSION: PG is a rare form of neutrophilic dermatosis that can be difficult to diagnose and treat. PG has a mixed nutritional deficiency and a history of ulcers. It is crucial to have a high degree of suspicion when making a diagnosis, as well as to look for associated diseases and start treatment as soon as possible.PMID:36923778 | PMC:PMC10010805 | DOI:10.1097/MS9.0000000000000253 (Source: Hand Surgery)
Source: Hand Surgery - March 16, 2023 Category: Surgery Authors: Seema Sitaula Sanjeev Kharel Aakash Sherpali Vijay Shrees Atul Mainali Source Type: research
Idiopathic recurrent pyoderma gangrenosum with cobalamin deficiency in a 62-year-old male: a case report
CONCLUSION: PG is a rare form of neutrophilic dermatosis that can be difficult to diagnose and treat. PG has a mixed nutritional deficiency and a history of ulcers. It is crucial to have a high degree of suspicion when making a diagnosis, as well as to look for associated diseases and start treatment as soon as possible.PMID:36923778 | PMC:PMC10010805 | DOI:10.1097/MS9.0000000000000253 (Source: Annals of Medicine)
Source: Annals of Medicine - March 16, 2023 Category: Internal Medicine Authors: Seema Sitaula Sanjeev Kharel Aakash Sherpali Vijay Shrees Atul Mainali Source Type: research
Seeing Red: Hydroxocobalamin and Result Interference
Intravenous high dose hydroxocobalamin (CyanoKit ®, BTG Pharmaceuticals, London, United Kingdom) is indicated for the treatment of cyanide toxicity.1 In the last 10 years, the nitric oxide scavenging properties of hydroxocobalamin have brought it to the forefront for use in the treatment of vasoplegia.1–3 Despite a lack of randomized evidence, many retrospective studies have demonstrated its value in this context, and hydroxocobalamin has a number of characteristics favorable to critically ill patients with vasoplegia including a lack of serotonergic activity or evidence of contributing to a hypercoagulable state. (Sour...
Source: Journal of Cardiothoracic and Vascular Anesthesia - March 16, 2023 Category: Anesthesiology Authors: Jamel Ortoleva, Alexander D. Shapeton Tags: Editorial Source Type: research
Structural basis for activation of cobalt-carbon bond and control of adenosyl radical in coenzyme B12 catalysis
Chembiochem. 2023 Mar 14:e202300021. doi: 10.1002/cbic.202300021. Online ahead of print.ABSTRACTAdenosylcobalamin (AdoCbl) or coenzyme B12 is a naturally occurring organometallic compound that serves as a cofactor for enzymes that catalyze intramolecular group-transfer reactions and ribonucleotide reduction in a wide variety of organisms from bacteria to animals. AdoCbl-dependent enzymes are radical enzymes and generate an adenosyl radical by homolysis of the coenzyme's cobalt-carbon (Co-C) bond for catalysis. How do the enzymes activate and cleave the Co-C bond to form the adenosyl radical? How do the enzymes utilize the ...
Source: Chembiochem - March 14, 2023 Category: Biochemistry Authors: Naoki Shibata Tetsuo Toraya Source Type: research
Structural basis for activation of cobalt-carbon bond and control of adenosyl radical in coenzyme B12 catalysis
Chembiochem. 2023 Mar 14:e202300021. doi: 10.1002/cbic.202300021. Online ahead of print.ABSTRACTAdenosylcobalamin (AdoCbl) or coenzyme B12 is a naturally occurring organometallic compound that serves as a cofactor for enzymes that catalyze intramolecular group-transfer reactions and ribonucleotide reduction in a wide variety of organisms from bacteria to animals. AdoCbl-dependent enzymes are radical enzymes and generate an adenosyl radical by homolysis of the coenzyme's cobalt-carbon (Co-C) bond for catalysis. How do the enzymes activate and cleave the Co-C bond to form the adenosyl radical? How do the enzymes utilize the ...
Source: Chembiochem - March 14, 2023 Category: Biochemistry Authors: Naoki Shibata Tetsuo Toraya Source Type: research
Vitamin B12 attenuates leukocyte inflammatory signature in COVID-19 via methyl-dependent changes in epigenetic markings
COVID-19 induces chromatin remodeling in host immune cells, and it had previously been shown that vitamin B12 downregulates some inflammatory genes via methyl-dependent epigenetic mechanisms. In this work, whole blood cultures from moderate or severe COVID-19 patients were used to assess the potential of B12 as adjuvant drug. The vitamin normalized the expression of a panel of inflammatory genes still dysregulated in the leukocytes despite glucocorticoid therapy during hospitalization. B12 also increased the flux of the sulfur amino acid pathway, that regulates the bioavailability of methyl. Accordingly, B12-induced downre...
Source: Frontiers in Immunology - March 13, 2023 Category: Allergy & Immunology Source Type: research
Genes, Vol. 14, Pages 709: Folate & ndash;Methionine Cycle Disruptions in ASD Patients and Possible Interventions: A Systematic Review
Genes, Vol. 14, Pages 709: Folate–Methionine Cycle Disruptions in ASD Patients and Possible Interventions: A Systematic Review
Genes doi: 10.3390/genes14030709
Authors:
Melissa Roufael
Tania Bitar
Yonna Sacre
Christian Andres
Walid Hleihel
Autism Spectrum Disorder (ASD) has become a major public health concern due to its rapidly rising incidence over the past few years. Disturbances in folate or methionine metabolism have been identified in many individuals with ASD, suggesting that the folate–methionine cycle may play an essential role in the pathogenesis of autism. Thus, changes in...
Source: Genes - March 13, 2023 Category: Genetics & Stem Cells Authors: Melissa Roufael Tania Bitar Yonna Sacre Christian Andres Walid Hleihel Tags: Review Source Type: research
Genetically predicted levels of folate, vitamin B12, and risk of autoimmune diseases: A Mendelian randomization study
ConclusionThe study provides convincing evidence for an inverse association between serum folate level and risk of vitiligo. Further studies are warranted to elucidate the possible association between vitamin B12 and risk of IBD. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 10, 2023 Category: Allergy & Immunology Source Type: research
Molecules, Vol. 28, Pages 2544: Co-Encapsulation of Epigallocatechin-3-Gallate and Vitamin B12 in Zein Microstructures by Electrospinning/Electrospraying Technique
evinho
EGCG is a catechin known for its antioxidant and anti-inflammatory characteristics. Vitamin B12 is an essential vitamin found in animal-derived products, and its deficiency may cause serious health problems such as anemia. The effectiveness of both catechin and vitamin B12 depends on their stability and bioavailability, which can be lost during industrial processes due to degradation when exposed to external factors. A potential solution to this issue is the microencapsulation, which protects the compounds from external agents. The current study aims to microencapsulate EGCG and vitamin B12 in a polymer matrix o...
Source: Molecules - March 10, 2023 Category: Chemistry Authors: Ana F. Couto Ma éna Favretto Raphael Paquis Berta N. Estevinho Tags: Article Source Type: research
Association between adherence to the Mediterranean diet with anthropometric measurements and nutritional status in adolescents
CONCLUSION: adolescents' adherence to the Mediterranean diet was low and correlated with some anthropometric measures. Increasing adherence to the Mediterranean diet may contribute to preventing obesity and adequate and balanced nutrition in adolescents.PMID:36880734 | DOI:10.20960/nh.04545 (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - March 7, 2023 Category: Nutrition Authors: Bet ül Kocaadam-Bozkurt Merve Şeyda Karaçil Ermumcu Nazl ıcan Erdoğan Gövez Osman Bozkurt Şerife Akpinar Özge Mengi Çelik Eda K öksal Nil üfer Acar Tek Source Type: research
