A review of dairy food intake for improving health among black geriatrics in the US
J Natl Med Assoc. 2024 Feb 15:S0027-9684(24)00014-2. doi: 10.1016/j.jnma.2024.01.017. Online ahead of print.ABSTRACTThe transition to older adulthood is generally marked by progressive declines in body composition, metabolism, cognitive function, and immunity. For socially disadvantaged geriatric populations such as Black Americans, this life stage may also include additional stressors, including dealing with discrimination, poor access to healthcare, and food insecurity. These types of chronic stressors are linked to a higher allostatic load, which is associated with accelerated biological aging, higher rates of adverse h...
Source: Journal of the National Medical Association - February 16, 2024 Category: General Medicine Authors: Edith Mitchell Kevin Comerford Michael Knight Kevin McKinney Yolanda Lawson Source Type: research
Global DNA Methylation Levels Viz-a-Viz Genetic and Biochemical Variations in One Carbon Metabolic Pathway: An Exploratory Study from North India
This study aimed to understand the variations in global DNA methylation levels with respect to selected genetic (CBS 844ins68, MTRR A66G, MTR A2756G, and MTHFR C677T polymorphisms) and biochemical (folate, vitamin B12, and homocysteine) markers associated with OCMP among healthy North Indian adults. The study has been conducted among 1095 individuals of either sex (69.5% females), aged 30-75 years. A sample of 5 mL of blood was collected from each participant. Homocysteine, folate, and vitamin B12 levels were determined using the chemiluminescence technique. Restriction digestion was performed for genotyping MTRR A66G, MTR...
Source: Biochemical Genetics - February 15, 2024 Category: Genetics & Stem Cells Authors: Vineet Chaudhary Debashis Bhattacharjee Naorem Kiranmala Devi Kallur Nava Saraswathy Source Type: research
Hyaluronan/B12-chitosan polyelectrolyte complex for oral colistin administration
This study describes the procedure for obtaining CT-containing PECs based on HA and CS modified with cyanocobalamin (vitamin B12). In this case, vitamin B12 is used as a targeting ligand because it is absorbed in the ileum via specific transporter proteins. The resulting PECs had a hydrodynamic size of about 284 nm and a positive ζ-potential of about 26 mV; the encapsulation efficiency was 88.2 % and the CT content was 42.2 μg/mg. The developed systems provided a two-phase drug release: about 50 % of the CT was released in 0.5-1 h, and about 60 % of the antibiotic was cumulatively released in 5 h. The antimicrobial activ...
Source: International Journal of Biological Macromolecules - February 15, 2024 Category: Biochemistry Authors: Natallia V Dubashynskaya Anton N Bokatyi Tatiana S Sall Tatiana S Egorova Elena V Demyanova Yaroslav A Dubrovskii Ekaterina A Murashko Yuri A Anufrikov Anna Y Shasherina Elena N Vlasova Yury A Skorik Source Type: research
Global DNA Methylation Levels Viz-a-Viz Genetic and Biochemical Variations in One Carbon Metabolic Pathway: An Exploratory Study from North India
This study aimed to understand the variations in global DNA methylation levels with respect to selected genetic (CBS 844ins68, MTRR A66G, MTR A2756G, and MTHFR C677T polymorphisms) and biochemical (folate, vitamin B12, and homocysteine) markers associated with OCMP among healthy North Indian adults. The study has been conducted among 1095 individuals of either sex (69.5% females), aged 30-75 years. A sample of 5 mL of blood was collected from each participant. Homocysteine, folate, and vitamin B12 levels were determined using the chemiluminescence technique. Restriction digestion was performed for genotyping MTRR A66G, MTR...
Source: Biochemical Genetics - February 15, 2024 Category: Genetics & Stem Cells Authors: Vineet Chaudhary Debashis Bhattacharjee Naorem Kiranmala Devi Kallur Nava Saraswathy Source Type: research
Hyaluronan/B12-chitosan polyelectrolyte complex for oral colistin administration
This study describes the procedure for obtaining CT-containing PECs based on HA and CS modified with cyanocobalamin (vitamin B12). In this case, vitamin B12 is used as a targeting ligand because it is absorbed in the ileum via specific transporter proteins. The resulting PECs had a hydrodynamic size of about 284 nm and a positive ζ-potential of about 26 mV; the encapsulation efficiency was 88.2 % and the CT content was 42.2 μg/mg. The developed systems provided a two-phase drug release: about 50 % of the CT was released in 0.5-1 h, and about 60 % of the antibiotic was cumulatively released in 5 h. The antimicrobial activ...
Source: International Journal of Biological Macromolecules - February 15, 2024 Category: Biochemistry Authors: Natallia V Dubashynskaya Anton N Bokatyi Tatiana S Sall Tatiana S Egorova Elena V Demyanova Yaroslav A Dubrovskii Ekaterina A Murashko Yuri A Anufrikov Anna Y Shasherina Elena N Vlasova Yury A Skorik Source Type: research
Combined effect of Neurotropin ® and methylcobalamin on postherpetic neuralgia in mice infected with herpes simplex virus type-1
Postherpetic pain (PHP) is difficult to control. Although Neurotropin ® (NTP) and methylcobalamin (MCB) are often prescribed to treat the pain, the efficacy of combined treatment for PHP remains imcompletely understood. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 12, 2024 Category: Dermatology Authors: Tsugunobu Andoh, Takashi Kikukawa, Atsushi Kotani, Yoko Kurokawa, Wakana Asakura, Kengo Houmoto, Daisuke Fukutomi, Diasuke Uta, Hisashi Okai, Koji Koike Source Type: research
Hydrogen bioelectrogeneration with pH-resilient and oxygen-tolerant cobalt apoenzyme-saccharide
Chem Commun (Camb). 2024 Feb 9. doi: 10.1039/d3cc06185j. Online ahead of print.ABSTRACTHydrogenases are enzymes that catalyze the reversible conversion of protons to hydrogen gas, using earth-abundant metals such as nickel and/or iron. This characteristic makes them promising for sustainable energy applications, particularly in clean hydrogen production. However, their widespread use faces challenges, including a limited pH range and susceptibility to oxygen. In response to these issues, SacCoMyo is introduced as an artificial enzyme. SacCoMyo is designed by replacing the native metal in the myoglobin (Myo) scaffold with a...
Source: Chemical Communications - February 9, 2024 Category: Chemistry Authors: Rodrigo M Iost Radhakrishnan Venkatkarthick Steffane Q Nascimento Fabio H B Lima Frank N Crespilho Source Type: research
Microbiome function and neurodevelopment in Black infants: vitamin B12 emerges as a key factor
Volume 16, Issue 1, January-December 2024 . (Source: Gut Microbes)
Source: Gut Microbes - February 2, 2024 Category: Microbiology Authors: Kaitlyn OliphantWilfredo Cruz AyalaRimma IlyumzhinovaKimberley MbayiwaAnna SrokaBingqing XieBree AndrewsKate KeenanErika C. Clauda Department of Pediatrics, University of Chicago, Chicago, USAb Department of Psychiatry and Behavioral Neuroscience, Univers Source Type: research
Vitamin B12 Protects Against Genotoxicity Induced by Cisplatin
CONCLUSION: Vitamin B12 can protect human lymphocytes against genotoxicity associated with cisplatin.PMID:38299397 | DOI:10.2174/0115680096284684240110044954 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - February 1, 2024 Category: Cancer & Oncology Authors: Wejdan M Al-Bataineh Karem H Alzoubi Omar F Khabour Amjad Mahasneh Enaam M Almomani Source Type: research
Development of a diet quality score and adherence to the Swiss dietary recommendations for vegans
CONCLUSION: The newly developed DQS-V provides a single score for estimating diet quality among vegan adults. Further validation studies examining the DQS-V in relation to an independent dietary assessment method and to biomarkers of nutritional intake and status are still needed before the general application of the DQS-V.PMID:38291526 | PMC:PMC10829326 | DOI:10.1186/s41043-024-00498-3 (Source: Journal of Health, Population, and Nutrition)
Source: Journal of Health, Population, and Nutrition - January 30, 2024 Category: International Medicine & Public Health Authors: Natalie S Bez Joyce Haddad Giulia S Tedde Karolin Rose Aljoscha V Ivanov Marina Milazzo Jo ëlle Wickart Giulia Casale Michele D'Ascanio Klazine Van der Horst Isabelle Herter-Aeberli Leonie H Bogl Source Type: research
Association between < em > MTHFR C677T < /em > Gene Polymorphisms and the Efficacy of Vitamin Therapy in lowering Homocysteine Levels among Stroke Patients with Hyperhomocysteinemia
CONCLUSIONS: Our findings suggested that the TT genotype and T allele of MTHFR C677T polymorphism were independently associated with an insufficient Hcy lowering treatment effect in stroke patients with HHcy.PMID:38287840 | DOI:10.31083/j.jin2301003 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - January 30, 2024 Category: Neuroscience Authors: Zhi-Can Li Min Huang Qing-Yang Yao Cai-Hong Lin Bing-Cong Hong Jie-Hua Wang Zedan Zhang Source Type: research
Association between < em > MTHFR C677T < /em > Gene Polymorphisms and the Efficacy of Vitamin Therapy in lowering Homocysteine Levels among Stroke Patients with Hyperhomocysteinemia
CONCLUSIONS: Our findings suggested that the TT genotype and T allele of MTHFR C677T polymorphism were independently associated with an insufficient Hcy lowering treatment effect in stroke patients with HHcy.PMID:38287840 | DOI:10.31083/j.jin2301003 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - January 30, 2024 Category: Neuroscience Authors: Zhi-Can Li Min Huang Qing-Yang Yao Cai-Hong Lin Bing-Cong Hong Jie-Hua Wang Zedan Zhang Source Type: research
Association between < em > MTHFR C677T < /em > Gene Polymorphisms and the Efficacy of Vitamin Therapy in lowering Homocysteine Levels among Stroke Patients with Hyperhomocysteinemia
CONCLUSIONS: Our findings suggested that the TT genotype and T allele of MTHFR C677T polymorphism were independently associated with an insufficient Hcy lowering treatment effect in stroke patients with HHcy.PMID:38287840 | DOI:10.31083/j.jin2301003 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - January 30, 2024 Category: Neuroscience Authors: Zhi-Can Li Min Huang Qing-Yang Yao Cai-Hong Lin Bing-Cong Hong Jie-Hua Wang Zedan Zhang Source Type: research
