National Trends in Incidence, Mortality, Hospitalizations, and Expenditures for Pemphigus in Taiwan
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 12, 2020 Category: Dermatology Authors: Hsien-Yi Chiu, Chee Jen Chang, Yu Jr Lin, Tsen-Fang Tsai Source Type: research

Familial aggregation of atopic dermatitis and co-aggregation of allergic diseases in affected families in Taiwan
Atopic dermatitis (AD) is a chronic and relapsing dermatitis, mainly presenting in infants and children. AD affects 6.7 % of the total population in Taiwan. The prevalence in females is 7.5 %, which is higher than males (5.9 %) [1]. The recent findings of gene-gene and gene-environment interaction hypothesized the three phases of the natural history of AD. The genetically determined skin-barrier dysfunction and the effect of environmental factors result in the initial phase of atopic dermatitis. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 10, 2020 Category: Dermatology Authors: Yu-Huei Huang, Lu-Hsiang Huang, Chang-Fu Kuo, Kuang-Hui Yu Source Type: research

Dihydroartemisinin inhibits melanoma by regulating CTL/Treg anti-tumor immunity and STAT3-mediated apoptosis via IL-10 dependent manner
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 9, 2020 Category: Dermatology Authors: Ran Yu, Linbo Jin, Fangfang Li, Manabu Fujimoto, Qiang Wei, Zhenhua Lin, Xiangshan Ren, Quanxin Jin, Honghua Li, Fanping Meng, Guihua Jin Source Type: research

Novel ex vivo disease model for extramammary Paget ’s disease using the cancer tissue-originated spheroid method
Extramammary Paget ’s disease (EMPD) is a rare cutaneous adenocarcinoma that was initially described in 1889 [1]. Clinically, EMPD presents as a well-circumscribed, erythematous plaque that is often eczematoid and ulcerated. EMPD frequently presents on the genitalia and perianal region in the elderly [2]. Histopatho logically, EMPD is characterized by the intraepidermal proliferation of Paget's cells, which are large cells with an abundant basophilic or amphophilic cytoplasm. The EMPD tumor cells can, with time, invade the dermis and metastasize to local lymph nodes and distant sites [3]. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 5, 2020 Category: Dermatology Authors: Takahiro Arita, Jumpei Kondo, Yuka Kaneko, Miho Tsutsumi, Mai Kanemaru, Mari Matsui, Yukiyasu Arakawa, Norito Katoh, Masahiro Inoue, Jun Asai Source Type: research

Expression of long interspersed nuclear elements-1 as a surrogate marker for global genomic hypomethylation of malignant skin tumors
Epigenetic modifications are recognized to be cooperated with genetic alterations for cancer initiation and progression. Aberrant DNA methylation, which is an epigenetic change, has an important contributing role in the regulation of gene expression and the silencing of repeat elements in the genome [1]. Both local hypermethylation and global genome hypomethylation occur in tumor cells. While hypermethylation of CpG islands located in the promoter regions of tumor suppressor genes inactivates its expression, global DNA hypomethylation promotes genomic instability and tumorigenesis via transcriptional activation of oncogene...
Source: Journal of Dermatological Science - August 2, 2020 Category: Dermatology Authors: Yuko Kuriyama, Akira Shimizu, Saki Kanai, Osamu Ishikawa Tags: Letter to the Editor Source Type: research

Effect of IFN- γ on the kynurenine/tryptophan ratio in monolayer-cultured keratinocytes and a 3D reconstructed human epidermis model
The skin provides a continuously renewed protective barrier formed by differentiating keratinocytes. The outermost layer of the skin, the epidermis, can be divided into four layers: stratum basale, stratum spinosum, stratum granulosum and stratum corneum. These layers are characterized by the properties and degree of differentiation of the keratinocytes, as the undifferentiated cells move from the basal layer to the outermost cornified layer [1]. Keratinocytes can release anti-microbial peptides and inflammatory cytokines when activated by an immune response caused by injury, or stimulated by exogenous factors such as UV-r...
Source: Journal of Dermatological Science - July 17, 2020 Category: Dermatology Authors: Anna Gustafsson, Zdenka Prgomet, Skaidre Jankovskaja, Tautgirdas Ruzgas, Johan Engblom, Lars Ohlsson, Anette Gj örloff Wingren Source Type: research

Dimethyl fumarate suppresses metastasis and growth of melanoma cells by inhibiting the nuclear translocation of NF- κB
Melanoma is among the most aggressive forms of human cancer, with an increasing incidence worldwide [1]. Despite recent advancements leading to novel therapies, such as molecular-targeted treatments [2], metastatic melanoma has considerably poor prognoses with low 5-year survival rates 16% [3]. Therefore, novel therapies for metastatic melanoma need to be developed. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 16, 2020 Category: Dermatology Authors: Tomoya Takeda, Masanobu Tsubaki, Ryota Asano, Tatsuki Itoh, Motohiro Imano, Takao Satou, Shozo Nishida Source Type: research

Involvement of the lipoprotein receptor LRP1 in AMP-IBP5-mediated migration and proliferation of human keratinocytes and fibroblasts
Skin-derived host defense peptides (HDPs) have been documented as important effector molecules of the innate defense against microorganisms. HDPs also possess immunomodulatory properties, including induction of cytokine/chemokine production, stimulation of chemotaxis and regulation of cutaneous wound healing by promoting cell migration and proliferation [1]. A previous study involving proteomic-based technologies developed an antimicrobial peptide derived from insulin-like growth factor binding protein-5 (AMP-IBP5) that showed broad-spectrum activity against pathogens [2]. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 14, 2020 Category: Dermatology Authors: Panjit Chieosilapatham, Hainan Yue, Shigaku Ikeda, Hideoki Ogawa, Fran çois Niyonsaba Source Type: research

Scratch wound-induced CXCL8 upregulation is EGFR-dependent in keratinocytes
Wound healing is a sophisticated defense mechanism involving cell activation, migration, and proliferation, which are orchestrated by the coordinated production of various cytokines/chemokines such as chemokine (C-X-C motif) ligand 8 (CXCL8) [1] and chemokine (C-C motif) ligand 20 (CCL20) [2]. CXCL8 and CCL20 are potent chemoattractants for neutrophils and IL-17A –producing immune cells, respectively [1,3]. Notably, CXCL8, CCL20, and IL-17A accelerate epithelial wound healing [1,2,4]. In addition, neutrophils are the first immune cells to infiltrate wounded sites, and appropriate neutrophilic recruitment is critical ...
Source: Journal of Dermatological Science - July 13, 2020 Category: Dermatology Authors: Kazuhisa Furue, Takamichi Ito, Gaku Tsuji, Takeshi Nakahara, Masutaka Furue Tags: Letter to the Editor Source Type: research

Hydroa vacciniforme-like lymphoproliferative disorder: A study of clinicopathology and whole-exome sequencing in Chinese patients
Hydroa vacciniforme-like lymphoproliferative disorder (HVLPD) encompasses a group of chronic Epstein-Barr virus (EBV)-associated lymphoproliferative diseases characterized by papulovesicular skin lesions [1]. However, dermatologists and oncologists have limited clinical experience with this disease because HVLPD is relatively rare with an obvious difference in regional distribution, as it is more common in Asia [2] and Latin America [3,4] than in the United States and Europe. Moreover, HVLPD often manifests as diverse skin lesions, with frequent atypical cases, and the clinical manifestations often deviate from the patholo...
Source: Journal of Dermatological Science - July 9, 2020 Category: Dermatology Authors: Yao Xie, Tingting Wang, Lin Wang Source Type: research

Prediction of the invasive level of basal cell carcinomas in the facial area: Analysis of 718 Japanese cases
Basal cell carcinoma (BCC) is the most common skin cancer, and its incidence rate is increasing [1]. BCC characteristically arises in body parts that are exposed to the sun and is most common on the head and neck (80%), followed by the trunk (15%), and the arms and legs [2]. Since BCC has low metastatic potential, treatment focuses on local control. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 4, 2020 Category: Dermatology Authors: Shigeto Matsushita, Yasuhiro Nakamura, Ryota Tanaka, Ryuichiro Araki, Kentaro Yamamura, Manabu Yoshioka, Akiha Inoue, Takaya Komori, Shintaro Saito, Yukiko Teramoto, Yoshiyuki Nakamura, Yasuhiro Fujisawa, Megumi Aoki Source Type: research

Editorial board
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 1, 2020 Category: Dermatology Source Type: research

Editors Choice
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 1, 2020 Category: Dermatology Source Type: research

Investigating proteome changes between primary and metastatic cutaneous squamous cell carcinoma using SWATH mass spectrometry
Cutaneous squamous cell carcinoma (cSCC) is one of the most common malignancies in humans. It is responsible for 20 % of all non-melanoma skin cancer (NMSC) cases globally and attributing to as high as 20 % of skin cancer deaths [1,2]. While the majority of the cSCC lesions are curable with surgical removal [3], around 5% metastasize, and for biologically more aggressive tumours, this rate could be as high as 37 % [4]. The 5-year survival rate for cSCC patients with stage II disease (nodal disease) is 63 %, and for patients with stage III (metastatic) disease it is only 11 % [4]. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - June 30, 2020 Category: Dermatology Authors: Ali Azimi, Kitty Lo, Jennifer Kim, Pablo Fernandez-Penas Source Type: research

Immunohistochemical analysis of rhododendrol-induced leukoderma in improved and aggravated cases
Rhododendrol (RD, Rhododenol ®) is cytotoxic to melanocytes and can occasionally cause leukoderma at its application site [1], although it is a known competitive tyrosinase inhibitor that prevents melanin biosynthesis and reduces pigmented spots [2]. While most patients with RD-induced leukoderma have shown gradual recovery af ter discontinuing treatment (improved cases), expansion of leukoderma or development of new lesions at unapplied sites was observed in some patients (aggravated cases). Why some patients show aggravation even after discontinuing RD application remains unclear. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - June 28, 2020 Category: Dermatology Authors: Masahito Yasuda, Akiko Sekiguchi, Chikako Kishi, Sayaka Toki, Noriko Arase, Aya Takahashi, Fei Yang, Atsushi Tanemura, Masahiro Hayashi, Yuko Abe, Toshihisa Hamada, Tamio Suzuki, Ichiro Katayama, Osamu Ishikawa Tags: Letter to the Editor Source Type: research

Exploring mRNA expression in adipose tissue beneath the lesional skin of psoriasis patients
Psoriasis is not merely a chronic inflammatory skin disease, but its association with cardiovascular diseases has been indicated [1]. Furthermore, accumulating evidence revealed that adipokines, factors that are secreted by adipose tissue, affect not only inflammation, insulin resistance, and atherosclerosis but also psoriasis [2], which suggests that adipose tissues play an important role in the pathogenesis of psoriasis. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - June 26, 2020 Category: Dermatology Authors: Shogo Okinaga, Masahiro Kamata, Teruo Shimizu, Makoto Ito, Hideaki Uchida, Mayumi Nagata, Saki Fukaya, Kotaro Hayashi, Atsuko Fukuyasu, Takamitsu Tanaka, Takeko Ishikawa, Takamitsu Ohnishi, Yayoi Tada Tags: Letter to the Editor Source Type: research

Loss of dynamin-related protein 1 (Drp1) does not affect epidermal development or UVB-induced apoptosis but does accelerate UVB-induced carcinogenesis
Mitochondria continuously fuse and divide to control their morphology depending on the condition of the cell [1 –3]. Three conserved dynamin-related GTPases are mediators of mitochondrial dynamics. Mitochondrial fusion is mediated by Mitofusin 1 (Mfn1), Mitofusin 2 (Mfn2) and optic atrophy 1 (Opa1), which are located on the outer or inner mitochondrial membranes [4]. Mitochondrial fission is mediated by dyn amin-related protein 1 (Drp1; alternative name: dynamin-1-like protein (Dnml1)), a cytosolic protein [5]. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - June 26, 2020 Category: Dermatology Authors: Teruki Yanagi, Shinya Kitamura, Keisuke Imafuku, Asuka Suto, Takuya Maeda, Shinya Tanaka, Hiromi Sesaki, Riichiro Abe, Hiroshi Shimizu Source Type: research

Gene silencing of extracellular matrix protein 1 (ECM1) results in phenotypic alterations of dermal fibroblasts reminiscent of clinical features of lichen sclerosus
Lichen sclerosus (LS) is an acquired inflammatory mucocutaneous disease that mainly affects the anogenital area [1,2]. Anogenital LS is often refractory to conventional topical therapy and is associated with increased risk for developing secondary malignancy (4 –6%), primarily squamous cell carcinoma (SCC) [3,4]. Moreover, retrospective analyses suggest that pre-existing LS may be underestimated as the cause of vulvar SCC and melanoma; 20%–60% of vulvar SCC arise from skin sites adjacent to histologically confirmed LS, and female vulvar LS shows a high relative risk (RR 341) for secondary development of melanom...
Source: Journal of Dermatological Science - June 25, 2020 Category: Dermatology Authors: Natsuko Utsunomiya, Akira Utsunomiya, Takenao Chino, Minoru Hasegawa, Noritaka Oyama Source Type: research

TGF- β3 suppresses melanogenesis in human melanocytes cocultured with UV-irradiated neighboring cells and human skin
Although melanin plays a crucial role in protecting skin from ultraviolet radiation (UVR) and carcinogenesis via somatic mutations [1 –4], excessive melanin production can induce pathologic hyperpigmentation conditions such as melasma, mottling, uneven skin, post-inflammatory hyperpigmentation, and solar lentigo [5]. In the pathogenesis of UVR-associated hyperpigmentation conditions, one of the most important determinants is par acrine stimulation of melanocytes (MCs) by constituent cells of the skin [3–11]. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - June 24, 2020 Category: Dermatology Authors: Hye-Rim Moon, Joon Min Jung, Su Yeon Kim, Youngsup Song, Sung Eun Chang Source Type: research

Facile skin targeting of a thalidomide analog containing benzyl chloride moiety alleviates experimental psoriasis via the suppression of MAPK/NF- κB/AP-1 phosphorylation in keratinocytes
Psoriasis is an immune-mediated skin inflammation affecting 1% ∼4% of people worldwide [1,2]. More than 80% of patients show a mild-to-moderate level of severity [3], which can be controlled by topical therapy. Conventional topical application treatment is usually time-consuming with incomplete lesion resolution and some adverse effects. The development of ne w topically applied agents is needed. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - June 21, 2020 Category: Dermatology Authors: Kai-Wei Tang, Zih-Chan Lin, Pei-Wen Wang, Ahmed Alalaiwe, Chih-Hua Tseng, Jia-You Fang Source Type: research

Short-term effectiveness of biologics in patients with moderate-to-severe plaque psoriasis: a systematic review and network meta-analysis
Psoriasis is a chronic systemic inflammatory disorder characterized by persistent or repeating skin lesions [1]. Estimates suggest that more than 125 million people worldwide are affected by psoriasis [1], with the prevalence ranging from 2.7% in the USA to 8.7% in Norway [2]. The chronic activation of the innate and adaptive immune systems is involved in psoriatic disease manifestations, leading to increased release of pro-inflammatory cytokines, such as tumor necrosis factor- α (TNF-α), interleukin (IL)-17, IL-12, and IL-23 [1]. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - June 18, 2020 Category: Dermatology Authors: Yayoi Tada, Rei Watanabe, Hisashi Noma, Yasumasa Kanai, Takanobu Nomura, Kenji Kaneko Source Type: research

Analysis of the mechanism underlying a mild phenotype of hereditary coproporphyria due to a homozygous missense mutation in the transcription initiation codon of the coproporphyrinogen III oxidase gene
Hereditary porphyrias are disorders caused by abnormalities in eight enzymes in the heme biosynthetic pathway. Hereditary coproporphyria (HCP) is a rare autosomal dominant disorder caused by deficiency of coproporphyrinogen III oxidase (CPOX) [1,2]. CPOX, the sixth enzyme in the heme biosynthetic pathway, converts coproporphyrinogen III to protoporphyrinogen IX through two sequential oxidative decarboxylation steps [3]. CPOX activity is located in the mitochondrial membrane. CPOX is expressed as a precursor and contains an amino-terminal mitochondrial targeting signal. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - June 15, 2020 Category: Dermatology Authors: Tomohisa Fukui, Eijiro Akasaka, Daiki Rokunohe, Yasushi Matsuzaki, Daisuke Sawamura, Kenji Kabashima, Hajime Nakano Tags: Letter to the Editor Source Type: research

Safety, Tolerability and Efficacy of Repeated Intravenous Infusions of KHK4083, a Fully Human Anti-OX40 Monoclonal Antibody, in Japanese Patients with Moderate to Severe
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease, affecting both adults and children with worldwide prevalence rates of up to 20% [1 –3]. Of these, one-third of adults are affected with moderate to severe disease [4,5]. The standard care for skin inflammation in Japan includes topical treatments such as topical corticosteroids or tacrolimus ointment [6]. While oral therapy including cyclosporine and systemic corticosteroids can be effective in cases of AD refractory to topical treatments, systemic side effects are commonly observed in long-term use [6,7]. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - June 12, 2020 Category: Dermatology Authors: H. Nakagawa, H. Iizuka, O. Nemoto, M. Shimabe, Y. Furukawa, N. Kikuta, K. Ootaki Source Type: research

Chemical induced pathognomonic features observed in human vitiligo are mediated through miR-2909 RNomics pathway
Vitiligo is an acquired depigmentory disorder of the skin and or mucosa characterized by circumscribed patches or macules of any size owing to the loss or dysfunctioning of melanocytes [1]. Although cause of specific destruction of melanocytes is elusive, an endless number of theories have been proposed amongst which, ‘autoimmune destruction of melanocytes' is the most commonly accepted theory [2]. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - June 12, 2020 Category: Dermatology Authors: Hitaishi Kaushik, Deepak Kaul, Muthu Sendhil Kumaran, Davinder Parsad Source Type: research

Application of single-cell RNA sequencing on human skin: Technical evolution and challenges
Recent advances in molecular biology, particularly next-generation sequencing (NGS) technologies, have enabled development of targeted therapies for many skin disorders with high disease burden. For example, genetic linkage analysis and transcriptome profiling, such as interleukin (IL)-23 and T helper 17 profiles in psoriasis, IL-4 and IL-13 signatures in atopic dermatitis (AD), and aberrant JAK-STAT activation in alopecia areata, have defined core pathogenic processes for which successful therapeutics were developed [1]. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - June 11, 2020 Category: Dermatology Authors: Doyoung Kim, Kyung Bae Chung, Tae-Gyun Kim Tags: Invited Review Article Source Type: research

RIPK1: a rising star in inflammatory and neoplastic skin diseases
Receptor-interacting serine threonine kinase 1 (RIPK1), a key driver of various pathways of inflammation downstream of tumor necrosis factor receptor 1 (TNFR1), Fas ligand (FasL), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), Toll-like receptors (TLRs), as well as correlated with interferon and interleukin 1 α (IL-1α), is a multifunctional protein involved in regulating cell death and NF-κB signaling pathway [1–6]. RIPK1 contains N-terminal serine / threonine kinase domain, C-terminal death domain (DD) and intermediate domain (ID) which contains a RIP homotypic interaction motif (...
Source: Journal of Dermatological Science - June 10, 2020 Category: Dermatology Authors: Jin Liping, Liu Panpan, Yin Mingzhu, Zhang Mi, Kuang Yehong, Zhu Wu Tags: Review article Source Type: research

Involvement of Disabled-2 on skin fibrosis in systemic sclerosis
Systemic sclerosis (SSc) is a connective tissue disease, which is featured by abnormal inflammation, extensive dermal and internal organ fibrosis [1]. It is clinically classified into limited cutaneous SSc (lcSSc) and diffuse cutaneous SSc (dcSSc) [2]. Skin fibrosis causes various disabilities including hair loss, subcutaneous atrophy, irreversible structural and functional impairment such as joint contracture [3]. Skin fibrosis of SSc can progress over the years and lead to significant cosmetic, functional and psychological disabilities [4]. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - June 2, 2020 Category: Dermatology Authors: Xueqian Mei, Han Zhao, Yan Huang, Yulong Tang, Xiangguang Shi, Weilin Pu, Shuai Jiang, Yanyun Ma, Yuting Zhang, Lu Bai, Wenzhen Tu, Yinhuan Zhao, Li Jin, Wenyu Wu, Jiucun Wang, Qingmei Liu Source Type: research

Metformin inhibits the inflammatory and oxidative stress response induced by skin UVB-irradiation and provides 4-hydroxy-2-nonenal and nitrotyrosine formation and p53 protein activation
It has been established that UV irradiation induces DNA damage by forming dimers that can lead to cancer cell initiation [1]. UV also yields to tissue oxidative stress, inflammation and apoptosis pathways activation [2] [3]. There is no information if these events may generate compounds related to the proliferation or elimination of the cells that may contribute to tumor development. Oxidative stress generates 4- hidroxynonenal (4-HNE) involved in cell proliferation [4]. Also, it produces H2O2 that, direct or indirectly, activates NF κb leading to pro-inflammatory cytokines and nitric oxide synthase (iNOS) expression...
Source: Journal of Dermatological Science - June 2, 2020 Category: Dermatology Authors: Fernando Pinheiro Souza-Neto, Poliana Camila Marinello, Alessandra Louren ço Cecchini, Gabriela Pasqual Melo, Leandra Zambeli Naira Ramalho, Eliana M. Cela, Valeria E. Campo, Daniel H. González Maglio, Rubens Cecchini Tags: Letter to Editor Source Type: research

Editorial board
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - June 1, 2020 Category: Dermatology Source Type: research

Editors Choice
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - June 1, 2020 Category: Dermatology Source Type: research

Genomic DNA methylation in HLA-Cw*0602 carriers and non-carriers of psoriasis
Psoriasis (Ps) is a chronic immune-mediated skin disorder with a strong and albeit polygenic genetic basis affecting 0.09% –11.4% population worldwide [1], making it a serious global problem. The clinical manifestation, areas of skin lesions and response to the treatment in Ps patients may vary greatly due to the complex interactions between genetics, environmental factors and immune pathways [2]. Increasing evidence have clearly suggested that epigenetic mechanisms, specifically the methylation of cytosine residue at CpG dinucleotides, contributed to the development of Ps [3–5], mainly due to the effect of DNA...
Source: Journal of Dermatological Science - May 31, 2020 Category: Dermatology Authors: Lili Tang, Tianyu Yao, Miaohong Fang, Xiaodong Zheng, Gang Chen, Mengqing Li, Dan Wang, Xinyu Li, Haining Ma, Xiangru Wang, Yunhong Qian, Fusheng Zhou Source Type: research

Genetic predisposition to bullous pemphigoid
Bullous pemphigoid (BP) is a common autoimmune blistering skin disease that preferentially affects elderly patients. It is characterized by the presence of circulating IgG autoantibodies targeting the structural proteins BP180 (also termed COL17 or BPAG2) and BP230 (dystonin or BPAG1) of the epidermal basement membrane zone, which leads to the separation of the epidermis and dermis [1]. Globally, the incidence has been estimated as 11.38 per 1 million people per year, and the risk of BP increases up to 6-fold in patients over 80 years old when compared to patients at the 60 –69 age group [2]. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - May 31, 2020 Category: Dermatology Authors: Jieyu Zhang, Gang Wang Tags: Review article Source Type: research

Specific single nucleotide polymorphism genotypes and association of an IL-12B polymorphism with secondary failure of infliximab therapy in Japanese psoriasis patients
Genome-wide association studies have demonstrated associations between susceptibility to psoriasis and single nucleotide polymorphisms (SNPs). Part of the genetic susceptibility can be explained by the established susceptibility locus in the human leukocyte antigen complex on chromosome 6p21.3, as well as polymorphisms at the interleukin 12B (IL-12B), IL-23A, IL-23 receptor (IL-23R), tumor necrosis factor-a induced protein 3 (TNFAIP3), and TNIP1 (TNFAIP3 interacting protein 1) loci [1 –5]. Investigating susceptibility loci in patients with psoriasis vulgaris (PsV) and psoriatic arthritis (PsA) may help to determine w...
Source: Journal of Dermatological Science - May 31, 2020 Category: Dermatology Authors: K. Torii, A. Morita Tags: Letter to the Editor Source Type: research

Targeted next-generation sequencing of matched localized and metastatic primary high-risk SCCs identifies driver and co-occurring mutations and novel therapeutic targets
Cutaneous squamous cell carcinoma (SCC) is the second most common type of skin cancer with an estimated one million cases per year in the United States, resulting in up to 15,000 deaths annually.1 While only 3-5% of SCCs metastasize, those that do are associated with significant morbidity and mortality due to the lack of standardized and effective treatment options.2 SCC is particularly challenging to manage due to the difficulty in determining which tumors will recur and metastasize and which tumors will be cured with surgery alone. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - May 29, 2020 Category: Dermatology Authors: Marissa B. Lobl, Dillon Clarey, Shauna Higgins, Adam Sutton, Laura Hansen, Ashley Wysong Source Type: research

The current landscape of psoriasis genetics in 2020
Psoriasis is a chronic inflammatory disease of the skin and joints that is strongly associated with the major histocompatibility complex (MHC) region [1]; it is estimated to affect more than 125 million people worldwide [2]. The most common type of psoriasis is chronic plaque psoriasis (also known as psoriasis vulgaris: PV), which accounts for about 90 % of cases [1]. Approximately 6 % –42 % of psoriasis patients are also affected by chronic arthritis (psoriatic arthritis: PsA) in their lifetime [3]. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - May 28, 2020 Category: Dermatology Authors: Kotaro Ogawa, Yukinori Okada Tags: Invited review article Source Type: research

Implication of the zinc-epigenetic axis in epidermal homeostasis
Zinc deficiency (ZD) first manifests in the skin [1]. ZD leads to fragility and defects in the barrier function of the skin. A human skin equivalent model was generated, to investigate the association between ZD and regulation of acetylation, using 1 μM of TPEN (N,N,N,N-Tetrakis(2-pyridylmethyl)-ethylenediamine), a zinc specific chelator, to mimic ZD. This concentration did not show cytotoxicity (Fig. S1). We found that ZD induced improper stratification with an easily cracked stratum corneum (Fig. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - May 25, 2020 Category: Dermatology Authors: Mi-Gi Lee, Sehyun Chae, Kimiko Nakajima, Miho Ibi, Hozumi Sano, Takafumi Hara, Hantae Jo, Teruhisa Takagishi, Byungsun Cha, Jin-myoung Baek, Emi Yoshigai, Takuto Ohashi, Tarou Iri é, Shigetoshi Sano, Jong-Soo Lee, Toshiyuki Fukada, Bum-Ho Bin Tags: Letter to the Editor Source Type: research

Altered keratinization and vitamin D metabolism may be key pathogenetic pathways in syndromic Hidradenitis Suppurativa: a novel Whole Exome Sequencing approach
Hidradenitis suppurativa (HS) is a chronic-relapsing inflammatory disease affecting the apocrine gland-bearing skin and presenting with pseudocystic and inflammatory nodules, abscesses and fistulas [1]. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - May 21, 2020 Category: Dermatology Authors: Lucas Brandao, Ronald Moura, Paola Maura Tricarico, Rossella Gratton, Giovanni Genovese, Chiara Moltrasio, Simone Garcovich, Michele Boniotto, Sergio Crovella, Angelo Valerio Marzano Source Type: research

Selective PPAR α agonist pemafibrate inhibits TNF-α-induced S100A7 upregulation in keratinocytes
The S100A protein family is a group of EF-hand-type calcium-binding proteins encoded by genes located in the epidermal differentiation complex that regulates cell structure, proliferation, and differentiation [1]. Increased expression of S100A7, also named psoriasin, was first identified in psoriasis and is known as a useful marker of its disease activity [2 –4]. S100A7 works as an antimicrobial peptide, chemoattracts immune cells including neutrophils, and accelerates local inflammation [3]. The expression of S100A7 is upregulated by various proinflammatory cytokines including tumor necrosis factor-α (TNF-&alp...
Source: Journal of Dermatological Science - May 19, 2020 Category: Dermatology Authors: Ayako Yumine, Gaku Tsuji, Masutaka Furue Tags: Letter to the Editor Source Type: research

A heterozygous SERPINB7 mutation is a possible modifying factor for epidermolytic palmoplantar keratoderma
Recently, causative genes for the various types of palmoplantar keratoderma (PPK) have been found, resulting in a need for a genetic classification of PPK [1]. The most common type in the Japanese population is Nagashima-type PPK (NPPK) caused by loss-of-function mutations in SERPINB7, which encodes serpin B7, a member of the serine protease inhibitor superfamily [2]. Serpin B7 is found in the stratum corneum, and its main function is to regulate intercellular protease activity [3]. The clinical features of NPPK include diffuse hyperkeratosis and erythema on the palms and soles, and also on their dorsal aspects, known as t...
Source: Journal of Dermatological Science - May 16, 2020 Category: Dermatology Authors: Takenori Yoshikawa, Takuya Takeichi, Tomoo Ogi, Yasushi Suga, Yoshinao Muro, Masashi Akiyama Tags: Letter to the Editor Source Type: research

Unique skin manifestations of COVID-19: Is drug eruption specific to COVID-19?
COVID-19 is associated with specific skin manifestations and drug eruption in some affected patients. Here, we report a case of suspected COVID-19 –related drug eruption and specific clinical features. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - May 16, 2020 Category: Dermatology Authors: Takashi Sakaida, Tanimoto Isao, Akihiro Matsubara, Motoki Nakamura, Akimichi Morita Tags: Letter to the Editor Source Type: research

Increased expression of dermal LL37 may trigger migration of CCR7+ regulatory T cells in extramammary Paget ’s disease
LL37 is an autoantigen derived from keratinocytes that can bind to surface scavenger receptors expressed on myeloid dendritic cells (DCs), plasmacytoid DCs, and macrophages to recognize extracellular self-DNA [1]. Among such scavenger receptors, CD163 is a specific surface marker of macrophages [2]. The expression of LL37 on myeloid cells in the dermis is controlled by proinflammatory cytokines such as IL-17 and TNF- α [3]. Since Paget’s cells produce CCL20 and recruit Th17 in the lesional skin of EMPD [4], the expression of LL37 in invasive EMPD might be increased after the dermal invasion of Paget’s cel...
Source: Journal of Dermatological Science - May 16, 2020 Category: Dermatology Authors: Chunbing Lyu, Taku Fujimura, Ryo Amagai, Kentaro Ohuchi, Yota Sato, Kayo Tanita, Shigeto Matsushita, Yasuhiro Fujisawa, Atsushi Otsuka, Yuki Yamamoto, Toshiya Takahashi, Setsuya Aiba Tags: Letter to the Editor Source Type: research

Detection of autoantibodies against alpha-2-macroglobulin-like 1 in paraneoplastic pemphigus sera utilizing novel green fluorescent protein-based immunoassays
Paraneoplastic pemphigus (PNP), also termed paraneoplastic autoimmune multi-organ syndrome (PAMS), is a severe autoimmune blistering disease of the skin and mucosae associated with an underlying neoplasia. PNP patients have circulating autoantibodies binding to components of stratified as well as non-stratified epithelia [1,2,3]. Specifically, PNP autoantibodies typically bind to members of the plakin family of proteins, including envoplakin, periplakin, desmoplakin, and, more rarely, the bullous pemphigoid antigen 230 and plectin [1,4 –14]. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - May 7, 2020 Category: Dermatology Authors: C. Bazzini, N. Begr é, B. Favre, T. Hashimoto, M. Hertl, C. Schlapbach, L. Borradori Source Type: research

Ectopic expression of SOX18 in Basal cell carcinoma negatively regulates tumour progression
Basal Cell Carcinoma (BCC) is the most common malignancy in Caucasian populations. Despite its low metastasis potential, the burden of the disease is important and is defined by the multiplicity of tumours in the field of UV exposure. Current targeted therapies have poor response rates in patients with advanced disease [1] and there are currently no accepted chemoprevention of BCCs justifying a better understanding of BCC molecular pathogenesis. BCC is caused by oncogenic activation of Hedgehog signaling, most commonly through inactivating mutations in the PTCH1 tumor suppressor gene [2]. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - May 7, 2020 Category: Dermatology Authors: Rehan Villani, Seen Ling Sim, Edwige Roy, Brandon Wainwright, Mathias Francois, Kiarash Khosrotehrani Source Type: research

Dysregulation of microRNA expression in diabetic skin
Diabetes is a chronic metabolic disease whose incidence and prevalence are high and constantly growing [1]. It arises as consequence of increased glucose levels due to insulin unbalance or impaired responsiveness. The vast majority of diabetic patients suffers from type 2 diabetes due to insulin resistance, while 5-10% of patients are affected by type 1 insulin-dependent diabetes [1]. Clinical skin manifestations are common in diabetes, often being the first sign of the metabolic disorder [2]. They involve at least 30% of patients and include increased propensity to infections, hyperpigmentation, dermal thickening, spontan...
Source: Journal of Dermatological Science - May 4, 2020 Category: Dermatology Authors: Enke Baldini, Erika Testa, Christine Voellenkle, Emanuela De Domenico, Francesca Cianfarani, Fabio Martelli, Salvatore Ulisse, Teresa Odorisio Source Type: research

Editorial board
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - May 1, 2020 Category: Dermatology Source Type: research

Editors Choice
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - May 1, 2020 Category: Dermatology Source Type: research

Obituary: Hironobu Ihn, MD, PhD (1964-2020)
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - May 1, 2020 Category: Dermatology Source Type: research

Clinical and Histopathological study of skin dermatoses in patients affected by COVID-19 infection in the Northern part of Italy
The current novel coronavirus (SARS-CoV-2) infection is rapidly spreading worldwide. The dissemination of the virus has been particularly severe in the Northern part of Italy (Lombardia region). (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - April 29, 2020 Category: Dermatology Authors: Raffaele Gianotti, Pietro Zerbi, Roni P. Dodiuk-Gad Tags: Letter to the Editor Source Type: research

Cutaneous manifestations of COVID-19: Report of three cases and a review of literature
Various cutaneous manifestations have been observed in patients with COVID-19 infection. However, overall similarities in the clinical presentation of these dermatological manifestations have not yet been summarized. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - April 29, 2020 Category: Dermatology Authors: Muskaan Sachdeva, Raffaele Gianotti, Monica Shah, Bradanini Lucia, Diego Tosi, Stefano Veraldi, Michael Ziv, Eyal Leshem, Roni P. Dodiuk-Gad Tags: Review article Source Type: research

Regulatory T cells suppress skin inflammation in the imiquimod-induced psoriasis-like mouse model
In this study, imiquimod was applied longer than usual previous studies, and the role of Treg cells in imiquimod-induced psoriasis-like mouse model pathogenesis was investigated. The 7-day imiquimod application (a topical dose of 62.5  mg of 5% imiquimod cream (Aldara®; 3 M Pharmaceuticals, UK), applied to a shaved area of the back and ears) revealed that psoriasis-like inflammation severity increased with the initiation of imiquimod application, but reached a plateau after 5 days of application (Fig. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - April 28, 2020 Category: Dermatology Authors: Chong Won Choi, Bo Ri Kim, Seoyun Yang, Yejin Kim, Jae Seung Kang, Sang Woong Youn Tags: Letter to the Editor Source Type: research