JSID ’s Fellowship Shiseido Research Grant
The Japanese Society for Investigative Dermatology (JSID) is seeking candidates for JSID ’s Fellowship Shiseido Research Grant. This research grant is intended to promote innovative research that will contribute to the progress of cutaneous biology. This research grant is aimed at researchers working in the following fields: (1) skin aging, (2) keratinocyte biology, (3) pigment cell b iology, (4) hair biology, (5) cosmeceuticals, and (6) all the basic research areas related to (1)-(5), e.g. immunology. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 13, 2024 Category: Dermatology Authors: Manabu Ohyama Source Type: research

LEKTI domain 6 displays anti-inflammatory action in vitro and in a murine atopic dermatitis model
Lympho-epithelial Kazal-type-related inhibitor (LEKTI) is a serine protease inhibitor consisting of multiple domains. A loss of function mutation is described in Netherton patients that show severe symptoms of atopic lesions and itch. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 12, 2024 Category: Dermatology Authors: Pascal Canbolat, Jenny Wilzopolski, Sabine Kaessmeyer, Viviane Filor, Jonathan Vidak, Marc R üger, Hans-Jürgen Mägert, Wolf-Georg Forssmann, Wolfgang Bäumer Source Type: research

RAS-activated PI3K/AKT signaling sustains cellular senescence via P53/P21 axis in experimental models of psoriasis
Psoriasis is a chronic immune-mediated skin disease in which upper epidermal keratinocytes exhibit a senescent-like phenotype. In psoriatic skin, a variety of inflammatory cytokines can activate intracellular pathways including phosphatidylinositol 3-kinase (PI3K)/AKT signaling and RAS effectors. AKT and RAS participate to cellular senescence, but currently their role in senescence responses occurring in psoriasis have not yet been investigated. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 7, 2024 Category: Dermatology Authors: Laura Mercurio, Jacob Bailey, Adam Bleier Glick, Elena Dellambra, Claudia Scarponi, Sabatino Pallotta, Cristina Albanesi, Stefania Madonna Tags: Original Article Source Type: research

Targeting antibody-mediated complement-independent mechanism in bullous pemphigoid with diacerein
Bullous pemphigoid (BP) is an antibody-mediated blistering disease predominantly affecting the elderly. The pathogenesis involves both complement-dependent and complement-independent mechanisms. The therapeutic potential of targeting complement-independent mechanism has not yet been determined. The mainstay of treatment, corticosteroid, has many side effects, indicating the needs of better treatments. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 5, 2024 Category: Dermatology Authors: Yung-Tsu Cho, Chih-Hung Lee, Jing-Yi Lee, Chia-Yu Chu Tags: Original Article Source Type: research

High α-diversity of skin microbiome and mycobiome in Japanese patients with vitiligo
Vitiligo is an acquired pigmentary disorder characterized by depigmented patches on the skin that majorly impact patients' quality of life. Although its etiology involves genetic and environmental factors, the role of microorganisms as environmental factors in vitiligo pathology remains under-researched. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 29, 2024 Category: Dermatology Authors: Yasutaka Kuroda, Lingli Yang, Takakazu Shibata, Masahiro Hayashi, Yuta Araki, Makiko Nishida, Takeshi Namiki, Teruhiko Makino, Tadamichi Shimizu, Tamio Suzuki, Tetsuya Sayo, Yoshito Takahashi, Daisuke Tsuruta, Ichiro Katayama Tags: Original Article Source Type: research

Rh family C glycoprotein contributes to psoriatic inflammation through regulating the dysdifferentiation and cytokine secretion of keratinocytes
Keratinocyte dysdifferentiation and proinflammatory cytokine production play a central role in psoriatic inflammation. According to recent studies, the Rh family C glycoprotein (RHCG) enhances cell proliferation and disrupts cell differentiation. However, the specific role of RHCG psoriasis development remains unclear. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 29, 2024 Category: Dermatology Authors: Wei Liu, Yaqi Wang, Yitian Zhang, Mingzhu Zhou, Hanjiang Gu, Mei Lu, Yumin Xia Tags: Original Article Source Type: research

Oxidative stress-induced hypermethylation and low expression of ANXA2R: novel insights into the dysfunction of melanocytes in vitiligo
Vitiligo is a skin disorder with melanocyte destruction caused by complex interplay between multiple genetic and environmental factors. Recent studies have suggested DNA methylation is involved in the melanocyte damage, but the underlying mechanism remains unknown. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 28, 2024 Category: Dermatology Authors: Jiaxi Chen, Yinghan Wang, Wei Dai, Xinyuan Xu, Qingrong Ni, Xiuli Yi, Pan Kang, Jingjing Ma, Lili Wu, Chunying Li, Shuli Li Tags: Original Article Source Type: research

KTN1 mediated unfolded protein response protects keratinocytes from ionizing radiation-induced DNA damage
The unfolded protein response (UPR) is one of the cytoprotective mechanisms against various stresses and essential for the normal function of skin. Skin injury caused by ionizing radiation (IR) is a common side effect of radiotherapy and it is unclear how UPR affects IR-induced skin injury. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 23, 2024 Category: Dermatology Authors: Xinli Niu, Yi Shen, Yunhan Wen, Xing Mi, Jing Xie, Ying Zhang, Zhenhua Ding Tags: Original Article Source Type: research

DNA repair ability in a patient with voriconazole-related squamous cell carcinoma that required differential diagnosis from xeroderma pigmentosum
Voriconazole is a triazole antifungal agent used to treat intractable fungal infections [1]. However, voriconazole may cause photosensitivity as a side effect [1,2]. Voriconazole-induced photosensitivity causes erythema, hyperpigmentation, and skin tumors at sun-exposed sites. These symptoms are similar to those observed in patients with xeroderma pigmentosum (XP), who are susceptible to developing skin cancers and accelerated freckle-like pigmented maculae owing to impaired DNA lesion repair caused by ultraviolet radiation (UV) exposure [3]. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 17, 2024 Category: Dermatology Authors: Takeshi Fukumoto, Tomoka Harada, Takamichi Ito, Satoshi Fukushima, Ryusuke Ono, Masutaka Furue, Chikako Nishigori Source Type: research

Combined effect of Neurotropin ® and methylcobalamin on postherpetic neuralgia in mice infected with herpes simplex virus type-1
Postherpetic pain (PHP) is difficult to control. Although Neurotropin ® (NTP) and methylcobalamin (MCB) are often prescribed to treat the pain, the efficacy of combined treatment for PHP remains imcompletely understood. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 12, 2024 Category: Dermatology Authors: Tsugunobu Andoh, Takashi Kikukawa, Atsushi Kotani, Yoko Kurokawa, Wakana Asakura, Kengo Houmoto, Daisuke Fukutomi, Diasuke Uta, Hisashi Okai, Koji Koike Source Type: research

Acquired curved hair is caused by fusion of multiple hair matrix cells
“Curved hair” caused by acquired factors is considered to have adverse cosmetic effects, but the detailed mechanism behind curved hair remains obscure. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 11, 2024 Category: Dermatology Authors: Ippei Horibe, Sara Izumi, Yuru Ke, Nanami Tanahashi, Yusuke Takagi, Ryoji Ishihara, Takaya Nakano, Takaaki Sumiyoshi, Yasuo Nagaoka Tags: Original Article Source Type: research

The GRHL3-regulated long non-coding RNA lnc-DC modulates keratinocytes differentiation by interacting with IGF2BP2 and up-regulating ZNF750
Aberrant keratinocytes differentiation has been demonstrated to be associated with a number of skin diseases. The roles of lncRNAs in keratinocytes differentiation remain to be largely unknown. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 11, 2024 Category: Dermatology Authors: Xue-ting Hu, Xiao-feng Wu, Lu-min Sui, Luo-quan Ao, Cheng-xiu Pu, Mu Yuan, Wei Xing, Xiang Xu Source Type: research

Calcitriol modulates epidermal tight junction barrier function in human keratinocytes
The aberrant expression of tight junction (TJ) proteins play an important role in several diseases with impaired skin barriers, including atopic dermatitis, psoriasis, and chronic wounds. The evidence provided thus far suggests an important role of calcitriol in skin homeostasis. However, it is not known whether calcitriol improves the impaired skin barrier. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 6, 2024 Category: Dermatology Authors: Juan Valentin Trujillo-Paez, Ge Peng, Hai Le Thanh Nguyen, Masahiro Nakamura, Yoshie Umehara, Hainan Yue, Risa Ikutama, Miho Takahashi, Shigaku Ikeda, Hideoki Ogawa, Ko Okumura, Fran çois Niyonsaba Source Type: research

Editorial board
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 1, 2024 Category: Dermatology Source Type: research

Editor's Choice
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 1, 2024 Category: Dermatology Source Type: research