LEKTI domain 6 displays anti-inflammatory action in vitro and in a murine atopic dermatitis model

Lympho-epithelial Kazal-type-related inhibitor (LEKTI) is a serine protease inhibitor consisting of multiple domains. A loss of function mutation is described in Netherton patients that show severe symptoms of atopic lesions and itch.

Source: Journal of Dermatological Science - March 12, 2024 Category: Dermatology Authors: Pascal Canbolat, Jenny Wilzopolski, Sabine Kaessmeyer, Viviane Filor, Jonathan Vidak, Marc R üger, Hans-Jürgen Mägert, Wolf-Georg Forssmann, Wolfgang Bäumer Source Type: research