TRPA1 promotes melanosome phagocytosis in keratinocytes via PAR-2/CYLD axis
Keratinocytes are recipients of melanosomes. Although the chemical basis of melanogenesis is well documented, the molecular mechanism of melanosome transfer must be elucidated. TRPA1 is a member of the transient receptor potential A subfamily. Previous studies have shown that inhibition of TRPA1 activity reduces melanin synthesis inhuman primary melanocytes (HEMs); however, the mechanism remains unknown. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - May 17, 2022 Category: Dermatology Authors: Yupeng Wang, Zhou Li, Wei Wu, Ying Liu, Yu Xiao, Dongdong Qi, Guangming Zhao, Meijuan Zhou, Hua Wang, Jing Liu, Zhiqi Song Source Type: research
Evaluating differential expression of fibrosis-related genes and their correlation with blood vessel density in chronic cutaneous graft-versus-host disease
Sclerodermoid graft-versus-host disease (GVHD) is the most severe form of chronic GVHD (cGVHD) and represents a considerable therapeutic challenge. Due to the scarcity of human studies on sclerodermoid cGVHD, the pathogenesis of this entity is not fully understood. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - May 13, 2022 Category: Dermatology Authors: Shoshana Greenberger, Karin Warshavsky, Gal Goldstein, Gil S. Leichner, Yaron Tsafrir, Eugenia Manevitz-Mendelson, Sharon Baum, Aviv Barzilai Source Type: research
-Evaluating differential expression of fibrosis-related genes and their correlation with blood vessel density in chronic cutaneous graft-versus-host disease
Sclerodermoid graft-versus-host disease (GVHD) is the most severe form of chronic GVHD (cGVHD) and represents a considerable therapeutic challenge. Due to the scarcity of human studies on sclerodermoid cGVHD, the pathogenesis of this entity is not fully understood. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - May 13, 2022 Category: Dermatology Authors: Shoshana Greenberger, Karin Warshavsky, Gal Goldstein, Gil S. Leichner, Yaron Tsafrir, Eugenia Manevitz-Mendelson, Sharon Baum, Aviv Barzilai Source Type: research
Novel GSK-3 kinase inhibitor Pym-5 induces GSK-3 β rather than GSK-3α-dependent melanogenesis in murine melanoma cells
Glycogen synthase kinase-3 (GSK-3) inhibitors are considered to activate Wnt/ β-catenin, which remains a controversial topic in melanoma treatment. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - May 11, 2022 Category: Dermatology Authors: Qi Jia, Li Tao, Yinyin Zhou, Li Song, Zhonghong Wei, Tao Lu, James R. Woodgett, Yin Lu Source Type: research
Nicotinamide mononucleotide reduces melanin production in aged melanocytes by inhibiting cAMP/Wnt signaling
Nicotinamide mononucleotide (NMN) is a representative anti-aging drug that, after long-term administration in mice, causes an increase in energy and lipid metabolism, improves eye function, immune response, and increases insulin sensitivity. However, the effects of NMN on skin pigmentation are still unknown. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - May 7, 2022 Category: Dermatology Authors: Sofia Brito, Jin-Myoung Baek, Byungsun Cha, Hyojin Heo, Su-Hyun Lee, Lei Lei, So Young Jung, So Min Lee, Sang Hun Lee, Byeong-Mun Kwak, Sehyun Chae, Mi-Gi Lee, Bum-Ho Bin Source Type: research
Increase in Inhibin beta A/Activin-A expression in the human epidermis and the suppression of epidermal stem/progenitor cell proliferation with aging
Age-related thinning and reduced cell proliferation in the human epidermis are associated with the accumulation of senescent cells and decreases in the number and function of epidermal stem cells. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - May 7, 2022 Category: Dermatology Authors: Mika Kawagishi-Hotta, Seiji Hasegawa, Yuichi Hasebe, Yu Inoue, Ryosuke Okuno, Masaru Arima, Yohei Iwata, Kazumitsu Sugiura, Hirohiko Akamatsu Source Type: research
Editorial board
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - May 1, 2022 Category: Dermatology Source Type: research
Editors Choice
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - May 1, 2022 Category: Dermatology Source Type: research
Keratinocytes Take Part in the Regulation of Substance P in Melanogenesis Through the HPA Axis
Clinical findings have shown that skin depigmentation disorder such as vitiligo may be closely associated with the release of central and peripheral substance P (SP) resulted from chronic psychological stress or sudden mental blow. But the regulatory role of SP and its receptor, tachykinin receptor in the pathogenesis of vitiligo is unclear. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - April 28, 2022 Category: Dermatology Authors: Minghan Chen, Jie Cai, Xiaofeng Zhang, Zixian Liao, Min Zhong, Jing Shang, Yunyun Yue Source Type: research
Protective effects of moisturizers on topical corticosteroid-induced and age-related eccrine sweating impairment in the murine footpad
Dear Editors, (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - April 25, 2022 Category: Dermatology Authors: Takaaki Doi, Hironobu Ishimaru, Yoshiko Mizukawa, Tetsuo Shiohara Tags: Letter to the Editor Source Type: research
Two cases of the intermediate phenotype of recessive dystrophic epidermolysis bullosa harboring the novel COL7A1 mutation c.3570G > A
Letter to the Editor (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - April 23, 2022 Category: Dermatology Authors: Eijiro Akasaka, Hajime Nakano, Daisuke Sawamura Source Type: research
Influence of flg loss-of-function mutations in host –microbe interactions during atopic skin inflammation
Loss-of-function mutations in the filaggrin (FLG) gene directly alter skin barrier function and critically influence atopic inflammation. While skin barrier dysfunction, Th2-associated inflammation and bacterial dysbiosis are well-known characteristics of atopic dermatitis (AD), the mechanisms interconnecting genotype, transcriptome and microbiome remain largely elusive. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - April 15, 2022 Category: Dermatology Authors: Peter Ol áh, Eszter Szlávicz, Marcus Kuchner, Jana Nemmer, Patrick Zeeuwen, Alain Lefèvre-Utile, Nanna Fyhrquist, Stefanie Prast-Nielsen, Tiina Skoog, Angela Serra, Elke Rodríguez, Ulrike Raap, Stephan Meller, Rolland Gyulai, Philippe Hupé, Juha Kere Source Type: research
Possible suppressive effects of baricitinib on serum IL-22 levels in atopic dermatitis
Baricitinib is an oral selective Janus kinase (JAK) 1 and 2 inhibitor used for moderate-to-severe atopic dermatitis (AD). Although its efficacy has been demonstrated in clinical trials [1,2], the immunological effects of baricitinib on AD are not yet fully understood. Interleukin (IL)-22 is a key molecule in several inflammatory skin diseases, including psoriasis and AD [3]. Here, 14 Japanese adult patients with moderate-to-severe AD who were treated with baricitinib at Gunma University Hospital were analyzed, and the relationship between serum IL-22 levels and disease activity of AD was presented. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - April 14, 2022 Category: Dermatology Authors: Akihiko Uchiyama, Chisako Fujiwara, Yuta Inoue, Mai Ishikawa, Sei-ichiro Motegi Tags: Letter to the Editor Source Type: research
The effect of a topical vitamin D3 analog on repigmentation in mice with rhododendrol-induced leukoderma
Rhododendrol (RD), 4-(4-hydroxyphenyl)-2-butanol, which was present on cosmetics, is the causative agent of skin depigmentation called RD-induced leukoderma (RDIL). Several treatment options are available for RDIL; however, their efficacy is unsatisfactory. Vitamin D3 analogs have been used for the treatment of vitiligo. They are known to stimulate melanocyte maturation and differentiation and to induce melanogenesis [1,2]. The effectiveness of vitamin D3 analogues in skin is still controversial with limited data [3]. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - April 14, 2022 Category: Dermatology Authors: Yuko Abe, Ken Okamura, Shosuke Ito, Yutaka Hozumi, Tamio Suzuki Tags: Letter to the Editor Source Type: research
ABCB6 knockdown suppresses melanogenesis through the GSK3- β/β-catenin signaling axis in human melanoma and melanocyte cell lines
Melanogenesis is a multistep process in which melanocytes produce melanin pigments within melanosomes. However, the roles played by the biological factors and pathways in this process are not yet fully understood. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - April 12, 2022 Category: Dermatology Authors: Qiuyun She, Yingying Dong, Dong Li, Ran An, Ting Zhou, Xiaoqi Nie, Ronghua Pan, Yunhua Deng Source Type: research
