TRPA1 promotes melanosome phagocytosis in keratinocytes via PAR-2/CYLD axis

Keratinocytes are recipients of melanosomes. Although the chemical basis of melanogenesis is well documented, the molecular mechanism of melanosome transfer must be elucidated. TRPA1 is a member of the transient receptor potential A subfamily. Previous studies have shown that inhibition of TRPA1 activity reduces melanin synthesis inhuman primary melanocytes (HEMs); however, the mechanism remains unknown.

Source: Journal of Dermatological Science - May 17, 2022 Category: Dermatology Authors: Yupeng Wang, Zhou Li, Wei Wu, Ying Liu, Yu Xiao, Dongdong Qi, Guangming Zhao, Meijuan Zhou, Hua Wang, Jing Liu, Zhiqi Song Source Type: research