Decreased TET2/5-hmC reduces the integrity of the epidermal barrier via epigenetic dysregulation of filaggrin in psoriatic lesions
TET2 participates in tumor progression and intrinsic immune homeostasis via epigenetic regulation. TET2 has been reported to be involved in maintaining epithelial barrier homeostasis and inflammation. Abnormal epidermal barrier function and TET2 expression have been detected in psoriatic lesions. However, the mechanisms underlying the role of TET2 in psoriasis have not yet been elucidated. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - January 20, 2024 Category: Dermatology Authors: Huan Zhang, Tao Jia, Delu Che, Bin Peng, Zhaowei Chu, Xiangjin Song, Weihui Zeng, Songmei Geng Source Type: research
Resident memory T cell contributes to the phenotype of inflammatory vitiligo
Inflammatory vitiligo, also known as vitiligo with inflammatory raised borders, is a rare form of vitiligo; its incidence is reported to be 0.5% of all vitiligo cases [1]. This type of vitiligo is thought to be one of the markers of the active progressive phase of the disease [2]. However, the aetiology of this condition is poorly understood. Here, we report two distinct cases of inflammatory vitiligo and provide new insights into its development. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - January 19, 2024 Category: Dermatology Authors: Ken Okamura, Takanobu Kabasawa, Toru Saito, Yosuke Arai, Mitsuru Futakuchi, Tamio Suzuki Source Type: research
JAK inhibitors for the treatment of vitiligo
Vitiligo is an autoimmune disease involving melanocyte-targeting T cells initiated by environmental and genetic factors. Steroids and tacrolimus have been used as topical treatments. Recently, novel topical agents targeting Janus kinase (JAK), a family of tyrosine kinases that regulates cytokine signaling, have emerged. Ruxolitinib is the first approved in vitiligo therapy. Furthermore, ritlecitinib is currently under clinical trials for oral treatment of active vitiligo. In this review, we discuss the possibility of topical JAK inhibitors as promising options for the treatment of vitiligo with regard to their mechanism of...
Source: Journal of Dermatological Science - January 10, 2024 Category: Dermatology Authors: Shintaro Inoue, Tamio Suzuki, Shigetoshi Sano, Ichiro Katayama Source Type: research
FTO-mediated regulation of m6A methylation is closely related to apoptosis induced by repeated UV irradiation
Ultraviolet (UV) damage is closely related to skin photoaging and many skin diseases, including dermatic tumors. N6-methyladenosine (m6A) modification is an important epigenetic regulatory mechanism. However, the role of m6A methylation in apoptosis induced by repeated UV irradiation has not been characterized. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - January 9, 2024 Category: Dermatology Authors: Yao Lin, Yu Sun, Wenyi Hou, Xinling Chen, Feng Zhou, QingFang Xu, Yue Zheng Source Type: research
Editorial board
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - January 1, 2024 Category: Dermatology Source Type: research
Editor's Choice
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - January 1, 2024 Category: Dermatology Source Type: research
Transcriptome network analysis of inflammation and fibrosis in keloids
Keloid (KL) is a common benign skin tumor. KL is typically characterized by significant fibrosis and an intensive inflammatory response. Therefore, a comprehensive understanding of the interactions between cellular inflammation and fibrotic cells is essential to elucidate the mechanisms driving the progression of KL and to develop therapeutics. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - December 27, 2023 Category: Dermatology Authors: Jiayi Mao, Lu Chen, Shutong Qian, Yuhuan Wang, Binfan Zhao, Qiuyu Zhao, Bolun Lu, Xiyuan Mao, Peisong Zhai, Yuguang Zhang, Liucheng Zhang, Xiaoming Sun Source Type: research
Exosomes Containing miR-1469 Regulate Natural Killer Cells by Targeting CD122 in Non-Segmental Vitiligo
Plasma exosomal microRNAs (miRNAs) have been used as potential biomarkers for various diseases and have been investigated for their possible involvement in the pathogenesis of vitiligo. However, the miRNA expression profile of plasma exosomes in patients with non-segmental vitiligo (NSV) has not been determined yet. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - December 23, 2023 Category: Dermatology Authors: Yujia Wei, Ting Zhou, Ronghua Pan, Xiaoqi Nie, Zhong Liu, Zeqi Shi, Ying Zeng, Ri Zhang, Yunhua Deng, Dong Li Source Type: research
Low-dose imiquimod induces melanogenesis in melanoma cells through an ROS-mediated pathway
Melanogenesis is the process of melanin maturation which not only protects skin from UV radiation but also plays an important role in antigenicity of melanomas. Imiquimod (IMQ) is a toll-like receptor 7 (TLR7) agonist that exhibits antiviral and anticancer activity. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - December 22, 2023 Category: Dermatology Authors: Zheng-Yi Li, Shu-Hao Chang, Kuang-Ting Liu, Alaina Edelie Wu, Chien-Sheng Hsu, Shi-Wei Huang, Mu-Chi Chung, Shih-Chung Wang, Jun-Kai Kao, Yi-Ju Chen, Jeng-Jer Shieh Source Type: research
Comparison of skin barrier abnormalities and epidermal ceramide profiles among three ω-O-acylceramide synthesis-deficient mouse strains
The epidermis contains many structurally diverse ceramides, which form the skin permeability barrier (skin barrier). Mutations in genes involved in the synthesis of ω-O-acylceramides (acylceramides) and protein-bound ceramides cause ichthyosis. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - December 11, 2023 Category: Dermatology Authors: Yuta Yamamoto, Takayuki Sassa, Akio Kihara Source Type: research
Mechanical stiffness promotes skin fibrosis through FAP α-AKT signaling pathway
Myofibroblasts contribute to the excessive production, remodeling and cross-linking of the extracellular matrix that characterizes the progression of skin fibrosis. An important insight into the pathogenesis of tissue fibrosis has been the discovery that increased matrix stiffness during fibrosis progression is involved in myofibroblast activation. However, mechanistic basis for this phenomenon remains elusive. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - December 9, 2023 Category: Dermatology Authors: Jiahao He, Bin Fang, Shengzhou Shan, Qingfeng Li Source Type: research
The Novel Adiponectin Receptor Agonist APN5N Alleviates Sensitive Skin By Upregulating Adiponectin Expression
To the Editor (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - December 8, 2023 Category: Dermatology Authors: Eun Ju Kim, Qing-Ling Quan, Soo Ick Cho, Yeon Kyung Kim, Dong Hun Lee, Jin Ho Chung Tags: Letter to the Editor Source Type: research
Interleukin-36 γ/interleukin-37 ratio in the stratum corneum correlates with facial redness
Facial redness is a common dermatological complaint resulting from the dilation of blood vessels and increased blood flow to the skin. Facial redness is known to be a normal, transient neurological response to intense emotions, exercise, or heat exposure. There are also forms of inflammatory erythema related to skin diseases, such as rosacea, acne, seborrheic dermatitis, and eczematous dermatitis, and noninflammatory redness, which appears as dilated changes in microvascular structures related to the wound healing process, such as post-acne erythema [1,2]. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - December 7, 2023 Category: Dermatology Authors: Tetsuya Kuwano, Takatoshi Murase Source Type: research
Editorial board
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - December 1, 2023 Category: Dermatology Source Type: research
Editor's Choice
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - December 1, 2023 Category: Dermatology Source Type: research
