Mechanical stiffness promotes skin fibrosis through FAP α-AKT signaling pathway

Myofibroblasts contribute to the excessive production, remodeling and cross-linking of the extracellular matrix that characterizes the progression of skin fibrosis. An important insight into the pathogenesis of tissue fibrosis has been the discovery that increased matrix stiffness during fibrosis progression is involved in myofibroblast activation. However, mechanistic basis for this phenomenon remains elusive.

Source: Journal of Dermatological Science - December 9, 2023 Category: Dermatology Authors: Jiahao He, Bin Fang, Shengzhou Shan, Qingfeng Li Source Type: research