Decreased TET2/5-hmC reduces the integrity of the epidermal barrier via epigenetic dysregulation of filaggrin in psoriatic lesions

TET2 participates in tumor progression and intrinsic immune homeostasis via epigenetic regulation. TET2 has been reported to be involved in maintaining epithelial barrier homeostasis and inflammation. Abnormal epidermal barrier function and TET2 expression have been detected in psoriatic lesions. However, the mechanisms underlying the role of TET2 in psoriasis have not yet been elucidated.

Source: Journal of Dermatological Science - January 20, 2024 Category: Dermatology Authors: Huan Zhang, Tao Jia, Delu Che, Bin Peng, Zhaowei Chu, Xiangjin Song, Weihui Zeng, Songmei Geng Source Type: research