Evaluation of the immune colloidal gold technique for BP180-NC16A-specific antibodies in the quick diagnosis and monitoring of bullous pemphigoid
Bullous pemphigoid (BP) mostly involves elderly patients. The diagnosis of BP requires special immunological tests, which makes some patients unable to be diagnosed and treated timely. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - December 24, 2022 Category: Dermatology Authors: Birao Fan, Yuchen Tang, Yuan Chang, Xixue Chen, Ping Tu, Mingyue Wang Source Type: research
Evaluation of the Value of Immune Colloidal Gold Technique for BP180-NC16A-specific Antibodies in the Quick Diagnosis and Monitoring of Bullous Pemphigoid
Bullous pemphigoid (BP) mostly involves elderly patients. The diagnosis of BP requires special immunological tests, which makes some patients unable to be diagnosed and treated timely. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - December 24, 2022 Category: Dermatology Authors: Birao Fan, Yuchen Tang, Yuan Chang, Xixue Chen, Ping Tu, Mingyue Wang Source Type: research
Cathepsin B/NLRP3/GSDMD axis-mediated Macrophage Pyroptosis Induces Inflammation and Fibrosis in Systemic Sclerosis
Pyroptosis is a newly discovered type of programmed cell death associated with inflammatory and fibrotic diseases. Macrophages play an important role in inducing early immune inflammation in systemic sclerosis (SSc). (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - December 24, 2022 Category: Dermatology Authors: Chaofan Liu, Jiaxuan Tang, Shiying Liu, Chen Shen, Xing Zhou, Jinghao Lu, Ming Li, Lubing Zhu Source Type: research
Sestrin2 Contributes to BRAF Inhibitor Resistance Via Reducing Redox Vulnerability of Melanoma Cells
Treatment resistance often occurs with BRAF inhibitor (BRAFi) therapy for melanoma, bringing in a great challenge to the treatment of melanoma patients harboring mutant BRAF gene. Recent studies revealed redox vulnerability constitutes a novel opportunity to overcome BRAFi resistance. Previously we found Sestrin2 provided protection to metastatic melanoma cells by detoxifying reactive oxygen species (ROS) induced by anoikis, but its defensive role against redox stimuli elicited by BRAFi was unclear. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - December 24, 2022 Category: Dermatology Authors: Sen Guo, Qiao Yue, Shiyu Wang, Huina Wang, Zhubiao Ye, Weigang Zhang, Qiong Shi, Tianwen Gao, Chunying Li, Guannan Zhu Source Type: research
The involvement of gremlin-1 in external stress-induced melanogenesis
External stress such as ultraviolet (UV) radiation and pollutants enhances skin pigmentation. In response to external stressors, skin cells such as keratinocytes, melanocytes, and fibroblasts, release secretory proteins to deliver signals to neighboring cells. Along with communication among skin cells, melanin production is a critical step for protecting skin cells against external stressors. It is well known that a variety of mediators such as alpha-melanocyte stimulating hormone ( α-MSH), stem cell factor (SCF), keratinocyte growth factor, and fibroblast growth factor stimulate melanin synthesis [1]. (Source: Journal of...
Source: Journal of Dermatological Science - December 23, 2022 Category: Dermatology Authors: Ji Young Kim, Eun Jung Lee, Yu Jeong Bae, Sujin Park, Sung Hee Kim, Joohee Lee, Il Joo Kwon, Seol Hwa Seong, Jinu Lee, Tae-Gyun Kim, Sang Ho Oh Source Type: research
Uncoupling melanogenesis from proliferation in epidermal melanocytes responding to stimulation with psoriasis-related proinflammatory cytokines
Few studies have addressed the impact of the psoriasis-related proinflammatory cytokines on the proliferation and melanogenesis of melanocytes (MCs) in lesional psoriatic skin. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - December 14, 2022 Category: Dermatology Authors: Yun-Zhu Yao, Zhi-Kai Liao, Shan Jiang, Bing-Qi Dong, Long-Fei Luo, Fang Miao, Tie-Chi Lei Source Type: research
A cell-based evaluation of human tyrosinase-mediated metabolic activation of leukoderma-inducing phenolic compounds
Chemical leukoderma is a skin depigmentation disorder induced through contact with certain chemicals, most of which have a p-substituted phenol structure similar to the melanin precursor tyrosine. The tyrosinase-catalyzed oxidation of phenols to highly reactive o-quinone metabolites is a critical step in inducing leukoderma through the production of melanocyte-specific damage and immunological responses. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - December 12, 2022 Category: Dermatology Authors: Tomoko Nishimaki-Mogami, Shosuke Ito, Hongyan Cui, Takumi Akiyama, Norimasa Tamehiro, Reiko Adachi, Kazumasa Wakamatsu, Yoshiaki Ikarashi, Kazunari Kondo Source Type: research
Fc γRIIB inhibits inflammation in a murine model of psoriasis
Psoriasis is a chronic, inflammatory cutaneous disease. Fc γRIIB is a low-affinity receptor for the IgG Fc fragment that provides a negative feedback pathway to down-regulate B-cell antigen receptor signaling. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - December 12, 2022 Category: Dermatology Authors: Irisu Nakabori, Yasuhito Hamaguchi, Kaori Sawada, Motoki Horii, Natsumi Fushida, Tasuku Kitano, Wang Chenyang, Jia Xibei, Yuichi Ikawa, Akito Komuro, Takashi Matsushita Source Type: research
Ultraviolet B irradiation leads to the development of experimental bullous pemphigoid targeting BPAG1e
Antibodies in the serum of patients with bullous pemphigoid (BP) target two hemidesmosomal proteins, BP180 and BP230/bullous pemphigoid antigen (BPAG)1e [1]. In patients with BP who have only anti-BPAG1e antibodies, the autoantibodies primarily react with the C-terminal domain of BPAG1e (BPAG1e-C) [2,3]. Recently, we found that adoptive transfer of splenocytes from conditional knockout (K5-Cre;Bpag1-/-) mice immunized with murine BPAG1e-C leads to BP-like phenotypes in the recipient immunodeficient mice [4]. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - December 5, 2022 Category: Dermatology Authors: Kazuhito Kogawa, Yasushi Matsuzaki, Atsuko Kimura, Satoko Minakawa, Hajime Nakano, Koichi Ito, Hiroshi Kijima, Daisuke Sawamura Source Type: research
Editorial board
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - December 1, 2022 Category: Dermatology Source Type: research
Editor's Choice
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - December 1, 2022 Category: Dermatology Source Type: research
The temperature-sensitive receptors TRPV4 and TRPM8 have important roles in the pruritus of rosacea
Certain sensations are the secondary phenotypes of rosacea and affect patients ’ quality of life. Transient receptor potential (TRP) channels may be involved in its occurrence. However, there is a lack of research independently discussing itch in rosacea. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - November 30, 2022 Category: Dermatology Authors: Xiyuan Zhou, Yaoxi Su, Shuwei Wu, Hao Wang, Ruotian Jiang, Xian Jiang Source Type: research
Erratum to “Two cases of the intermediate phenotype of recessive dystrophic epidermolysis bullosa harbouring the novel COL7A1 mutation c.3570G > A ” [J. Dermatol. Sci. 106(3) (2022) 193–195]
The publisher regrets that when the above referenced paper was originally printed the figures appeared in black and white. It was the authors' intention that they appear in colour and the correct figures are represented below. The publisher would like to apologise for any inconvenience caused. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - November 17, 2022 Category: Dermatology Authors: Eijiro Akasaka, Hajime Nakano, Daisuke Sawamura Tags: Erratum Source Type: research
C118P exerted potent anti-tumor effects against melanoma with induction of G2/M arrest via inhibiting the expression of BUB1B
The incidence of melanoma rapidly increased in the past decades, and the clinical treatment of melanoma met huge challenges because of tumor heterogeneity and drug resistance. C118P, a novel tubulin polymerization inhibitor, exhibited strong anticancer effects in many tumors. However, there was no data regarding the potential effects of C118P in melanoma cells. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - November 17, 2022 Category: Dermatology Authors: Kun Ren, Meng Zhou, Lingjun Li, Cheng Wang, Shengtao Yuan, Hongyang Li Source Type: research
DNA methylation markers in peripheral blood for psoriatic arthritis
The clinical manifestations of psoriatic arthritis (PsA) are highly heterogeneous and no reliable diagnostic biomarkers exist. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - November 9, 2022 Category: Dermatology Authors: Min Deng, Yuwen Su, Ruifang Wu, Siying Li, Yanshan Zhu, Guishao Tang, Xiaoli Shi, Tian Zhou, Ming Zhao, Qianjin Lu Source Type: research
