A cell-based evaluation of human tyrosinase-mediated metabolic activation of leukoderma-inducing phenolic compounds

Chemical leukoderma is a skin depigmentation disorder induced through contact with certain chemicals, most of which have a p-substituted phenol structure similar to the melanin precursor tyrosine. The tyrosinase-catalyzed oxidation of phenols to highly reactive o-quinone metabolites is a critical step in inducing leukoderma through the production of melanocyte-specific damage and immunological responses.
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research