Editors Choice
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 1, 2022 Category: Dermatology Source Type: research
3,4,5-Trimethoxycinnamate thymol ester inhibits melanogenesis in normal human melanocytes and 3D human epidermal equivalents via the PGC-1 α-independent PPARγ partial agonism
3,4,5-Trimethoxycinnamate thymol ester (TCTE), an anti-melanogenic cosmetic agent prescribed currently, promotes adiponectin synthesis during adipogenesis in human bone marrow mesenchymal stem cells (hBM-MSCs). Adiponectin inhibits melanin biosynthesis and its biosynthesis is directly regulated by peroxisome proliferator-activated receptor (PPAR) γ. In this regard, TCTE may potentially affect PPARγ activity. However, contradicting effects of PPARγ agonists with different chemical structures on human melanogenesis have been reported. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 28, 2022 Category: Dermatology Authors: Hyejin Ko, Hyunjung Choi, Yujia Han, Seungchan An, Daejin Min, Won-Seok Park, Sun Hee Jin, Hyoung-June Kim, Minsoo Noh Source Type: research
Early onset female pattern hair loss: a case –control study for analyzing clinical features and genetic variants
Female pattern hair loss (FPHL), the most common cause of alopecia in adult women, is classified into two subtypes: early onset and late onset (or postmenopausal). Little is known about the clinical features and genetic characteristics of early onset female pattern hair loss (eFPHL). (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 28, 2022 Category: Dermatology Authors: Jungyoon Ohn, Ho-Young Son, Da-Ae Yu, Min Su Kim, Sijin Kwon, Won-Seok Park, Jong-Il Kim, Ohsang Kwon Source Type: research
Postnatal epidermal maturation is associated with the competence of the skin barrier
To the Editor, (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 24, 2022 Category: Dermatology Authors: Jungyoon Ohn, Minji Park, Jin Yong Kim, Jin Ho Chung, Kyu Han Kim, Seong Jin Jo, Ohsang Kwon Tags: Letter to the Editor Source Type: research
Epidermal CD8+CD103+ skin resident memory T cells in psoriasis plaques are reduced in number but remain in the basement membrane zone after topical application of corticosteroid and vitamin D3
To the editor (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 21, 2022 Category: Dermatology Authors: Kazuo Kurihara, Toshiharu Fujiyama, Pawit Phadungsaksawasdi, Taisuke Ito, Tetsuya Honda, Yoshiki Tokura Tags: Letter to the Editor Source Type: research
Effectiveness of brodalumab in achieving treatment satisfaction for patients with plaque psoriasis: the ProLOGUE study
Real-life evidence on the quality of treatment with brodalumab in patients with plaque psoriasis based on patient-reported outcomes remains limited. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 14, 2022 Category: Dermatology Authors: Shinichi Imafuku, Chika Ohata, Yukari Okubo, Rie Tobita, Hidehisa Saeki, Tomotaka Mabuchi, Yuki Hashimoto, Kenta Murotani, Hiroki Kitabayashi, Yasumasa Kanai Source Type: research
Itching and skin pain in real-life patients with plaque psoriasis: baseline analysis of the ProLOGUE study
We are unable to share the data at this time because the study began enrolling patients before January 1, 2019, and the informed consent does not specify data sharing, although it does mention secondary use. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 9, 2022 Category: Dermatology Authors: Masaru Honma, Yasumasa Kanai, Kenta Murotani, Takanobu Nomura, Kei Ito, Shinichi Imafuku Tags: Letter to the Editor Source Type: research
A new susceptibility index to predict the risk of severe herpes zoster-associated pain: A Japanese regional population-based cohort study, the Shizuoka study
Approximately 7% –20% of patients with herpes zoster (HZ) develop zoster-associated pain (ZAP). ZAP not only impairs quality of life and psychological well-being, but also can reduce work effectiveness, which has negative economic effects. Reports of ZAP risk factors are inconsistent. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 8, 2022 Category: Dermatology Authors: Hideo Hashizume, Eiji Nakatani, Yoko Sato, Haruka Goto, Hiroaki Yagi, Yoshiki Miyachi Source Type: research
Qa-1b functions as an oncogenic factor in mouse melanoma cells
Malignant melanoma is one kind of rare cancer in human and animals, which occurs not only in skin but also in the mucous membranes of the nose, mouth, anus, digestive tract, and in the uvea (choroid) of the eye. In order to develop therapies, a better understanding of the genetic landscape and signal pathways are needed. Numerous studies highlighted the importance of NKG2A-HLA-E in tumor immunotherapy, but the function and mechanism of HLA-E in tumor cells have seldom been studied alone. The statistical analyses from publicly available database Oncomine and The Cancer Genome Atlas (TCGA) showed that HLA-E is highly express...
Source: Journal of Dermatological Science - February 7, 2022 Category: Dermatology Authors: Xiang Guo, Yi Fang, Congfang Guo, Qiong Jia, Zhiduan Chi, Jiaming Li, Rongfen Qin, Jingjing Tian, Ruiwen Fan Source Type: research
Replication-related genes are upregulated in XP-A cells after UV-C irradiation
Xeroderma pigmentosum (XP) is hereditary disorder characterized by photosensitivity, predisposition to skin cancers of sun-exposed body sites and progressive neurologic symptoms in some cases. Cells from XP patients show higher sensitivity to ultraviolet radiation (UV) than normal cells. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 4, 2022 Category: Dermatology Authors: Seiji Takeuchi, Toshiro Matsuda, Mariko Tsujimoto, Takeshi Fukumoto, Ryusuke Ono, Chikako Nishigori Source Type: research
Profiling immune network in regressing histiocytic dermatosis: a case report
Histiocytic disorders, heterogeneous inflammatory conditions characterized by myeloid cell proliferation, are often accompanied by infiltrates of mixed inflammatory cells. The pathophysiology of chronic inflammation and regression of histiocytosis remain poorly understood, especially the immune profiles of cutaneous Rosai-Dorfman disease (RDD), a rare and heterogeneous disorder presenting therapeutic challenges [1]. Herein, we report an in-depth, single-cell level transcriptome analysis of regressing RDD. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 4, 2022 Category: Dermatology Authors: Kyung Bae Chung, Ji-Hye Hwang, Do-Young Kim Tags: Letter to the Editor Source Type: research
Racial differences in dysregulation of the renin-angiotensin-aldosterone system in patients with prurigo nodularis
There are limited data characterizing the association between renal disease and prurigo nodularis (PN). (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 4, 2022 Category: Dermatology Authors: Nishadh Sutaria, Melika Marani, Justin Choi, Youkyung Sophie Roh, Varsha Parthasarathy, Junwen Deng, Zachary A. Bordeaux, Matthew T. Taylor, Kevin K. Lee, Thomas Pritchard, Ali Alajmi, Waleed Adawi, Yevgeniy R. Semenov, Martin P. Alphonse, Shawn G. Kwatra Source Type: research
MiR-155 Inhibits TP53INP1 Expression Leading to Enhanced Glycolysis of Psoriatic Mesenchymal Stem Cells
Psoriasis is a systemic disease with multiple associated comorbidities, including metabolic syndrome. Studies suggest that chronic inflammation is a central link between psoriasis and metabolic abnormalities. MiR-155 is a well-known microRNA that plays an important regulatory role in inflammation. Studies from our group and others have demonstrated an upregulation of miR-155 in psoriasis. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 3, 2022 Category: Dermatology Authors: Yanmin Liu, Xincheng Zhao, Juan Li, Ling Zhou, Wenjuan Chang, Jiajie Li, Ruixia Hou, Junqin Li, Guohua Yin, Xinhua Li, Kaiming Zhang Source Type: research
Editorial board
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 1, 2022 Category: Dermatology Source Type: research
Editors Choice
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 1, 2022 Category: Dermatology Source Type: research
