Chain length of covalently bound ceramides correlates with skin barrier function in healthy subjects
The stratum corneum (SC), the outermost cellular layer of the epidermis, consists of several layers of corneocytes surrounded by multiple lipid layers known as the extracellular lipid lamellae. Ceramides (CERs), the major components of the lipid lamellae, play a pivotal role in epidermal permeability barrier function in combination with cholesterol and free fatty acids (FAs). Corneocytes also have a lipid monolayer called the corneocyte lipid envelope (CLE), in which ω-hydroxy CERs are covalently bound to structural proteins in the epidermal cornified envelope via an ester linkage. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 21, 2023 Category: Dermatology Authors: Akane Kawamoto, Hiroyuki Yoshida, Mai Haneoka, Shun Nakamura, Kenji Kabashima, Yoshito Takahashi Tags: Letter to the Editor Source Type: research
Blockade of CD122 on Memory T cells in the Skin Suppresses Sclerodermatous Graft-versus-host Disease
Antigen-stimulated na ïve T cells differentiate into effector and memory T cells, of which resident memory T (TRM) cells reside permanently in organ tissues. Involvement of TRM cells has been indicated in pathological conditions of various skin diseases. CD122, which is the β chain subunit of interleukin (IL)-2 and IL- 15 receptors, is expressed on immune cells including TRM cells. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 20, 2023 Category: Dermatology Authors: Noriko Kubota, Ryota Tanaka, Yuki Ichimura, Risa Konishi, J Yun Tso, Naoya Tsurushita, Toshifumi Nomura, Naoko Okiyama Source Type: research
Differences in the Immune Microenvironment Between Improved and Non-improved Cases of Vitiligo After Halo Nevus Excision
Halo nevus, also called Sutton ’s nevus, is a nevus cell nevus surrounded by vitiligo thought to be caused by a T-cell mediated immune response to the nevus antigen. The immune microenvironment is mysterious, however, as vitiligo often does not improve even when the nevus cells are removed. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 20, 2023 Category: Dermatology Authors: Shinji Kano, Motoki Nakamura, Yuka Nojiri, Tetsuya Magara, Maki Yoshimitsu, Hiroshi Kato, Akimichi Morita Source Type: research
Large intragenic deletion of KRT14 causes autosomal-dominant epidermolysis bullosa simplex with generalized hyperpigmentation
Epidermolysis bullosa (EB) comprises a heterogeneous group of rare hereditary genodermatoses characterized by increased mucocutaneous fragility and blisters induced by mild trauma. EBS is the most common type, exhibiting skin blistering within the basal or suprabasal layer of the epidermis[1]. Up to now, more than 75% of EBS cases can be ascribed to heterozygous or homozygous variants in KRT5 (OMIM # 148040) and KRT14 (OMIM # 148066)[1]. Herein, we present two patients in a family with autosomal-dominant EBS with hyperpigmentation harboring a previously unreported heterozygous large deletion of KRT14. (Source: Journal of D...
Source: Journal of Dermatological Science - March 13, 2023 Category: Dermatology Authors: Zhuoqing Gong, Xueke Zou, Ruoning Xue, Xuejun Zhu, Xingyuan Jiang Source Type: research
Increased production of natural moisturizing factors and bleomycin hydrolase activity in elderly human skin
Bleomycin hydrolase (BH), which is expressed in the stratum granulosum and lower stratum corneum (SC), is involved in final filaggrin degradation. Furthermore, BH plays an essential role in producing free amino acids, which constitute the majority of natural moisturizing factors (NMF). However, the effects of BH expression and protease activity on human skin aging remain unclear. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 5, 2023 Category: Dermatology Authors: Munehiro Tsurumachi, Yayoi Kamata, Mitsutoshi Tominaga, Junko Ishikawa, Tomoki Hideshima, Eri Shimizu, Takahide Kaneko, Yasushi Suga, Kenji Takamori Source Type: research
Editors Choice
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 1, 2023 Category: Dermatology Source Type: research
Editorial board
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 1, 2023 Category: Dermatology Source Type: research
Targeting Neutrophil Extracellular Traps (NETs) ameliorates inflammation in murine psoriasiform dermatitis
To the editor (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 1, 2023 Category: Dermatology Authors: M.M. Hollstein, V. Manzke, S.E.F. Scheidmann, S. Schrenker, M. Schaffrinski, E. Neubert, D. Kramer, V.K. Raker, M.P. Sch ön, L. Erpenbeck Tags: Letter to the Editor Source Type: research
Prostaglandin E2 prevents radiotherapy-induced alopecia by attenuating transit amplifying cell apoptosis through promoting G1 arrest
Growing hair follicles (HFs) harbor actively dividing transit amplifying cells (TACs), rendering them highly sensitive to radiotherapy (RT). Clinically, there is still a lack of treatment options for radiotherapy-induced alopecia (RIA). (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 20, 2023 Category: Dermatology Authors: Shih-Fan Lai, Wen-Yen Huang, Wei-Hung Wang, Jin-Bon Hong, Sung-Hsin Kuo, Sung-Jan Lin Source Type: research
Transcriptome-wide assessment of N6-methyladenosine modification identifies different gene expression and infection-associated pathways in Treponema pallidum-infected macrophage
Treponema pallidum (Tp) is a widespread and destructive pathogen that leads to syphilis. As the acknowledged executor of host immunity, macrophage plays vital roles in combating the invasion and migration of Tp. However, the mechanisms of these processes are largely unknown, especially the critical driver genes and associated modifications. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 18, 2023 Category: Dermatology Authors: Zhijia Li, Litian Zhang, Yinbo Jiang, Xiaoxin Lin, Yuhui Liao, Bin Yang, Muzhou Teng Source Type: research
Prognostic analysis of smoldering ATLL with skin eruptions based on genomic aberrations
Patients with smoldering ATLL often present with a skin eruption due to skin infiltration of ATLL cells. Although skin eruption type is known to be associated with prognosis based on its pattern, it is unknown why different types of skin eruptions are associated with different prognoses. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 14, 2023 Category: Dermatology Authors: Kosuke Mochida, Shingo Nakahata, Yutaka Suzuki, Kentaro Inoue, Sayaka Moriguchi, Atsushi Yamashita, Masahiro Amano, Kazuhiro Morishita Source Type: research
Sex-Specific Association of SELL Gene Polymorphisms with Pattern Hair Loss in the Thai Population: A Candidate Gene Association Study and In Silico Functional Characterization
Pattern hair loss (PHL) is a common heritable trait affecting both males and females (MPHL and FPHL, respectively). Although follicular miniaturization is the hallmark of PHL, assumptions implicating inflammatory infiltration around perifollicular areas have received attention. Leukocyte migration requires L-selectin, which is encoded by SELL. Several genes, including AR and SRD5A2, were associated with PHL under a non-Asian genetic architecture in a previous genome-wide association study [1]. However, no study has yet evaluated the possible genetic effects of SELL polymorphisms in PHL. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 14, 2023 Category: Dermatology Authors: Chiranan Khantham, Warintorn Ruksiriwanich, Tanakarn Chaitep, Pichchapa Linsaenkart, Anurak Muangsanguan, Andrea Guzm án-Jiménez, Miriam Cerván-Martín, Lara Bossini-Castillo, Sara Gonzalez-Muñoz, Rogelio J. Palomino-Morales, Nipapan Leetrakool, Banph Tags: Letter to the Editor Source Type: research
Sodium thiosulfate inhibits epithelial-mesenchymal transition in melanoma via regulating the Wnt/ β-catenin signaling pathway
Melanoma is the most common form of skin cancer. Given its high metastasis and high recurrence, its therapies are constantly updated. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 14, 2023 Category: Dermatology Authors: Di Wang, Shuheng Li, Yishan Chen, Jialiang Luo, Lei Li, Bocheng Wang, Yingping Xu, Yunsheng Liang Source Type: research
Editors Choice
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 1, 2023 Category: Dermatology Source Type: research
Editorial board
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 1, 2023 Category: Dermatology Source Type: research
