Rh family C glycoprotein contributes to psoriatic inflammation through regulating the dysdifferentiation and cytokine secretion of keratinocytes
Keratinocyte dysdifferentiation and proinflammatory cytokine production play a central role in psoriatic inflammation. According to recent studies, the Rh family C glycoprotein (RHCG) enhances cell proliferation and disrupts cell differentiation. However, the specific role of RHCG psoriasis development remains unclear. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 29, 2024 Category: Dermatology Authors: Wei Liu, Yaqi Wang, Yitian Zhang, Mingzhu Zhou, Hanjiang Gu, Mei Lu, Yumin Xia Tags: Original Article Source Type: research
Oxidative stress-induced hypermethylation and low expression of ANXA2R: novel insights into the dysfunction of melanocytes in vitiligo
Vitiligo is a skin disorder with melanocyte destruction caused by complex interplay between multiple genetic and environmental factors. Recent studies have suggested DNA methylation is involved in the melanocyte damage, but the underlying mechanism remains unknown. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 28, 2024 Category: Dermatology Authors: Jiaxi Chen, Yinghan Wang, Wei Dai, Xinyuan Xu, Qingrong Ni, Xiuli Yi, Pan Kang, Jingjing Ma, Lili Wu, Chunying Li, Shuli Li Tags: Original Article Source Type: research
KTN1 mediated unfolded protein response protects keratinocytes from ionizing radiation-induced DNA damage
The unfolded protein response (UPR) is one of the cytoprotective mechanisms against various stresses and essential for the normal function of skin. Skin injury caused by ionizing radiation (IR) is a common side effect of radiotherapy and it is unclear how UPR affects IR-induced skin injury. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 23, 2024 Category: Dermatology Authors: Xinli Niu, Yi Shen, Yunhan Wen, Xing Mi, Jing Xie, Ying Zhang, Zhenhua Ding Tags: Original Article Source Type: research
DNA repair ability in a patient with voriconazole-related squamous cell carcinoma that required differential diagnosis from xeroderma pigmentosum
Voriconazole is a triazole antifungal agent used to treat intractable fungal infections [1]. However, voriconazole may cause photosensitivity as a side effect [1,2]. Voriconazole-induced photosensitivity causes erythema, hyperpigmentation, and skin tumors at sun-exposed sites. These symptoms are similar to those observed in patients with xeroderma pigmentosum (XP), who are susceptible to developing skin cancers and accelerated freckle-like pigmented maculae owing to impaired DNA lesion repair caused by ultraviolet radiation (UV) exposure [3]. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 17, 2024 Category: Dermatology Authors: Takeshi Fukumoto, Tomoka Harada, Takamichi Ito, Satoshi Fukushima, Ryusuke Ono, Masutaka Furue, Chikako Nishigori Source Type: research
Combined effect of Neurotropin ® and methylcobalamin on postherpetic neuralgia in mice infected with herpes simplex virus type-1
Postherpetic pain (PHP) is difficult to control. Although Neurotropin ® (NTP) and methylcobalamin (MCB) are often prescribed to treat the pain, the efficacy of combined treatment for PHP remains imcompletely understood. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 12, 2024 Category: Dermatology Authors: Tsugunobu Andoh, Takashi Kikukawa, Atsushi Kotani, Yoko Kurokawa, Wakana Asakura, Kengo Houmoto, Daisuke Fukutomi, Diasuke Uta, Hisashi Okai, Koji Koike Source Type: research
Acquired curved hair is caused by fusion of multiple hair matrix cells
“Curved hair” caused by acquired factors is considered to have adverse cosmetic effects, but the detailed mechanism behind curved hair remains obscure. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 11, 2024 Category: Dermatology Authors: Ippei Horibe, Sara Izumi, Yuru Ke, Nanami Tanahashi, Yusuke Takagi, Ryoji Ishihara, Takaya Nakano, Takaaki Sumiyoshi, Yasuo Nagaoka Tags: Original Article Source Type: research
The GRHL3-regulated long non-coding RNA lnc-DC modulates keratinocytes differentiation by interacting with IGF2BP2 and up-regulating ZNF750
Aberrant keratinocytes differentiation has been demonstrated to be associated with a number of skin diseases. The roles of lncRNAs in keratinocytes differentiation remain to be largely unknown. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 11, 2024 Category: Dermatology Authors: Xue-ting Hu, Xiao-feng Wu, Lu-min Sui, Luo-quan Ao, Cheng-xiu Pu, Mu Yuan, Wei Xing, Xiang Xu Source Type: research
Calcitriol modulates epidermal tight junction barrier function in human keratinocytes
The aberrant expression of tight junction (TJ) proteins play an important role in several diseases with impaired skin barriers, including atopic dermatitis, psoriasis, and chronic wounds. The evidence provided thus far suggests an important role of calcitriol in skin homeostasis. However, it is not known whether calcitriol improves the impaired skin barrier. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 6, 2024 Category: Dermatology Authors: Juan Valentin Trujillo-Paez, Ge Peng, Hai Le Thanh Nguyen, Masahiro Nakamura, Yoshie Umehara, Hainan Yue, Risa Ikutama, Miho Takahashi, Shigaku Ikeda, Hideoki Ogawa, Ko Okumura, Fran çois Niyonsaba Source Type: research
Editorial board
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 1, 2024 Category: Dermatology Source Type: research
Editor's Choice
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - February 1, 2024 Category: Dermatology Source Type: research
A Staphylococcus epidermidis strain inhibits the uptake of Staphylococcus aureus derived from atopic dermatitis skin into the keratinocytes
Various bacterial species form a microbiome in the skin. In the past, dead Staphylococcus aureus derived from atopic dermatitis (AD) are taken up by keratinocytes; however, whether live S. aureus can be taken up by keratinocytes is unknown. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - January 30, 2024 Category: Dermatology Authors: Tomofumi Numata, Kazumasa Iwamoto, Kyouka Matsunae, Ryu Miyake, Masataka Suehiro, Nozomi Yanagida, Takanobu Kan, Shunsuke Takahagi, Michihiro Hide, Akio Tanaka Tags: Original Article Source Type: research
Mass spectrometry -based proteomic analysis of the skin of patients with localized scleroderma
Letter to the Editor (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - January 24, 2024 Category: Dermatology Authors: Katariina M ähönen, Salla Keskitalo, Kari Salokas, Antti Tuhkala, Jaana Panelius, Annamari Ranki, Markku Varjosalo Tags: Original Article Source Type: research
Proteomic changes related to actin cytoskeleton function in the skin of vildagliptin-treated mice
Vildagliptin, a dipeptidyl peptidase-4 inhibitor (DPP-4i) is a widely used type 2 diabetes medication that is associated with an up-to 10-fold increased risk for the development of bullous pemphigoid (BP), an autoimmune skin disease. The mechanism by which vildagliptin promotes the development of BP remains unknown. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - January 20, 2024 Category: Dermatology Authors: Antti N ätynki, Nina Kokkonen, Jussi Tuusa, Steffen Ohlmeier, Ulrich Bergmann, Kaisa Tasanen Source Type: research
Decreased TET2/5-hmC reduces the integrity of the epidermal barrier via epigenetic dysregulation of filaggrin in psoriatic lesions
TET2 participates in tumor progression and intrinsic immune homeostasis via epigenetic regulation. TET2 has been reported to be involved in maintaining epithelial barrier homeostasis and inflammation. Abnormal epidermal barrier function and TET2 expression have been detected in psoriatic lesions. However, the mechanisms underlying the role of TET2 in psoriasis have not yet been elucidated. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - January 20, 2024 Category: Dermatology Authors: Huan Zhang, Tao Jia, Delu Che, Bin Peng, Zhaowei Chu, Xiangjin Song, Weihui Zeng, Songmei Geng Source Type: research
Resident memory T cell contributes to the phenotype of inflammatory vitiligo
Inflammatory vitiligo, also known as vitiligo with inflammatory raised borders, is a rare form of vitiligo; its incidence is reported to be 0.5% of all vitiligo cases [1]. This type of vitiligo is thought to be one of the markers of the active progressive phase of the disease [2]. However, the aetiology of this condition is poorly understood. Here, we report two distinct cases of inflammatory vitiligo and provide new insights into its development. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - January 19, 2024 Category: Dermatology Authors: Ken Okamura, Takanobu Kabasawa, Toru Saito, Yosuke Arai, Mitsuru Futakuchi, Tamio Suzuki Source Type: research
