Editors Choice
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 1, 2022 Category: Dermatology Source Type: research
IL-33/ST2 axis contributes to the dermal fibrosis of systemic sclerosis via promoting fibroblasts activation
Systemic sclerosis (SSc) is a chronic immune-mediated rheumatic disease that is characterized by fibrosis of the skin and internal organs. Interleukin-33 (IL-33) has been recently implicated in several autoimmune diseases through its receptor ST2. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 1, 2022 Category: Dermatology Authors: Xuefen Wu, Bingxia Ming, Tong Wu, Rongfen Gao, Peng Hu, Jungen Tang, Jixin Zhong, Fang Zheng, Lingli Dong Source Type: research
SPARC promotes production of type IV and VII collagen and their skin basement membrane accumulation
Matricellular proteins are a group of extracellular matrix (ECM) –associated proteins with no primary structural roles that modulate cell-matrix interactions, cellular function, and ECM assembly. In the skin, secreted protein acidic and rich in cysteine (SPARC), an original member of the matricellular protein family, regulates the homeostasis of type I collagen , e.g. SPARC-null mice exhibit reduced tensile strength, decreased collagen content, and smaller fibril diameter [1]. Recently, we reported that SPARC upregulates the production and pericellular organization of type I collagen and hyaluronan via transforming growt...
Source: Journal of Dermatological Science - July 20, 2022 Category: Dermatology Authors: Tomomi Nakamura, Hiroyuki Yoshida, Yukiko Ota, Yoko Endo, Tetsuya Sayo, Ushio Hanai, Kotaro Imagawa, Masashi Sasaki, Yoshito Takahashi Tags: Letter to the Editor Source Type: research
The role of HMGB1 in inflammatory skin diseases
High-mobility group box 1 protein (HMGB1) is a highly abundant, non-histone nuclear protein that can serve as an alarmin to promote the pathogenesis of inflammatory diseases. In response to various stimuli, HMGB1 can translocate from the nucleus to the cytoplasm as well as the extracellular space through passive or active release, accompanied with different post-translational modifications. Depending on the redox state of three cysteine residues, HMGB1 determines its activity to induce cytokine production or tissue repair through binding with several different receptors. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 13, 2022 Category: Dermatology Authors: Takashi K. Satoh Tags: Invited Review Article Source Type: research
Risk factors for sepsis and effects of pretreatment with systemic steroid therapy for underlying condition in SJS/TEN patients: Results of a nationwide cross-sectional survey in 489 Japanese patients
Stevens –Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening severe cutaneous adverse reactions (SCARs). Sepsis has been shown to be the main cause of death in SJS/TEN. The European SCAR study reported that 14.8% of SJS/TEN patients were receiving systemic steroid therapy for their underlying condition prior to onset. However, it remained unclear whether this factor affected the mortality rate. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 13, 2022 Category: Dermatology Authors: Yuma Sunaga, Natsumi Hama, Hirotaka Ochiai, Akatsuki Kokaze, Eun Seon Lee, Hideaki Watanabe, Michiko Kurosawa, Hiroaki Azukizawa, Hideo Asada, Yuko Watanabe, Yukie Yamaguchi, Michiko Aihara, Yoshiko Mizukawa, Manabu Ohyama, Riichiro Abe, Hideo Hashizume, Source Type: research
Plasma metabolomic profiling reflects the malnourished and chronic inflammatory state in recessive dystrophic epidermolysis bullosa
Recessive dystrophic epidermolysis bullosa (RDEB) is a hereditary blistering disorder characterized by skin fragility, chronic inflammation, malnutrition, and fibrosis. Metabolomics is an emerging investigative field that helps elucidate disease pathophysiology and identify biomarkers. However, previous metabolomic studies in RDEB are limited. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 12, 2022 Category: Dermatology Authors: Ya-Fen Chen, Hsin-Chin Lu, Ping-Chen Hou, Yu-Ching Lin, Wilson Jr Aala, Alexandros Onoufriadis, John A. McGrath, Ying-Lan Chen, Chao-Kai Hsu Source Type: research
Erratum to “Clinical and laboratory parameters predicting cancer in dermatomyositis patients with anti-TIF1γ antibodies” [J. Dermatol. Sci. 104 (2021) 177–84]
The publisher regrets that Fig. 3 has been provided in black and white in the print version of the article. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 8, 2022 Category: Dermatology Authors: Nhung Thi My Ly, Ni Ma, Ikuko Ueda-Hayakawa, Chuyen Thi Hong Nguyen, Reiko Anada, Hiroyuki Okamoto, Manabu Fujimoto Tags: Erratum Source Type: research
Abnormal inflammatory traits and downregulated caveolin-1 expression in monocytes of psoriasis patients may be associated with psoriatic inflammation and atherosclerosis
Monocytes and macrophages are implicated in inflammation and atherosclerosis, whereas monocytes are involved in psoriasis lesion formation. We previously reported a psoriatic inflammation-associated significant decrease in the membrane protein caveolin-1 (CAV-1) in psoriasis patient monocytes. However, the phenotype of circulating monocytes and their macrophage differentiation in psoriasis patients remain unclear. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 4, 2022 Category: Dermatology Authors: Miho Asami, Yasushi Ototake, Naoko Takamura, Yuko Watanabe, Michiko Aihara, Yukie Yamaguchi Source Type: research
Yohimbine hydrochloride inhibits skin melanin synthesis by regulating wnt/ β-catenin and p38/MAPK signal pathways
Yohimbine hydrochloride (YH) is a prescription drug to treat erectile dysfunction. It also had potential in fighting high blood pressure and diabetic neuropathy as well as promoting weight loss. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 3, 2022 Category: Dermatology Authors: Ting Fu, Xiaofeng Qin, Yining Ma, Xin Yue Yuan, Siyun Wu, Xiyun Ye, Yongyan Dang Source Type: research
Staphylococcus aureus phenol-soluble modulins induce itch sensation
To the editor (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 3, 2022 Category: Dermatology Authors: Yeseul Nho, Katy Lawson, Frane Banovic, Liang Han Tags: Letter to the Editor Source Type: research
Actinic lentigines from Japanese and European volunteers share similar impaired biological functions
Hyperpigmented spots develop earlier and with a higher incidence in Asian individuals compared with Europeans. Although actinic lentigines (AL) are very common, the biological events underlying their formation remain ill-defined. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 2, 2022 Category: Dermatology Authors: Emilie Warrick, Christine Duval, St éphanie Nouveau, Virginie Piffaut, Emilie Bourreau, Philippe Bastien, Olivier de Lacharrière, Akimichi Morita, Françoise Bernerd Source Type: research
Editorial board
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 1, 2022 Category: Dermatology Source Type: research
Editors Choice
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 1, 2022 Category: Dermatology Source Type: research
Aberrant Serine Protease Activities in Atopic Dermatitis
Atopic dermatitis (AD) is a chronic inflammatory skin disease; the three major factors responsible for AD, i.e., epidermal barrier dysfunction, allergic inflammation, and itching, interact with each other to form a pathological condition. Excessive protease activities are characteristic abnormalities that affect the epidermal barrier in patients with AD. In normal skin, epidermal serine protease activities are controlled by kallikrein-related peptidases (KLKs) and their inhibitors, including lympho-epithelial Kazal-type-related inhibitor (LEKTI). (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - June 28, 2022 Category: Dermatology Authors: Shin Morizane, Ko Sunagawa, Hayato Nomura, Mamoru Ouchida Tags: Review article Source Type: research
Impaired holocrine secretion and intracellular retention of autophagosomal components in comedones
In this study, we performed immunological and histological analyses using the follicular plug of the human nose and excised human skin, including clogged hair follicles, to investigate the mechanism of comedo formation. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - June 22, 2022 Category: Dermatology Authors: Toru Atsugi, Takashi Teramura, Hiroki Ota, Tomoko Aida, Mika Yamashita, Mathieu Lacroix, Anne-Laure Desroches, Nico Forraz, Colin McGuckin, Eiji Naru Tags: Letter to the Editor Source Type: research
