SPARC promotes production of type IV and VII collagen and their skin basement membrane accumulation

Matricellular proteins are a group of extracellular matrix (ECM) –associated proteins with no primary structural roles that modulate cell-matrix interactions, cellular function, and ECM assembly. In the skin, secreted protein acidic and rich in cysteine (SPARC), an original member of the matricellular protein family, regulates the homeostasis of type I collagen , e.g. SPARC-null mice exhibit reduced tensile strength, decreased collagen content, and smaller fibril diameter [1]. Recently, we reported that SPARC upregulates the production and pericellular organization of type I collagen and hyaluronan via transforming growth factor (TGF)-β signaling in human dermal fibroblasts [2].

Source: Journal of Dermatological Science - July 20, 2022 Category: Dermatology Authors: Tomomi Nakamura, Hiroyuki Yoshida, Yukiko Ota, Yoko Endo, Tetsuya Sayo, Ushio Hanai, Kotaro Imagawa, Masashi Sasaki, Yoshito Takahashi Tags: Letter to the Editor Source Type: research