Editorial board
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - May 1, 2023 Category: Dermatology Source Type: research
Editors Choice
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - May 1, 2023 Category: Dermatology Source Type: research
PDE4 inhibition by difamilast regulates filaggrin and loricrin expression via keratinocyte proline-rich protein in human keratinocytes
Difamilast, a topical phosphodiesterase 4 (PDE4) inhibitor, has been shown to be effective for treating atopic dermatitis (AD), but the molecular mechanism involved is unclear. Since skin barrier dysfunction including reduced expression of filaggrin (FLG) and loricrin (LOR) contributes to AD development, difamilast treatment may be able to improve this dysfunction. PDE4 inhibition increases transcriptional activity of cAMP-responsive element binding protein (CREB). Therefore, we hypothesized that difamilast may affect FLG and LOR expression via CREB in human keratinocytes. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - April 27, 2023 Category: Dermatology Authors: Gaku Tsuji, Akiko Hashimoto-Hachiya, Ayako Yumine, Masaki Takemura, Makiko Kido-Nakahara, Takamichi Ito, Kazuhiko Yamamura, Takeshi Nakahara Source Type: research
Isolation of a new line of Syrian hamster having a novel p.Leu262Pro mutation of tyrosinase with progressive pigmentation in its eyes and ears
The hereditary defect in melanin synthesis (melanogenesis) in eyes, skin and hair is referred to as oculocutaneous albinism (OCA) [1,2]. Melanogenesis is performed by a series of enzymes including tyrosinase (TYR) [3] in melanosomes [4]. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - April 25, 2023 Category: Dermatology Authors: Aiji Sakamoto, Tomohisa Hirobe Source Type: research
Targeting the Elevated IFN- γ in Vitiligo Patients by Human Anti- IFN-γ Monoclonal Antibody Hampers Direct Cytototoxicity in Melanocyte
Vitiligo is an autoimmune disease that progressively destroys melanocytes in the skin, resulting in patchy disfiguring depigmentation. The direct pathological effect of IFN- γ, CXCL10 to the melanocytes in vitiligo has been reported, but there are contradictory results to which cytokine exerts the critical cytotoxic effect on melanocytes. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - April 24, 2023 Category: Dermatology Authors: Chau Yee Ng, Yu-Pei Chan, Yen-Chuan Chiu, Han-Po Shih, You-Ning Lin, Pei-Han Chung, Jing-Yi Huang, Hung-Kai Chen, Wen-Hung Chung, Cheng-Lung Ku Source Type: research
AHNAK, Regulated by the OSM/OSMR Signaling, Involved in the Development of Primary Localized Cutaneous Amyloidosis
Primary localized cutaneous amyloidosis (PLCA) is a chronic skin disease characterized by aberrant keratinocyte differentiation, epidermal hyperproliferation, and amyloid deposits. Previously, we demonstrated OSMR loss-function mutants enhanced basal keratinocyte differentiation through the OSMR/STAT5/KLF7 signaling in PLCA patients. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - April 14, 2023 Category: Dermatology Authors: Huiting Liu, Biying Qiu, Huan Yang, Wen Zheng, Yingying Luo, Yadan Zhong, Ping Lu, Junyi Chen, Ying Luo, Jun Liu, Bin Yang Source Type: research
μ-opioid receptor overexpression in acquired reactive perforating collagenosis associated with IL-31
Dear Editor, (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - April 14, 2023 Category: Dermatology Authors: Tamihiro KAWAKAMI, Takaharu IKEDA, Kae YOKOYAMA, Yupeng Dong Tags: Letter to the Editor Source Type: research
JSID ’s Fellowship Shiseido Research Grant
The Japanese Society for Investigative Dermatology (JSID) is seeking candidates for JSID ’s Fellowship Shiseido Research Grant. This research grant is intended to promote innovative research that will contribute to the progress of cutaneous biology. This research grant is aimed at researchers working in the following fields: (1) skin aging, (2) keratinocyte biology, (3) pigment cell b iology, (4) hair biology, (5) cosmeceuticals, and (6) all the basic research areas related to (1)-(5), e.g. immunology. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - April 6, 2023 Category: Dermatology Authors: Manabu Fujimoto Source Type: research
Roflumilast enhances the melanogenesis and attenuates oxidative stress-triggered damage in melanocytes
The management of vitiligo is challenging due to limited treatment options, and therapeutic strategy varies according to the active or stable stage of vitiligo. PDE4 inhibitor has been used to treat various skin diseases, but the efficacy in vitiligo treatment is mixed. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - April 3, 2023 Category: Dermatology Authors: Zile Chen, Yiting Li, Yongyi Xie, Shu Nie, Bin Chen, Zhouwei Wu Source Type: research
Editorial board
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - April 1, 2023 Category: Dermatology Source Type: research
Editors Choice
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - April 1, 2023 Category: Dermatology Source Type: research
Translation-Dependent Skin Hyperplasia Is Promoted by Type 1/17 Inflammation in Psoriasis
Psoriasis vulgaris (PV) is a chronic skin inflammatory disease and characterized by aberrant epidermal hyperplasia. The molecule initiation factor (eIF) 4E controls translation initiation of certain protein synthesis and determines cell cycle or differentiation fate. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 30, 2023 Category: Dermatology Authors: Rui Xu, Xiangyun Li, Xiaobao Huang, Zhenjia Lin, Ying Xiong, Xiaohong Chen, Coco Chu, Jiande Han, Fang Wang Source Type: research
Analyzing the relationship between the efficacy of first-line immune checkpoint inhibitors and cumulative sun damage in Japanese patients with advanced BRAF wild-type nonacral cutaneous melanoma: A retrospective real-world, multicenter study
Efficacy of anti-PD-1 antibody monotherapy (PD1) or anti-PD-1 plus anti-CTLA-4 combination therapy (PD1+CTLA4) for melanoma is affected by its clinical subtype. The amount of tumor mutation burden (TMB) caused by cumulative sun damage (CSD) is occasionally used to explain this; however, their relationship in Japanese nonacral cutaneous melanoma (NACM) is still unclear. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 30, 2023 Category: Dermatology Authors: Takashi Inozume, Kenjiro Namikawa, Hiroshi Kato, Shusuke Yoshikawa, Yukiko Kiniwa, Koji Yoshino, Satoru Mizuhashi, Takamichi Ito, Tatsuya Takenouchi, Shigeto Matsushita, Yasuhiro Fujisawa, Takamitsu Matsuzawa, Satoru Sugihara, Jun Asai, Hiroshi Kitagawa, Source Type: research
Councilor ’s Meeting/General Assembly of Members at the 47th Annual General Meeting of the Japanese Society for Investigative Dermatology (JSID)
Date: Thursday, December １, 2022, 4:30 pm–5:25pm (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 25, 2023 Category: Dermatology Tags: Minutes Source Type: research
Impaired circadian rhythm may disturb epithelialization in the wound healing of the skin in diabetic mice
Organisms have an internal circadian clock entrained by environmental cues. In mammals, the suprachiasmatic nucleus, located in the anterior part of the hypothalamus, sets the timing of the body ’s internal clock every morning by light signals from the retina [1]. Of note, the skin is governed by autonomous clock (as are other peripheral organs), as suggested by time-dependent variations of the skin barrier function [1,2]. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 21, 2023 Category: Dermatology Authors: Junko Okano, Miwako Katagi, Takahiko Nakagawa, Hideto Kojima Source Type: research
