Editors Choice
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - June 28, 2023 Category: Dermatology Source Type: research
Induced skin aging by blue-light irradiation in human skin fibroblasts via TGF- β, JNK and EGFR pathways
Studies indicate that blue light (BL) irradiation can damage human skins, but the impact of BL irradiation on skin aging is unknown. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - June 27, 2023 Category: Dermatology Authors: Ge Ge, Yiyu Wang, Yang Xu, Weilin Pu, Yimei Tan, Peiyi Liu, Hao Ding, Yu-Meng Lu, Jiucun Wang, Wei Liu, Yanyun Ma Source Type: research
Kaempferol therapy improved MC903 induced-atopic dermatitis in a mouse by suppressing TSLP, oxidative stress, and type 2 inflammation.
Atopic dermatitis is a common skin disease caused by genetic susceptibility, environmental factors, immune response, and skin barrier dysfunction. Kaempferol is a natural flavonoid widely found in tea, vegetables, and fruits and has been reported to have excellent anti-inflammation activity. However, the therapeutic effect of kaempferol on atopic dermatitis is unclear. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - June 27, 2023 Category: Dermatology Authors: Bolor Nasanbat, Akihiko Uchiyama, Syahla Nisaa Amalia, Yuta Inoue, Yoko Yokoyama, Sachiko Ogino, Ryoko Torii, Mari Hosoi, Sei-ichiro Motegi Source Type: research
Reversine enhances skin barrier functions by suppressing the IL-4- and IL-13-mediated STAT6 pathway
Atopic dermatitis (AD) is an inflammatory skin disorder that significantly impairs the quality of life. Defects in the skin barrier associated with the downregulation of epidermal differentiation complex genes, such as filaggrin (FLG), loricrin (LOR), and involucrin (IVL), have been revealed to play critical roles in the pathogenesis of AD [1]. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - June 26, 2023 Category: Dermatology Authors: Yukyung Park, Janghwan Jung, Sunmun Jeong, Amy van Ee, Luis A. Gaza, Minsoo Jang, Dongwon Kim, Jongbin Park Source Type: research
Updated skin transcriptomic atlas depicted by reciprocal contribution of single-nucleus RNA sequencing and single-cell RNA sequencing
Single-cell RNA sequencing (scRNA-seq) has advanced our understanding of skin biology, but its utility is restricted by the requirement of fresh samples, inadequate dissociation-induced cell loss or death, and activation during tissue digestion. Single-nucleus RNA sequencing (snRNA-seq) can use frozen, hard-to-dissociate materials, which might be a promising method to circumvent the limitations of scRNA-seq for the skin tissue. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - June 19, 2023 Category: Dermatology Authors: Ronghui Zhu, Xiaoyu Pan, Shangshang Wang, Zhuoqiong Qiu, Chaoying Gu, Xu Yao, Wei Li Source Type: research
Plucked scalp hair follicle samples are useful RNA sources for mRNA analysis of most genodermatosis-associated genes
To the Editor, (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - June 15, 2023 Category: Dermatology Authors: So Takeuchi, Takuya Takeichi, Yoshinao Muro, Teppei Shimamura, Masashi Akiyama Tags: Letter to the Editor Source Type: research
Cracking the Cytokine Code in Atopic Dermatitis Reveals IL-13 as Dominant Driver of Disease Activity
Following a brief historical review of the immunopathogenesis of psoriasis including the cytokine network operative in psoriasis, a focus on the role of IL-13 in the cytokine hierarchy for atopic dermatitis (AD) will be presented. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - June 13, 2023 Category: Dermatology Authors: Brian J Nickoloff Source Type: research
Peripheral blood mononuclear cell- transcriptome signatures of atopic dermatitis and prediction for the efficacy of dupilumab
Few studies have explored transcriptome of the peripheral blood mononuclear cells (PBMCs) of atopic dermatitis (AD). Parameters for prediction of the efficacy of dupilumab in AD remain obscure. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - June 8, 2023 Category: Dermatology Authors: Yu Wang, Yuemeng Wu, Chaoying Gu, Shangshang Wang, Huibin Yin, Ronghui Zhu, Ce Wang, Zheng Li, Xu Yao, Wei Li Source Type: research
Circ_TNFRSF21 promotes cSCC metastasis and M2 macrophage polarization via miR-214-3p/CHI3L1
Cutaneous squamous cell carcinoma (cSCC) is a highly invasive disease with the potential to metastasize and cause fatality. Therefore, it is crucial to understand the mechanism behind cSCC in order to devise effective strategies to combat this disease. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - June 5, 2023 Category: Dermatology Authors: Jun Ma, Lei Huang, Yan-Bin Gao, Min-Xiong Li, Liang-Long Chen, Lei Yang Source Type: research
Editorial Board
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - June 1, 2023 Category: Dermatology Source Type: research
Editors Choice
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - June 1, 2023 Category: Dermatology Source Type: research
SIRT1 downregulation provokes immune-inflammatory responses in hair follicle outer root sheath cells and may contribute to development of alopecia areata
Silent information regulator 1 (SIRT1), a type III histone deacetylase, is involved in various cutaneous and systemic autoimmune diseases including systemic lupus erythematosus, rheumatoid arthritis, and psoriasis. However, little is known about the role of SIRT1 in the development of alopecia areata (AA). (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - May 23, 2023 Category: Dermatology Authors: Lihua Hao, Kyung-Hwa Nam, Geon-Jong Lee, Doyeon Kim, Jung-Min Shin, Young Lee, Chang-Deok Kim, Seong-Jin Kim, Seok-Kweon Yun, Byung-Hyun Park, Jin Park Source Type: research
IGFBP-7 secreted by adipose-derived stem cells inhibits keloid formation via the BRAF/MEK/ERK signaling pathway
Adipose tissue-derived stem cells (ASCs) have important clinical significance as regulators of skin scar tissue regeneration. ASCs inhibit keloid formation and increase insulin-like growth factor-binding protein-7 (IGFBP-7) expression. However, whether ASCs inhibit keloid formation through IGFBP-7 remains unclear. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - May 18, 2023 Category: Dermatology Authors: Fang Liu, Tingting Yu, Jianlan Liu, Quyang Yang, Jinyan Wu, Jie Ren, Ningwen Zhu Source Type: research
Prevalence of human T-lymphotropic virus type I in patients with psoriasis and its effect on treatment choice: a multicenter observational study
Biologics have benefited psoriasis patients due to their high therapeutic efficacy. In 2019, the Japanese Dermatological Association has revised Guidance for the Use of Biologics in Psoriasis [1] for the safe use of biologics. It recommended screening tests for latent infections such as tuberculosis and viral hepatitis before starting the use of biologics. Human T-lymphotropic virus type I (HTLV-1) is a human retrovirus [2]. Some individuals with HTLV-1 infection develop adult T-cell leukemia-lymphoma (ATL) [3]. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - May 12, 2023 Category: Dermatology Authors: Kentaro Yonekura, Noriko Tsuruta, Takuya Miyagi, Yuta Koike, Yuko Higashi, Takeshi Nakahara, Chika Ohata, Sakae Kaneko, Michiya Yamaguchi, Kanami Saito, Tetsuji Yanase, Shinichi Imafuku Source Type: research
Topical histone deacetylase 1 inhibitor Entinostat ameliorates psoriasiform dermatitis through suppression of IL-17A response
Biologics against IL-17A, IL-23 and TNF- α achieve a great success in treating psoriasis. However, the majority of patients still have some residual lesions left and require combination therapy to reach complete clearance. Topical medicine is an optional choice but only has limited categories. Besides, drug resistance is very often. Thus, topical medicine targeting new signaling pathway is still in an urgent need in the biologics era. ObjectiveTo investigate the role of topical Entinostat, a selective inhibitor of histone deacetylases 1 (HDAC1) has been tested in clinic trials to treat solid tumors and hematological malig...
Source: Journal of Dermatological Science - May 4, 2023 Category: Dermatology Authors: Yanyun Jiang, Siyao Lu, Yuhsien Lai, Liangchun Wang Source Type: research
