Reversine enhances skin barrier functions by suppressing the IL-4- and IL-13-mediated STAT6 pathway

Atopic dermatitis (AD) is an inflammatory skin disorder that significantly impairs the quality of life. Defects in the skin barrier associated with the downregulation of epidermal differentiation complex genes, such as filaggrin (FLG), loricrin (LOR), and involucrin (IVL), have been revealed to play critical roles in the pathogenesis of AD [1].

https://www.jdsjournal.com/article/S0923-1811(23)00149-4/fulltext?rss=yes

Source: Journal of Dermatological Science - June 26, 2023 Category: Dermatology Authors: Yukyung Park, Janghwan Jung, Sunmun Jeong, Amy van Ee, Luis A. Gaza, Minsoo Jang, Dongwon Kim, Jongbin Park Source Type: research