SIRT1 downregulation provokes immune-inflammatory responses in hair follicle outer root sheath cells and may contribute to development of alopecia areata

Silent information regulator 1 (SIRT1), a type III histone deacetylase, is involved in various cutaneous and systemic autoimmune diseases including systemic lupus erythematosus, rheumatoid arthritis, and psoriasis. However, little is known about the role of SIRT1 in the development of alopecia areata (AA).

Source: Journal of Dermatological Science - May 23, 2023 Category: Dermatology Authors: Lihua Hao, Kyung-Hwa Nam, Geon-Jong Lee, Doyeon Kim, Jung-Min Shin, Young Lee, Chang-Deok Kim, Seong-Jin Kim, Seok-Kweon Yun, Byung-Hyun Park, Jin Park Source Type: research