Imiquimod-induced ROS production causes lysosomal membrane permeabilization and activates caspase-8-mediated apoptosis in skin cancer cells
Lysosomal cell death is induced by lysosomal membrane permeabilization (LMP) and the subsequent release of lysosomal proteolytic enzymes, including cathepsins (CTSs), which results in mitochondrial dysfunction and apoptosis. Imiquimod (IMQ), a synthetic TLR7 ligand, has both antiviral and antitumor activity against various skin malignancies in clinical treatment. Previously, we demonstrated IMQ not only caused lysosomal dysfunction but also triggered lysosome biogenesis to achieve lysosomal adaptation in cancer cells. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 25, 2022 Category: Dermatology Authors: Shu-Hao Chang, Pei-Ying Lin, Tsai-Kun Wu, Chien-Sheng Hsu, Shi-Wei Huang, Zheng-Yi Li, Kuang-Ting Liu, Jun-Kai Kao, Yi-Ju Chen, Tak-Wah Wong, Chun-Ying Wu, Jeng-Jer Shieh Source Type: research
Understanding the Systemic Burden of Disease in Hidradenitis Suppurativa from Plasma Lipidomic Analysis
Hidradenitis suppurativa (HS) is an inflammatory skin condition that is often considered a systemic disease due to its association with metabolic comorbidity. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 14, 2022 Category: Dermatology Authors: Ellie Choi, Sartaj Ahmad Mir, Shanshan Ji, Ooi Xue Ting, Esther W.L. Chua, Yeo Yi Wei, Markus R. Wenk, Anne K. Bendt, Nisha Suyien Chandran Source Type: research
Transcriptome profiling in psoriasis: NB-UVB treatment-associated transcriptional changes and modulation of autoinflammation in perilesional skin in early-phase disease
Psoriasis is a chronic inflammatory skin condition. It is widely treated with phototherapy using narrowband ultraviolet B (NB-UVB). The therapeutic mechanisms of NB-UVB, however, remain unclear, particularly in the early phases of the disease. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 11, 2022 Category: Dermatology Authors: Pinyadapat Vacharanukrauh, Jitlada Meephansan, Saranyoo Ponnikorn, Pattarin Tangtanatakul, Wipasiri Soonthornchai, Jongkonnee Wongpiyabovorn, Patlada Ingkaninanda, Morita Akimichi Source Type: research
0.005 % hypochlorite reduces serine protease in cultured human keratinocytes: Evidences supporting bleach bath improves atopic dermatitis
Atopic dermatitis (AD) is a chronically relapsing inflammatory skin disease. Current treatment strategy for AD includes alleviating inflammation, normalizing microbiome, and restoring barrier function. Because epidermal density of Staphylococcus aureus (SA) was reported to positively correlate with the disease severity of AD [1], bleach bath (with 0.005 % hypochlorite (HOCl) solution) was originally considered as a beneficial anti-septic therapy for AD patients with skin lesions heavily colonized SA [2]. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 8, 2022 Category: Dermatology Authors: Shu-Mei Huang, Yang-Yi Chen, Yin-Chun Chen, Ching-Shuang Wu, Cheng-Che E. Lan Tags: Letter to the Editor Source Type: research
0.005% hypochlorite reduces serine protease in cultured human keratinocytes: Evidences supporting bleach bath improves atopic dermatitis
Atopic dermatitis (AD) is a chronically relapsing inflammatory skin disease. Current treatment strategy for AD includes alleviating inflammation, normalizing microbiome, and restoring barrier function. Because epidermal density of Staphylococcus aureus (SA) was reported to positively correlate with the disease severity of AD [1], bleach bath (with 0.005% hypochlorite (HOCl) solution) was originally considered as a beneficial anti-septic therapy for AD patients with skin lesions heavily colonized SA [2]. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 8, 2022 Category: Dermatology Authors: Shu-Mei Huang, Yang-Yi Chen, Yin-Chun Chen, Ching-Shuang Wu, Cheng-Che E. Lan Source Type: research
Ceramide profiling of stratum corneum in Sj ögren–Larsson syndrome
Sj ögren–Larsson syndrome (SLS) is a neurocutaneous disorder whose causative gene is the fatty aldehyde dehydrogenase ALDH3A2 and of which ichthyosis is the major skin symptom. The stratum corneum contains a variety of ceramides, among which ω-O-acylceramides (acylceramides) and protein-bound ceram ides are essential for skin permeability barrier formation. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 8, 2022 Category: Dermatology Authors: Ayami Arai, Takuya Takeichi, Hiroyuki Wakamoto, Takayuki Sassa, Yasutoshi Ito, Yuya Murase, Tomoo Ogi, Masashi Akiyama, Akio Kihara Source Type: research
Protective effect of autophagy in particulate matter-induced hair loss
Particulate matter (PM) is among the leading environmental causes of diseases worldwide, and increases mortality and morbidity from cardiovascular and respiratory diseases [1]. Interestingly, increasing evidence suggests that PM is related to hair growth. PM of small diameters can penetrate hair follicles (HFs) in vivo and induce cutaneous inflammatory responses [2]. Recently, an epidemiological study demonstrated that PM concentration partially corresponds to the flare pattern of alopecia areata, the most common inflammatory hair loss disorder [3]. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 8, 2022 Category: Dermatology Authors: Da-Ae Yu, Sunhyae Jang, Jungyoon Ohn, Sungjoo Tommy Hwang, Ohsang Kwon Tags: Letter to the Editor Source Type: research
Impaired production of skin barrier lipid acylceramides and abnormal localization of PNPLA1 due to ichthyosis-causing mutations in PNPLA1
PNPLA1 is a causative gene of autosomal recessive congenital ichthyosis. The transacylase PNPLA1 produces ω-O-acylceramides (acylceramides), lipids essential for the skin barrier function, by catalyzing the transfer of a linoleic acid from triglycerides to ω-hydroxyceramides. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 3, 2022 Category: Dermatology Authors: Tomohiro Nohara, Yusuke Ohno, Akio Kihara Source Type: research
Editorial board
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 1, 2022 Category: Dermatology Source Type: research
Editors Choice
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 1, 2022 Category: Dermatology Source Type: research
IL-33/ST2 axis contributes to the dermal fibrosis of systemic sclerosis via promoting fibroblasts activation
Systemic sclerosis (SSc) is a chronic immune-mediated rheumatic disease that is characterized by fibrosis of the skin and internal organs. Interleukin-33 (IL-33) has been recently implicated in several autoimmune diseases through its receptor ST2. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - August 1, 2022 Category: Dermatology Authors: Xuefen Wu, Bingxia Ming, Tong Wu, Rongfen Gao, Peng Hu, Jungen Tang, Jixin Zhong, Fang Zheng, Lingli Dong Source Type: research
SPARC promotes production of type IV and VII collagen and their skin basement membrane accumulation
Matricellular proteins are a group of extracellular matrix (ECM) –associated proteins with no primary structural roles that modulate cell-matrix interactions, cellular function, and ECM assembly. In the skin, secreted protein acidic and rich in cysteine (SPARC), an original member of the matricellular protein family, regulates the homeostasis of type I collagen , e.g. SPARC-null mice exhibit reduced tensile strength, decreased collagen content, and smaller fibril diameter [1]. Recently, we reported that SPARC upregulates the production and pericellular organization of type I collagen and hyaluronan via transforming growt...
Source: Journal of Dermatological Science - July 20, 2022 Category: Dermatology Authors: Tomomi Nakamura, Hiroyuki Yoshida, Yukiko Ota, Yoko Endo, Tetsuya Sayo, Ushio Hanai, Kotaro Imagawa, Masashi Sasaki, Yoshito Takahashi Tags: Letter to the Editor Source Type: research
The role of HMGB1 in inflammatory skin diseases
High-mobility group box 1 protein (HMGB1) is a highly abundant, non-histone nuclear protein that can serve as an alarmin to promote the pathogenesis of inflammatory diseases. In response to various stimuli, HMGB1 can translocate from the nucleus to the cytoplasm as well as the extracellular space through passive or active release, accompanied with different post-translational modifications. Depending on the redox state of three cysteine residues, HMGB1 determines its activity to induce cytokine production or tissue repair through binding with several different receptors. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 13, 2022 Category: Dermatology Authors: Takashi K. Satoh Tags: Invited Review Article Source Type: research
Risk factors for sepsis and effects of pretreatment with systemic steroid therapy for underlying condition in SJS/TEN patients: Results of a nationwide cross-sectional survey in 489 Japanese patients
Stevens –Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening severe cutaneous adverse reactions (SCARs). Sepsis has been shown to be the main cause of death in SJS/TEN. The European SCAR study reported that 14.8% of SJS/TEN patients were receiving systemic steroid therapy for their underlying condition prior to onset. However, it remained unclear whether this factor affected the mortality rate. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 13, 2022 Category: Dermatology Authors: Yuma Sunaga, Natsumi Hama, Hirotaka Ochiai, Akatsuki Kokaze, Eun Seon Lee, Hideaki Watanabe, Michiko Kurosawa, Hiroaki Azukizawa, Hideo Asada, Yuko Watanabe, Yukie Yamaguchi, Michiko Aihara, Yoshiko Mizukawa, Manabu Ohyama, Riichiro Abe, Hideo Hashizume, Source Type: research
Plasma metabolomic profiling reflects the malnourished and chronic inflammatory state in recessive dystrophic epidermolysis bullosa
Recessive dystrophic epidermolysis bullosa (RDEB) is a hereditary blistering disorder characterized by skin fragility, chronic inflammation, malnutrition, and fibrosis. Metabolomics is an emerging investigative field that helps elucidate disease pathophysiology and identify biomarkers. However, previous metabolomic studies in RDEB are limited. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - July 12, 2022 Category: Dermatology Authors: Ya-Fen Chen, Hsin-Chin Lu, Ping-Chen Hou, Yu-Ching Lin, Wilson Jr Aala, Alexandros Onoufriadis, John A. McGrath, Ying-Lan Chen, Chao-Kai Hsu Source Type: research
