Transient receptor potential vanilloid 4 promotes cutaneous wound healing by regulating keratinocytes and fibroblasts migration and collagen production in fibroblasts in a mouse model
Transient receptor potential vanilloid 4 (TRPV4), a cation ion channel, is expressed in different cells, and it regulates the development of different diseases. We recently found a high TRPV4 expression in the wounded skin area. However, the role of TRPV4 in cutaneous wound healing is unknown. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - October 11, 2023 Category: Dermatology Authors: Bayarmaa Taivanbat, Sahori Yamazaki, Bolor Nasanbat, Akihiko Uchiyama, Syahla Nisaa Amalia, Munkhjargal Nasan-Ochir, Yuta Inoue, Mai Ishikawa, Keiji Kosaka, Akiko Sekiguchi, Sachiko Ogino, Yoko Yokoyama, Ryoko Torii, Mari Hosoi, Koji Shibasaki, Sei-ichiro Source Type: research
In Vitro Evaluation of Neosetophomone B Inducing Apoptosis in Cutaneous T Cell Lymphoma by Targeting the FOXM1 Signaling Pathway
Cutaneous T cell lymphoma (CTCL) is a T cell-derived non-Hodgkin lymphoma primarily affecting the skin, with treatment posing a significant challenge and low survival rates. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - October 5, 2023 Category: Dermatology Authors: Shilpa Kuttikrishnan, Tariq Masoodi, Fareed Ahmad, Gulab Sher, Kirti S. Prabhu, Jericha M. Mateo, Joerg Buddenkotte, Tamam El-Elimat, Nicholas H. Oberlies, Cedric J. Pearce, Ajaz A. Bhat, Feras Q. Alali, Martin Steinhoff, Shahab Uddin Source Type: research
Editorial board
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - October 1, 2023 Category: Dermatology Source Type: research
Editor's Choice
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - October 1, 2023 Category: Dermatology Source Type: research
Management of the human hair follicle microbiome by a synthetic odorant
Human scalp hair follicles (HFs) engage in olfactory receptor (OR)-dependent chemosensation. Activation of olfactory receptor family 2 subfamily AT member 4 (OR2AT4) by the synthetic, sandalwood-like odorant Sandalore ® up-regulated HF antimicrobial peptide expression of dermcidin (DCD), thought to be produced exclusively by sweat and sebaceous glands. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - September 30, 2023 Category: Dermatology Authors: Janin Edelkamp, Marta B. Lousada, Daniela Pinto, J érémy Chéret, Francesco Maria Calabrese, Francisco Jiménez, Hanieh Erdmann, Julia Wessel, Bodo Phillip, Maria De Angelis, Fabio Rinaldi, Marta Bertolini, Ralf Paus Source Type: research
High glucose environment induces NEDD4 deficiency that impairs angiogenesis and diabetic wound healing
Healing of diabetic wounds, characterized by impaired angiogenesis, remains a clinical challenge. E3 ligase have been identified as potential therapeutic targets of wound healing. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - September 30, 2023 Category: Dermatology Authors: Yu Guo, Yongjie Wang, Haiwei Liu, Xulei Jiang, Shaorong Lei Source Type: research
Alopecia areata: What ’s new in the epidemiology, comorbidities, and pathogenesis?
Alopecia areata (AA) is a common, acquired, and nonscarring type of hair loss that affects people of every generation and is intractable in severe and relapsing cases. Patients with AA, especially those with greater scalp involvement, have poor health-related quality-of-life scores. Purpose: Following our previous review article in the April 2017 issue of the Journal of Dermatological Science, we aim to provide a pair of review articles on recent progress in multidisciplinary approaches to AA. Main findings: We found more than 1,800 publications on AA from July 2016 to December 2022. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - September 30, 2023 Category: Dermatology Authors: Teruki Dainichi, Masashi Iwata, Yo Kaku Source Type: research
Presence of microfibril associated glycoprotein 4 and type V collagen and the possible absence of fibrillin-1 in bead-like structures in elastofibroma
Elastofibroma is a relatively rare benign tumor that occurs mostly in the subscapular regions, as well as in the olecranon, gluteal, and thigh regions [1]. Although the pathogenesis of this disease remains unknown, repeated mechanical friction may play a crucial role. Accordingly, we analyzed the unique bead-like structures (BLSs) of the elastic components in elastofibromas, which were morphologically distinct from the elastic fibers in the dermis. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - September 28, 2023 Category: Dermatology Authors: Haruto Nishida, Takako Sasaki, Yuki Taga, Yusuke Murasawa, Siro Simizu, Shigeto Matsushita, Zenzo Isogai, Shunji Hattori, Tsutomu Daa, Nobuo Nagamine, Akihiro Sekine, Sakuhei Fujiwara Tags: Letter to the Editor Source Type: research
Bath-psoralen plus UVA therapy changes inflammatory proteomic signatures for systemic effects beyond the skin
To the Editor (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - September 26, 2023 Category: Dermatology Authors: Yoshifumi Kanayama, Kyoko Ikumi, Mai Sakurai, Yuki Enomoto, Emi Nishida, Aya Yamamoto, Akimichi Morita Source Type: research
Invention of automated numerical algorithm adopting binarization for the evaluation of scalp hair coverage: an image analysis providing a substitute for phototrichogram and global photography assessment for hair diseases
The efficacy of therapeutic modalities for hair disease can be evaluated globally by photo assessment and more precisely by phototrichogram (PTG). However, the latter procedure is laborious, time consuming, subject to inter-observer variation, and requires hair clipping. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - September 20, 2023 Category: Dermatology Authors: Masaya Takagi, Misaki Kinoshita-Ise, Masahiro Fukuyama, Saori Nishikawa, Mami Miyoshi, Takaki Sugimoto, Masako Yamazaki, Masashi Ogo, Manabu Ohyama Source Type: research
A20 ameliorates advanced glycation end products-induced melanogenesis by inhibiting NLRP3 in flammasome activation in human dermal fibroblasts
Advanced glycation end products (AGEs) promote melanogenesis through activating NLRP3 in flammasome in fibroblasts. Although A20 has been highlighted to inhibit NLRP3 inflammasome activation, its roles and mechanisms remain elusive in photoaging-associated pigmentation. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - September 6, 2023 Category: Dermatology Authors: Mengyao Wang, Xianyin Huang, Mengting Ouyang, Jingjing Lan, Jingqian Huang, Hongpeng Li, Wei Lai, Yifeng Gao, Qingfang Xu Source Type: research
Exosomes from human adipose –derived mesenchymal stem cells attenuate localized scleroderma fibrosis by the let-7a-5p/TGF-βR1/Smad axis
Inflammation and fibrosis of the skin are characteristics of localized scleroderma (LS). Emerging evidence has demonstrated that exosomes from human adipose tissue –derived mesenchymal stem cells (ADSC-Exo) could alleviate skin fibrosis. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - September 5, 2023 Category: Dermatology Authors: Liquan Wang, Tianhao Li, Xuda Ma, Yunzhu Li, Zhujun Li, Ziming Li, Nanze Yu, Jiuzuo Huang, Qin Han, Xiao Long Source Type: research
Editor's Choice
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - September 1, 2023 Category: Dermatology Source Type: research
Editorial board
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - September 1, 2023 Category: Dermatology Source Type: research
Characterisation of superficial corneocyte properties over category i pressure ulcers: insights into topographical and maturation changes
Pressure ulcers (PUs) are chronic wounds that are detrimental to the quality of life of patients. Despite advances in monitoring skin changes, the structure and function of skin cells over the site of pressure ulcers are not fully understood. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - September 1, 2023 Category: Dermatology Authors: Ana S. Évora, Nkemjika Abiakam, Zhibing Zhang, Simon A. Johnson, Michael J. Adams, Dan L. Bader, Peter R. Worsley Source Type: research
