Management of the human hair follicle microbiome by a synthetic odorant

Human scalp hair follicles (HFs) engage in olfactory receptor (OR)-dependent chemosensation. Activation of olfactory receptor family 2 subfamily AT member 4 (OR2AT4) by the synthetic, sandalwood-like odorant Sandalore ® up-regulated HF antimicrobial peptide expression of dermcidin (DCD), thought to be produced exclusively by sweat and sebaceous glands.

Source: Journal of Dermatological Science - September 30, 2023 Category: Dermatology Authors: Janin Edelkamp, Marta B. Lousada, Daniela Pinto, J érémy Chéret, Francesco Maria Calabrese, Francisco Jiménez, Hanieh Erdmann, Julia Wessel, Bodo Phillip, Maria De Angelis, Fabio Rinaldi, Marta Bertolini, Ralf Paus Source Type: research