Exosomes from human adipose –derived mesenchymal stem cells attenuate localized scleroderma fibrosis by the let-7a-5p/TGF-βR1/Smad axis

Inflammation and fibrosis of the skin are characteristics of localized scleroderma (LS). Emerging evidence has demonstrated that exosomes from human adipose tissue –derived mesenchymal stem cells (ADSC-Exo) could alleviate skin fibrosis.

https://www.jdsjournal.com/article/S0923-1811(23)00186-X/fulltext?rss=yes

Source: Journal of Dermatological Science - September 5, 2023 Category: Dermatology Authors: Liquan Wang, Tianhao Li, Xuda Ma, Yunzhu Li, Zhujun Li, Ziming Li, Nanze Yu, Jiuzuo Huang, Qin Han, Xiao Long Source Type: research