Cathepsin B/NLRP3/GSDMD axis-mediated Macrophage Pyroptosis Induces Inflammation and Fibrosis in Systemic Sclerosis

Pyroptosis is a newly discovered type of programmed cell death associated with inflammatory and fibrotic diseases. Macrophages play an important role in inducing early immune inflammation in systemic sclerosis (SSc).

Source: Journal of Dermatological Science - December 24, 2022 Category: Dermatology Authors: Chaofan Liu, Jiaxuan Tang, Shiying Liu, Chen Shen, Xing Zhou, Jinghao Lu, Ming Li, Lubing Zhu Source Type: research