Novel GSK-3 kinase inhibitor Pym-5 induces GSK-3 β rather than GSK-3α-dependent melanogenesis in murine melanoma cells

Glycogen synthase kinase-3 (GSK-3) inhibitors are considered to activate Wnt/ β-catenin, which remains a controversial topic in melanoma treatment.

Source: Journal of Dermatological Science - May 11, 2022 Category: Dermatology Authors: Qi Jia, Li Tao, Yinyin Zhou, Li Song, Zhonghong Wei, Tao Lu, James R. Woodgett, Yin Lu Source Type: research