The effect of a topical vitamin D3 analog on repigmentation in mice with rhododendrol-induced leukoderma

Rhododendrol (RD), 4-(4-hydroxyphenyl)-2-butanol, which was present on cosmetics, is the causative agent of skin depigmentation called RD-induced leukoderma (RDIL). Several treatment options are available for RDIL; however, their efficacy is unsatisfactory. Vitamin D3 analogs have been used for the treatment of vitiligo. They are known to stimulate melanocyte maturation and differentiation and to induce melanogenesis [1,2]. The effectiveness of vitamin D3 analogues in skin is still controversial with limited data [3].
Source: Journal of Dermatological Science - Category: Dermatology Authors: Tags: Letter to the Editor Source Type: research