IL-4-induced decrease in both the number and CTLA-4 expression of Treg impairs suppression of Th2 type inflammation in severe atopic dermatitis

Treg plays a pivotal role in the suppression of Th2 cell and the maintenance of immune homeostasis. The precise molecular mechanism underlying the disruption of Treg suppression of Th2 cell and the promotion of Th2 type inflammation in allergic diseases remains elusive.

Source: Journal of Dermatological Science - March 23, 2024 Category: Dermatology Authors: Bocheng Wang, Zhiying Yu, Jiao Liu, Yuyang Tian, Yijia Ruan, Tinghui Kong, Mingjun Hou, Bihui Yu, Shiqi Ling, Di Wang, Yishan Chen, Yingping Xu, Weiwei Deng, Yunsheng Liang Source Type: research