Vitamin B12 Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Non-indicated vitamin B12- and D-testing among Dutch hospital clinicians: a cross-sectional analysis in data registries
Conclusion Hospital clinicians order vitamin B12- and D-tests without a clear indication on a large scale. Only a small proportion of the unexplained variation could be attributed to differences between hospitals. (Source: BMJ Open)
Source: BMJ Open - February 28, 2024 Category: General Medicine Authors: Müskens, J. L., Kool, R. B., Westert, G. P., Zaal, M., Muller, H., Atsma, F., van Dulmen, S. A. Tags: Open access, Health services research Source Type: research

High serum total vitamin B12 may mask biologically active B12 deficiency
Ann Clin Biochem. 2024 Feb 26:45632241236091. doi: 10.1177/00045632241236091. Online ahead of print.NO ABSTRACTPMID:38407076 | DOI:10.1177/00045632241236091 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - February 26, 2024 Category: Biochemistry Authors: Nathan Lorde Jayne Parkes Harminder Sensi Ross Valentine Morven Baker Clare Ford Tejas Kalaria Rousseau Gama Source Type: research

Vitamin B12 inhibits peptidylarginine deiminases and ameliorates rheumatoid arthritis in CAIA mice
Biochem Biophys Res Commun. 2024 Feb 15;704:149668. doi: 10.1016/j.bbrc.2024.149668. Online ahead of print.ABSTRACTRheumatoid arthritis is an autoimmune disease whose early onset correlates with dysregulated citrullination, a process catalyzed by peptidylarginine deiminase isoform 4 (PADI-4). Here, we report that PADI-4 is a novel target of vitamin B12, a water-soluble vitamin that serves as a cofactor in DNA synthesis and the metabolism of fatty and amino acids. Vitamin B12 preferentially inhibited PADI-4 over PADI-2 with comparable inhibitory activity to the reference compound Cl-amidine in enzymatic inhibition assays, a...
Source: Biochemical and Biophysical Research communications - February 24, 2024 Category: Biochemistry Authors: Cheng-Wei Yang Hsing-Yu Hsu Yue-Zhi Lee Shiow-Ju Lee Source Type: research

Comprehensive assessment of nutritional and functional status of patients with ulcerative colitis and their impact on quality of life
ConclusionsMacronutrient deficiency, micronutrient deficiency, lower functional status and poorer QOL are highly prevalent among patients with UC. The independent predictors of poor QOL were histologically active disease and low serum vitamin D levels. Identifying and correcting the deficiencies may help in improving the QOL of patients with UC.Graphical Abstract (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - February 23, 2024 Category: Gastroenterology Source Type: research

The MMACHC variant c.158T & gt;C: Mild clinical and biochemical phenotypes and marked hydroxocobalamin response in cblC patients
Mol Genet Metab. 2024 Feb 10;142(1):108345. doi: 10.1016/j.ymgme.2024.108345. Online ahead of print.ABSTRACTMutations in MMACHC cause cobalamin C disease (cblC, OMIM 277400), the commonest inborn error of vitamin B12 metabolism. In cblC, deficient activation of cobalamin results in methylcobalamin and adenosylcobalamin deficiency, elevating methylmalonic acid (MMA) and total plasma homocysteine (tHcy). We retrospectively reviewed the medical files of seven cblC patients: three compound heterozygotes for the MMACHC (NM_015506.3) missense variant c.158T>C p.(Leu53Pro) in trans with the common pathogenic mutation c.271dupA...
Source: Molecular Medicine - February 22, 2024 Category: Molecular Biology Authors: Tanguy Demaret Karine B édard Jean-Fran çois Soucy David Watkins Pierre Allard Alina Levtova Alan O'Brien Catherine Brunel-Guitton David S Rosenblatt Grant A Mitchell Source Type: research

Potential of postbiotics for the treatment of metabolic disorders
Drug Discov Today. 2024 Feb 19:103921. doi: 10.1016/j.drudis.2024.103921. Online ahead of print.ABSTRACTPostbiotics, the next generation of probiotics, are extracts that are free of living and nonviable bacteria and show strong modulatory effects on the gut flora. Examples include vitamin B12, vitamin K, folate, lipopolysaccharides, enzymes, and short-chain fatty acids (SCFAs), representing a subset of essential nutrients commonly found in the human diet. Postbiotics have been observed to demonstrate antiobesity and antidiabetic effects through a variety of mechanisms. These pathways primarily involve an elevation in energ...
Source: Drug Discovery Today - February 21, 2024 Category: Drugs & Pharmacology Authors: Neeraj Mishra Ashish Garg Sumel Ashique Shvetank Bhatt Source Type: research

Vitamin B12 deficiency in diabetic patients treated with metformin: A narrative review
AbstractMetformin is the most prescribed oral hypoglycemic drug and is considered by many health practitioners as the first-line treatment for non-insulin-dependent diabetes mellitus (T2DM). It is used either as a monotherapy or adjuvant to other anti-hyperglycemic agents. Most of its side effects are usually mild and self-limiting. However, several studies have shown an association between the use of metformin and low vitamin B12 levels in diabetic patients. The current review aimed to provide a literature review of the current published reports on the association, the possible mechanisms, and the related individualized r...
Source: Irish Journal of Medical Science - February 21, 2024 Category: General Medicine Source Type: research

Prevalence and clinical correlates of hyperhomocysteinemia in Chinese urban population with hypertension
ConclusionThe high prevalence of HHcy among hypertensive patients in this Chinese urban population underscores the necessity for interventions targeting modifiable risk factors such as dietary choices and lifestyle practices. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 20, 2024 Category: Endocrinology Source Type: research

Reversible dementia and seizures due to metformin-induced vitamin B12 deficiency
Encephale. 2024 Feb 17:S0013-7006(24)00020-4. doi: 10.1016/j.encep.2023.11.030. Online ahead of print.NO ABSTRACTPMID:38369428 | DOI:10.1016/j.encep.2023.11.030 (Source: L Encephale)
Source: L Encephale - February 18, 2024 Category: Psychiatry Authors: Sirine Laroussi Nadia Bouattour Sawsan Daoud Khadija Sonda Moalla Salma Sakka Mariem Damak Nouha Farhat Chokri Mhiri Source Type: research