Knuckle hyperpigmentation in a young male: A clinical sign of B12 deficiency not to be missed
Trop Doct. 2024 Feb 29:494755241234081. doi: 10.1177/00494755241234081. Online ahead of print.ABSTRACTVitamin B12 and folate deficiency are reversible causes of megaloblastic anemia. Strict vegetarians are at risk of megaloblastic anemia due to low cobalamin in their diet. Knuckle hyperpigmentation in patients with megaloblastic anemia is due to excess melanin synthesis in skin. Here we present a case of a young vegetarian male with megaloblastic anemia with knuckle hyperpigmentation managed successfully with intravenous followed by oral vitamin b12 and folate supplementation.PMID:38419508 | DOI:10.1177/00494755241234081 (...
Source: Tropical Doctor - February 29, 2024 Category: Tropical Medicine Authors: Harpreet Singh Arvind Subramanian Deba P Dibhar Vikas Suri Ashish Bhalla Source Type: research
Can supplementing vitamin B12 improve mental health outcomes?: a literature review
CONCLUSION: The findings show that this area of research is still to be developed. The effects of B12 supplementation with other B vitamins on mental health have shown to be inconclusive. There is a case for its use to be considered within certain patient groups to aid recovery of mental health or in some high-risk patient groups. Recommendations are made for further research into high-risk groups of people that may have symptoms or symptoms that could be improved through the supplementation of B12.PMID:38421889 | DOI:10.12968/bjcn.2024.29.3.137 (Source: British Journal of Community Nursing)
Source: British Journal of Community Nursing - February 29, 2024 Category: Nursing Authors: Tiago Reis da Silva Source Type: research
Knuckle hyperpigmentation in a young male: A clinical sign of B12 deficiency not to be missed
Trop Doct. 2024 Feb 29:494755241234081. doi: 10.1177/00494755241234081. Online ahead of print.ABSTRACTVitamin B12 and folate deficiency are reversible causes of megaloblastic anemia. Strict vegetarians are at risk of megaloblastic anemia due to low cobalamin in their diet. Knuckle hyperpigmentation in patients with megaloblastic anemia is due to excess melanin synthesis in skin. Here we present a case of a young vegetarian male with megaloblastic anemia with knuckle hyperpigmentation managed successfully with intravenous followed by oral vitamin b12 and folate supplementation.PMID:38419508 | DOI:10.1177/00494755241234081 (...
Source: Tropical Doctor - February 29, 2024 Category: Tropical Medicine Authors: Harpreet Singh Arvind Subramanian Deba P Dibhar Vikas Suri Ashish Bhalla Source Type: research
Can supplementing vitamin B12 improve mental health outcomes?: a literature review
CONCLUSION: The findings show that this area of research is still to be developed. The effects of B12 supplementation with other B vitamins on mental health have shown to be inconclusive. There is a case for its use to be considered within certain patient groups to aid recovery of mental health or in some high-risk patient groups. Recommendations are made for further research into high-risk groups of people that may have symptoms or symptoms that could be improved through the supplementation of B12.PMID:38421889 | DOI:10.12968/bjcn.2024.29.3.137 (Source: British Journal of Community Nursing)
Source: British Journal of Community Nursing - February 29, 2024 Category: Nursing Authors: Tiago Reis da Silva Source Type: research
Knuckle hyperpigmentation in a young male: A clinical sign of B12 deficiency not to be missed
Trop Doct. 2024 Feb 29:494755241234081. doi: 10.1177/00494755241234081. Online ahead of print.ABSTRACTVitamin B12 and folate deficiency are reversible causes of megaloblastic anemia. Strict vegetarians are at risk of megaloblastic anemia due to low cobalamin in their diet. Knuckle hyperpigmentation in patients with megaloblastic anemia is due to excess melanin synthesis in skin. Here we present a case of a young vegetarian male with megaloblastic anemia with knuckle hyperpigmentation managed successfully with intravenous followed by oral vitamin b12 and folate supplementation.PMID:38419508 | DOI:10.1177/00494755241234081 (...
Source: Tropical Doctor - February 29, 2024 Category: Tropical Medicine Authors: Harpreet Singh Arvind Subramanian Deba P Dibhar Vikas Suri Ashish Bhalla Source Type: research
Can supplementing vitamin B12 improve mental health outcomes?: a literature review
CONCLUSION: The findings show that this area of research is still to be developed. The effects of B12 supplementation with other B vitamins on mental health have shown to be inconclusive. There is a case for its use to be considered within certain patient groups to aid recovery of mental health or in some high-risk patient groups. Recommendations are made for further research into high-risk groups of people that may have symptoms or symptoms that could be improved through the supplementation of B12.PMID:38421889 | DOI:10.12968/bjcn.2024.29.3.137 (Source: British Journal of Community Nursing)
Source: British Journal of Community Nursing - February 29, 2024 Category: Nursing Authors: Tiago Reis da Silva Source Type: research
Knuckle hyperpigmentation in a young male: A clinical sign of B12 deficiency not to be missed
Trop Doct. 2024 Feb 29:494755241234081. doi: 10.1177/00494755241234081. Online ahead of print.ABSTRACTVitamin B12 and folate deficiency are reversible causes of megaloblastic anemia. Strict vegetarians are at risk of megaloblastic anemia due to low cobalamin in their diet. Knuckle hyperpigmentation in patients with megaloblastic anemia is due to excess melanin synthesis in skin. Here we present a case of a young vegetarian male with megaloblastic anemia with knuckle hyperpigmentation managed successfully with intravenous followed by oral vitamin b12 and folate supplementation.PMID:38419508 | DOI:10.1177/00494755241234081 (...
Source: Tropical Doctor - February 29, 2024 Category: Tropical Medicine Authors: Harpreet Singh Arvind Subramanian Deba P Dibhar Vikas Suri Ashish Bhalla Source Type: research
Can supplementing vitamin B12 improve mental health outcomes?: a literature review
CONCLUSION: The findings show that this area of research is still to be developed. The effects of B12 supplementation with other B vitamins on mental health have shown to be inconclusive. There is a case for its use to be considered within certain patient groups to aid recovery of mental health or in some high-risk patient groups. Recommendations are made for further research into high-risk groups of people that may have symptoms or symptoms that could be improved through the supplementation of B12.PMID:38421889 | DOI:10.12968/bjcn.2024.29.3.137 (Source: British Journal of Community Nursing)
Source: British Journal of Community Nursing - February 29, 2024 Category: Nursing Authors: Tiago Reis da Silva Source Type: research
Can supplementing vitamin B12 improve mental health outcomes?: a literature review
CONCLUSION: The findings show that this area of research is still to be developed. The effects of B12 supplementation with other B vitamins on mental health have shown to be inconclusive. There is a case for its use to be considered within certain patient groups to aid recovery of mental health or in some high-risk patient groups. Recommendations are made for further research into high-risk groups of people that may have symptoms or symptoms that could be improved through the supplementation of B12.PMID:38421889 | DOI:10.12968/bjcn.2024.29.3.137 (Source: British Journal of Community Nursing)
Source: British Journal of Community Nursing - February 29, 2024 Category: Nursing Authors: Tiago Reis da Silva Source Type: research
Can supplementing vitamin B12 improve mental health outcomes?: a literature review
CONCLUSION: The findings show that this area of research is still to be developed. The effects of B12 supplementation with other B vitamins on mental health have shown to be inconclusive. There is a case for its use to be considered within certain patient groups to aid recovery of mental health or in some high-risk patient groups. Recommendations are made for further research into high-risk groups of people that may have symptoms or symptoms that could be improved through the supplementation of B12.PMID:38421889 | DOI:10.12968/bjcn.2024.29.3.137 (Source: British Journal of Community Nursing)
Source: British Journal of Community Nursing - February 29, 2024 Category: Nursing Authors: Tiago Reis da Silva Source Type: research
Can supplementing vitamin B12 improve mental health outcomes?: a literature review
CONCLUSION: The findings show that this area of research is still to be developed. The effects of B12 supplementation with other B vitamins on mental health have shown to be inconclusive. There is a case for its use to be considered within certain patient groups to aid recovery of mental health or in some high-risk patient groups. Recommendations are made for further research into high-risk groups of people that may have symptoms or symptoms that could be improved through the supplementation of B12.PMID:38421889 | DOI:10.12968/bjcn.2024.29.3.137 (Source: British Journal of Community Nursing)
Source: British Journal of Community Nursing - February 29, 2024 Category: Nursing Authors: Tiago Reis da Silva Source Type: research
The Rhodium Analogue of Coenzyme B12 as an Anti-Photoregulatory Ligand Inhibiting Bacterial CarH Photoreceptors
Angew Chem Int Ed Engl. 2024 Feb 28:e202401626. doi: 10.1002/anie.202401626. Online ahead of print.ABSTRACTCoenzyme B12 (AdoCbl; 5´-deoxy-5'-adenosylcobalamin), the quintessential biological organometallic radical catalyst, has a formerly unanticipated, yet extensive, role in photoregulation in bacteria. The light-responsive cobalt-corrin AdoCbl performs this nonenzymatic role by facilitating the assembly of CarH photoreceptors into DNA-binding tetramers in the dark, suppressing gene expression. Conversely, exposure to light triggers the decomposition of this AdoCbl-bound complex by a still elusive photochemical mechanism...
Source: Angewandte Chemie - February 28, 2024 Category: Chemistry Authors: Ricardo Perez-Castano Juan Aranda Florian J Widner Christoph Kieninger Evelyne Deery Martin J Warren Modesto Orozco Montserrat Elias-Arnanz S Padmanabhan Bernhard Kr äutler Source Type: research
The Rhodium Analogue of Coenzyme B12 as an Anti-Photoregulatory Ligand Inhibiting Bacterial CarH Photoreceptors
Angew Chem Int Ed Engl. 2024 Feb 28:e202401626. doi: 10.1002/anie.202401626. Online ahead of print.ABSTRACTCoenzyme B12 (AdoCbl; 5´-deoxy-5'-adenosylcobalamin), the quintessential biological organometallic radical catalyst, has a formerly unanticipated, yet extensive, role in photoregulation in bacteria. The light-responsive cobalt-corrin AdoCbl performs this nonenzymatic role by facilitating the assembly of CarH photoreceptors into DNA-binding tetramers in the dark, suppressing gene expression. Conversely, exposure to light triggers the decomposition of this AdoCbl-bound complex by a still elusive photochemical mechanism...
Source: Angewandte Chemie - February 28, 2024 Category: Chemistry Authors: Ricardo Perez-Castano Juan Aranda Florian J Widner Christoph Kieninger Evelyne Deery Martin J Warren Modesto Orozco Montserrat Elias-Arnanz S Padmanabhan Bernhard Kr äutler Source Type: research
Non-indicated vitamin B12- and D-testing among Dutch hospital clinicians: a cross-sectional analysis in data registries
Conclusion
Hospital clinicians order vitamin B12- and D-tests without a clear indication on a large scale. Only a small proportion of the unexplained variation could be attributed to differences between hospitals. (Source: BMJ Open)
Source: BMJ Open - February 28, 2024 Category: General Medicine Authors: Müskens, J. L., Kool, R. B., Westert, G. P., Zaal, M., Muller, H., Atsma, F., van Dulmen, S. A. Tags: Open access, Health services research Source Type: research
High serum total vitamin B12 may mask biologically active B12 deficiency
Ann Clin Biochem. 2024 Feb 26:45632241236091. doi: 10.1177/00045632241236091. Online ahead of print.NO ABSTRACTPMID:38407076 | DOI:10.1177/00045632241236091 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - February 26, 2024 Category: Biochemistry Authors: Nathan Lorde Jayne Parkes Harminder Sensi Ross Valentine Morven Baker Clare Ford Tejas Kalaria Rousseau Gama Source Type: research
