Preventive effects of vasohibin-2-targeting peptide vaccine for diabetic nephropathy
In this study, the preventive effects of the VASH2-targeting peptide vaccine against glomerular injury were examined in a streptozotocin (STZ)-induced diabetic mouse model. The mice were subcutaneously injected with the vaccine at two doses 2 weeks apart and then intraperitoneally injected with 50 mg/kg STZ for 5 consecutive days. Glomerular injury was evaluated 20 weeks after the first vaccination. Treatment with the VASH2-targeting peptide vaccine successfully induced circulating anti-VASH2 antibody without inflammation in major organs. Although the vaccination did not affect blood glucose levels, it significantly preven...
Source: Am J Physiol Renal P... - May 2, 2024 Category: Urology & Nephrology Authors: Yuri Nakashima Katsuyuki Tanabe Tomoyo Mifune Takato Nakadoi Hiroki Hayashi Hironori Nakagami Yasufumi Sato Jun Wada Source Type: research
Localization of Intramuscular mRNA Delivery using Deep Eutectic-Lipid Nanocomposites
This article is protected by copyright. All rights reserved.PMID:38693774 | DOI:10.1002/adhm.202400327 (Source: Cancer Control)
Source: Cancer Control - May 2, 2024 Category: Cancer & Oncology Authors: A M Curreri M Dunne G Bibbey N Kapate J Kim S Mitragotri Source Type: research
Follow-up of Immune Response in Patients with Common Variable Immunodeficiency following SARS-CoV-2 Vaccination
In this study, we evaluated the humoral and cellular immune responses after four doses of mRNA-1273 and one BNT162b2 bivalent vaccine in a cohort of patients with CVID and XLA. The response in this population was lower than in the control group. However, the administration of the third dose improved the number of patients with seroconversion and the intensity of the humoral response, as well as the number of patients with a positive cellular response. Finally, the administration of the fourth and fifth doses improves the antibody titer and neutralization against wild type variant, but not against the prevalent XBB1.5 varia...
Source: Clinical and Developmental Immunology - May 2, 2024 Category: Allergy & Immunology Authors: Juan Francisco Guti érrez-Bautista Irene D íaz-Alberola Mar ía Tarriño Mar ía Aguilera Fernando Cobo Juan Antonio Reguera Javier Rodr íguez-Granger Joaqu ín Mendoza Miguel Ángel López-Nevot Antonio Sampedro Source Type: research
Cancer Nanovaccines: Nanomaterials and Clinical Perspectives
This review provides detailed insight into cancer nanovaccines. It examines current developments, innovative strategies, and technologies, encompassing preclinical/clinical advancements. Key focuses include antigen/adjuvant selection, biomaterial-based delivery, and the impact of nanoscale properties on vaccine performance. It also discusses the interplay between the tumor microenvironment and nanovaccine responses alongside ongoing clinical trials, aiming to guide researchers/clinicians in optimizing therapeutic outcomes. AbstractCancer nanovaccines represent a promising frontier in cancer immunotherapy, utilizing nanotec...
Source: Small - May 2, 2024 Category: Nanotechnology Authors: Nimeet Desai,
Vivek Chavda,
Thakur Raghu Raj Singh,
Nanasaheb D. Thorat,
Lalitkumar K. Vora Tags: Review Source Type: research
Effect of maternal vaccination on infant morbidity in Bangladesh
Risk factors of infant mortality in Africa and south Asian countries have been broadly discussed. However, infant morbidity is largely underestimated. We analyzed the data from a randomized vaccine trial in Ba... (Source: BMC Public Health)
Source: BMC Public Health - May 2, 2024 Category: Consumer Health News Authors: Shiqiao Zhao, Jing Zhang, Chenxin Zhang, Mark C. Steinhoff, Yanting Zhang and Bin Zhang Tags: Research Source Type: research
Deceptive tactics: Misappropriation of scientific literature by ‘Gazeta do Povo’ in undermining COVID-19 vaccination efforts
Volume 20, Issue 1, December 2024 . (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - May 2, 2024 Category: Allergy & Immunology Authors: Heslley Machado SilvaDepartment of Science and Education, State University of Minas Gerais and University Center of Formiga, Ibirit é, Brazil Source Type: research
Seroprevalence of IgG antibodies against pertussis toxin in the Chinese population: A systematic review and meta-analysis
Volume 20, Issue 1, December 2024 . (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - May 2, 2024 Category: Allergy & Immunology Authors: Yao ZhuWanting ZhangJie HuShuying LuoYang ZhouXuewen TangRui YanXuan DengHanqing Hea Department of Immunization Program, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Chinab Jiaxing Center for Disease Control and Prevention, Jia Source Type: research
Statistical Experimental Designs for cLTB-Syn Vaccine Production Using Daucus carota Cell Suspension Cultures
In this study, the effect of two nitrogen sources (urea and glutamate) on callus cultures producing cLTB-Syn was studied, observing that the addition of 17 mM urea to MS medium favored the biomass yield. To optimize the MS media composition, the influence of seven medium components on biomass and cLTB-Syn production was first evaluated by a Plackett–Burman design (PBD). Then, three factors were further analyzed using a central composite design (CCD) and response surface methodology (RSM). The results showed a 1.2-fold improvement in biomass, and a 4.5-fold improvement in cLTB-Syn production was achieved at the shake-fl...
Source: Planta Medica - May 2, 2024 Category: Drugs & Pharmacology Authors: Carre ño-Campos, Christian Villegas, Elba Villarreal, Mar ía Luisa Morales-Aguilar, M ónica Govea-Alonso, Dania Romero-Maldonado, Andrea Jimenez-Capdeville, Mar ía E. Rosales-Mendoza, Sergio Ortiz-Caltempa, Anabel Tags: Original Papers Source Type: research
Impact of Booster Vaccination Interval on SARS-CoV-2 Infection, Hospitalization, and Death
Vaccination plays a very important role in preventing SARS-CoV-2 infection and severe Covid-19 disease. Primary vaccination was highly effective against infection, hospitalization, and death, but its effectiveness waned gradually over time and was further reduced by the emergence of new variants [1-4]. Booster vaccination restored some immunity, but the added protection declined rapidly over time, especially against newer variants [5-8]. Bivalent boosters were more effective than monovalent boosters, but their effectiveness also waned over time [9-10]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - May 2, 2024 Category: Infectious Diseases Authors: Dan-Yu Lin, Yangjianchen Xu, Yu Gu, Shadia K Sunny, Zack Moore, Donglin Zeng Source Type: research
A combined cross-sectional analysis and case-control study evaluating tick-borne encephalitis vaccination coverage, disease and vaccine effectiveness in children and adolescents, Switzerland, 2005 to 2022
ConclusionsEven children younger than 5 years can experience severe TBE. Incomplete and complete vaccination protect against neurological manifestations of the disease. Complete vaccination offers durable protection up to 10 years against TBE. (Source: Eurosurveillance)
Source: Eurosurveillance - May 2, 2024 Category: Infectious Diseases Authors: Kyra D Zens, Ekkehardt Altpeter, Monica N Wymann, Annora Mack, Nora B Baer, Sarah R Haile, Robert Steffen, Jan S Fehr and Phung Lang Source Type: research
UTIs make life miserable — scientists are finding new ways to tackle them
Nature, Published online: 02 May 2024; doi:10.1038/d41586-024-01322-yResearchers are developing vaccines and fresh drug approaches to prevent and treat recurring infections without antibiotics. (Source: Nature AOP)
Source: Nature AOP - May 2, 2024 Category: Research Authors: Carissa Wong Source Type: research
Biases and limitations in observational studies of Long COVID prevalence and risk factors: A rapid systematic umbrella review
ConclusionA high level of heterogeneity render the interpretation of pooled prevalence estimates of Long COVID challenging, further hampered by the lack of robust critical appraisals in the included reviews. Risk factor reviews were of higher quality overall and suggested consistent associations between Long COVID risk and patient characteristics. (Source: PLoS One)
Source: PLoS One - May 2, 2024 Category: Biomedical Science Authors: Miao Jenny Hua Source Type: research
“It’s My Moral Responsibility to Protect Others!” Examining the Effects of Moral Framing and Message Format on Influenza Vaccination Attitude and Intention
. (Source: Health Communication)
Source: Health Communication - May 2, 2024 Category: Health Management Authors: Bingbing ZhangSchool of Journalism & Mass Communication, University of Iowa Source Type: research
Therapeutic vaccines for herpesviruses
Herpesviruses establish latent infections, and most reactivate frequently, resulting in symptoms and virus shedding in healthy individuals. In immunocompromised patients, reactivating virus can cause severe disease. Persistent EBV has been associated with several malignancies in both immunocompromised and nonimmunocompromised persons. Reactivation and shedding occur with most herpesviruses, despite potent virus-specific antibodies and T cell immunity as measured in the blood. The licensure of therapeutic vaccines to reduce zoster indicates that effective therapeutic vaccines for other herpesviruses should be feasible. Howe...
Source: Journal of Clinical Investigation - May 1, 2024 Category: Biomedical Science Authors: Jeffrey I. Cohen Source Type: research
Trends in Animal Bites and Rabies-related Deaths in Northern Iran: Implications for Public Health Interventions
CONCLUSION: The elderly are at higher risk of animal bites, especially in rural areas. It is important to emphasize the use of protective clothing, washing wounds with soap water and rabies vaccination as initial treatment. Targeted vaccination efforts for eligible animals should be prioritized to minimize unnecessary financial burden. Educating farmers about rabies prevention programs, especially in cases of cow bites, is also important.PMID:38690794 | DOI:10.34172/aim.2024.39 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - May 1, 2024 Category: Middle East Health Authors: Ali Davoudi Kiakalayeh Zakiye Gharib Reza Mohammadi Leila Kanafi Vahed Sajad Davoudi-Kiakalayeh Source Type: research
