Multivariate data analysis of process parameters affecting the growth and productivity of stable Chinese hamster ovary cell pools expressing SARS ‐CoV‐2 spike protein as vaccine antigen in early process development
In this study, we analyze early process development data of recombinant trimeric spike protein Cumate-inducible manufacturing platform utilizing CHO stable pool as a preferred production host across three different stirred-tank bioreactor scales (0.75, 1, and 10 L). The impact of cell passage number as an indicator of cell age, methionine sulfoximine (MSX) concentration as a selection pressure, and cell seeding density was investigated using stable pools expressing three variants of concern. Multivariate data analysis with principal component analysis an d batch-wise unfolding technique was applied to evaluate the effec...
Source: Biotechnology Progress - April 26, 2024 Category: Biotechnology Authors: Sebastian ‐Juan Reyes,
Lucas Lemire,
Raul‐Santiago Molina,
Marjolaine Roy,
Helene L'Ecuyer‐Coelho,
Yuliya Martynova,
Brian Cass,
Robert Voyer,
Yves Durocher,
Olivier Henry,
Phuong Lan Pham Tags: RESEARCH ARTICLE Source Type: research
Viruses, Vol. 16, Pages 680: Human Papillomavirus and Associated Cancers: A Review
Rysavy
The human papillomavirus is the most common sexually transmitted infection in the world. Most HPV infections clear spontaneously within 2 years of infection; however, persistent infection can result in a wide array of diseases, ranging from genital warts to cancer. Most cases of cervical, anal, and oropharyngeal cancers are due to HPV infection, with cervical cancer being one of the leading causes of cancer death in women worldwide. Screening is available for HPV and cervical cancer, but is not available everywhere, particularly in lower-resource settings. HPV infection disproportionally affects individuals liv...
Source: Viruses - April 26, 2024 Category: Virology Authors: JaNiese E. Jensen Greta L. Becker J. Brooks Jackson Mary B. Rysavy Tags: Review Source Type: research
Viruses, Vol. 16, Pages 685: Impact of Prior COVID-19 Immunization and/or Prior Infection on Immune Responses and Clinical Outcomes
oglou
Cellular and humoral immunity exhibit dynamic adaptation to the mutating SARS-CoV-2 virus. It is noteworthy that immune responses differ significantly, influenced by whether a patient has received vaccination or whether there is co-occurrence of naturally acquired and vaccine-induced immunity, known as hybrid immunity. The different immune reactions, conditional on vaccination status and the viral variant involved, bear implications for inflammatory responses, patient outcomes, pathogen transmission rates, and lingering post-COVID conditions. Considering these developments, we have performed a review of recently ...
Source: Viruses - April 26, 2024 Category: Virology Authors: Achilleas Livieratos Charalambos Gogos Karolina Akinosoglou Tags: Review Source Type: research
Physical Activity at Different Life Stages and Its Consequence on the Initial Immunization and Inflammatory Response Against COVID-19
CONCLUSION: Our results suggest that adults that accumulated at least 150 minutes of MVPA per week or practiced PA during adolescence developed an improved immune and inflammatory response against COVID-19 vaccination.PMID:38663845 | DOI:10.1123/jpah.2023-0370 (Source: Health Physics)
Source: Health Physics - April 25, 2024 Category: Physics Authors: Priscila Almeida Queiroz Rossi Regis Gomes Teresa Cristina do Nascimento Salazar Esmeralda Maria Lustosa Barros Silvia Vasconcelos Adalberto Socorro da Silva Ester Miranda Pereira Vitoria Braga Melo Marcela Helena Gambin Fonseca Clarissa Romero Teixeira G Source Type: research
Lived Religion in Religious Vaccine Exemptions
Perspect Biol Med. 2024;67(1):96-113. doi: 10.1353/pbm.2024.a919713.ABSTRACTThis essay explores a more inclusive and equitable interpretation of "religion" within the context of religious vaccine exemptions. The existing literature critiques the prevalent interpretation of the meaning of religion in religious exemption cases, but frequently overlooks the importance of incorporating the concept of "lived religion." This essay introduces the concept of lived religion from religious studies, elucidates why this lived religion approach is crucial for redefining "religion," and illustrates its application in the domain of relig...
Source: Perspectives in Biology and Medicine - April 25, 2024 Category: Medical Ethics Authors: Hajung Lee Source Type: research
Historical Lessons on Vaccine Hesitancy: Smallpox, Polio, and Measles, and Implications for COVID-19
This study examines the history of US vaccination efforts against smallpox, polio, and measles, highlighting persistent drivers of vaccine hesitancy as well as factors that helped overcome it. The research reveals that logistical barriers, negative portrayals in the media, and fears about safety stymied inoculation efforts as early as the 18th century and continue to do so. However, vaccine hesitancy has been markedly diminished when trusted community leaders have guided efforts, when ordinary citizens have felt personally invested in the success of the vaccine, and when vaccination efforts have been tied to broader projec...
Source: Perspectives in Biology and Medicine - April 25, 2024 Category: Medical Ethics Authors: J J Eddy H A Smith J E Abrams Source Type: research
On Antiscience and Antisemitism
This article provides both historical and recent perspectives on the links between antiscience and antisemitism, together with the author's personal experience as a Jewish vaccine scientist targeted by both dark forces. New approaches to uncoupling antisemitism from antiscience, while combating both, are essential for saving lives and preserving democratic values.PMID:38661936 | DOI:10.1353/pbm.2023.a902035 (Source: Perspectives in Biology and Medicine)
Source: Perspectives in Biology and Medicine - April 25, 2024 Category: Medical Ethics Authors: Peter Hotez Source Type: research
Herd Immunity: History, Concepts, and Ethical Rationale
This article provides a conceptual framework tailored to uncover the ethical rationale behind such strategies. Clarity on this issue is important in order to facilitate the terms of the political debate when tackling future health emergencies.PMID:38662008 | DOI:10.1353/pbm.2023.0003 (Source: Perspectives in Biology and Medicine)
Source: Perspectives in Biology and Medicine - April 25, 2024 Category: Medical Ethics Authors: Davide Vecchi Giorgio Airoldi Source Type: research
Use of an Additional Updated 2023-2024 COVID-19 Vaccine Dose for Adults Aged ≥65 Years: Recommendations of the Advisory Committee on Immunization Practices - United States, 2024
MMWR Morb Mortal Wkly Rep. 2024 Apr 25;73(16):377-381. doi: 10.15585/mmwr.mm7316a4.ABSTRACTCOVID-19 remains an important public health threat, despite overall decreases in COVID-19-related severe disease since the start of the COVID-19 pandemic. COVID-19-associated hospitalization rates remain higher among adults aged ≥65 years relative to rates in younger adults, adolescents, and children; during October 2023-January 2024, 67% of all COVID-19-associated hospitalizations were among persons aged ≥65 years. On September 12, 2023, CDC's Advisory Committee on Immunization Practices (ACIP) recommended updated (2023-2024 For...
Source: MMWR Morb Mortal Wkl... - April 25, 2024 Category: Epidemiology Authors: Lakshmi Panagiotakopoulos Monica Godfrey Danielle L Moulia Ruth Link-Gelles Christopher A Taylor Kevin Chatham-Stephens Oliver Brooks Matthew F Daley Katherine E Fleming-Dutra Megan Wallace Source Type: research
Use of Ebola Vaccines - Worldwide, 2021-2023
This report describes the use of Ebola vaccines and the role of the stockpile developed and managed by the International Coordinating Group (ICG) on Vaccine Provision during 2021-2023. A total of 145,690 doses have been shipped from the ICG stockpile since 2021. However, because outbreaks since 2021 have been limited and rapidly contained, most doses (139,120; 95%) shipped from the ICG stockpile have been repurposed for preventive vaccination of high-risk groups, compared with 6,570 (5%) used for outbreak response. Repurposing doses for preventive vaccination could be prioritized in the absence of Ebola outbreaks to preven...
Source: MMWR Morb Mortal Wkl... - April 25, 2024 Category: Epidemiology Authors: Ruth Kallay Reena H Doshi Pierre Muhoza Mary J Choi Ana ïs Legand Emma Aberle-Grasse Aminata Bagayoko Terri B Hyde Pierre Formenty Alejandro Costa Source Type: research
Comprehensive Overview of Treponema pallidum Outer Membrane Proteins
Curr Protein Pept Sci. 2024 Apr 24. doi: 10.2174/0113892037293502240328042224. Online ahead of print.ABSTRACTTreponema pallidum, the causative agent of syphilis, is a sexually transmitted microorganism that exhibits remarkable motility capabilities, allowing it to affect various systems. Despite its structural resemblance to gram-negative bacteria due to its dual-membrane, T. pallidum possesses a lower abundance of outer membrane proteins (OMPs), which enables it to effectively conceal itself. This review presents a comprehensive analysis of the clinical diagnostic potential associated with the OMPs of T. pallidum. Further...
Source: Current Protein and Peptide Science - April 25, 2024 Category: Biochemistry Authors: Sirui Wu Lan Luo Fei Ye Yuanfang Wang Dongdong Li Source Type: research
Vaccine Attitudes and Uptake Among Latino Residents of a Former COVID-19 Hotspot
This study uses spatial, survey, and qualitative data to understand attitudes towards vaccine uptake among PWC Latinos. A quantitative analysis (n=266) estimates the association for vaccine acceptance among Latinos. Next, qualitative interviews with Latinos (n=37) examine vaccine attitudes. Finally, a spatial analysis identifies clusters of social vulnerability and low vaccine uptake in PWC and adjacent counties. Our findings show that a substantial proportion of PWC Latinos had low vaccination rates as of December 2022, two years after the vaccine's release. Side effects and safety and approval concerns were cited in both...
Source: Journal of Health Care for the Poor and Underserved - April 25, 2024 Category: International Medicine & Public Health Authors: Carol Cleaveland Taylor Anderson Kimberly McNally Amira A Roess Source Type: research
Promoting COVID-19 Vaccine Confidence and Access among Youth Experiencing Homelessness: Community-Engaged Public Health Practice
CONCLUSIONS: This community-engaged project highlighted the value of cross-sector partnership and consistent youth engagement in addressing vaccine confidence among YEH.PMID:38661829 (Source: Progress in Community Health Partnerships)
Source: Progress in Community Health Partnerships - April 25, 2024 Category: International Medicine & Public Health Authors: Ingie Osman Renee Sieving Lauren Vasilakos Katie Pierson Asha Elgonda Trenton Bartlett Janna R Gewirtz O'Brien Source Type: research
Differential Utility Losses in Herpes Zoster Cases Between Vaccinated and Unvaccinated Subjects: A Meta-analysis of Three Clinical Trials
CONCLUSIONS: Recombinant zoster vaccine is effective in alleviating disease severity in breakthrough cases of herpes zoster. The results may be useful in distinguishing QALY losses between vaccinated and unvaccinated cohorts in health economics studies, particularly cost-effectiveness analyses.PMID:38662318 | DOI:10.1007/s40261-024-01355-1 (Source: Herpes)
Source: Herpes - April 25, 2024 Category: Infectious Diseases Authors: Nikolaos Giannelos Bernard Francq Desmond Curran Source Type: research
Medical students' knowledge about human papillomavirus (HPV), HPV vaccine and head and neck cancer
Hum Vaccin Immunother. 2024 Dec 31;20(1):2344248. doi: 10.1080/21645515.2024.2344248. Epub 2024 Apr 24.ABSTRACTThe Human Papillomavirus (HPV) is a sexually transmitted infection that significantly affects the population worldwide. HPV preventive methods include vaccination, prophylactics, and education. Different types of cancers associated with HPV usually take years or decades to develop after infections, such as Head and Neck Cancer(HNC). Therefore, HPV prevention can be considered cancer prevention. A sample of medical students in Puerto Rico was evaluated to assess their knowledge about HPV, HPV vaccine, and HNC throu...
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Norangelys Solis-Torres Isardo Braverman-Diaz Luis A Rivera-Morales Jose J Perez-Sanchez Valeria S Perez-Bravo Angel J Neris-Sanchez Alexis Vera Yaritza Diaz-Algorri Source Type: research
