Brazilian Ministry of Health strategy to increase vaccination coverage at bordersEstrategia del Ministerio de Salud de Brasil para aumentar las tasas de cobertura de vacunaci ón en las fronteras
CONCLUSION: There was an increase in vaccination coverage in children up to 1 year of age in the locations evaluated after the intervention, helping to increase VC in Brazil.PMID:38686133 | PMC:PMC11053370 | DOI:10.26633/RPSP.2024.31 (Source: Pan American Journal of Public Health)
Source: Pan American Journal of Public Health - April 30, 2024 Category: International Medicine & Public Health Authors: Luciana Maiara Diogo Nascimento Ana Catarina de Melo Ara újo Priscila Caldeira Alencar de Souza Fernanda Penido Matozinhos Thales Philipe Rodrigues da Silva Eder Gatti Fernandes Source Type: research
Space-time heterogeneity of measles, mumps, and rubella vaccination indicators in children from BrazilHeterogeneidad espaciotemporal de los indicadores de inmunizaci ón con la vacuna triple viral en la población infantil de Brasil
CONCLUSIONS: In some Brazilian regions, the dropout rate has been high since 2014, signaling a risk of measles resurgence. In turn, space-time analysis indicated lower vaccination coverage in 2020, suggesting the influence of the COVID-19 pandemic.PMID:38686134 | PMC:PMC11053372 | DOI:10.26633/RPSP.2024.34 (Source: Pan American Journal of Public Health)
Source: Pan American Journal of Public Health - April 30, 2024 Category: International Medicine & Public Health Authors: L ívia de Lima Moura Mercedes Neto Reinaldo Souza-Santos Source Type: research
Cross-protection against influenza viruses by chimeric M2e-H3 stalk protein or multi-subtype neuraminidase plus M2e virus-like particle vaccine in ferrets
Virology. 2024 Apr 25;595:110097. doi: 10.1016/j.virol.2024.110097. Online ahead of print.ABSTRACTCurrent influenza vaccine is not effective in providing cross-protection against variants. We evaluated the immunogenicity and efficacy of multi-subtype neuraminidase (NA) and M2 ectodomain virus-like particle (m-cNA-M2e VLP) and chimeric M2e-H3 stalk protein vaccines (M2e-H3 stalk) in ferrets. Our results showed that ferrets with recombinant m-cNA-M2e VLP or M2e-H3 stalk vaccination induced multi-vaccine antigen specific IgG antibodies (M2e, H3 stalk, NA), NA inhibition, antibody-secreting cells, and IFN-γ secreting cell res...
Source: Virology - April 30, 2024 Category: Virology Authors: Ki-Hye Kim Noopur Bhatnagar Jeeva Subbiah Rong Liu Surya Sekhar Pal Jannatul Ruhan Raha Phillip Grovenstein Chong Hyun Shin Bao-Zhong Wang Sang-Moo Kang Source Type: research
Reduced Immunogenicity of COVID-19 Vaccine in Obese Patients with Type 2 Diabetes: A Cross-Sectional Study
Acta Med Okayama. 2024 Apr;78(2):185-191. doi: 10.18926/AMO/66927.ABSTRACTThe global pandemic of coronavirus infection 2019 (COVID-19) was an unprecedented public health emergency. Several clinical studies reported that heart disease, lung disease, diabetes, hypertension, dyslipidemia, and obesity are critical risk factors for increased severity of and hospitalization for COVID-19. This is largely because patients with these underlying medical conditions can show poor immune responses to the COVID-19 vaccinations. Diabetes is one of the underlying conditions most highly associated with COVID-19 susceptibility and is consid...
Source: Acta Medica Okayama - April 30, 2024 Category: General Medicine Authors: Hiroko Takahashi Jun Eguchi Mayu Watanabe Masanori Nakayama Jun Wada Source Type: research
Size effect of mesoporous silica nanoparticles on regulating the immune effect of oral influenza split vaccine
Colloids Surf B Biointerfaces. 2024 Apr 16;238:113920. doi: 10.1016/j.colsurfb.2024.113920. Online ahead of print.ABSTRACTMucosal immunization is a powerful weapon against viral infection. In this paper, large pore mesoporous silica nanoparticles (LMSN) with different particle sizes were synthesized for loading influenza split vaccine (SV) to explore the effect of nanoparticle sizes on mucosal immunization and adjuvant efficacy. Interestingly, it was found that among the three particle sizes of nanoparticles, only LMSN-M with around 250 nm could significantly enhance the mucosal immune effect of SV, possessing adjuvant eff...
Source: Colloids and Surfaces - April 30, 2024 Category: Biotechnology Authors: Zhu Liu Hongyan Lu Shi Li Bin Liu Qinfu Zhao Yikun Gao Yuling Mao Jinghai Zhang Siling Wang Source Type: research
Reduction in Acute Post-Streptococcal Glomerulonephritis Incidence in Counties Manukau, New Zealand, after the COVID-19 Pandemic
We describe a marked, sustained reduction in APSGN hospitalizations, temporally associated with the COVID-19 pandemic. This ongoing reduction in APSGN incidence is notable in light of contrasting reports of increasing incidence of rheumatic fever in New Zealand and invasive GAS disease internationally.PMID:38688264 | DOI:10.4269/ajtmh.23-0762 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - April 30, 2024 Category: Infectious Diseases Authors: Amanda Taylor Jocelyn Neutze Nicole J Moreland Rachel Webb Source Type: research
Using UAV Images and Deep Learning in Investigating Potential Breeding Sites of Aedes albopictus
Acta Trop. 2024 Apr 28:107234. doi: 10.1016/j.actatropica.2024.107234. Online ahead of print.ABSTRACTAedes albopictus (Diptera: Culicidae) plays a crucial role as a vector for mosquito-borne diseases like dengue and zika. Given the limited availability of effective vaccines, the prevention of Aedes-borne diseases mainly relies on extensive efforts in vector surveillance and control. In multiple mosquito control methods, the identification and elimination of potential breeding sites (PBS) for Aedes are recognized as effective methods for population control. Previous studies utilizing unmanned aerial vehicles (UAVs) and deep...
Source: Acta Tropica - April 30, 2024 Category: Infectious Diseases Authors: Keyi Yu Jianping Wu Minghao Wang Yizhou Cai Minhui Zhu Shenjun Yao Yibin Zhou Source Type: research
Exploring the genetic diversity pattern of PvEBP/DBP2: A promising candidate for an effective Plasmodium vivax vaccine
Acta Trop. 2024 Apr 27:107231. doi: 10.1016/j.actatropica.2024.107231. Online ahead of print.ABSTRACTMalaria remains a public health challenge. Since many control strategies have proven ineffective in eradicating this disease, new strategies are required, among which the design of a multivalent vaccine stands out. However, the effectiveness of this strategy has been hindered, among other reasons, by the genetic diversity observed in parasite antigens. In Plasmodium vivax, the Erythrocyte Binding Protein (PvEBP, also known as DBP2) is an alternate ligand to Duffy Binding Protein (DBP); given its structural resemblance to DB...
Source: Acta Tropica - April 30, 2024 Category: Infectious Diseases Authors: Laura J Hern ández-Zambrano Heliairis Alfonso-Gonz ález Sindy P Buitrago Carlos J Castro-Cavad ía Diego Garz ón-Ospina Source Type: research
Herpes zoster vaccination and the risk of dementia: A systematic review and meta-analysis
CONCLUSION: Herpes zoster vaccination is associated with a reduction of the risk of dementia. More epidemiological studies are needed to confirm the association.PMID:38687552 | PMC:PMC10839537 | DOI:10.1002/brb3.3415 (Source: Herpes)
Source: Herpes - April 30, 2024 Category: Infectious Diseases Authors: Sangam Shah Krishna Dahal Sangharsha Thapa Prativa Subedi Basanta Sharma Paudel Swati Chand Amr Salem Markus Lammle Ranjit Sah Martin Krsak Source Type: research
Reduced Immunogenicity of COVID-19 Vaccine in Obese Patients with Type 2 Diabetes: A Cross-Sectional Study
Acta Med Okayama. 2024 Apr;78(2):185-191. doi: 10.18926/AMO/66927.ABSTRACTThe global pandemic of coronavirus infection 2019 (COVID-19) was an unprecedented public health emergency. Several clinical studies reported that heart disease, lung disease, diabetes, hypertension, dyslipidemia, and obesity are critical risk factors for increased severity of and hospitalization for COVID-19. This is largely because patients with these underlying medical conditions can show poor immune responses to the COVID-19 vaccinations. Diabetes is one of the underlying conditions most highly associated with COVID-19 susceptibility and is consid...
Source: Acta Med Okayama - April 30, 2024 Category: Universities & Medical Training Authors: Hiroko Takahashi Jun Eguchi Mayu Watanabe Masanori Nakayama Jun Wada Source Type: research
Reduction in Acute Post-Streptococcal Glomerulonephritis Incidence in Counties Manukau, New Zealand, after the COVID-19 Pandemic
We describe a marked, sustained reduction in APSGN hospitalizations, temporally associated with the COVID-19 pandemic. This ongoing reduction in APSGN incidence is notable in light of contrasting reports of increasing incidence of rheumatic fever in New Zealand and invasive GAS disease internationally.PMID:38688264 | DOI:10.4269/ajtmh.23-0762 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - April 30, 2024 Category: Tropical Medicine Authors: Amanda Taylor Jocelyn Neutze Nicole J Moreland Rachel Webb Source Type: research
Vaccine effectiveness against COVID-19 related hospital admission in the Netherlands by medical risk condition: A test-negative case-control study
CONCLUSION: Although VE against hospitalization was 78% and increased to 89% after boosting during the Delta-dominant study period, VE was lower in certain high risk groups, for which indirect protection or other protective measures might be of added importance.PMID:38688804 | DOI:10.1016/j.vaccine.2024.04.017 (Source: Vaccine)
Source: Vaccine - April 30, 2024 Category: Allergy & Immunology Authors: F A Niessen P C J L Bruijning-Verhagen M J M Bonten VECTOR study group M J Knol Source Type: research
Effects of parental childhood cultural health environment on children's influenza and COVID-19 vaccination status
We examined whether the childhood cultural health environment (CHE) of parents (measured by self-reported regular attendance at doctor and dentist visits during childhood) was associated with flu and COVID-19 vaccination of their children. Using 2023 survey data from 397 US parents and causal inference methods, we estimated the average causal effect of parental CHE on flu vaccination rates (0.16 [95 % confidence interval: 0.06,0.27]) and COVID-19 (0.14 [95 % confidence interval: 0.04,0.24]), indicating that if all parents had attended regular doctor/dentist visits as children, flu and COVID-19 vaccination rates in children...
Source: Vaccine - April 30, 2024 Category: Allergy & Immunology Authors: Sasha A Fleary Zachary Shahn Chloe A Teasdale Source Type: research
Size effect of mesoporous silica nanoparticles on regulating the immune effect of oral influenza split vaccine
Colloids Surf B Biointerfaces. 2024 Apr 16;238:113920. doi: 10.1016/j.colsurfb.2024.113920. Online ahead of print.ABSTRACTMucosal immunization is a powerful weapon against viral infection. In this paper, large pore mesoporous silica nanoparticles (LMSN) with different particle sizes were synthesized for loading influenza split vaccine (SV) to explore the effect of nanoparticle sizes on mucosal immunization and adjuvant efficacy. Interestingly, it was found that among the three particle sizes of nanoparticles, only LMSN-M with around 250 nm could significantly enhance the mucosal immune effect of SV, possessing adjuvant eff...
Source: Colloids and Surfaces - April 30, 2024 Category: Biotechnology Authors: Zhu Liu Hongyan Lu Shi Li Bin Liu Qinfu Zhao Yikun Gao Yuling Mao Jinghai Zhang Siling Wang Source Type: research
Cross-protection against influenza viruses by chimeric M2e-H3 stalk protein or multi-subtype neuraminidase plus M2e virus-like particle vaccine in ferrets
Virology. 2024 Apr 25;595:110097. doi: 10.1016/j.virol.2024.110097. Online ahead of print.ABSTRACTCurrent influenza vaccine is not effective in providing cross-protection against variants. We evaluated the immunogenicity and efficacy of multi-subtype neuraminidase (NA) and M2 ectodomain virus-like particle (m-cNA-M2e VLP) and chimeric M2e-H3 stalk protein vaccines (M2e-H3 stalk) in ferrets. Our results showed that ferrets with recombinant m-cNA-M2e VLP or M2e-H3 stalk vaccination induced multi-vaccine antigen specific IgG antibodies (M2e, H3 stalk, NA), NA inhibition, antibody-secreting cells, and IFN-γ secreting cell res...
Source: Virology - April 30, 2024 Category: Virology Authors: Ki-Hye Kim Noopur Bhatnagar Jeeva Subbiah Rong Liu Surya Sekhar Pal Jannatul Ruhan Raha Phillip Grovenstein Chong Hyun Shin Bao-Zhong Wang Sang-Moo Kang Source Type: research
