Viruses, Vol. 16, Pages 730: Regional Variation of the CD4 and CD8 T Cell Epitopes Conserved in Circulating Dengue Viruses and Shared with Potential Vaccine Candidates
nmol Chandele
As dengue expands globally and many vaccines are under trials, there is a growing recognition of the need for assessing T cell immunity in addition to assessing the functions of neutralizing antibodies during these endeavors. While several dengue-specific experimentally validated T cell epitopes are known, less is understood about which of these epitopes are conserved among circulating dengue viruses and also shared by potential vaccine candidates. As India emerges as the epicenter of the dengue disease burden and vaccine trials commence in this region, we have here aligned known dengue specific T cell ep...
Source: Viruses - May 5, 2024 Category: Virology Authors: Yadya M. Chawla Prashant Bajpai Keshav Saini Elluri Seetharami Reddy Ashok Kumar Patel Kaja Murali-Krishna Anmol Chandele Tags: Article Source Type: research
Development and assessment of a multiepitope synthetic antigen for the diagnosis of Dengue virus infection
Braz J Infect Dis. 2024 May 1:103746. doi: 10.1016/j.bjid.2024.103746. Online ahead of print.ABSTRACTImmunodiagnostic tests for detecting dengue virus infections encounter challenges related to cross-reactivity with other related flaviviruses. Our research focuses on the development of a synthetic multiepitope antigen tailored for dengue immunodiagnostics. Selected dengue epitopes involved structural linearity and dissimilarity from the proteomes of Zika and Yellow fever viruses which served for computationally modeling the three-dimensional protein structure, resulting in the design of two proteins: rDME-C and rDME-BR. Bo...
Source: Braz J Infect Dis - May 4, 2024 Category: Infectious Diseases Authors: Isis Botelho Nunes da Silva Juliano de Moraes Rodrigues Ramon Cid Gismonti Batista Vivian Dos Santos Gomes Clarissa de Souza Chacon Marcius da Silva Almeida Talita Stelling de Araujo Bianca Ortiz da Silva Terezinha Marta Pereira Pinto Casti ñeiras Orland Source Type: research
Determinants of uptake of influenza, zoster and pneumococcal vaccines in patients with cardiovascular diseases
CONCLUSION: Influenza, pneumococcal and zoster vaccine uptake among cardiac patients was low. Encouraging physician recommendations for vaccination for cardiac patients under 65 years of age and addressing vaccination challenges among people from culturally and linguistically diverse backgrounds and pharmacy, workplace, and hospital vaccination may help increase vaccination uptake among cardiac patients.PMID:38704255 | DOI:10.1016/j.vaccine.2024.04.031 (Source: Herpes)
Source: Herpes - May 4, 2024 Category: Infectious Diseases Authors: Elizabeth Benedict Kpozehouen C Raina Macintyre Timothy C Tan Source Type: research
A novel vaccine strategy against Brucellosis using Brucella abortus multi-epitope OMPs vaccine based on Lactococcus lactis live bacterial vectors
This study evaluated the effectiveness of orally administering Lactococcus lactis (L. lactis) for producing the Brucella abortus multi-epitope OMPs peptide. A multi-epitope plasmid was generated through a reverse vaccinology method, and mice were administered the genetically modified L. lactis orally as a vaccine. The plasmid underwent digestion, synthesizing a 39 kDa-sized protein known as OMPs by the target group. The sera of mice that were administered the pNZ8124-OMPs-L. lactis vaccine exhibited a notable presence of IgG1 antibodies specific to outer membrane proteins (OMPs), heightened levels of interferon (IFN-λ) an...
Source: International Immunopharmacology - May 4, 2024 Category: Allergy & Immunology Authors: Tohid Piri-Gharaghie Ghazal Ghajari Golnoosh Rezaeizadeh Mohaned Adil Mohammed H Mahdi Source Type: research
Effectiveness of 13-valent pneumococcal conjugate vaccine for prevention of invasive pneumococcal disease among children in the United States between 2010 and 2019: An indirect cohort study
CONCLUSIONS: At least three doses of PCV13 continue to be effective in preventing VT-IPD among children aged < 5 years in the US. PCV13 was protective against serotypes 19A and 19F IPD; protection against serotype 3 IPD did not reach statistical significance.PMID:38704263 | DOI:10.1016/j.vaccine.2024.04.061 (Source: Vaccine)
Source: Vaccine - May 4, 2024 Category: Allergy & Immunology Authors: Kristin L Andrejko Ryan Gierke Jemma V Rowlands Jennifer B Rosen Ann Thomas Zachary Q Landis Maria Rosales Sue Petit William Schaffner Corinne Holtzman Meghan Barnes Monica M Farley Lee H Harrison Lesley McGee Sopio Chochua Jennifer R Verani Adam L Cohen Source Type: research
Examining the influence of community leaders and other community actors on immunisation practices in Australia: A national cross-sectional study
CONCLUSION: Significant variations in vaccine practices and vaccine information-seeking behaviours were found, especially in those who speak a language other than English. To enhance vaccine uptake and to address vaccine hesitancy in Australia, vaccine promotion strategies and health communication efforts require significant consideration of information accessibility and communication source preferences.PMID:38704260 | DOI:10.1016/j.vaccine.2024.04.076 (Source: Vaccine)
Source: Vaccine - May 4, 2024 Category: Allergy & Immunology Authors: Pippa McDermid Ikram Abdi Kinza Mustafa Katrina Blazek Ben Harris-Roxas Chris J Jackson Holly Seale Source Type: research
Factors associated with vaccination intention and uptake over time in a sample of older Australians
This study sought to identify the behavioural and social drivers of vaccination in 16,745 older Australians. We analysed and compared influences on COVID-19 vaccination intention and uptake using prospectively collected survey data from the Sax Institute's 45 and Up Study. Vaccination intention increased with older age (adjusted odds ratio [aOR]:1.03; 95 % confidence interval [CI]: 1.01-1.04; p = .002), a belief that the vaccine is important for the person's own health (aOR: 5.17; 95 % CI: 4.23-6.24; p < .001), is safe (aOR:2.64; 95 % CI: 2.19-3.2; p < .001), and trusted by the person (aOR:6.79; 95 % CI: 5.59-8.26 p ...
Source: Vaccine - May 4, 2024 Category: Allergy & Immunology Authors: Maria Christou-Ergos Kerrin Bleicher Julie Leask Source Type: research
Introduction of the smallpox vaccine in Napoleonic France, as recorded in contemporary medals
Vaccine. 2024 May 3:S0264-410X(24)00503-6. doi: 10.1016/j.vaccine.2024.04.064. Online ahead of print.ABSTRACTThe smallpox vaccine developed by Jenner in 1798 was successfully introduced in France in 1800 with the support of Napoleon Bonaparte. The medals and tokens (coin-like medals) issued to encourage early-day vaccination activities are described in the context of the changing political situation in that country. In 1800 a private society of subscribers, led by the Duke of La Rochefoucauld-Liancourt was created, along with a Vaccine Committee charged with evaluating the safety and efficacy of vaccination before deciding...
Source: Vaccine - May 4, 2024 Category: Allergy & Immunology Authors: Jos é Esparza Source Type: research
Assessment of potential adverse events following the 2022-2023 seasonal influenza vaccines among U.S. adults aged 65 years and older
CONCLUSIONS: Rates of encephalitis/encephalomyelitis, GBS, or transverse myelitis were not elevated following 2022-2023 seasonal influenza vaccinations among U.S. adults ≥ 65 years. There was an increased rate of anaphylaxis following influenza vaccination that may have been influenced by concomitant vaccination.PMID:38704258 | DOI:10.1016/j.vaccine.2024.04.051 (Source: Vaccine)
Source: Vaccine - May 4, 2024 Category: Allergy & Immunology Authors: Xiangyu Chianti Shi Joann F Gruber Michelle Ondari Patricia C Lloyd Pablo Freyria Duenas Tainya C Clarke Gita Nadimpalli Sylvia Cho Laurie Feinberg Mao Hu Yoganand Chillarige Jeffrey A Kelman Richard A Forshee Steven A Anderson Azadeh Shoaibi Source Type: research
Exploring the effect of clinical case definitions on influenza vaccine effectiveness estimation at primary care level: Results from the end-of-season 2022-23 VEBIS multicentre study in Europe
DISCUSSION: Among all analyses, we found similar VE estimates between the EU ILI and EU ARI populations, with few (10%) additional non-ILI ARI patients recruited. These results indicate that VE in the 2022-23 influenza season was not affected by use of a different clinical case definition for recruitment, although we recommend investigating whether this holds true for next seasons.PMID:38704257 | DOI:10.1016/j.vaccine.2024.04.060 (Source: Vaccine)
Source: Vaccine - May 4, 2024 Category: Allergy & Immunology Authors: Marine Maurel Clara Mazagatos Luise Goerlitz Beatrix Oroszi Mariette Hooiveld Ausenda Machado Lisa Domegan Maja Ili ć Rodica Popescu No émie Sève Iv án Martínez-Baz Amparo Larrauri Silke Buda Gerg ő Túri Adam Meijer Ver ónica Gomez Joan O'Donnell Source Type: research
An intranasal nanoparticle vaccine elicits protective immunity against Mycobacterium tuberculosis
In this study, we tested NanoSTING, a liposomal formulation of the endogenous activator of the stimulator of interferon genes (STING) pathway, cyclic guanosine adenosine monophosphate (cGAMP), as a mucosal adjuvant. We formulated a vaccine based on the H1 antigen (fusion protein of Ag85b and ESAT-6) adjuvanted with NanoSTING. Intranasal immunization of NanoSTING-H1 elicited a strong T-cell response in the lung of vaccinated animals characterized by (a) CXCR3+ KLRG1- lung resident T cells that are known to be essential for controlling bacterial infection, (b) IFNγ-secreting CD4+ T cells which is necessary for intracellular...
Source: Vaccine - May 4, 2024 Category: Allergy & Immunology Authors: K M Samiur Rahman Sefat Monish Kumar Stephanie Kehl Rohan Kulkarni Ankita Leekha Melisa-Martinez Paniagua David F Ackart Nicole Jones Charles Spencer Brendan K Podell Hugues Ouellet Navin Varadarajan Source Type: research
Determinants of uptake of influenza, zoster and pneumococcal vaccines in patients with cardiovascular diseases
CONCLUSION: Influenza, pneumococcal and zoster vaccine uptake among cardiac patients was low. Encouraging physician recommendations for vaccination for cardiac patients under 65 years of age and addressing vaccination challenges among people from culturally and linguistically diverse backgrounds and pharmacy, workplace, and hospital vaccination may help increase vaccination uptake among cardiac patients.PMID:38704255 | DOI:10.1016/j.vaccine.2024.04.031 (Source: Vaccine)
Source: Vaccine - May 4, 2024 Category: Allergy & Immunology Authors: Elizabeth Benedict Kpozehouen C Raina Macintyre Timothy C Tan Source Type: research
The impact of COVID-19 vaccination campaign on pediatric vaccine uptake based on parents' attitudes towards mandatory and recommended vaccination in Southern Italy
CONCLUSIONS: The study underscores the importance of co-administration approaches and well-planned vaccination schedules in enhancing vaccine coverage. It suggests that integrating newer vaccines, like the COVID-19 vaccine, into established vaccination schedules could potentially increase acceptance and coverage. The findings highlight the urgency of addressing vaccine hesitancy, particularly in the pediatric population, to ensure high vaccination coverage and effective disease control. Further research is needed to explore the potential strategies to increase vaccine acceptance.PMID:38704254 | DOI:10.1016/j.vaccine.2024.0...
Source: Vaccine - May 4, 2024 Category: Allergy & Immunology Authors: Francesco Baglivo Luigi De Angelis Mariano Magr ì Ingrid De Nicola Erica De Vita Pietro Luigi Lopalco Caterina Rizzo Alberto Fedele Source Type: research
Evaluation of the precision of the Plasmodium knowlesi growth inhibition assay for Plasmodium vivax Duffy-binding protein-based malaria vaccine development
Vaccine. 2024 May 3:S0264-410X(24)00514-0. doi: 10.1016/j.vaccine.2024.04.073. Online ahead of print.ABSTRACTRecent data indicate increasing disease burden and importance of Plasmodium vivax (Pv) malaria. A robust assay will be essential for blood-stage Pv vaccine development. Results of the in vitro growth inhibition assay (GIA) with transgenic P. knowlesi (Pk) parasites expressing the Pv Duffy-binding protein region II (PvDBPII) correlate with in vivo protection in the first PvDBPII controlled human malaria infection (CHMI) trials, making the PkGIA an ideal selection tool once the precision of the assay is defined. To de...
Source: Vaccine - May 4, 2024 Category: Allergy & Immunology Authors: Jonas E Mertens Cassandra A Rigby Martino Bardelli Doris Quinkert Mimi M Hou Ababacar Diouf Sarah E Silk Chetan E Chitnis Angela M Minassian Robert W Moon Carole A Long Simon J Draper Kazutoyo Miura Source Type: research
Predicting vaccination hesitancy: The role of basic needs satisfaction and institutional trust
Vaccine. 2024 May 3:S0264-410X(24)00507-3. doi: 10.1016/j.vaccine.2024.04.068. Online ahead of print.ABSTRACTAutonomous motivation is considered a powerful driver of health behaviour, but less is known about the specific roles played by basic needs. Drawing on the context of the COVID-19 pandemic, this research examined basic needs as a motivational determinant of vaccination. We hypothesized that satisfaction of basic needs (autonomy, competence, relatedness) has both a direct and an indirect effect (through trust in science and government) on vaccine hesitancy. Two studies (Study 1: N = 968 French and British; Study 2, p...
Source: Vaccine - May 4, 2024 Category: Allergy & Immunology Authors: Ga ëlle Marinthe Genavee Brown Mioara Cristea Maja Kutlaca Source Type: research
