Ureter and Renal Pelvis Cancer Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Attenuating Renal Interstitial Fibrosis by Shenqi Pill via Reducing Inflammation Response Regulated by NF-κB Pathway In Vitro and In Vivo
Conclusion. SQP has a reno-protective effect against RIF in vivo and in vitro, and the effect is partly linked to nuclear factor-kappa B (NF-κB) pathway related inflammatory response, which indicates that SQP may be a candidate drug for RIF. DOI: 10.52547/ijkd.7546.PMID:38660700 | DOI:10.5254/kv5ap920 (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - April 25, 2024 Category: Urology & Nephrology Authors: Hongshu Chen Yuanxiao Yang Xiaojie Zhou Yaorong Feng Source Type: research

Microvesicles from Mesenchymal Stem Cells Overexpressing MiR-34a Ameliorate Renal Fibrosis In Vivo
Conclusion. Our study demonstrates that miR34a further enhances the effects of MSC-MV on renal fibrosis in mice through the regulation of epithelial-to-mesenchymal transition (EMT) and Notch pathway. miR-34a may be a candidate molecular therapeutic target for the treatment of renal fibrosis. DOI: 10.52547/ijkd.7673.PMID:38660698 | DOI:10.5254/s9bdqs74 (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - April 25, 2024 Category: Urology & Nephrology Authors: Yan Wang Ping Hu Yangping Li Ruijuan Dong Juan He Source Type: research

CD226 promotes renal fibrosis by regulating macrophage activation and migration
J Leukoc Biol. 2024 Apr 25:qiae054. doi: 10.1093/jleuko/qiae054. Online ahead of print.ABSTRACTIt has been found that CD226 plays an important role in regulating macrophage function, but its expression and function in macrophages during renal fibrogenesis have not been studied. Our data demonstrated that CD226 expression in macrophages was obviously upregulated in the unilateral ureteral obstruction model, while CD226 deficiency attenuated collagen deposition in renal interstitium along with fewer M1 within renal cortex and renal medulla and a lower level of proinflammatory factors compared to that of control littermates. ...
Source: Journal of Leukocyte Biology - April 25, 2024 Category: Hematology Authors: Yun Song Yazhen Wang Juan Li Yuting Shen Yongli Hou Zhaoyue Fu Liang Fang Boquan Jin Lihua Chen Source Type: research

Predictive role of ureteral wall thickness and patient characteristics in endoscopic treatment outcomes for ureteral stricture disease following stone surgery
ConclusionsOur current results indicated that assessment of UWT value at the obstructing stone could be helpful enough to predict the likelihood of failure following endoscopic management of strictures with high sensitivity and specificity. Evaluation of this particular parameter could let the endourologists to look for more rational treatment alternatives with necessary measures taken on time. (Source: World Journal of Urology)
Source: World Journal of Urology - April 25, 2024 Category: Urology & Nephrology Source Type: research

Exosomes From Human Umbilical Cord Stem Cells Suppress Macrophage-to-myofibroblast Transition, Alleviating Renal Fibrosis
This study investigates their potential to lessen renal fibrosis by targeting macrophage-to-myofibroblast transformation (MMT), a key driver of fibrosis. We employed a mouse model of unilateral ureteral obstruction (UUO) and cultured cells exposed to transforming growth factor-β (TGF-β) to mimic MMT. HucMSC-Exos were administered to UUO mice, and their effects on kidney function and fibrosis were assessed. Additionally, RNA sequencing and cellul ar analysis were performed to elucidate the mechanisms by which HucMSC-Exos inhibit MMT. HucMSC-Exos treatment significantly reduced kidney damage and fibrosis in UUO mice. Th...
Source: Inflammation - April 25, 2024 Category: Allergy & Immunology Source Type: research

Percutaneous nephrolithotomy or flexible ureteral lithotripsy, which one is better for patients with upper ureteral calculi of 1.5 –2.0 cm in diameter
First research to evaluate the clinical efficacy and safety of flexible ureteral lithotripsy (FURSL) and percutaneous nephrolithotomy (PCNL) in the treatment of the upper ureteral stone is between 1.5 cm and 2... (Source: BMC Urology)
Source: BMC Urology - April 25, 2024 Category: Urology & Nephrology Authors: Wenpu Chen, Hengda Hu and Guofeng Yu Tags: Research Source Type: research