Ureter and Renal Pelvis Cancer Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Hypermethylation leads to the loss of HOXA5, resulting in JAG1 expression and NOTCH signaling contributing to kidney fibrosis
Epigenetic regulations, including DNA methylation, are critical to the development and progression of kidney fibrosis, but the underlying mechanisms remain elusive. Here, we show that fibrosis of the mouse kidney was associated with the induction of DNA methyltransferases and increases in global DNA methylation and was alleviated by the DNA methyltransferase inhibitor 5-Aza-2 ’-deoxycytidine (5-Aza). Genome wide analysis demonstrated the hypermethylation of 94 genes in mouse unilateral ureteral obstruction kidneys, which was markedly reduced by 5-Aza. (Source: Kidney International)
Source: Kidney International - March 21, 2024 Category: Urology & Nephrology Authors: Xiao Xiao, Wei Wang, Chunyuan Guo, Jiazhu Wu, Sheng Zhang, Huidong Shi, Sangho Kwon, Jiankang Chen, Zheng Dong Tags: basic research Source Type: research

Genitourinary Fistula: 5 Years ’ Experience of Five Referral Centers in Iran
ConclusionsOur patients with genitourinary fistula had a successful outcome following repair techniques, without any significant morbidity or mortality. (Source: International Urogynecology Journal)
Source: International Urogynecology Journal - March 21, 2024 Category: OBGYN Source Type: research

Genitourinary Fistula: 5 Years ’ Experience of Five Referral Centers in Iran
ConclusionsOur patients with genitourinary fistula had a successful outcome following repair techniques, without any significant morbidity or mortality. (Source: International Urogynecology Journal and Pelvic Floor Dysfunction)
Source: International Urogynecology Journal and Pelvic Floor Dysfunction - March 21, 2024 Category: OBGYN Source Type: research

Network pharmacology and experimental validation to reveal the pharmacological mechanisms of Sini decoction against renal fibrosis
J Tradit Chin Med. 2024 Apr;44(2):362-372. doi: 10.19852/j.cnki.jtcm.20230630.003.ABSTRACTOBJECTIVE: To investigate the mechanism by which Sini decoction (, SND) improves renal fibrosis (Rf) in rats based on transforming growth factor β1/Smad (TGF-β1/Smad) signaling pathway.METHODS: Network pharmacology was applied to obtain potentially involved signaling pathways in SND's improving effects on Rf. The targets of SND drug components and the targets of Rf were obtained by searching databases, such as the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCSMP) and GeenCard. The intersection ...
Source: Journal of Traditional Chinese Medicine - March 20, 2024 Category: Complementary Medicine Authors: Wang Yan Deng Fanying Liu Shiqi Wang Yingli Source Type: research

Spasmolytic Effect of Flopropione Does Not Involve Catechol-O- methyltransferase (COMT) Inhibition
Biol Pharm Bull. 2024;47(3):660-668. doi: 10.1248/bpb.b23-00808.ABSTRACTFlopropione (Flo) has been used for gallstone and urolithiasis as a spasmolytic agent almost exclusively in Japan. According to the package insert, its main mechanism is catechol-O-methyltransferase (COMT) inhibition and anti-serotonergic effect. This is obviously contrary to pharmacological common sense, but it is described that way in pharmacology textbooks and occurs in questions in the National Examination for Pharmacists in Japan. As this is a serious problem in education, we re-examined the action of Flo. The guinea pig ureter was hardly contract...
Source: Biological and Pharmaceutical Bulletin - March 20, 2024 Category: Drugs & Pharmacology Authors: Yoko Amagase Mari Hoshiyama Shiho Hasegawa Miwa Kanbara Yumiko Mizukawa Tetsuro Urushidani Source Type: research