Ureter and Renal Pelvis Cancer Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Early growth response protein 2 promotes partial epithelial-mesenchymal transition by phosphorylating Smad3 during renal fibrosis
In conclusion, this study demonstrated that EGR2 played a pathogenic role in renal fibrosis by a p-STAT3-EGR2-p-Smad3 axis. Thus, targeting EGR2 could be a promising strategy for CKD treatment.PMID:38679230 | DOI:10.1016/j.trsl.2024.04.005 (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - April 28, 2024 Category: Laboratory Medicine Authors: Anni Song Ruiwei Yan Wei Xiong Huiling Xiang Jing Huang Anni Jiang Chun Zhang Source Type: research

Peri- and post-operative outcomes of robot-assisted radical cystectomy after the implementation of the EAU guidelines recommendations for collecting and reporting complications at a high-volume referral center
ConclusionsThe rate of postoperative complications after RARC is > 90% when a standardized collection method and a long follow-up is implemented. These results should be used to identify potential areas of improvement and for preoperative patient counseling. (Source: World Journal of Urology)
Source: World Journal of Urology - April 28, 2024 Category: Urology & Nephrology Source Type: research

Iguratimod prevents renal fibrosis in unilateral ureteral obstruction model mice by suppressing M2 macrophage infiltration and macrophage-myofibroblast transition
This study aimed to investigate whether iguratimod could affect renal fibrosis progression. Three different concentrations of iguratimod (30 mg/kg/day, 10 mg/kg/day, and 3 mg/kg/day) were used to intervene in unilateral ureteral obstruction (UUO) model mice. Iguratimod at 10 mg/kg/day was observed to be effective in slowing UUO-mediated renal fibrosis. In addition, stimulating bone marrow-derived macrophages with IL-4 and/or iguratimod, or with TGF-β and iguratimod or SRC inhibitors in vitro, suggested that iguratimod mitigates the progression of renal fibrosis in UUO mice, at least in part, by inhibiting the IL-4/STAT6 s...
Source: Renal Failure - April 26, 2024 Category: Urology & Nephrology Authors: Yueyuan Zhou Zhilan Li Shenyi Yu Xuan Wang Tingting Xie Weiru Zhang Source Type: research

Role of the systemic immune-inflammation index in predicting spontaneous stone passage in patients with renal colic
CONCLUSION: Our findings showed that a low SII level was associated with SSP and could be used as a predictive marker of SSP as a more valuable parameter than NLR. SII and NLR, together with other indicators, are inflammatory markers that can be used in the clinical decision-making process for ureteral stone treatment.PMID:38669143 | DOI:10.1080/00325481.2024.2347198 (Source: Postgraduate Medicine)
Source: Postgraduate Medicine - April 26, 2024 Category: Internal Medicine Authors: H üseyin Mutlu Ekrem Taha Sert Kamil Kokulu Naz ım Abdulkadir Kankılıç Source Type: research

Low anterolateral incision for single-port extraperitoneal robot-assisted pyeloplasty: description of technique and initial experience
ConclusionSingle-port low anterolateral extraperitoneal pyeloplasty is a feasible alternative for surgical treatment of UPJO in adult and pediatric patients with improved recovery outcomes. (Source: World Journal of Urology)
Source: World Journal of Urology - April 26, 2024 Category: Urology & Nephrology Source Type: research

CD226 promotes renal fibrosis by regulating macrophage activation and migration
J Leukoc Biol. 2024 Apr 25:qiae054. doi: 10.1093/jleuko/qiae054. Online ahead of print.ABSTRACTIt has been found that CD226 plays an important role in regulating macrophage function, but its expression and function in macrophages during renal fibrogenesis have not been studied. Our data demonstrated that CD226 expression in macrophages was obviously upregulated in the unilateral ureteral obstruction model, while CD226 deficiency attenuated collagen deposition in renal interstitium along with fewer M1 within renal cortex and renal medulla and a lower level of proinflammatory factors compared to that of control littermates. ...
Source: Journal of Leukocyte Biology - April 25, 2024 Category: Hematology Authors: Yun Song Yazhen Wang Juan Li Yuting Shen Yongli Hou Zhaoyue Fu Liang Fang Boquan Jin Lihua Chen Source Type: research

Attenuating Renal Interstitial Fibrosis by Shenqi Pill via Reducing Inflammation Response Regulated by NF-κB Pathway In Vitro and In Vivo
Conclusion. SQP has a reno-protective effect against RIF in vivo and in vitro, and the effect is partly linked to nuclear factor-kappa B (NF-κB) pathway related inflammatory response, which indicates that SQP may be a candidate drug for RIF. DOI: 10.52547/ijkd.7546.PMID:38660700 | DOI:10.5254/kv5ap920 (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - April 25, 2024 Category: Urology & Nephrology Authors: Hongshu Chen Yuanxiao Yang Xiaojie Zhou Yaorong Feng Source Type: research

Microvesicles from Mesenchymal Stem Cells Overexpressing MiR-34a Ameliorate Renal Fibrosis In Vivo
Conclusion. Our study demonstrates that miR34a further enhances the effects of MSC-MV on renal fibrosis in mice through the regulation of epithelial-to-mesenchymal transition (EMT) and Notch pathway. miR-34a may be a candidate molecular therapeutic target for the treatment of renal fibrosis. DOI: 10.52547/ijkd.7673.PMID:38660698 | DOI:10.5254/s9bdqs74 (Source: Iranian Journal of Kidney Diseases)
Source: Iranian Journal of Kidney Diseases - April 25, 2024 Category: Urology & Nephrology Authors: Yan Wang Ping Hu Yangping Li Ruijuan Dong Juan He Source Type: research